{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:31:14Z","timestamp":1789871474605,"version":"4.0.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T00:00:00Z","timestamp":1304985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1007\/s12072-011-9277-8","type":"journal-article","created":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T15:31:34Z","timestamp":1304955094000},"page":"379-385","source":"Crossref","is-referenced-by-count":111,"title":["Clinical significance of serum autoantibodies in patients with NAFLD: results from the nonalcoholic steatohepatitis clinical research network"],"prefix":"10.1007","volume":"6","author":[{"name":"Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Vuppalanchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Gould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur","family":"Unalp-Arida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar W.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga","family":"Chalasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris V.","family":"Kowdley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,5,10]]},"reference":[{"issue":"5","key":"9277_CR1","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1572-0241.2003.07486.x","volume":"98","author":"JM Clark","year":"2003","unstructured":"Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003;98(5):960\u2013967","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"9277_CR2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/hep.21248","volume":"44","author":"JD Browning","year":"2006","unstructured":"Browning JD. Statins and hepatic steatosis: perspectives from the Dallas Heart Study. Hepatology 2006;44(2):466\u2013471","journal-title":"Hepatology"},{"issue":"3","key":"9277_CR3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cld.2004.04.004","volume":"8","author":"AJ McCullough","year":"2004","unstructured":"McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004;8(3):521\u201333. viii","journal-title":"Clin Liver Dis"},{"issue":"6","key":"9277_CR4","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1002\/hep.22622","volume":"48","author":"E Emanuele","year":"2008","unstructured":"Emanuele E. Is biopsy always necessary? Toward a clinico-laboratory approach for diagnosing nonalcoholic steatohepatitis in obesity. Hepatology 2008;48(6):2086\u20132087 (author reply 2087)","journal-title":"Hepatology"},{"issue":"35","key":"9277_CR5","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.3748\/wjg.15.4387","volume":"15","author":"Y Yilmaz","year":"2009","unstructured":"Yilmaz Y, Kedrah AE, Ozdogan O. Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis. World J Gastroenterol 2009;15(35):4387\u20134391","journal-title":"World J Gastroenterol"},{"issue":"11\u201312","key":"9277_CR6","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/j.1365-2036.2010.04480.x","volume":"32","author":"R Anty","year":"2010","unstructured":"Anty R, et al. A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients. Aliment Pharmacol Ther 2010;32(11\u201312):1315\u20131322","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"9277_CR7","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/hep.21496","volume":"45","author":"P Angulo","year":"2007","unstructured":"Angulo P, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007;45(4):846\u2013854","journal-title":"Hepatology"},{"issue":"6","key":"9277_CR8","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1053\/j.gastro.2004.08.052","volume":"127","author":"WM Rosenberg","year":"2004","unstructured":"Rosenberg WM, et al. Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology 2004;127(6):1704\u20131713","journal-title":"Gastroenterology"},{"issue":"2","key":"9277_CR9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/hep.21984","volume":"47","author":"IN Guha","year":"2008","unstructured":"Guha IN, et al. Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European Liver Fibrosis Panel and exploring simple markers. Hepatology 2008;47(2):455\u2013460","journal-title":"Hepatology"},{"key":"9277_CR10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-230X-6-6","volume":"6","author":"V Ratziu","year":"2006","unstructured":"Ratziu V, et al. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol 2006;6:6","journal-title":"BMC Gastroenterol"},{"issue":"7","key":"9277_CR11","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/j.1572-0241.2004.30444.x","volume":"99","author":"LA Adams","year":"2004","unstructured":"Adams LA, Lindor KD, Angulo P. The prevalence of autoantibodies and autoimmune hepatitis in patients with nonalcoholic fatty liver disease. Am J Gastroenterol 2004;99(7):1316\u20131320","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"9277_CR12","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s00535-005-1711-z","volume":"40","author":"S Yatsuji","year":"2005","unstructured":"Yatsuji S, et al. Diagnosing autoimmune hepatitis in nonalcoholic fatty liver disease: is the international autoimmune hepatitis group scoring system useful? J Gastroenterol 2005;40(12):1130\u20131138","journal-title":"J Gastroenterol"},{"issue":"11","key":"9277_CR13","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/j.1872-034X.2007.00150.x","volume":"37","author":"H Niwa","year":"2007","unstructured":"Niwa H, et al. Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis. Hepatol Res 2007;37(11):923\u2013931","journal-title":"Hepatol Res"},{"issue":"4","key":"9277_CR14","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0016-5085(94)90235-6","volume":"107","author":"BR Bacon","year":"1994","unstructured":"Bacon BR, et al. