{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:22:48Z","timestamp":1772202168065,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81772178"],"award-info":[{"award-number":["No. 81772178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University","award":["2019"],"award-info":[{"award-number":["2019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s12072-021-10172-z","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T18:14:52Z","timestamp":1618856092000},"page":"707-719","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2"],"prefix":"10.1007","volume":"15","author":[{"given":"Fengjuan","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanhua","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongjuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaodi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-8772","authenticated-orcid":false,"given":"Changzhu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"issue":"6","key":"10172_CR1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68(6):394\u2013424","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10172_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/hepr.12378","volume":"45","author":"Y Osaki","year":"2015","unstructured":"Osaki Y, Nishikawa H. Treatment for hepatocellular carcinoma in Japan over the last three decades: our experience and published work review. Hepatol Res 2015;45(1):59\u201374","journal-title":"Hepatol Res"},{"issue":"Supplementum 3","key":"10172_CR3","first-page":"34","volume":"33","author":"U Petr","year":"2020","unstructured":"Petr U, Petr H. Hepatocellular carcinoma from the view of gastroenterologist\/hepatologist. Klin Onkol 2020;33(Supplementum 3):34\u201344","journal-title":"Klin Onkol"},{"issue":"8","key":"10172_CR4","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1007\/s00535-011-0415-9","volume":"46","author":"S-A Ng","year":"2011","unstructured":"Ng S-A, Lee C. Hepatitis B virus X gene and hepatocarcinogenesis. J Gastroenterol 2011;46(8):974\u2013990","journal-title":"J Gastroenterol"},{"issue":"31","key":"10172_CR5","doi-asserted-by":"publisher","first-page":"26302","DOI":"10.1074\/jbc.M112.342113","volume":"287","author":"Y Du","year":"2012","unstructured":"Du Y, Kong G, You X, Zhang S, Zhang T, Gao Y, et al. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem 2012;287(31):26302\u201326311","journal-title":"J Biol Chem"},{"issue":"1","key":"10172_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10529-011-0751-0","volume":"34","author":"G Qian","year":"2012","unstructured":"Qian G, Jin F, Chang L, Yang Y, Peng H, Duan C. NIRF, a novel ubiquitin ligase, interacts with hepatitis B virus core protein and promotes its degradation. Biotech Lett 2012;34(1):29\u201336","journal-title":"Biotech Lett"},{"issue":"3","key":"10172_CR7","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.pharmthera.2007.06.003","volume":"115","author":"C Bronner","year":"2007","unstructured":"Bronner C, Achour M, Arima Y, Chataigneau T, Saya H, Schini-Kerth VB. The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future? Pharmacol Ther 2007;115(3):419\u2013434","journal-title":"Pharmacol Ther"},{"issue":"2","key":"10172_CR8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.canlet.2011.09.033","volume":"314","author":"F Wang","year":"2012","unstructured":"Wang F, Zhang P, Ma Y, Yang J, Moyer MP, Shi C, et al. NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA. Cancer Lett 2012;314(2):223\u2013231","journal-title":"Cancer Lett"},{"issue":"33","key":"10172_CR9","doi-asserted-by":"publisher","first-page":"23833","DOI":"10.1074\/jbc.M112.447276","volume":"288","author":"H Lu","year":"2013","unstructured":"Lu H, Hallstrom TC. The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis. J Biol Chem 2013;288(33):23833\u201323843","journal-title":"J Biol Chem"},{"issue":"8","key":"10172_CR10","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s10529-018-2577-5","volume":"40","author":"Y Wang","year":"2018","unstructured":"Wang Y, Yan X, Zeng S, Zhang T, Cheng F, Chen R, et al. UHRF2 promotes DNA damage response by decreasing p21 via RING finger domain. Biotech Lett 2018;40(8):1181\u20131188","journal-title":"Biotech Lett"},{"issue":"3","key":"10172_CR11","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/onc.2011.227","volume":"31","author":"J Wu","year":"2012","unstructured":"Wu J, Liu S, Liu G, Dombkowski A, Abrams J, Martin-Trevino R, et al. Identification and functional analysis of 9p24 amplified genes in human breast cancer. Oncogene 2012;31(3):333\u2013341","journal-title":"Oncogene"},{"issue":"3","key":"10172_CR12","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/s13238-016-0324-z","volume":"8","author":"S