{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:49:59Z","timestamp":1792028999360,"version":"4.4.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s12072-022-10426-4","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T10:02:39Z","timestamp":1665655359000},"page":"476-487","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["PIRO-CIC model can predict mortality and futility of care in critically ill cirrhosis patients in the intensive care unit"],"prefix":"10.1007","volume":"17","author":[{"given":"Rakhi","family":"Maiwall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samba Siva Rao","family":"Pasupuleti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh Vardhan","family":"Tevethia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-5610","authenticated-orcid":false,"given":"Shiv Kumar","family":"Sarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"10426_CR1","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1002\/hep.24622","volume":"54","author":"JC Olson","year":"2011","unstructured":"Olson JC, Wendon JA, Kramer DJ, et al. Intensive care of the patient with cirrhosis. Hepatology. 2011;54:1864\u20131872","journal-title":"Hepatology"},{"key":"10426_CR2","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/j.1365-2036.2006.02842.x","volume":"23","author":"E Cholongitas","year":"2006","unstructured":"Cholongitas E, Senzolo M, Patch D, et al. Risk factors, sequential organ failure assessment and model for end-stage liver disease scores for predicting short term mortality in cirrhotic patients admitted to intensive care unit. Aliment Pharmacol Ther. 2006;23:883\u2013893","journal-title":"Aliment Pharmacol Ther"},{"key":"10426_CR3","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1097\/CCM.0b013e3181f3dea9","volume":"38","author":"V Das","year":"2010","unstructured":"Das V, Boelle PY, Galbois A, et al. Cirrhotic patients in the medical intensive care unit: early prognosis and long-term survival. Crit Care Med. 2010;38:2108\u20132116","journal-title":"Crit Care Med"},{"key":"10426_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/hep.27849","volume":"62","author":"T Gustot","year":"2015","unstructured":"Gustot T, Fernandez J, Garcia E, et al. Clinical Course of acute-on-chronic liver failure syndrome and effects on prognosis. Hepatology. 2015;62:243\u2013252","journal-title":"Hepatology"},{"key":"10426_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1471-2253-14-123","volume":"14","author":"CM Fu","year":"2014","unstructured":"Fu CM, Chang CH, Fan PC, et al. Prognosis of critically ill cirrhotic versus non-cirrhotic patients: a comprehensive score-matched study. BMC Anesthesiol. 2014;14:123","journal-title":"BMC Anesthesiol"},{"issue":"9","key":"10426_CR6","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.gastrohep.2015.09.019","volume":"39","author":"J Fern\u00e1ndez","year":"2016","unstructured":"Fern\u00e1ndez J, Aracil C, Sol\u00e0 E, et al. Evaluaci\u00f3n y tratamiento del paciente cirr\u00f3tico cr\u00edtico [evaluation and treatment of the critically ill cirrhotic patient]. Gastroenterol Hepatol. 2016;39(9):607\u2013626","journal-title":"Gastroenterol Hepatol"},{"key":"10426_CR7","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14809","author":"R Maiwall","year":"2021","unstructured":"Maiwall R, Pasupuleti SSR, Chandel SS, Narayan A, Jain P, Mitra LG, et al. Co-orchestration of acute kidney injury and non-kidney organ failures in critically ill patients with cirrhosis. Liver Int. 2021. https:\/\/doi.org\/10.1111\/liv.14809","journal-title":"Liver Int"},{"key":"10426_CR8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/TP.0000000000003364","volume":"105","author":"E Weiss","year":"2021","unstructured":"Weiss E, Saner F, Asrani SK, et al. When is a critically ill cirrhotic patient too sick to transplant? Development of consensus criteria by a multidisciplinary panel of 35 international experts. Transplantation. 2021;105:561\u2013568","journal-title":"Transplantation"},{"key":"10426_CR9","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.jhep.2018.09.002","volume":"69","author":"J Fern\u00e1ndez","year":"2018","unstructured":"Fern\u00e1ndez J, Saliba F. Liver transplantation in patients with ACLF and multiple organ failure: time for priority after initial stabilization. J Hepatol. 