{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:57:24Z","timestamp":1786982244990,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"The National Infectious Disease Major Projects in China","award":["2018ZX10715005"],"award-info":[{"award-number":["2018ZX10715005"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2016-I2M-3-001"],"award-info":[{"award-number":["2016-I2M-3-001"]}]},{"name":"Special Fund of Chinese Central Government for Basic Scientific Research Operations in Commonweal Research Institutes","award":["2017PT63001"],"award-info":[{"award-number":["2017PT63001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12072-020-10086-2","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T13:03:00Z","timestamp":1599138180000},"page":"743-753","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hepatitis B virus infection and diabetes mellitus: the Kailuan prospective cohort study in China"],"prefix":"10.1007","volume":"14","author":[{"given":"Shaoyuan","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-2741","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"issue":"6","key":"10086_CR1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S2468-1253(18)30056-6","volume":"3","author":"D Razavi-Shearer","year":"2018","unstructured":"Razavi-Shearer D, Gamkrelidze I, Nguyen MH, Chen DS, Van Damme P, Abbas Z, Abdulla M, Abou Rached A, Adda D, Aho I, Akarca U. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. Lancet Gastroenterol Hepatol. 2018;3(6):383\u2013403.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10086_CR2","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","volume":"128","author":"K Ogurtsova","year":"2017","unstructured":"Ogurtsova K, da Rocha Fernandes JD, Huang Y, et al. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40\u201350.","journal-title":"Diabetes Res Clin Pract"},{"issue":"24","key":"10086_CR3","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1001\/jama.2017.7596","volume":"317","author":"L Wang","year":"2017","unstructured":"Wang L, Gao P, Zhang M, et al. Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA. 2017;317(24):2515\u201323.","journal-title":"JAMA"},{"issue":"47","key":"10086_CR4","doi-asserted-by":"publisher","first-page":"6550","DOI":"10.1016\/j.vaccine.2009.08.048","volume":"27","author":"X Liang","year":"2009","unstructured":"Liang X, Bi S, Yang W, et al. Epidemiological serosurvey of hepatitis B in China\u2013declining HBV prevalence due to hepatitis B vaccination. Vaccine. 2009;27(47):6550\u20137.","journal-title":"Vaccine"},{"key":"10086_CR5","first-page":"3","volume":"122","author":"FM Lu","year":"2009","unstructured":"Lu FM, Zhuang H. Management of hepatitis B in China. Chin Med J. 2009;122:3\u20134.","journal-title":"Chin Med J"},{"issue":"4","key":"10086_CR6","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1136\/gut.2004.052167","volume":"54","author":"JA Davila","year":"2005","unstructured":"Davila JA, Morgan RO, Shaib Y, et al. Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut. 2005;54(4):533\u20139.","journal-title":"Gut"},{"issue":"20","key":"10086_CR7","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1001\/jama.2009.726","volume":"301","author":"JCN Chan","year":"2009","unstructured":"Chan JCN, Malik V, Jia W, et al. Diabetes in Asia. J Am Med Assoc. 2009;301(20):2129\u201340.","journal-title":"J Am Med Assoc"},{"issue":"2","key":"10086_CR8","doi-asserted-by":"publisher","first-page":"693","DOI":"10.3892\/etm.2015.2537","volume":"10","author":"C Cai","year":"2015","unstructured":"Cai C, Zeng J, Wu H, et al. Association between hepatitis B virus infection and diabetes mellitus: a meta-analysis. Exp Ther Med. 2015;10(2):693\u20138.","journal-title":"Exp Ther Med"},{"issue":"6","key":"10086_CR9","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/j.1365-2893.2009.01077.x","volume":"16","author":"A Mavrogiannaki","year":"2009","unstructured":"Mavrogiannaki A, Karamanos B, Manesis EK, et al. Prevalence of glucose intolerance in patients with chronic hepatitis B or C: a prospective case-control study. J Viral Hepat. 2009;16(6):430\u20136.","journal-title":"J Viral Hepat"},{"issue":"8","key":"10086_CR10","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1111\/j.1440-1746.2010.06268.x","volume":"25","author":"ZS Huang","year":"2010","unstructured":"Huang ZS, Huang TS, Wu TH, et al. Asymptomatic chronic hepatitis B virus infection does not increase the risk of diabetes mellitus: a ten-year observation. J Gastroenterol Hepatol. 