Zeng","year":"2017","unstructured":"Zeng S, Wang Y, Zhang T, Bai L, Wang Y, Duan C. E3 ligase UHRF2 stabilizes the acetyltransferase TIP60 and regulates H3K9ac and H3K14ac via RING finger domain. Protein Cell 2017;8(3):202\u2013218","journal-title":"Protein Cell"},{"issue":"4","key":"10172_CR13","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.3892\/or.2014.3035","volume":"31","author":"S Lu","year":"2014","unstructured":"Lu S, Yan D, Wu Z, Jiang T, Chen J, Yuan L, et al. Ubiquitin-like with PHD and ring finger domains 2 is a predictor of survival and a potential therapeutic target in colon cancer. Oncol Rep 2014;31(4):1802\u20131810","journal-title":"Oncol Rep"},{"issue":"17","key":"10172_CR14","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.7150\/jca.25876","volume":"9","author":"C Jin","year":"2018","unstructured":"Jin C, Xiong D, Li H-R, Jiang J-H, Qi J-C, Ding J-Y. Loss of UHRF2 Is associated with non-small cell lung carcinoma progression. J Cancer 2018;9(17):2994\u20133005","journal-title":"J Cancer"},{"issue":"3","key":"10172_CR15","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jhep.2015.10.030","volume":"64","author":"FA Lempp","year":"2016","unstructured":"Lempp FA, Mutz P, Lipps C, Wirth D, Bartenschlager R, Urban S. Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor. J Hepatol 2016;64(3):556\u2013564","journal-title":"J Hepatol"},{"issue":"4","key":"10172_CR16","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1002\/hep.29912","volume":"68","author":"JH Ren","year":"2018","unstructured":"Ren JH, Hu JL, Cheng ST, Yu HB, Wong VKW, Law BYK, et al. SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3\u20139 homolog 1 and SET domain containing 1A histone methyltransferases. Hepatology 2018;68(4):1260\u20131276","journal-title":"Hepatology"},{"issue":"2","key":"10172_CR17","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.bbrc.2004.04.190","volume":"319","author":"Y Li","year":"2004","unstructured":"Li Y, Mori T, Hata H, Homma Y, Kochi H. NIRF induces G1 arrest and associates with Cdk2. Biochem Biophys Res Commun 2004;319(2):464\u2013468","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"10172_CR18","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s41416-019-0556-9","volume":"121","author":"R Kaul","year":"2019","unstructured":"Kaul R, Risinger AL, Mooberry SL. Eribulin rapidly inhibits TGF-beta-induced Snail expression and can induce slug expression in a Smad4-dependent manner. Br J Cancer 2019;121(7):611\u2013621","journal-title":"Br J Cancer"},{"issue":"1","key":"10172_CR19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.canlet.2016.06.009","volume":"380","author":"N Takase","year":"2016","unstructured":"Takase N, Koma Y, Urakawa N, Nishio M, Arai N, Akiyama H, et al. NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells. Cancer Lett 2016;380(1):47\u201358","journal-title":"Cancer Lett"},{"issue":"8","key":"10172_CR20","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/mc.21894","volume":"52","author":"F Zhang","year":"2013","unstructured":"Zhang F, Yang Q, Meng F, Shi H, Li H, Liang Y, et al. Astrocyte elevated gene-1 interacts with \u03b2-catenin and increases migration and invasion of colorectal carcinoma. Mol Carcinog 2013;52(8):603\u2013610","journal-title":"Mol Carcinog"},{"issue":"1","key":"10172_CR21","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.mrrev.2012.08.001","volume":"752","author":"N Kramer","year":"2013","unstructured":"Kramer N, Walzl A, Unger C, Rosner M, Krupitza G, Hengstschl\u00e4ger M, et al. In vitro cell migration and invasion assays. Mutat Res Rev Mutat Res 2013;752(1):10\u201324","journal-title":"Mutat Res Rev Mutat Res"},{"issue":"25","key":"10172_CR22","doi-asserted-by":"publisher","first-page":"21961","DOI":"10.1074\/jbc.M111.238238","volume":"286","author":"AK Singh","year":"2011","unstructured":"Singh AK, Swarnalatha M, Kumar V. c-ETS1 facilitates G1\/S-phase transition by up-regulating cyclin E and CDK2 genes and cooperates with hepatitis B virus X protein for their deregulation. J Biol Chem 2011;286(25):21961\u201321970","journal-title":"J Biol Chem"},{"issue":"8","key":"10172_CR23","first-page":"1773","volume":"158","author":"D Qin","year":"2013","unstructured":"Qin D, Li K, Qu J, Wang S, Zou C, Sheng Y, et al. HBx and HBs regulate RhoC expression by upregulating transcription factor Ets-1. Adv Virol 2013;158(8):1773\u20131781","journal-title":"Adv Virol"},{"key":"10172_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/jcar.JCar_9_16","volume":"16","author":"YA Ghouri","year":"2017","unstructured":"Ghouri YA, Mian I, Rowe JH. Review of hepatocellular carcinoma: epidemiology, etiology, and carcinogenesis. J Carcinog 2017;16:1","journal-title":"J Carcinog"},{"issue":"30","key":"10172_CR25","doi-asserted-by":"publisher","first-page":"10249","DOI":"10.3748\/wjg.v20.i30.10249","volume":"20","author":"LL Han","year":"2014","unstructured":"Han LL, Lv Y, Guo H, Ruan ZP, Nan KJ. Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy. World J Gastroenterol 2014;20(30):10249\u201310261","journal-title":"World J Gastroenterol"},{"issue":"3","key":"10172_CR26","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/S0006-291X(02)00890-2","volume":"296","author":"T Mori","year":"2002","unstructured":"Mori T, Li Y, Hata H, Ono K, Kochi H. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. Biochem Biophys Res Commun 2002;296(3):530\u2013536","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10172_CR27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1159\/000488860","volume":"95","author":"T Iguchi","year":"2018","unstructured":"Iguchi T, Ueda M, Masuda T, Nambara S, Kidogami S, Komatsu H, et al. Identification of UHRF2 as a negative regulator of epithelial-mesenchymal transition and its clinical significance in esophageal squamous cell carcinoma. Oncology 2018;95(3):179\u2013187","journal-title":"Oncology"},{"issue":"46","key":"10172_CR28","doi-asserted-by":"publisher","first-page":"76047","DOI":"10.18632\/oncotarget.12583","volume":"7","author":"HR Lu","year":"2016","unstructured":"Lu HR, Bhoopatiraju S, Wang HB, Schmitz NP, Wang XH, Freeman MJ, et al. Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity. Oncotarget 2016;7(46):76047\u201376061","journal-title":"Oncotarget"},{"key":"10172_CR29","doi-asserted-by":"publisher","first-page":"5863","DOI":"10.2147\/OTT.S149361","volume":"10","author":"R Peng","year":"2017","unstructured":"Peng R, Huang X, Zhang C, Yang X, Xu Y, Bai D. Overexpression of UHRF2 in intrahepatic cholangiocarcinoma and its clinical significance. OncoTargets Ther 2017;10:5863\u20135872","journal-title":"OncoTargets Ther"},{"issue":"7","key":"10172_CR30","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1074\/mcp.M115.057448","volume":"15","author":"M Lai","year":"2016","unstructured":"Lai M, Liang L, Chen J, Qiu N, Ge S, Ji S, et al. Multidimensional proteomics reveals a role of UHRF2 in the regulation of epithelial-mesenchymal transition (EMT). Mol Cell Proteom 2016;15(7):2263\u20132278","journal-title":"Mol Cell Proteom"},{"issue":"8","key":"10172_CR31","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1002\/ijc.33036","volume":"147","author":"L Li","year":"2020","unstructured":"Li L, Duan QH, Zeng ZY, Zhao JD, Lu JW, Sun JL, et al. UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt\/beta-catenin signaling. Int J Cancer 2020;147(8):2239\u20132252","journal-title":"Int J Cancer"},{"issue":"21","key":"10172_CR32","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1016\/j.febslet.2009.10.007","volume":"583","author":"X He","year":"2009","unstructured":"He X, Duan C, Chen J, Ou-Yang X, Zhang Z, Li C, et al. Let-7a elevates p21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells. FEBS Lett 2009;583(21):3501\u20133507","journal-title":"FEBS Lett"},{"issue":"10","key":"10172_CR33","doi-asserted-by":"publisher","first-page":"5137","DOI":"10.7314\/APJCP.2012.13.10.5137","volume":"13","author":"TF Wu","year":"2012","unstructured":"Wu TF, Zhang W, Su ZP, Chen SS, Chen GL, Wei YX, et al. UHRF2 mRNA expression is low in malignant glioma but silencing inhibits the growth of U251 glioma cells in vitro. Asian Pac J Cancer Prev 2012;13(10):5137\u20135142","journal-title":"Asian Pac J Cancer Prev"},{"issue":"16","key":"10172_CR34","doi-asserted-by":"publisher","first-page":"e00340","DOI":"10.1128\/JVI.00340-17","volume":"91","author":"N Liu","year":"2017","unstructured":"Liu N, Zhang J, Yang X, Jiao T, Zhao X, Li W, et al. HDM2 pmotes NEDDylation of Hepatitis B virus HBx to enhance its stability and function. J Virol 2017;91(16):e00340-17","journal-title":"J Virol"},{"issue":"19","key":"10172_CR35","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1016\/j.febslet.2011.08.015","volume":"585","author":"J Zhao","year":"2011","unstructured":"Zhao J, Wang C, Wang J, Yang X, Diao N, Li Q, et al. E3 ubiquitin ligase Siah-1 facilitates poly-ubiquitylation and proteasomal degradation of the hepatitis B viral X protein. FEBS Lett 2011;585(19):2943\u20132950","journal-title":"FEBS Lett"},{"issue":"4","key":"10172_CR36","doi-asserted-by":"publisher","first-page":"418","DOI":"10.7150\/jca.13019","volume":"7","author":"J Zhao","year":"2016","unstructured":"Zhao J, Wu J, Cai H, Wang D, Yu L, Zhang W-H. E3 ubiquitin ligase Siah-1 is down-regulated and