{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:53:19Z","timestamp":1788432799776,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Key Special Project of Ministry of Science and Technology, China","award":["2020YFC0845700"],"award-info":[{"award-number":["2020YFC0845700"]}]},{"name":"COVID-19 Rapid Response Call of Huazhong University of Science and Technology","award":["2020kfyXGYJ021"],"award-info":[{"award-number":["2020kfyXGYJ021"]}]},{"name":"COVID-19 Rapid Response Call of Huazhong University of Science and Technology","award":["2020kfyXGYJ026"],"award-info":[{"award-number":["2020kfyXGYJ026"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81570555"],"award-info":[{"award-number":["81570555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Emergency Projects of Science and Technology Department of Hubei Province","award":["No.2020FCA014"],"award-info":[{"award-number":["No.2020FCA014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12072-020-10087-1","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T13:02:46Z","timestamp":1599224566000},"page":"733-742","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Liver injury in patients with COVID-19: clinical profiles, CT findings, the correlation of the severity with liver injury"],"prefix":"10.1007","volume":"14","author":[{"given":"Ping","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuansheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoxia","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"10087_CR1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","volume":"395","author":"N Chen","year":"2020","unstructured":"Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395:507\u2013513.","journal-title":"Lancet"},{"key":"10087_CR2","first-page":"e17","volume":"8","author":"A Rismanbaf","year":"2020","unstructured":"Rismanbaf A, Zarei S. Liver and kidney injuries in COVID-19 and their effects on drug therapy; a letter to editor. Arch Acad Emerg Med 2020;8:e17.","journal-title":"Arch Acad Emerg Med"},{"key":"10087_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30084-4","author":"MN Bangash","year":"2020","unstructured":"Bangash MN, Patel J, Parekh D. COVID-19 and the liver: little cause for concern. Lancet Gastroenterol Hepatol 2020. https:\/\/doi.org\/10.1016\/S2468-1253(20)30084-4.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10087_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30057-1","author":"C Zhang","year":"2020","unstructured":"Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol 2020. https:\/\/doi.org\/10.1016\/S2468-1253(20)30057-1.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10087_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14435","author":"L Xu","year":"2020","unstructured":"Xu L, Liu J, Lu M, et al. Liver injury during highly pathogenic human coronavirus infections. Liver Int 2020. https:\/\/doi.org\/10.1111\/liv.14435.","journal-title":"Liver Int"},{"key":"10087_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30558-4","author":"T Wang","year":"2020","unstructured":"Wang T, Du Z, Zhu F, et al. Comorbidities and multi-organ injuries in the treatment of COVID-19. Lancet 2020. https:\/\/doi.org\/10.1016\/S0140-6736(20)30558-4.","journal-title":"Lancet"},{"key":"10087_CR7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.03.020","author":"Z Zhou","year":"2020","unstructured":"Zhou Z, Zhao N, Shu Y, et al. Effect of gastrointestinal symptoms on patients infected with COVID-19. Gastroenterology 2020. https:\/\/doi.org\/10.1053\/j.gastro.2020.03.020.","journal-title":"Gastroenterology"},{"key":"10087_CR8","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","volume":"395","author":"C Huang","year":"2020","unstructured":"Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497\u2013506.","journal-title":"Lancet"},{"key":"10087_CR9","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","volume":"382","author":"WJ Guan","year":"2020","unstructured":"Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of Coronavirus disease 2019 in China. N Engl J Med 2020;382:1708\u20131722.","journal-title":"N Engl J Med"},{"key":"10087_CR10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585","author":"D Wang","year":"2020","unstructured":"Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus-infected pneumonia in Wuhan, China. JAMA 2020. https:\/\/doi.org\/10.1001\/jama.2020.1585.","journal-title":"JAMA"},{"key":"10087_CR11","doi-asserted-by":"publisher","unstructured":"Fan Z, Chen L, Li J, et al. Clinical features of COVID-19-related liver damage. medRxiv 2020. https:\/\/doi.org\/10.1101\/2020.02.26.20026971","DOI":"10.1101\/2020.02.26.20026971"},{"key":"10087_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30076-X","author":"Z Xu","year":"2020","unstructured":"Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020. https:\/\/doi.org\/10.1016\/S2213-2600(20)30076-X.","journal-title":"Lancet Respir Med"},{"key":"10087_CR13","doi-asserted-by":"publisher","unstructured":"National Health Commission of the People\u2019s Republic of China and National Administration of Traditional Chinese Medicine of the People\u2019s Republic of China. Diagnosis and treatment plan of Corona Virus disease 2019 (tentative sixth edition). Global Health J. https:\/\/doi.org\/10.1016\/j.glohj.2020.03.001","DOI":"10.1016\/j.glohj.2020.03.001"},{"key":"10087_CR14","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200432","author":"Y Fang","year":"2020","unstructured":"Fang Y, Zhang H, Xie J, et al. Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR. Radiology 2020. https:\/\/doi.org\/10.1148\/radiol.2020200432.","journal-title":"Radiology"},{"key":"10087_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30086-4","author":"H Shi","year":"2020","unstructured":"Shi H, Han X, Jiang N, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis 2020. https:\/\/doi.org\/10.1016\/S1473-3099(20)30086-4.","journal-title":"Lancet Infect Dis"},{"key":"10087_CR16","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200843","author":"Y Wang","year":"2020","unstructured":"Wang Y, Dong C, Hu Y, et al. Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study. Radiology 2020. https:\/\/doi.org\/10.1148\/radiol.2020200843.","journal-title":"Radiology"},{"key":"10087_CR17","doi-asserted-by":"publisher","first-page":"37998","DOI":"10.1038\/srep37998","volume":"6","author":"X Kan","year":"2016","unstructured":"Kan X, Ye J, Rong X, et al. Diagnostic performance of contrast-enhanced CT in pyrrolizidine alkaloids-induced hepatic sinusoidal obstructive syndrome. Sci Rep 2016;6:37998.","journal-title":"Sci Rep"},{"key":"10087_CR18","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.cgh.2017.01.009","volume":"15","author":"X Li","year":"2017","unstructured":"Li X, Yang X, Xu D, et al. Magnetic resonance imaging findings in patients with pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome. Clin Gastroenterol Hepatol 2017;15:955\u2013957.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10087_CR19","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/s41598-018-37775-1","volume":"9","author":"T Guo","year":"2019","unstructured":"Guo T, Li X, Yang X, et al. Gadoxetic acid-enhanced hepatobiliary-phase magnetic resonance imaging for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome and association with liver function. Sci Rep 2019;9:1231.","journal-title":"Sci Rep"},{"key":"10087_CR20","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1148\/radiol.2363040958","volume":"236","author":"Y-C Chang","year":"2005","unstructured":"Chang Y-C, Yu C-J, Chang S-C, et al. Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome evaluation with thin section CT. Radiology 2005;236:1067\u20131075.","journal-title":"Radiology"},{"key":"10087_CR21","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200370","author":"F Pan","year":"2020","unstructured":"Pan F, Ye T, Sun P, et al. Time course of lung changes on chest CT during recovery from 2019 novel Coronavirus (COVID-19) pneumonia. Radiology 2020.https:\/\/doi.org\/10.1148\/radiol.2020200370","journal-title":"Radiology"},{"key":"10087_CR22","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.acra.2012.02.022","volume":"19","author":"I Zeb","year":"2012","unstructured":"Zeb I, Li D, Nasir K, et al. Computed tomography scans in the evaluation of fatty liver disease in a population based study: the multi-ethnic study of atherosclerosis. Acad Radiol 2012;19:811\u2013818.","journal-title":"Acad Radiol"},{"key":"10087_CR23","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1172\/JCI137244","volume":"130","author":"G Chen","year":"2020","unstructured":"Chen G, Wu D, Guo W, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest 2020;130:2620\u20132629.","journal-title":"J Clin Invest"},{"key":"10087_CR24","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248","author":"C Qin","year":"2020","unstructured":"Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan. China. Clin Infect Dis 2020. https:\/\/doi.org\/10.1093\/cid\/ciaa248.","journal-title":"China. Clin Infect Dis"},{"key":"10087_CR25","doi-asserted-by":"publisher","unstructured":"Hofmann M, Kleine-Weber H, Kr\u00fcger N, et al. The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells. bioRxiv 2020. https:\/\/doi.org\/10.1101\/2020.01.31.929042","DOI":"10.1101\/2020.01.31.929042"},{"key":"10087_CR26","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1182\/blood.2020006000","volume":"135","author":"JM Connors","year":"2020","unstructured":"Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood 2020;135:2033\u20132040.","journal-title":"Blood"},{"key":"10087_CR27","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004458","author":"T Iba","year":"2020","unstructured":"Iba T, Levy JH, Levi M, et al. Coagulopathy of Coronavirus disease 2019. Crit Care Med 2020. https:\/\/doi.org\/10.1097\/CCM.0000000000004458.","journal-title":"Crit Care Med"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-020-10087-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-020-10087-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-020-10087-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T03:02:28Z","timestamp":1630724548000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-020-10087-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10087"],"URL":"https:\/\/doi.org\/10.1007\/s12072-020-10087-1","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"28 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Ping Lei, Lan Zhang, Ping Han, Chuansheng Zheng, Qiaoxia Tong, Haitao Shang, Fan Yang, Yu Hu, Xin Li, Yuhu Song disclose no conflicts.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki. Our study was approved by Ethics Committee of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (No2020-0312).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was waived because of the retrospective nature of the study and the usage of anonymous clinical data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}