2018;69:1004\u20131006","journal-title":"J Hepatol"},{"key":"10426_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jhep.2016.03.002","volume":"65","author":"X Ariza","year":"2016","unstructured":"Ariza X, Graupera I, Coll M, et al. Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis. J Hepatol. 2016;65:57\u201365","journal-title":"J Hepatol"},{"key":"10426_CR11","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/hep.30151","volume":"69","author":"A Drolz","year":"2019","unstructured":"Drolz A, Horvatits T, Rutter K, et al. Lactate improves prediction of short-term mortality in critically ill patients with cirrhosis: a multinational study. Hepatology. 2019;69:258\u2013269","journal-title":"Hepatology"},{"key":"10426_CR12","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s12072-017-9816-z","volume":"11","author":"A Choudhury","year":"2017","unstructured":"Choudhury A, Jindal A, Maiwall R, et al. Liver failure determines the outcome in patients of acute-on-chronic liver failure (ACLF): comparison. Hepatol Int. 2017;11:461\u2013471","journal-title":"Hepatol Int"},{"key":"10426_CR13","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00134-015-4203-5","volume":"42","author":"C Edmark","year":"2016","unstructured":"Edmark C, McPhail MJW, Bell M, Whitehouse T, Wendon J, LiFe CKB. a liver injury score to predict outcome in critically ill patients. Intensive Care Med. 2016;42:361\u2013369","journal-title":"Intensive Care Med"},{"key":"10426_CR14","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1111\/liv.13443","volume":"37","author":"R Maiwall","year":"2017","unstructured":"Maiwall R, Sarin SK, Kumar S, et al. Development of predisposition, injury, response, organ failure model for predicting acute kidney injury in acute on chronic liver failure. Liver Int. 2017;37:1497\u20131507","journal-title":"Liver Int"},{"key":"10426_CR15","doi-asserted-by":"publisher","first-page":"R227","DOI":"10.1186\/cc11882","volume":"16","author":"R Jalan","year":"2012","unstructured":"Jalan R, Stadlbauer V, Sen S, Cheshire L, Chang YM, Mookerjee RP. Role of predisposition, injury, response and organ failure in the prognosis of patients with acute-on-chronic liver failure: a prospective cohort study. Crit Care. 2012;16:R227","journal-title":"Crit Care"},{"issue":"4","key":"10426_CR16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s12072-019-09946-3","volume":"13","author":"SK Sarin","year":"2019","unstructured":"Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int. 2019;13(4):353\u2013390","journal-title":"Hepatol Int"},{"issue":"3","key":"10426_CR17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0167-9473(98)00096-6","volume":"30","author":"C Contal","year":"1999","unstructured":"Contal C, O\u2019Quigley J. An application of changepoint methods in studying the effect of age on survival in breast cancer. Comput Stat Data Anal. 1999;30(3):253\u2013270","journal-title":"Comput Stat Data Anal"},{"key":"10426_CR18","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","volume":"149","author":"M Levi","year":"2017","unstructured":"Levi M, van der Poll T. Coagulation and sepsis. Thromb Res. 2017;149:38\u201344","journal-title":"Thromb Res"},{"key":"10426_CR19","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/hep.30794","volume":"71","author":"M Kumar","year":"2020","unstructured":"Kumar M, Ahmad J, Maiwall R, et al. Thromboelastography-guided blood component use in patients with cirrhosis with nonvariceal bleeding: a randomized controlled trial. Hepatology. 2020;71:235\u2013246","journal-title":"Hepatology"},{"key":"10426_CR20","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1053\/j.ajkd.2018.03.028","volume":"72","author":"SA Lee","year":"2018","unstructured":"Lee SA, et al. Distant organ dysfunction in acute kidney injury: a review\u201d. Am J Kidney Dis. 2018;72:846\u2013856. https:\/\/doi.org\/10.1053\/j.ajkd.2018.03.028","journal-title":"Am J Kidney Dis"},{"key":"10426_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01192","author":"V Andrade-Oliveira","year":"2019","unstructured":"Andrade-Oliveira V, et al. Inflammation in renal diseases: new and old players. Front Pharmacol. 