fails to target natural HBx truncates for degradation in hepatocellular carcinoma. J Cancer 2016;7(4):418\u2013426","journal-title":"J Cancer"},{"issue":"5","key":"10172_CR37","doi-asserted-by":"publisher","first-page":"e0127329","DOI":"10.1371\/journal.pone.0127329","volume":"10","author":"H Zhang","year":"2015","unstructured":"Zhang H, Huang C, Wang Y, Lu Z, Zhuang N, Zhao D, et al. Hepatitis B virus X protein sensitizes TRAIL-induced hepatocyte apoptosis by inhibiting the E3 ubiquitin ligase A20. PLoS One 2015;10(5):e0127329","journal-title":"PLoS One"},{"issue":"40","key":"10172_CR38","doi-asserted-by":"publisher","first-page":"6696","DOI":"10.1038\/s41388-019-0907-2","volume":"38","author":"J Wang","year":"2019","unstructured":"Wang J, Li N, Huang Z-B, Fu S, Yu S-M, Fu Y-M, et al. HBx regulates transcription factor PAX8 stabilization to promote the progression of hepatocellular carcinoma. Oncogene 2019;38(40):6696\u20136710","journal-title":"Oncogene"},{"issue":"4","key":"10172_CR39","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3390\/cells9040834","volume":"9","author":"MM Minor","year":"2020","unstructured":"Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, et al. Hepatitis B virus HBx protein mediates the degradation of host restriction factors through the Cullin 4 DDB1 E3 ubiquitin ligase complex. Cells 2020;9(4):834","journal-title":"Cells"},{"issue":"7","key":"10172_CR40","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1099\/jgv.0.000856","volume":"98","author":"S Yeom","year":"2017","unstructured":"Yeom S, Kim SS, Jeong H, Jang KL. Hepatitis B virus X protein activates E3 ubiquitin ligase Siah-1 to control virus propagation via a negative feedback loop. J Gen Virol 2017;98(7):1774\u20131784","journal-title":"J Gen Virol"},{"issue":"1","key":"10172_CR41","doi-asserted-by":"publisher","first-page":"115 e117","DOI":"10.1016\/j.ccell.2017.06.001","volume":"32","author":"Y Gu","year":"2017","unstructured":"Gu Y, Zhang J, Ma X, Kim BW, Wang H, Li J, et al. Stabilization of the c-Myc protein by CAMKIIgamma promotes T cell lymphoma. Cancer Cell 2017;32(1):115 e117\u2013128 e117","journal-title":"Cancer Cell"},{"issue":"14","key":"10172_CR42","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1038\/onc.2015.251","volume":"35","author":"S Lee","year":"2015","unstructured":"Lee S, Kim W, Ko C, Ryu WS. Hepatitis B virus X protein enhances Myc stability by inhibiting SCFSkp2 ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis. Oncogene 2015;35(14):1857\u20131867","journal-title":"Oncogene"},{"issue":"7","key":"10172_CR43","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2519","volume":"10","author":"DL Swaney","year":"2013","unstructured":"Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S,et al. Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Nat Methods 2013;10(7):676\u2013682","journal-title":"Nat Methods"},{"issue":"1","key":"10172_CR44","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1042\/BJ20061091","volume":"401","author":"A Mukherji","year":"2006","unstructured":"Mukherji A, Janbandhu Vaibhao C, Kumar V. HBx-dependent cell cycle deregulation involves interaction with cyclin E\/A\u2013cdk2 complex and destabilization of p27Kip1. Biochem J 2006;401(1):247\u2013256","journal-title":"Biochem J"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-021-10172-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-021-10172-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-021-10172-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T20:32:58Z","timestamp":1675197178000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-021-10172-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10172"],"URL":"https:\/\/doi.org\/10.1007\/s12072-021-10172-z","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,19]]},"assertion":[{"value":"19 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Fengjuan Cheng, Guanhua Qian, Xianyun Fang, Jingjie Sun, Siyuan Chen, Rongjuan Chen, Shangjing Liu, Zhaodi Li, Kejia Wu, Shiming Jiang, Yong Chen, Ni Tang, Juan Chen, and Changzhu Duan declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in accordance with the declaration of Helsinki. HBV-positive HCC tissue samples and paired adjacent normal tissues were collected from the First Affiliated Hospital of Chongqing Medical University. Usage of these patient tissue samples was approved by the Ethics Committee of Chongqing Medical University (committee\u2019s reference number: 2018027).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All data generated or analyzed during this study are included in this published article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}}]}}