2010;25(8):1420\u20135.","journal-title":"J Gastroenterol Hepatol"},{"key":"10086_CR11","unstructured":"Chinese center for disease control and prevention. Epidemiological serosurvey of hepatitis B in China. Beijing, People's Medical Publishing House, 2010;79."},{"issue":"2","key":"10086_CR12","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1093\/ije\/dyv079","volume":"44","author":"L Wang","year":"2015","unstructured":"Wang L, Cui L, Wang Y, et al. Resting heart rate and the risk of developing impaired fasting glucose and diabetes: the Kailuan prospective study. Int J Epidemiol. 2015;44(2):689\u201399.","journal-title":"Int J Epidemiol"},{"issue":"Suppl 1","key":"10086_CR13","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.2337\/dc10-S011","volume":"33","author":"AD Association","year":"2010","unstructured":"Association AD. Standards of medical care in diabetes\u20132010. Diabetes Care. 2010;33(Suppl 1):S11\u201361.","journal-title":"Diabetes Care"},{"issue":"1","key":"10086_CR14","first-page":"83","volume":"15","author":"BF Zhou","year":"2002","unstructured":"Zhou BF. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2013study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002;15(1):83\u201396.","journal-title":"Biomed Environ Sci"},{"issue":"2","key":"10086_CR15","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1158\/1055-9965.EPI-14-1112","volume":"24","author":"G Wang","year":"2015","unstructured":"Wang G, Li N, Chang S, et al. A prospective follow-up study of the relationship between C-reactive protein and human cancer risk in the Chinese Kailuan Female Cohort. Cancer Epidemiol Biomark Prev. 2015;24(2):459\u201365.","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"04","key":"10086_CR16","first-page":"34","volume":"v.38","author":"Society CD","year":"2018","unstructured":"Society CD. Guidelines for the prevention and control of type 2 diabetes in China (2017 edition). Chin J Pract Intern Med. 2018;v.38(04):34\u201386.","journal-title":"Chin J Pract Intern Med"},{"key":"10086_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v045.i03","volume":"45","author":"SV Buuren","year":"2011","unstructured":"Buuren SV, Groothuis-Oudshoorn K. mice: Multivariate imputation by chained equations in R. J Stat Softw. 2011;45:1\u201367.","journal-title":"J Stat Softw"},{"issue":"15","key":"10086_CR18","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1002\/sim.3618","volume":"28","author":"IR White","year":"2009","unstructured":"White IR, Royston P. Imputing missing covariate values for the Cox model. Stat Med. 2009;28(15):1982\u201398.","journal-title":"Stat Med"},{"issue":"6","key":"10086_CR19","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1111\/j.1572-0241.2007.01181.x","volume":"102","author":"JF Huang","year":"2007","unstructured":"Huang JF, Dai CY, Hwang SJ, et al. Hepatitis C viremia increases the association with type 2 diabetes mellitus in a hepatitis B and C endemic area: an epidemiological link with virological implication. Am J Gastroenterol. 2007;102(6):1237\u201343.","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10086_CR20","doi-asserted-by":"publisher","first-page":"4606","DOI":"10.1038\/s41598-017-04206-6","volume":"7","author":"YS Hong","year":"2017","unstructured":"Hong YS, Chang Y, Ryu S, et al. Hepatitis B and C virus infection and diabetes mellitus: a cohort study. Sci Rep. 2017;7(1):4606.","journal-title":"Sci Rep"},{"issue":"3","key":"10086_CR21","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/jvh.12815","volume":"25","author":"HY Choi","year":"2018","unstructured":"Choi HY, Kim Y, Cho H, et al. Risk of diabetes in viral hepatitis B or C patients compared to that in noninfected individuals in Korea, 2002\u20132013: a population-based cohort study. J Viral Hepat. 2018;25(3):272\u201380.","journal-title":"J Viral Hepat"},{"issue":"5","key":"10086_CR22","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.jhep.2008.08.006","volume":"49","author":"DL White","year":"2008","unstructured":"White DL, Ratziu V, El-Serag HB. Hepatitis C infection and risk of diabetes: a systematic review and meta-analysis. J Hepatol. 2008;49(5):831\u201344.","journal-title":"J Hepatol"},{"issue":"Suppl 1","key":"10086_CR23","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1016\/S0168-8278(12)60007-5","volume":"56","author":"E Bugianesi","year":"2012","unstructured":"Bugianesi E, Salamone F, Negro F. The interaction of metabolic factors with HCV infection: does it matter? J Hepatol. 