{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:53:24Z","timestamp":1772121204437,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030026"],"award-info":[{"award-number":["82030026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070837"],"award-info":[{"award-number":["82070837"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970704"],"award-info":[{"award-number":["81970704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["YY-086"],"award-info":[{"award-number":["YY-086"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Trials from the Affiliated Drum Tower Hospital, Medical School of Nanjing University","award":["2021-LCYJ-DBZ-10"],"award-info":[{"award-number":["2021-LCYJ-DBZ-10"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s12072-022-10409-5","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T17:08:09Z","timestamp":1662570489000},"page":"215-224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The association between visceral adipocyte hypertrophy and NAFLD in subjects with different degrees of adiposity"],"prefix":"10.1007","volume":"17","author":[{"given":"Haixiang","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huayang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianwei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3914-7854","authenticated-orcid":false,"given":"Yan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"10409_CR1","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","volume":"62","author":"CD Byrne","year":"2015","unstructured":"Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol 2015;62:S47\u201364","journal-title":"J Hepatol"},{"key":"10409_CR2","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1001\/jama.2015.5370","volume":"313","author":"ME Rinella","year":"2015","unstructured":"Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA 2015;313:2263\u20132273","journal-title":"JAMA"},{"key":"10409_CR3","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s13238-017-0436-0","volume":"9","author":"X Zhang","year":"2018","unstructured":"Zhang X, Ji X, Wang Q, Li JZ. New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Protein Cell 2018;9:164\u2013177","journal-title":"Protein Cell"},{"key":"10409_CR4","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1111\/j.1440-1746.2009.05996.x","volume":"24","author":"CZ Larter","year":"2009","unstructured":"Larter CZ, Yeh MM, Van Rooyen DM, Teoh NC, Brooling J, Hou JY, et al. Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice. J Gastroenterol Hepatol 2009;24:1658\u20131668","journal-title":"J Gastroenterol Hepatol"},{"key":"10409_CR5","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1002\/oby.21170","volume":"23","author":"F Haczeyni","year":"2015","unstructured":"Haczeyni F, Barn V, Mridha AR, Yeh MM, Estevez E, Febbraio MA, et al. Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice. Obesity (Silver Spring) 2015;23:1845\u20131855","journal-title":"Obesity (Silver Spring)"},{"key":"10409_CR6","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/obr.12646","volume":"19","author":"F Haczeyni","year":"2018","unstructured":"Haczeyni F, Bell-Anderson KS, Farrell GC. Causes and mechanisms of adipocyte enlargement and adipose expansion. Obes Rev 2018;19:406\u2013420","journal-title":"Obes Rev"},{"key":"10409_CR7","doi-asserted-by":"publisher","first-page":"863","DOI":"10.2147\/DMSO.S203937","volume":"12","author":"K Albracht-Schulte","year":"2019","unstructured":"Albracht-Schulte K, Rosairo S, Ramalingam L, Wijetunge S, Ratnayake R, Kotakadeniya H, et al. Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women. Diabetes Metab Syndr Obes 2019;12:863\u2013872","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10409_CR8","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1002\/oby.20114","volume":"21","author":"EM Petaja","year":"2013","unstructured":"Petaja EM, Sevastianova K, Hakkarainen A, Orho-Melander M, Lundbom N, Yki-Jarvinen H. Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype. Obesity (Silver Spring) 2013;21:1174\u20131179","journal-title":"Obesity (Silver Spring)"},{"key":"10409_CR9","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1002\/hep.25762","volume":"55","author":"N Chalasani","year":"2012","unstructured":"Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012;55:2005\u20132023","journal-title":"Hepatology"},{"key":"10409_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009997","volume":"5","author":"J O'Connell","year":"2010","unstructured":"O\u2019Connell J, Lynch L, Cawood TJ, Kwasnik A, Nolan N, Geoghegan J, et al. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS One 2010;5: e9997","journal-title":"PLoS One"},{"key":"10409_CR11","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.metabol.2014.09.001","volume":"63","author":"A Wree","year":"2014","unstructured":"Wree A, Schlattjan M, Bechmann LP, Claudel T, Sowa JP, Stojakovic T, et al. Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients. Metabolism 2014;63:1542\u20131552","journal-title":"Metabolism"},{"key":"10409_CR12","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","volume":"41","author":"DE Kleiner","year":"2005","unstructured":"Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313\u20131321","journal-title":"Hepatology"},{"key":"10409_CR13","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.jhep.2015.11.004","volume":"64","author":"European Association for the Study of the L, European Association for the Study of D, European Association for the Study of O","year":"2016","unstructured":"European Association for the Study of the L, European Association for the Study of D, European Association for the Study of O. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol 2016;64:1388\u20131402","journal-title":"J Hepatol"},{"key":"10409_CR14","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1002\/hep.25889","volume":"56","author":"P Bedossa","year":"2012","unstructured":"Bedossa P, Poitou C, Veyrie N, Bouillot JL, Basdevant A, Paradis V, et al. Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients. Hepatology 2012;56:1751\u20131759","journal-title":"Hepatology"},{"key":"10409_CR15","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/oby.21697","volume":"25","author":"S Laforest","year":"2017","unstructured":"Laforest S, Michaud A, Paris G, Pelletier M, Vidal H, Geloen A, et al. Comparative analysis of three human adipocyte size measurement methods and their relevance for cardiometabolic risk. Obesity (Silver Spring) 2017;25:122\u2013131","journal-title":"Obesity (Silver Spring)"},{"key":"10409_CR16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1210\/endrev\/bnab018","volume":"43","author":"RZ Ye","year":"2022","unstructured":"Ye RZ, Richard G, Gevry N, Tchernof A, Carpentier AC. Fat cell size: measurement methods, pathophysiological origins, and relationships with metabolic dysregulations. Endocr Rev 2022;43:35\u201360","journal-title":"Endocr Rev"},{"key":"10409_CR17","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1080\/21623945.2021.1982164","volume":"10","author":"AS Leven","year":"2021","unstructured":"Leven AS, Gieseler RK, Schlattjan M, Schreiter T, Niedergethmann M, Baars T, et al. Association of cell death mechanisms and fibrosis in visceral white adipose tissue with pathological alterations in the liver of morbidly obese patients with NAFLD. Adipocyte 2021;10:558\u2013573","journal-title":"Adipocyte"},{"key":"10409_CR18","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.2337\/db10-0585","volume":"59","author":"A Divoux","year":"2010","unstructured":"Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, Aissat A, et al. Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes 2010;59:2817\u20132825","journal-title":"Diabetes"},{"key":"10409_CR19","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/oby.21377","volume":"24","author":"LA Muir","year":"2016","unstructured":"Muir LA, Neeley CK, Meyer KA, Baker NA, Brosius AM, Washabaugh AR, et al. Adipose tissue fibrosis, hypertrophy, and hyperplasia: correlations with diabetes in human obesity. Obesity (Silver Spring) 2016;24:597\u2013605","journal-title":"Obesity (Silver Spring)"},{"key":"10409_CR20","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/ijo.2013.175","volume":"38","author":"F el Bouazzaoui","year":"2014","unstructured":"el Bouazzaoui F, Henneman P, Thijssen P, Visser A, Koning F, Lips MA, et al. Adipocyte telomere length associates negatively with adipocyte size, whereas adipose tissue telomere length associates negatively with the extent of fibrosis in severely obese women. Int J Obes (Lond) 2014;38:746\u2013749","journal-title":"Int J Obes (Lond)"},{"key":"10409_CR21","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1016\/j.bpj.2010.10.009","volume":"99","author":"J Jo","year":"2010","unstructured":"Jo J, Guo J, Liu T, Mullen S, Hall KD, Cushman SW, et al. Hypertrophy-driven adipocyte death overwhelms recruitment under prolonged weight gain. Biophys J 2010;99:3535\u20133544","journal-title":"Biophys J"},{"key":"10409_CR22","doi-asserted-by":"publisher","first-page":"R149","DOI":"10.1530\/EJE-20-0363","volume":"183","author":"C Poitou","year":"2020","unstructured":"Poitou C, Mosbah H, Clement K. MECHANISMS IN ENDOCRINOLOGY: update on treatments for patients with genetic obesity. Eur J Endocrinol 2020;183:R149\u2013R166","journal-title":"Eur J Endocrinol"},{"key":"10409_CR23","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1002\/hep.25539","volume":"55","author":"R Lomonaco","year":"2012","unstructured":"Lomonaco R, Ortiz-Lopez C, Orsak B, Webb A, Hardies J, Darland C, et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology 2012;55:1389\u20131397","journal-title":"Hepatology"},{"key":"10409_CR24","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.jhep.2019.06.031","volume":"71","author":"C Rosso","year":"2019","unstructured":"Rosso C, Kazankov K, Younes R, Esmaili S, Marietti M, Sacco M, et al. Crosstalk between adipose tissue insulin resistance and liver macrophages in non-alcoholic fatty liver disease. J Hepatol 2019;71:1012\u20131021","journal-title":"J Hepatol"},{"key":"10409_CR25","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1002\/hep.25739","volume":"56","author":"G Musso","year":"2012","unstructured":"Musso G, Cassader M, De Michieli F, Rosina F, Orlandi F, Gambino R. Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. Hepatology 2012;56:933\u2013942","journal-title":"Hepatology"},{"key":"10409_CR26","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1210\/jc.2006-1055","volume":"92","author":"T Skurk","year":"2007","unstructured":"Skurk T, Alberti-Huber C, Herder C, Hauner H. Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 2007;92:1023\u20131033","journal-title":"J Clin Endocrinol Metab"},{"key":"10409_CR27","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cca.2012.12.007","volume":"417","author":"A Yadav","year":"2013","unstructured":"Yadav A, Kataria MA, Saini V, Yadav A. Role of leptin and adiponectin in insulin resistance. Clin Chim Acta 2013;417:80\u201384","journal-title":"Clin Chim Acta"},{"key":"10409_CR28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nri2921","volume":"11","author":"N Ouchi","year":"2011","unstructured":"Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011;11:85\u201397","journal-title":"Nat Rev Immunol"},{"key":"10409_CR29","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1096\/fj.05-5678fje","volume":"20","author":"M Jernas","year":"2006","unstructured":"Jernas M, Palming J, Sjoholm K, Jennische E, Svensson PA, Gabrielsson BG, et al. Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J 2006;20:1540\u20131542","journal-title":"FASEB J"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-022-10409-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-022-10409-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-022-10409-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T17:44:08Z","timestamp":1675359848000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-022-10409-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10409"],"URL":"https:\/\/doi.org\/10.1007\/s12072-022-10409-5","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]},"assertion":[{"value":"25 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Haixiang Sun, Da Fang, Hongdong Wang, Jin Wang, Yue Yuan, Shanshan Huang, Huayang Ma, Tianwei Gu, Yan Bi declare that they have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal research (ethics)"}},{"value":"The study conforms to the guidelines of the Declaration of Helsinki and was approved by Nanjing Drum Tower Hospital Committee (201703008). Written informed consent was obtained from each subject in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate (ethics)"}},{"value":"All the authors contributed to the interpretation of the data and reviewed and approved the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish (ethics)"}}]}}