{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:59:20Z","timestamp":1788263960124,"version":"build-2803163510"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s12072-018-9886-6","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T12:17:55Z","timestamp":1533039475000},"page":"390-401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Algorithms for managing coagulation disorders in liver disease"],"prefix":"10.1007","volume":"12","author":[{"given":"R. Todd","family":"Stravitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"issue":"2","key":"9886_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1056\/NEJMra1011170","volume":"365","author":"A Tripodi","year":"2011","unstructured":"Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease N Engl J Med 2011;365(2):147\u2013156","journal-title":"N Engl J Med"},{"issue":"7","key":"9886_CR2","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","volume":"144","author":"R Moreau","year":"2013","unstructured":"Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology 2013;144(7):1426\u20131437","journal-title":"Gastroenterology"},{"issue":"2","key":"9886_CR3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jhep.2010.01.042","volume":"53","author":"T Lisman","year":"2010","unstructured":"Lisman T, Caldwell SH, Burroughs AK, Northup PG, Senzolo M, Stravitz RT, et al. Hemostasis and thrombosis in patients with liver disease: the ups and downs. J Hepatol 2010;53(2):362\u2013371","journal-title":"J Hepatol"},{"issue":"9","key":"9886_CR4","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1111\/j.1537-2995.2005.00546.x","volume":"45","author":"JB Segal","year":"2005","unstructured":"Segal JB, Dzik WH. Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review. Transfusion 2005;45(9):1413\u20131425","journal-title":"Transfusion"},{"issue":"6","key":"9886_CR5","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1053\/j.gastro.2009.08.045","volume":"137","author":"A Tripodi","year":"2009","unstructured":"Tripodi A, Primignani M, Chantarangkul V, Dell\u2019Era A, Clerici M, de FR, et al. An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology 2009;137(6):2105\u20132111","journal-title":"Gastroenterology"},{"issue":"5","key":"9886_CR6","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1055\/s-0035-1550441","volume":"41","author":"T Lisman","year":"2015","unstructured":"Lisman T, Stravitz RT. Rebalanced hemostasis in patients with acute liver failure. Semin Thromb Hemost 2015;41(5):468\u2013473","journal-title":"Semin Thromb Hemost"},{"issue":"4","key":"9886_CR7","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1053\/j.gastro.2004.07.015","volume":"127","author":"J Bosch","year":"2004","unstructured":"Bosch J, Thabut D, Bendtsen F, D\u2019Amico G, Albillos A, Gonzalez AJ, et al. Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial. Gastroenterology 2004;127(4):1123\u20131130","journal-title":"Gastroenterology"},{"issue":"5","key":"9886_CR8","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1002\/hep.22216","volume":"47","author":"J Bosch","year":"2008","unstructured":"Bosch J, Thabut D, Albillos A, Carbonell N, Spicak J, Massard J, et al. Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: a randomized, controlled trial. Hepatology 2008;47(5):1604\u20131614","journal-title":"Hepatology"},{"issue":"3","key":"9886_CR9","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/hep.20569","volume":"41","author":"A Tripodi","year":"2005","unstructured":"Tripodi A, Salerno F, Chantarangkul V, Clerici M, Cazzaniga M, Primignani M, et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology 2005;41(3):553\u2013558","journal-title":"Hepatology"},{"issue":"2","key":"9886_CR10","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/hep.21266","volume":"44","author":"A Tripodi","year":"2006","unstructured":"Tripodi A, Primignani M, Chantarangkul V, Clerici M, Dell\u2019Era A, Fabris F, et al. Thrombin generation in patients with cirrhosis: the role of platelets. Hepatology 2006;44(2):440\u2013445","journal-title":"Hepatology"},{"issue":"10","key":"9886_CR11","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.cgh.2010.03.025","volume":"8","author":"LB Seeff","year":"2010","unstructured":"Seeff LB, Everson GT, Morgan TR, Curto TM, Lee WM, Ghany MG, et al. Complication rate of percutaneous liver biopsies among persons with advanced chronic liver disease in the HALT-C trial. Clin Gastroenterol Hepatol 2010;8(10):877\u2013883","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"9886_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/hep.21231","volume":"44","author":"T Lisman","year":"2006","unstructured":"Lisman T, Bongers TN, Adelmeijer J, Janssen HL, de Maat MP, de Groot PG, et al. Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity. Hepatology 2006;44(1):53\u201361","journal-title":"Hepatology"},{"issue":"7","key":"9886_CR13","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s11739-016-1467-x","volume":"11","author":"S Lancellotti","year":"2016","unstructured":"Lancellotti S, Basso M, Veca V, Sacco M, Riccardi L, Pompili M, et al. Presence of portal vein thrombosis in liver cirrhosis is strongly associated with low levels of ADAMTS-13: a pilot study. Intern Emerg Med 2016;11(7):959\u2013967","journal-title":"Intern Emerg Med"},{"issue":"5","key":"9886_CR14","first-page":"1238","volume":"21","author":"IR Wanless","year":"1995","unstructured":"Wanless IR, Wong F, Blendis LM, Greig P, Heathcote EJ, Levy G. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. Hepatology 1995;21(5):1238\u20131247","journal-title":"Hepatology"},{"issue":"7","key":"9886_CR15","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1111\/j.1572-0241.2006.00588.x","volume":"101","author":"PG Northup","year":"2006","unstructured":"Northup PG, McMahon MM, Ruhl AP, Altschuler SE, Volk-Bednarz A, Caldwell SH, et al. Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism. Am J Gastroenterol 2006;101(7):1524\u20131528","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"9886_CR16","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1007\/s10620-008-0265-3","volume":"53","author":"D Gulley","year":"2008","unstructured":"Gulley D, Teal E, Suvannasankha A, Chalasani N, Liangpunsakul S. Deep vein thrombosis and pulmonary embolism in cirrhosis patients. Dig Dis Sci 2008;53(11):3012\u20133017","journal-title":"Dig Dis Sci"},{"issue":"1","key":"9886_CR17","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/ajg.2008.34","volume":"104","author":"KK Sogaard","year":"2009","unstructured":"Sogaard KK, Horvath-Puho E, Gronbaek H, Jepsen P, Vilstrup H, Sorensen HT. Risk of venous thromboembolism in patients with liver disease: a nationwide population-based case-control study. Am J Gastroenterol 2009;104(1):96\u2013101","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"9886_CR18","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1001\/jamaneurol.2017.0923","volume":"74","author":"NS Parikh","year":"2017","unstructured":"Parikh NS, Navi BB, Schneider Y, Jesudian A, Kamel H. Association between cirrhosis and stroke in a nationally representative cohort. JAMA Neurol 2017;74(8):927\u2013932","journal-title":"JAMA Neurol"},{"issue":"1","key":"9886_CR19","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1160\/TH16-06-0450","volume":"117","author":"P Ambrosino","year":"2017","unstructured":"Ambrosino P, Tarantino L, Di MG, Paternoster M, Graziano V, Petitto M, et al. The risk of venous thromboembolism in patients with cirrhosis. A systematic review and meta-analysis. Thromb Haemost 2017;117(1):139\u2013148","journal-title":"Thromb Haemost"},{"issue":"3","key":"9886_CR20","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.jhep.2009.05.028","volume":"51","author":"B Agarwal","year":"2009","unstructured":"Agarwal B, Shaw S, Shankar HM, Burroughs AK, Davenport A. Continuous renal replacement therapy (CRRT) in patients with liver disease: is circuit life different? J Hepatol 2009;51(3):504\u2013509","journal-title":"J Hepatol"},{"issue":"5","key":"9886_CR21","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.jhep.2016.06.002","volume":"65","author":"GN Kalambokis","year":"2016","unstructured":"Kalambokis GN, Oikonomou A, Christou L, Kolaitis NI, Tsianos EV, Christodoulou D, et al. von Willebrand factor and procoagulant imbalance