2012;56(Suppl 1):S56\u2013S65.","journal-title":"J Hepatol"},{"issue":"1","key":"10086_CR24","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jhep.2007.04.002","volume":"47","author":"IA Leclercq","year":"2007","unstructured":"Leclercq IA, Da Silva MA, Schroyen B, et al. Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol. 2007;47(1):142\u201356.","journal-title":"J Hepatol"},{"issue":"1","key":"10086_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/011542650802300103","volume":"23","author":"B Collier","year":"2008","unstructured":"Collier B, Dossett LA, May AK, et al. Glucose control and the inflammatory response. Nutr Clin Pract. 2008;23(1):3\u201315.","journal-title":"Nutr Clin Pract"},{"issue":"2","key":"10086_CR26","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/hep.1840120202","volume":"12","author":"B Yoffe","year":"1990","unstructured":"Yoffe B, Burns DK, Bhatt HS, et al. Extrahepatic hepatitis B virus DNA sequences in patients with acute hepatitis B infection. Hepatology. 1990;12(2):187\u201392.","journal-title":"Hepatology"},{"issue":"5","key":"10086_CR27","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1111\/j.1572-0241.2002.05706.x","volume":"97","author":"LY Chan","year":"2002","unstructured":"Chan LY, Tsang SW-C, Leung NW-Y, et al. Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection. Am J Gastroenterol. 2002;97(5):1211\u20135.","journal-title":"Am J Gastroenterol"},{"key":"10086_CR28","doi-asserted-by":"publisher","unstructured":"Zhao Y, Huichun X. A different perspective for management of diabetes mellitus: controlling viral liver diseases. J Diabetes Res. 2017;2017:5625371. https:\/\/doi.org\/10.1155\/2017\/5625371.","DOI":"10.1155\/2017\/5625371"},{"issue":"5","key":"10086_CR29","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1002\/hep.23464","volume":"51","author":"J Simonetti","year":"2010","unstructured":"Simonetti J, Bulkow L, McMahon BJ, et al. Clearance of hepatitis B surface antigen and risk of hepatocellular carcinoma in a cohort chronically infected with hepatitis B virus. Hepatology. 2010;51(5):1531\u20137.","journal-title":"Hepatology"},{"issue":"4","key":"10086_CR30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nrendo.2011.235","volume":"8","author":"BG Drew","year":"2012","unstructured":"Drew BG, Rye KA, Duffy SJ, et al. The emerging role of HDL in glucose metabolism. Nat Rev Endocrinol. 2012;8(4):237\u201345.","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"10086_CR31","first-page":"648","volume":"29","author":"S Anderson","year":"2015","unstructured":"Anderson S, Emdin C, Woodward M, et al. Usual blood pressure and risk of new-onset diabetes evidence from 4.1 million adults and a meta-analysis of prospective studies. J Am Coll Cardiol. 2015;29(10):648\u20139.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10086_CR32","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/1753-0407.12317","volume":"8","author":"M Li","year":"2016","unstructured":"Li M, Zhou H, Guan Y, et al. Positive hepatitis B surface antibody is associated with reduced risk of diabetes mellitus in retired female Chinese workers. J Diabetes. 2016;8(1):158\u201361.","journal-title":"J Diabetes"},{"issue":"10","key":"10086_CR33","doi-asserted-by":"publisher","first-page":"e0139730","DOI":"10.1371\/journal.pone.0139730","volume":"10","author":"J Huang","year":"2015","unstructured":"Huang J, Ou HY, Lin J, et al. The impact of hepatitis B vaccination status on the risk of diabetes, implicating diabetes risk reduction by successful vaccination. PLoS ONE. 2015;10(10):e0139730.","journal-title":"PLoS ONE"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-020-10086-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-020-10086-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-020-10086-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T16:13:17Z","timestamp":1630685597000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-020-10086-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10086"],"URL":"https:\/\/doi.org\/10.1007\/s12072-020-10086-2","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"15 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors do not have any conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study followed the guidelines of the Helsinki Declaration and was approved by the Ethics Committees of the Kailuan General Hospital and the Institute of Basic Medical Sciences Chinese Academy of Medical Sciences. All patients enrolled in this study provided and signed informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}