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994;107(4):1103\u20131109","journal-title":"Gastroenterology"},{"issue":"3","key":"9277_CR15","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/hep.510290347","volume":"29","author":"SH Caldwell","year":"1999","unstructured":"Caldwell SH, et al. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology 1999;29(3):664\u2013659","journal-title":"Hepatology"},{"issue":"5","key":"9277_CR16","first-page":"475","volume":"26","author":"N Laroussi","year":"2002","unstructured":"Laroussi N, et al. Non alcoholic steatohepatitis: a multifactorial, frequent, paucysymptomatic liver disease with a fibrotic outcome. Gastroenterol Clin Biol 2002;26(5):475\u2013479","journal-title":"Gastroenterol Clin Biol"},{"issue":"9","key":"9277_CR17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/01.mcg.0000139072.38580.a0","volume":"38","author":"SJ Cotler","year":"2004","unstructured":"Cotler SJ, et al. Prevalence and significance of autoantibodies in patients with non-alcoholic steatohepatitis. J Clin Gastroenterol 2004;38(9):801\u2013804","journal-title":"J Clin Gastroenterol"},{"issue":"11","key":"9277_CR18","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1023\/B:DDAS.0000004522.36120.08","volume":"48","author":"P Loria","year":"2003","unstructured":"Loria P, et al. Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: prevalence and correlates. Dig Dis Sci 2003;48(11):2173\u20132181","journal-title":"Dig Dis Sci"},{"issue":"100","key":"9277_CR19","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1572-0241.2005.41837_3.x","volume":"5","author":"P Loria","year":"2005","unstructured":"Loria P, Carulli N, Lonardo A. The prevalence of autoantibodies and autoimmune hepatitis in patients with nonalcoholic fatty liver disease letters to the editor. Am J Gastroenterol 2005;5(100):1200\u20131201","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"9277_CR20","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1572-0241.2005.41837_4.x","volume":"100","author":"A Adams","year":"2005","unstructured":"Adams A, Angulo P. Insulin resistance, auto-antibodies, and nonalcoholic fatty liver disease, response to letter. Am J Gastroenterol 2005;100(5):1201\u20131202","journal-title":"Am J Gastroenterol"},{"key":"9277_CR21","doi-asserted-by":"crossref","unstructured":"Nonalcoholic Steatohepatitis Clinical Research Network. Hepatology 2003;37:244.","DOI":"10.1002\/hep.510370203"},{"issue":"1","key":"9277_CR22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cct.2008.09.003","volume":"30","author":"NP Chalasani","year":"2009","unstructured":"Chalasani NP, et al. Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design. Contemp Clin Trials 2009;30(1):88\u201396","journal-title":"Contemp Clin Trials"},{"issue":"9","key":"9277_CR23","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/art.1780400909","volume":"40","author":"EM Tan","year":"1997","unstructured":"Tan EM, et al. Range of antinuclear antibodies in \u201chealthy\u201d individuals. Arthritis Rheum 1997;40(9):1601\u20131611","journal-title":"Arthritis Rheum"},{"issue":"6","key":"9277_CR24","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","volume":"41","author":"DE Kleiner","year":"2005","unstructured":"Kleiner DE, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41(6):1313\u20131321","journal-title":"Hepatology"},{"key":"9277_CR25","doi-asserted-by":"crossref","unstructured":"Syn WK, et al. Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. Hepatology 2010;51(6):1998\u20132007","DOI":"10.1002\/hep.23599"},{"issue":"3","key":"9277_CR26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1365-2249.2002.01910.x","volume":"129","author":"T Naito","year":"2002","unstructured":"Naito T, et al. Simultaneous activation of natural killer T cells and autoantibody production in mice injected with denatured syngeneic liver tissue. Clin Exp Immunol 2002;129(3):397\u2013404","journal-title":"Clin Exp Immunol"},{"key":"9277_CR27","doi-asserted-by":"crossref","unstructured":"Fujii Y et al. Co-appearance of autoantibody-producing B220(low) B cells with NKT cells in the course of hepatic injury. Cell Immunol 2010;260(2):105\u2013112","DOI":"10.1016\/j.cellimm.2009.09.009"},{"issue":"3","key":"9277_CR28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10165-009-0155-3","volume":"19","author":"M Satoh","year":"2009","unstructured":"Satoh M, Del Vazquez-Mercado M, Chan EK. Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases. Mod Rheumatol 2009;19(3):219\u2013228","journal-title":"Mod Rheumatol"},{"issue":"6","key":"9277_CR29","doi-asserted-by":"crossref","first-page":"1961e2","DOI":"10.1053\/j.gastro.2008.08.050","volume":"135","author":"HM Patton","year":"2008","unstructured":"Patton HM, et al. Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis. Gastroenterology 2008;135(6):1961e2\u20131971e2","journal-title":"Gastroenterology"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-011-9277-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12072-011-9277-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-011-9277-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T13:06:16Z","timestamp":1560171976000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12072-011-9277-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,10]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["9277"],"URL":"https:\/\/doi.org\/10.1007\/s12072-011-9277-8","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,10]]}}}