predict outcome in patients with cirrhosis and thrombocytopenia. J Hepatol 2016;65(5):921\u2013928","journal-title":"J Hepatol"},{"issue":"3","key":"9886_CR22","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1111\/j.1365-2036.2009.04182.x","volume":"31","author":"EA Tsochatzis","year":"2010","unstructured":"Tsochatzis EA, Senzolo M, Germani G, Gatt A, Burroughs AK. Systematic review: portal vein thrombosis in cirrhosis. Aliment Pharmacol Ther 2010;31(3):366\u2013374","journal-title":"Aliment Pharmacol Ther"},{"issue":"9","key":"9886_CR23","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1001\/jamainternmed.2015.3184","volume":"175","author":"W Ageno","year":"2015","unstructured":"Ageno W, Riva N, Schulman S, Beyer-Westendorf J, Bang SM, Senzolo M, et al. Long-term clinical outcomes of splanchnic vein thrombosis: results of an international registry. JAMA Intern Med 2015;175(9):1474\u20131480","journal-title":"JAMA Intern Med"},{"issue":"2","key":"9886_CR24","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1002\/hep.27546","volume":"61","author":"F Nery","year":"2015","unstructured":"Nery F, Chevret S, Condat B, de RE, Boudaoud L, Rautou PE, et al. Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study. Hepatology 2015;61(2):660\u2013667","journal-title":"Hepatology"},{"issue":"4","key":"9886_CR25","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.jhep.2009.06.009","volume":"51","author":"JC Garcia-Pagan","year":"2009","unstructured":"Garcia-Pagan JC, Valla DC. Portal vein thrombosis: a predictable milestone in cirrhosis? J Hepatol 2009;51(4):632\u2013634","journal-title":"J Hepatol"},{"issue":"5","key":"9886_CR26","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.jhep.2017.07.002","volume":"67","author":"R Carnevale","year":"2017","unstructured":"Carnevale R, Raparelli V, Nocella C, Bartimoccia S, Novo M, Severino A, et al. Gut-derived endotoxin stimulates factor VIII secretion from endothelial cells. Implications for hypercoagulability in cirrhosis. J Hepatol 2017;67(5):950\u2013956","journal-title":"J Hepatol"},{"issue":"5","key":"9886_CR27","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1053\/j.gastro.2012.07.018","volume":"143","author":"E Villa","year":"2012","unstructured":"Villa E, Camma C, Marietta M, Luongo M, Critelli R, Colopi S, et al. Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis. Gastroenterology 2012;143(5):1253\u20131260","journal-title":"Gastroenterology"},{"issue":"2","key":"9886_CR28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1136\/gut.43.2.267","volume":"43","author":"TN Chau","year":"1998","unstructured":"Chau TN, Chan YW, Patch D, Tokunaga S, Greenslade L, Burroughs AK. Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding. Gut 1998;43(2):267\u2013271","journal-title":"Gut"},{"issue":"4","key":"9886_CR29","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0168-8278(02)00208-8","volume":"37","author":"P Montalto","year":"2002","unstructured":"Montalto P, Vlachogiannakos J, Cox DJ, Pastacaldi S, Patch D, Burroughs AK. Bacterial infection in cirrhosis impairs coagulation by a heparin effect: a prospective study. J Hepatol 2002;37(4):463\u2013470","journal-title":"J Hepatol"},{"issue":"4","key":"9886_CR30","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.jhep.2013.03.040","volume":"59","author":"EB Tapper","year":"2013","unstructured":"Tapper EB, Robson SC, Malik R. Coagulopathy in cirrhosis\u2014the role of the platelet in hemostasis. J Hepatol 2013;59(4):889\u2013890","journal-title":"J Hepatol"},{"issue":"5","key":"9886_CR31","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/hep.27033","volume":"60","author":"PE Rautou","year":"2014","unstructured":"Rautou PE, Vion AC, Luyendyk JP, Mackman N. Circulating microparticle tissue factor activity is increased in patients with cirrhosis. Hepatology 2014;60(5):1793\u20131795","journal-title":"Hepatology"},{"issue":"1","key":"9886_CR32","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1053\/j.gastro.2012.03.040","volume":"143","author":"PE Rautou","year":"2012","unstructured":"Rautou PE, Bresson J, Sainte-Marie Y, Vion AC, Paradis V, Renard JM, et al. Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis. Gastroenterology 2012;143(1):166\u2013176","journal-title":"Gastroenterology"},{"key":"9886_CR33","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jcrc.2017.07.053","volume":"43","author":"C Fisher","year":"2018","unstructured":"Fisher C, Patel VC, Stoy SH, Singanayagam A, Adelmeijer J, Wendon J, et al. Balanced haemostasis with both hypo- and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure. J Crit Care 2018;43:54\u201360","journal-title":"J Crit Care"},{"key":"9886_CR34","first-page":"300A","volume":"66","author":"A Blasi","year":"2018","unstructured":"Blasi A, Calvo A, Hernandez M, Reverter JC, Fernandez J, Cardenas A. Prosepective evaluation of the thromboelastography (ROTEM\u00ae) profile in patients with acute-on-chronic liver failure and decompensated cirrhosis. Hepatology 2018;66:300A","journal-title":"Hepatology"},{"issue":"2","key":"9886_CR35","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/hep.28628","volume":"64","author":"A Drolz","year":"2016","unstructured":"Drolz A, Horvatits T, Roedl K, Rutter K, Staufer K, Kneidinger N, et al. Coagulation parameters and major bleeding in critically ill patients with cirrhosis. Hepatology 2016;64(2):556\u2013568","journal-title":"Hepatology"},{"issue":"6758","key":"9886_CR36","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1136\/bmj.301.6758.964","volume":"301","author":"PM Harrison","year":"1990","unstructured":"Harrison PM, O\u2019Grady JG, Keays RT, Alexander GJ, Williams R. Serial prothrombin time as prognostic indicator in paracetamol induced fulminant hepatic failure. BMJ 1990;301(6758):964\u2013966","journal-title":"BMJ"},{"issue":"5","key":"9886_CR37","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1002\/hep.29694","volume":"67","author":"RT Stravitz","year":"2018","unstructured":"Stravitz RT, Ellerbe C, Durkalski V, Schilsky M, Fontana RJ, Peterseim C, et al. Bleeding complications in acute liver failure. Hepatology 2018;67(5):1931\u20131942","journal-title":"Hepatology"},{"issue":"4","key":"9886_CR38","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.cgh.2015.09.029","volume":"14","author":"RT Stravitz","year":"2016","unstructured":"Stravitz RT, Ellerbe C, Durkalski V, Reuben A, Lisman T, Lee WM. Thrombocytopenia is associated with multi-organ system failure in patients with acute liver failure. Clin Gastroenterol Hepatol 2016;14(4):613\u2013620","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"9886_CR39","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/hep.1840100414","volume":"10","author":"D Valla","year":"1989","unstructured":"Valla D, Flejou JF, Lebrec D, Bernuau J, Rueff B, Salzmann JL, et al. Portal hypertension and ascites in acute hepatitis: clinical, hemodynamic and histological correlations. Hepatology 1989;10(4):482\u2013487","journal-title":"Hepatology"},{"issue":"4 Pt 1","key":"9886_CR40","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1053\/jhep.2000.17687","volume":"32","author":"N Rolando","year":"2000","unstructured":"Rolando N, Wade J, Davalos M, Wendon J, Philpott-Howard J, Williams R. The systemic inflammatory response syndrome in acute liver failure. Hepatology 2000;32(4 Pt 1):734\u2013739","journal-title":"Hepatology"},{"issue":"1","key":"9886_CR41","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/hep.26307","volume":"58","author":"RT Stravitz","year":"2013","unstructured":"Stravitz RT, Bowling R, Bradford RL, Key NS, Glover S, Thacker LR, et al. Role of procoagulant microparticles in mediating complications and outcome of acute liver injury\/acute liver failure. Hepatology 2013;58(1):304\u2013313","journal-title":"Hepatology"},{"issue":"1","key":"9886_CR42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jhep.2011.04.020","volume":"56","author":"RT Stravitz","year":"2012","unstructured":"Stravitz RT, Lisman T, Luketic VA, Sterling RK, Puri P, Fuchs M, et al. Minimal effects of acute liver injury\/acute liver failure on hemostasis as assessed by thromboelastography. J Hepatol 2012;56(1):129\u2013136","journal-title":"J Hepatol"},{"issue":"2","key":"9886_CR43","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/hep.26372","volume":"58","author":"GC