{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:59:14Z","timestamp":1784221154377,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["IR\/SB\/EF\/02\/2016"],"award-info":[{"award-number":["IR\/SB\/EF\/02\/2016"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s12072-021-10244-0","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T13:03:51Z","timestamp":1629896631000},"page":"1389-1401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction"],"prefix":"10.1007","volume":"15","author":[{"given":"Nidhi","family":"Nautiyal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepanshu","family":"Maheshwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Mani","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Parasar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chhagan","family":"Bihari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhrajit","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhi","family":"Maiwall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-5610","authenticated-orcid":false,"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"issue":"3","key":"10244_CR1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nrgastro.2015.219","volume":"13","author":"SK Sarin","year":"2016","unstructured":"Sarin SK, Choudhury A. Acute-on-chronic liver failure: terminology, mechanismsand management. Nat Rev Gastroenterol Hepatol 2016;13(3):131\u2013149","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"10244_CR2","doi-asserted-by":"publisher","first-page":"16041","DOI":"10.1038\/nrdp.2016.41","volume":"9","author":"V Arroyo","year":"2016","unstructured":"Arroyo V, Moreau R, Kamath PS, Jalan R, Gin\u00e8s P, Nevens F, et al. Acute-on-chronic liver failure in cirrhosis. Nat Rev Dis Primers 2016;9(2):16041","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"10244_CR3","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1002\/hep.30056","volume":"68","author":"JS Bajaj","year":"2018","unstructured":"Bajaj JS, Moreau R, Kamath PS, Vargas HE, Arroyo V, Reddy KR, et al. Acute-on-chronic liver failure: getting ready for prime time? Hepatology 2018;68(4):1621\u20131632","journal-title":"Hepatology"},{"issue":"12","key":"10244_CR4","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1136\/gutjnl-2017-314641","volume":"67","author":"T Wu","year":"2018","unstructured":"Wu T, Li J, Shao L, Xin J, Jiang L, Zhou Q, et al. Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure. Gut 2018;67(12):2181\u20132191","journal-title":"Gut"},{"issue":"4","key":"10244_CR5","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1080\/17474124.2018.1426459","volume":"12","author":"RH Zhao","year":"2018","unstructured":"Zhao RH, Shi Y, Zhao H, Wu W, Sheng JF. Acute-on-chronic liver failure in chronic hepatitis B: an update. Expert Rev Gastroenterol Hepatol 2018;12(4):341\u2013350","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"6","key":"10244_CR6","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.jhep.2012.06.026","volume":"57","author":"R Jalan","year":"2012","unstructured":"Jalan R, Gines P, Olson JC, Mookerjee RP, Moreau R, Garcia-Tsao G, et al. Acute-on chronic liver failure. J Hepatol 2012;57(6):1336\u20131348","journal-title":"J Hepatol"},{"key":"10244_CR7","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1002\/lt.23678","volume":"19","author":"A Finkenstedt","year":"2013","unstructured":"Finkenstedt A, Nachbaur K, Graziadei W, Vogel W. Acute on chronic liver failure: excellent outcomes after liver transplantation but high mortality on the wait list. Liver Transpl 2013;19:879\u2013886","journal-title":"Liver Transpl"},{"issue":"5","key":"10244_CR8","doi-asserted-by":"publisher","first-page":"G1069","DOI":"10.1152\/ajpgi.90689.2008","volume":"296","author":"A Kuhla","year":"2009","unstructured":"Kuhla A, Eipel C, Abshagen K, Siebert N, Menger MD, Vollmar B. Role of the perforin\/granzyme cell death pathway in D-Gal\/LPS-induced inflammatory liver injury. Am J Physiol Gastrointest Liver Physiol 2009;296(5):G1069\u2013G1076","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"7","key":"10244_CR9","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00011-013-0624-1","volume":"62","author":"X Li","year":"2013","unstructured":"Li X, Wang LK, Wang LW, Han XQ, Yang F, Gong ZJ. Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats. Inflamm Res 2013;62(7):703\u2013709","journal-title":"Inflamm Res"},{"issue":"6","key":"10244_CR10","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.jhep.2013.01.023","volume":"58","author":"V Balasubramaniyan","year":"2013","unstructured":"Balasubramaniyan V, Dhar DK, Warner AE, Vivien Li WY, Amiri AF, Bright B, et al. Importance of connexin-43 based gap junction in cirrhosis and acute-on-chronic liver failure. J Hepatol 2013;58(6):1194\u20131200","journal-title":"J Hepatol"},{"issue":"3","key":"10244_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.apsb.2016.09.003","volume":"7","author":"F Li","year":"2017","unstructured":"Li F, Miao L, Sun H, Zhang Y, Bao X, Zhang D. Establishment of a new acute-on-chronic liver failure model. Acta Pharm Sin B 2017;7(3):326\u2013333","journal-title":"Acta Pharm Sin B"},{"issue":"5","key":"10244_CR12","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1053\/j.gastro.2018.07.022","volume":"155","author":"DM Tripathi","year":"2018","unstructured":"Tripathi DM, Vilaseca M, Lafoz E, Garcia-Calder\u00f3 H, Viegas Haute G, Fernandez-Iglesias A, et al. Simvastatin prevents progression of acute on chronic liver failure in rats with cirrhosis and portal hypertension. Gastroenterology 2018;155(5):1564\u20131577","journal-title":"Gastroenterology"},{"issue":"4","key":"10244_CR13","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.jhep.2019.11.013","volume":"72","author":"X Xiang","year":"2020","unstructured":"Xiang X, Feng D, Hwang S, Ren T, Wang X, Trojnar E, et al. Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice. J Hepatol. 2020;72(4):736\u2013745","journal-title":"J Hepatol."},{"issue":"10","key":"10244_CR14","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1136\/gutjnl-2017-314240","volume":"67","author":"J Fern\u00e1ndez","year":"2018","unstructured":"Fern\u00e1ndez J, Acevedo J, Wiest R, Gustot T, Amoros A, Deulofeu C, et al. Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis. Gut. 2018;67(10):1870\u20138180","journal-title":"Gut"},{"issue":"10","key":"10244_CR15","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.4049\/jimmunol.1600818","volume":"197","author":"J Cl\u00e0ria","year":"2016","unstructured":"Cl\u00e0ria J, Arroyo V, Moreau R. The acute-on-chronic liver failure syndrome, or when the innate immune system goes astray. J Immunol 2016;197(10):3755\u20133761","journal-title":"J Immunol"},{"issue":"2","key":"10244_CR16","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1055\/s-0038-1657751","volume":"38","author":"L Yang","year":"2018","unstructured":"Yang L, Wu T, Li J, Li J. Bacterial infections in acute-on-chronic liver failure. Semin Liver Dis 2018;38(2):121\u2013133","journal-title":"Semin Liver Dis"},{"issue":"4","key":"10244_CR17","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s12072-014-9580-2","volume":"8","author":"SK Sarin","year":"2014","unstructured":"Sarin SK, Kedarisetty CK, Abbas Z, Amarapurkar D, Bihari C, Chan AC, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL) 2014. Hepatol Int 2014;8(4):453\u2013471","journal-title":"Hepatol Int"},{"issue":"4","key":"10244_CR18","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s12072-019-09946-3","volume":"13","author":"SK Sarin","year":"2019","unstructured":"Sarin SK, Choudhury A, Sharma MK, Maiwall R, Alahtab M, Rahman S, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int 2019;13(4):353\u2013390","journal-title":"Hepatol Int"},{"issue":"12","key":"10244_CR19","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1111\/jgh.13799","volume":"32","author":"A Choudhury","year":"2017","unstructured":"Choudhury A, Kumar M, Sharma BC, Maiwall R, Pamecha V, Moreau R, et al. Systemic inflammatory response syndrome in acute-on-chronic liver failure: Relevance of \u2018golden window\u2019: a prospective study. J Gastroenterol Hepatol 2017;32(12):1989\u20131997","journal-title":"J Gastroenterol Hepatol"},{"issue":"11","key":"10244_CR20","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1136\/gut.2009.189639","volume":"59","author":"A Katoonizadeh","year":"2010","unstructured":"Katoonizadeh A, Laleman W, Verslype C, Wilmer A, Maleux G, Roskams T, et al. Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study. Gut 2010;59(11):1561\u20131569","journal-title":"Gut"},{"issue":"6","key":"10244_CR21","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1365-3083.2009.02255.x","volume":"69","author":"A Castellheim","year":"2009","unstructured":"Castellheim A, Brekke OL, Espevik T, Harboe M, Mollnes TE. Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis. Scand J Immunol 2009;69(6):479\u2013491","journal-title":"Scand J Immunol"},{"issue":"3","key":"10244_CR22","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jhep.2009.04.017","volume":"51","author":"M Cazzaniga","year":"2009","unstructured":"Cazzaniga M, Dionigi E, Gobbo G, Fioretti A, Monti V, Salerno F. The systemic inflammatory response syndrome in cirrhotic patients: relationship with their in-hospital outcome. J Hepatol 2009;51(3):475\u2013482","journal-title":"J Hepatol"},{"issue":"4","key":"10244_CR23","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.ajpath.2018.12.006","volume":"189","author":"B Bhushan","year":"2019","unstructured":"Bhushan B, Apte U. Liver regeneration after acetaminophen hepatotoxicity: mechanisms and therapeutic opportunities. Am J Pathol 2019;189(4):719\u2013729","journal-title":"Am J Pathol"},{"issue":"6","key":"10244_CR24","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s12072-019-09983-y","volume":"13","author":"S Shubham","year":"2019","unstructured":"Shubham S, et al. Cellular and functional loss of liver endothelial cells correlates with poor hepatocyte regeneration in acute-on-chronic liver failure. Hepatol Int 2019;13(6):777\u2013877","journal-title":"Hepatol Int"},{"issue":"3","key":"10244_CR25","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1136\/gutjnl-2016-312670","volume":"66","author":"R Hernaez","year":"2017","unstructured":"Hernaez R, Sol\u00e0 E, Moreau R, Gin\u00e8s P. Acute-on-chronic liver failure: an update. Gut 2017;66(3):541\u2013553","journal-title":"Gut"},{"key":"10244_CR26","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00428-014-1547-0","volume":"464","author":"A Rastogi","year":"2014","unstructured":"Rastogi A, Maiwall R, Bihari C, Trehanpati N, Pamecha V, Sarin SK. Two-tier regenerative response in liver failure in humans. Virchows Arch 2014;464:565\u2013573","journal-title":"Virchows Arch"},{"issue":"4","key":"10244_CR27","doi-asserted-by":"publisher","first-page":"5035","DOI":"10.3892\/mmr.2015.4029","volume":"12","author":"LY Chen","year":"2015","unstructured":"Chen LY, et al. Promotion of mitochondrial energy metabolism during hepatocyte apoptosis in a rat model of acute liver failure. Mol Med Rep 2015;12(4):5035\u20135041","journal-title":"Mol Med Rep"},{"issue":"3","key":"10244_CR28","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1172\/JCI1018","volume":"102","author":"JP Iredale","year":"1998","unstructured":"Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, et al. Mechanisms of spontaneous resolution of rat liver fibrosis Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998;102(3):538\u2013549","journal-title":"J Clin Invest"},{"issue":"1","key":"10244_CR29","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/01926230590881808","volume":"33","author":"HM Mehendale","year":"2005","unstructured":"Mehendale HM. Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol Pathol 2005;33(1):41\u201351","journal-title":"Toxicol Pathol"},{"issue":"4","key":"10244_CR30","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s12072-015-9653-x","volume":"9","author":"R Maiwall","year":"2015","unstructured":"Maiwall R, et al. AKI in patients with acute on chronic liver failure is different from acute decompensation of cirrhosis. Hepatol Int 2015;9(4):627\u2013639","journal-title":"Hepatol Int"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-021-10244-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-021-10244-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-021-10244-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T21:04:11Z","timestamp":1638911051000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-021-10244-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10244"],"URL":"https:\/\/doi.org\/10.1007\/s12072-021-10244-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-438031\/v1","asserted-by":"object"}]},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,25]]},"assertion":[{"value":"17 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal care and all experimental procedures were approved by the Institutional Animal Ethics Committee (IAEC) under the project approval (IAEC\/ILB\/17\/03) from Department of Science and Technology, Government of India.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Nautiyal Nidhi, Maheshwari Deepanshu, Tripathi Dinesh Mani, Kumar Dhananjay, Kumari Rekha, Gupta Suchi, Sharma Sachin, Mohanty Sujata, Parasar Anupama, Bihari Chhagan, Biswas Subhrajit, Rastogi Archana, Maiwall Rakhi, Kumar Anupam, Shiv Kumar Sarin have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}