{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:44:58Z","timestamp":1784169898032,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Key Technology Support Program","award":["2014BAI03B01"],"award-info":[{"award-number":["2014BAI03B01"]}]},{"name":"National Key Scientific Instrument and Equipment Development Project of China","award":["2013YQ49085906"],"award-info":[{"award-number":["2013YQ49085906"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s12072-017-9841-y","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T04:07:16Z","timestamp":1515730036000},"page":"26-36","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Pathogenesis of non-alcoholic fatty liver disease mediated by YAP"],"prefix":"10.1007","volume":"12","author":[{"given":"Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Like","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,12]]},"reference":[{"key":"9841_CR1","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/ajg.2012.128","volume":"107","author":"N Chalasani","year":"2012","unstructured":"Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol 2012;107:811\u2013826","journal-title":"Am J Gastroenterol"},{"key":"9841_CR2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/MPG.0b013e31817e2bfb","volume":"47","author":"MB Vos","year":"2008","unstructured":"Vos MB, Barve S, Joshi BS, Carew JD, Whitington PF, McClain CJ. Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2008;47:481\u2013485","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"9841_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1053\/j.gastro.2005.04.014","volume":"129","author":"LA Adams","year":"2005","unstructured":"Adams LA, Lymp JF, Sauver JS, Sanderson SO, Lindor KD, Feldstein A, Angulo P. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology (Orlando) 2005;129:113\u2013121","journal-title":"Gastroenterology (Orlando)"},{"key":"9841_CR4","first-page":"5","volume":"40","author":"JM Clark","year":"2006","unstructured":"Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 2006;40:5\u201310","journal-title":"J Clin Gastroenterol"},{"key":"9841_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","volume":"64","author":"ZM Younossi","year":"2016","unstructured":"Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of non-alcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence and outcomes. Hepatology 2016;64:73\u201384","journal-title":"Hepatology"},{"key":"9841_CR6","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1038\/ncomms3823","volume":"4","author":"I Mederacke","year":"2013","unstructured":"Mederacke I, Hsu CC, Troeger JS, Huebener P, Mu X, Dapito DH, et al. Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun 2013;4:2823","journal-title":"Nat Commun"},{"key":"9841_CR7","doi-asserted-by":"publisher","first-page":"L344","DOI":"10.1152\/ajplung.00300.2014","volume":"308","author":"F Liu","year":"2015","unstructured":"Liu F, Lagares D, Choi KM, Stopfer L, Marinkovi\u0107 A, Vladimir V, et al. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. Am J Physiol Lung Cell Mol Physiol 2015;308:L344\u2013L357","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"9841_CR8","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/nrc3458","volume":"13","author":"KF Harvey","year":"2013","unstructured":"Harvey KF, Zhang X, Thomas DM. The Hippo pathway and human cancer. Nat Rev Cancer 2013;13:246\u201357","journal-title":"Nat Rev Cancer"},{"key":"9841_CR9","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1681\/ASN.2015050499","volume":"27","author":"SG Szeto","year":"2016","unstructured":"Szeto SG, Narimatsu M, Lu M, He XL, Sidiqi AM, Tolosa MF, et al. YAP\/TAZ are mechanoregulators of TGF-\u03b2-Smad signaling and renal fibrogenesis. J Am Soc Nephrol 2016;27:3117\u20133128","journal-title":"J Am Soc Nephrol"},{"key":"9841_CR10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1053\/j.gastro.2007.05.012","volume":"133","author":"M Richardson","year":"2007","unstructured":"Richardson M, Jonsson J, Powell E, Brunt E, Neuschwander-Tetri B, Bhathal PS, et al. Progressive fibrosis in nonalcoholic steato hepatitis: association with altered regeneration and a ductular reaction. Gastroenterology 2007;133:80\u201390","journal-title":"Gastroenterology"},{"key":"9841_CR11","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1002\/hep.27368","volume":"61","author":"M Ekstedt","year":"2015","unstructured":"Ekstedt M, Hagstr\u00f6m H, Nasr P, Fredrikson M, St\u00e5l P, Kechagias S, et al. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology 2015;61:1547\u20131554","journal-title":"Hepatology"},{"key":"9841_CR12","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","volume":"41","author":"DE Kleinerl","year":"2005","unstructured":"Kleinerl DE, Brunt EM, Natta MV, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313\u20131321","journal-title":"Hepatology"},{"key":"9841_CR13","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1002\/hep.20466","volume":"40","author":"JD Browning","year":"2004","unstructured":"Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Jonathan C, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40:1387\u20131395","journal-title":"Hepatology"},{"key":"9841_CR14","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.jhep.2005.02.042","volume":"43","author":"JG Fan","year":"2005","unstructured":"Fan JG, Zhu J, Li XJ, Chen L, Li L, Dai F, et al. Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. J Hepatol 2005;43:508\u2013514","journal-title":"J Hepatol"},{"key":"9841_CR15","first-page":"142","volume":"27","author":"N Hideyuki","year":"1988","unstructured":"Hideyuki N, Seizaburo K, Jun H, Wataru K, Shunichi T, Masashi G. Prevalence of fatty liver in a general population of Okinawa, Japan. Intern Med 1988;27:142\u2013149","journal-title":"Intern Med"},{"key":"9841_CR16","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/nm.3218","volume":"19","author":"VS LeBleul","year":"2013","unstructured":"LeBleul VS, Taduri G, O\u2019Connell J, Teng YQ, Cooke VG, Woda C, et al. Origin and function of myofibroblasts in kidney fibrosis. Nat Med 2013;19:1047\u20131053","journal-title":"Nat Med"},{"key":"9841_CR17","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.jhep.2015.04.011","volume":"63","author":"I Mannaerts","year":"2015","unstructured":"Mannaerts I, Leite SB, Verhulst S, Claerhout S, Eysackers N, Hoorens A, et al. The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. J Hepatol 2015;63:679\u2013688","journal-title":"J Hepatol"},{"key":"9841_CR18","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jhep.2015.05.031","volume":"63","author":"MV Machado","year":"2015","unstructured":"Machado MV, Michelotti GA, Pereira TA, Xie G, Premont R, Premont R, et al. Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease. J Hepatol 2015;63:962\u2013970","journal-title":"J Hepatol"},{"key":"9841_CR19","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1096\/fj.03-1273rev","volume":"18","author":"A Leask","year":"2004","unstructured":"Leask A, Abraham DJ. TGF-beta signaling and the fibrotic response. FASEB J 2004;18:816\u2013827","journal-title":"FASEB J"},{"key":"9841_CR20","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1097\/01.ASN.0000014252.37680.E4","volume":"13","author":"JH Li","year":"2002","unstructured":"Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, Lan HY. Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol 2002;13:1464\u20131472","journal-title":"J Am Soc Nephrol"},{"key":"9841_CR21","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S0016-5085(03)00666-8","volume":"125","author":"S Dooley","year":"2003","unstructured":"Dooley S, Hamzavi J, Breitkopf K, Wiercinska E, Said HM, Lorenzen J, et al. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology 2003;125:178\u2013191","journal-title":"Gastroenterology"},{"key":"9841_CR22","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1016\/j.jmb.2015.04.015","volume":"427","author":"K Grannas","year":"2015","unstructured":"Grannas K, Arng\u00e5rden L, L\u00f6nn P, Mazurkiewicz M, Blokzijl A, Zieba A, et al. Crosstalk between Hippo and TGF\u03b2: subcellular localization of YAP\/TAZ\/Smad complexes J Mol Biol. 2015;427:3407\u20133415","journal-title":"J Mol Biol"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12072-017-9841-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-017-9841-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-017-9841-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:42:55Z","timestamp":1547253775000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12072-017-9841-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["9841"],"URL":"https:\/\/doi.org\/10.1007\/s12072-017-9841-y","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"13 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Ping Chen, Qihui Luo, Chao Huang, Qi Gao, Like Li, Jingfei Chen, Bing Chen, Wentao Liu, Wen Zeng and Zhengli Chen declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments were performed in accordance with the Animal Care and Use Committee Guidelines of Sichuan Agricultural University, China.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}