Hugenholtz","year":"2013","unstructured":"Hugenholtz GC, Adelmeijer J, Meijers JC, Porte RJ, Stravitz RT, Lisman T. An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: implications for hemostasis and clinical outcome. Hepatology 2013;58(2):752\u2013761","journal-title":"Hepatology"},{"issue":"2","key":"9886_CR44","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1034\/j.1600-0676.2003.00808.x","volume":"23","author":"AM Williams","year":"2003","unstructured":"Williams AM, Langley PG, Osei-Hwediah J, Wendon JA, Hughes RD. Hyaluronic acid and endothelial damage due to paracetamol-induced hepatotoxicity. Liver Int 2003;23(2):110\u2013115","journal-title":"Liver Int"},{"issue":"4","key":"9886_CR45","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.jhep.2012.06.020","volume":"57","author":"B Agarwal","year":"2012","unstructured":"Agarwal B, Wright G, Gatt A, Riddell A, Vemala V, Mallett S, et al. Evaluation of coagulation abnormalities in acute liver failure. J Hepatol 2012;57(4):780\u2013786","journal-title":"J Hepatol"},{"issue":"7","key":"9886_CR46","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1111\/j.1538-7836.2012.04770.x","volume":"10","author":"T Lisman","year":"2012","unstructured":"Lisman T, Bakhtiari K, Adelmeijer J, Meijers JC, Porte RJ, Stravitz RT. Intact thrombin generation and decreased fibrinolytic capacity in patients with acute liver injury or acute liver failure. J Thromb Haemost 2012;10(7):1312\u20131319","journal-title":"J Thromb Haemost"},{"issue":"5","key":"9886_CR47","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/liv.12369","volume":"34","author":"M Habib","year":"2014","unstructured":"Habib M, Roberts LN, Patel RK, Wendon J, Bernal W, Arya R. Evidence of rebalanced coagulation in acute liver injury and acute liver failure as measured by thrombin generation. Liver Int 2014;34(5):672\u2013678","journal-title":"Liver Int"},{"issue":"10","key":"9886_CR48","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1161\/CIRCRESAHA.110.233056","volume":"108","author":"AP Owens III","year":"2011","unstructured":"Owens AP III, Mackman N. Microparticles in hemostasis and thrombosis. Circ Res 2011;108(10):1284\u20131297","journal-title":"Circ Res"},{"issue":"Suppl 1","key":"9886_CR49","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1016\/j.thromres.2010.01.035","volume":"125","author":"NS Key","year":"2010","unstructured":"Key NS. Analysis of tissue factor positive microparticles. Thromb Res 2010;125(Suppl 1):S42\u2013S45","journal-title":"Thromb Res"},{"issue":"2","key":"9886_CR50","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1136\/gut.15.2.83","volume":"15","author":"P Hillenbrand","year":"1974","unstructured":"Hillenbrand P, Parbhoo SP, Jedrychowski A, Sherlock S. Significance of intravascular coagulation and fibrinolysis in acute hepatic failure. Gut 1974;15(2):83\u201388","journal-title":"Gut"},{"issue":"4","key":"9886_CR51","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1002\/hep.21779","volume":"46","author":"PE Ganey","year":"2007","unstructured":"Ganey PE, Luyendyk JP, Newport SW, Eagle TM, Maddox JF, Mackman N, Roth RA. Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology 2007;46(4):1177\u20131186","journal-title":"Hepatology"},{"issue":"26","key":"9886_CR52","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1056\/NEJM199106273242604","volume":"324","author":"PM Harrison","year":"1991","unstructured":"Harrison PM, Wendon JA, Gimson AE, Alexander GJ, Williams R. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 1991;324(26):1852\u20131857","journal-title":"N Engl J Med"},{"issue":"2","key":"9886_CR53","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/hep.28148","volume":"63","author":"PL De","year":"2016","unstructured":"De PL, Bianchini M, Montalti R, De MN, Di MT, Begliomini B, et al. Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: a randomized, controlled trial. Hepatology 2016;63(2):566\u2013573","journal-title":"Hepatology"},{"issue":"3","key":"9886_CR54","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1002\/hep.21907","volume":"46","author":"G Garcia-Tsao","year":"2007","unstructured":"Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007;46(3):922\u2013938","journal-title":"Hepatology"},{"issue":"4","key":"9886_CR55","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1053\/jhep.2001.23437","volume":"33","author":"B Castaneda","year":"2001","unstructured":"Castaneda B, Morales J, Lionetti R, Moitinho E, Andreu V, Perez-Del-Pulgar S, et al. Effects of blood volume restitution following a portal hypertensive-related bleeding in anesthetized cirrhotic rats. Hepatology 2001;33(4):821\u2013825","journal-title":"Hepatology"},{"issue":"4","key":"9886_CR56","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1002\/hep.27029","volume":"60","author":"EG Giannini","year":"2014","unstructured":"Giannini EG, Stravitz RT, Caldwell SH. Correction of hemostatic abnormalities and portal pressure variations in patients with cirrhosis. Hepatology 2014;60(4):1442","journal-title":"Hepatology"},{"issue":"1","key":"9886_CR57","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1211801","volume":"368","author":"C Villanueva","year":"2013","unstructured":"Villanueva C, Colomo A, Bosch A, Concepcion M, Hernandez-Gea V, Aracil C, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013;368(1):11\u201321","journal-title":"N Engl J Med"},{"issue":"3","key":"9886_CR58","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jhep.2015.10.019","volume":"64","author":"MK Nadim","year":"2016","unstructured":"Nadim MK, Durand F, Kellum JA, Levitsky J, O\u2019Leary JG, Karvellas CJ, et al. Management of the critically ill patient with cirrhosis: a multidisciplinary perspective. J Hepatol 2016;64(3):717\u2013735","journal-title":"J Hepatol"},{"key":"9886_CR59","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13882","author":"T Lisman","year":"2018","unstructured":"Lisman T, Kleiss S, Patel VC, Fisher C, Adelmeijer J, Bos S, Singanayagam A, Stoy SH, Shawcross DL, Bernal W. In vitro efficacy of pro- and anticoagulant strategies in compensated and acutely ill patients with cirrhosis. Liver Int 2018. \n                    https:\/\/doi.org\/10.1111\/liv.13882\n                    \n                   (epub ahead of print)","journal-title":"Liver Int"},{"issue":"Suppl 1","key":"9886_CR60","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/liv.12723","volume":"35","author":"DC Valla","year":"2015","unstructured":"Valla DC, Rautou PE. The coagulation system in patients with end-stage liver disease. Liver Int 2015;35(Suppl 1):139\u2013144","journal-title":"Liver Int"},{"issue":"6","key":"9886_CR61","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/j.1478-3231.2012.02785.x","volume":"32","author":"M Senzolo","year":"2012","unstructured":"Senzolo M, Sartori M, Rossetto V, Burra P, Cillo U, Boccagni P, et al. Prospective evaluation of anticoagulation and transjugular intrahepatic portosystemic shunt for the management of portal vein thrombosis in cirrhosis. Liver Int 2012;32(6):919\u2013927","journal-title":"Liver Int"},{"issue":"2","key":"9886_CR62","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1053\/j.gastro.2017.04.042","volume":"153","author":"L Loffredo","year":"2017","unstructured":"Loffredo L, Pastori D, Farcomeni A, Violi F. Effects of anticoagulants in patients with cirrhosis and portal vein thrombosis: a systematic review and meta-analysis. Gastroenterology 2017;153(2):480\u2013487","journal-title":"Gastroenterology"},{"issue":"6","key":"9886_CR63","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1136\/gut.2010.228023","volume":"60","author":"A Luca","year":"2011","unstructured":"Luca A, Miraglia R, Caruso S, Milazzo M, Sapere C, Maruzzelli L, et al. Short- and long-term effects of the transjugular intrahepatic portosystemic shunt on portal vein thrombosis in patients with cirrhosis. Gut 2011;60(6):846\u2013852","journal-title":"Gut"},{"issue":"7","key":"9886_CR64","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nrgastro.2014.36","volume":"11","author":"X Qi","year":"2014","unstructured":"Qi X, Han G, Fan D. Management of portal vein thrombosis in liver cirrhosis. Nat Rev Gastroenterol Hepatol 