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The procedure is generally safe and well tolerated, but nevertheless, some patients demand for sedation. However, it is unknown whether propofol sedation would impair the accuracy of portal pressure measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective observational cohort study including cirrhotic patients with suspected portal hypertension undergoing invasive measurement of HVPG. Measurements of HVPG were performed in awake condition as well as under sedation with propofol infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 37 patients were included. Mean HVPG in awake condition was 15.9\u00a0mmHg (IQR 13\u201319) and during sedation 14.1\u00a0mmHg (IQR 12\u201317). While measures of free hepatic vein pressure (FHVP) were not altered after propofol sedation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.34), wedged hepatic vein pressure values (WHVP) decreased in an average by \u00a02.05\u00a0mmHg (95% CI \u2212 2.46 to \u2212 1.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) which was proportional to the magnitude of HVPG. In 31 out of 37 patients (83.8%), portal hypertension with HVPG\u2009\u2265\u200912\u00a0mmHg was found. Under sedation with propofol, two patients (5.4%) with borderline values would have been incorrectly classified as\u2009&lt;\u200912\u00a0mmHg. After adjustment for the average difference of \u2212 10%, all patients were correctly classified. Intraclass correlation coefficient between HVPG measurement in awake condition and under propofol sedation was 0.927 (95% CI 0.594\u20130.975).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Propofol sedation during HVPG measurements is generally safe, however it may lead to relevant alterations of HVPG readings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12072-021-10261-z","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T07:48:01Z","timestamp":1635234481000},"page":"817-823","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of propofol sedation on the diagnostic accuracy of hepatic venous pressure gradient measurements in patients with cirrhosis"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5862-966X","authenticated-orcid":false,"given":"Fahim","family":"Ebrahimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Semela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Heim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"10261_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","volume":"44","author":"G D\u2019Amico","year":"2006","unstructured":"D\u2019Amico G, Garcia-Tsao G, Pagliaro L. 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