2014;11(7):435\u2013446","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"9886_CR65","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/hep.27783","volume":"62","author":"F Cerini","year":"2015","unstructured":"Cerini F, Gonzalez JM, Torres F, Puente A, Casas M, Vinaixa C, et al. Impact of anticoagulation on upper-gastrointestinal bleeding in cirrhosis. A retrospective multicenter study. Hepatology 2015;62(2):575\u201383","journal-title":"Hepatology"},{"issue":"9","key":"9886_CR66","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1111\/j.1538-7836.2012.04824.x","volume":"10","author":"M Senzolo","year":"2012","unstructured":"Senzolo M, Rodriguez-Castro KI, Rossetto V, Radu C, Gavasso S, Carraro P, et al. Increased anticoagulant response to low-molecular-weight heparin in plasma from patients with advanced cirrhosis. J Thromb Haemost 2012;10(9):1823\u20131829","journal-title":"J Thromb Haemost"},{"issue":"1","key":"9886_CR67","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1478-3231.2010.02358.x","volume":"31","author":"LP Bechmann","year":"2011","unstructured":"Bechmann LP, Sichau M, Wichert M, Gerken G, Kroger K, Hilgard P. Low-molecular-weight heparin in patients with advanced cirrhosis. Liver Int 2011;31(1):75\u201382","journal-title":"Liver Int"},{"issue":"6","key":"9886_CR68","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1007\/s10620-015-4012-2","volume":"61","author":"NM Intagliata","year":"2016","unstructured":"Intagliata NM, Henry ZH, Maitland H, Shah NL, Argo CK, Northup PG, et al. Direct oral anticoagulants in cirrhosis patients pose similar risks of bleeding when compared to traditional anticoagulation. Dig Dis Sci 2016;61(6):1721\u20131727","journal-title":"Dig Dis Sci"},{"issue":"4","key":"9886_CR69","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1002\/hep.27350","volume":"61","author":"W Potze","year":"2015","unstructured":"Potze W, Adelmeijer J, Lisman T. Decreased in vitro anticoagulant potency of rivaroxaban and apixaban in plasma from patients with cirrhosis. Hepatology 2015;61(4):1435\u20131436","journal-title":"Hepatology"},{"issue":"2","key":"9886_CR70","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1053\/jlts.2003.50017","volume":"9","author":"VM Shami","year":"2003","unstructured":"Shami VM, Caldwell SH, Hespenheide EE, Arseneau KO, Bickston SJ, Macik BG. Recombinant activated factor VII for coagulopathy in fulminant hepatic failure compared with conventional therapy. Liver Transpl 2003;9(2):138\u2013143","journal-title":"Liver Transpl"},{"issue":"1","key":"9886_CR71","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/BF03018576","volume":"52","author":"P Pavese","year":"2005","unstructured":"Pavese P, Bonadona A, Beaubien J, Labrecque P, Pernod G, Letoublon C, et al. FVIIa corrects the coagulopathy of fulminant hepatic failure but may be associated with thrombosis: a report of four cases. Can J Anaesth 2005;52(1):26\u201329","journal-title":"Can J Anaesth"},{"issue":"5","key":"9886_CR72","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/cc11492","volume":"16","author":"S Patel","year":"2012","unstructured":"Patel S, Wendon J. Regional citrate anticoagulation in patients with liver failure\u2013time for a rethink? Crit Care 2012;16(5):153","journal-title":"Crit Care"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12072-018-9886-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-018-9886-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-018-9886-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T23:24:07Z","timestamp":1564529047000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12072-018-9886-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,31]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["9886"],"URL":"https:\/\/doi.org\/10.1007\/s12072-018-9886-6","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,31]]},"assertion":[{"value":"5 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This review article does not contain any original data, only previously published studies with\u00a0human\u00a0and\/or animal subjects, previously vetted by appropriate Institutional Review Boards.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}