2019. https:\/\/doi.org\/10.3389\/fphar.2019.01192","journal-title":"Front Pharmacol"},{"key":"10426_CR22","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1002\/hep.29303","volume":"66","author":"R Amathieu","year":"2017","unstructured":"Amathieu R, Al-Khafaji A, Sileanu FE, et al. Significance of oliguria in critically ill patients with chronic liver disease. Hepatology. 2017;66:1592\u20131600","journal-title":"Hepatology"},{"key":"10426_CR23","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1002\/hep.30859","volume":"71","author":"R Maiwall","year":"2020","unstructured":"Maiwall R, Pasupuleti SSR, Bihari C, et al. Incidence, risk factors, and outcomes of transition of acute kidney injury to chronic kidney disease in cirrhosis: a prospective cohort study. Hepatology. 2020;71:1009\u20131022","journal-title":"Hepatology"},{"key":"10426_CR24","doi-asserted-by":"publisher","first-page":"4808","DOI":"10.1074\/jbc.M111.275719","volume":"287","author":"G Xu","year":"2012","unstructured":"Xu G, Ahn J, Chang S, et al. Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation. J Biol Chem. 2012;287:4808\u20134817","journal-title":"J Biol Chem"},{"key":"10426_CR25","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1002\/hep.27779","volume":"62","author":"J Michelena","year":"2015","unstructured":"Michelena J, Altamirano J, Abraldes JG, et al. Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis. Hepatology. 2015;62:762\u2013772","journal-title":"Hepatology"},{"key":"10426_CR26","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.jhep.2018.04.025","volume":"69","author":"P Meersseman","year":"2018","unstructured":"Meersseman P, Langouche L, du Plessis J, et al. The intensive care unit course and outcome in acute-on-chronic liver failure are comparable to other populations. J Hepatol. 2018;69:803\u2013809","journal-title":"J Hepatol"},{"key":"10426_CR27","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/MCC.0b013e32835f0c17","volume":"19","author":"F Saliba","year":"2013","unstructured":"Saliba F, Ichai P, Levesque E, Samuel D. Cirrhotic patients in the intensive care unit: prognostic markers and outcome. Curr Opin Crit Care. 2013;19:154\u2013160","journal-title":"Curr Opin Crit Care"},{"key":"10426_CR28","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.jhep.2013.11.012","volume":"60","author":"E Levesque","year":"2014","unstructured":"Levesque E, Saliba F, Icha\u00ef P, Samuel D. Outcome of patients with cirrhosis requiring mechanical ventilation in intensive care unit. J Hepatol. 2014;60:570\u2013578","journal-title":"J Hepatol"},{"issue":"19","key":"10426_CR29","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1186\/s13054-015-1070-y","volume":"13","author":"J Campbell","year":"2015","unstructured":"Campbell J, McPeake J, Shaw M, et al. Validation and analysis of prognostic scoring systems for critically ill patients with cirrhosis admitted to intensive care unit. Crit Care. 2015;13(19):364","journal-title":"Crit Care"},{"key":"10426_CR30","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1002\/hep.30265","volume":"68","author":"FS Cardoso","year":"2018","unstructured":"Cardoso FS. Acute-on-chronic liver failure defined by NACSELD: the impact on prognosis and futility of care. Hepatology. 2018;68:2046","journal-title":"Hepatology"},{"key":"10426_CR31","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-219320","author":"P Berry","year":"2017","unstructured":"Berry P, Cheent K, Lewis H, Peck M. Navigating the benefits and burdens of life-saving treatment in severely decompensated cirrhosis: an illustrative, multisourced narrative. BMJ Case Rep. 2017. https:\/\/doi.org\/10.1136\/bcr-2017-219320","journal-title":"BMJ Case Rep"},{"issue":"12","key":"10426_CR32","doi-asserted-by":"publisher","first-page":"e13115","DOI":"10.1111\/ctr.13115","volume":"31","author":"B Michard","year":"2017","unstructured":"Michard B, Artzner T, Lebas B, Besch C, Guillot M, Faitot F, et al. Liver transplantation in critically ill patients: preoperative predictive factors of post-transplant mortality to avoid futility. Clin Transplant. 2017;31(12):e13115","journal-title":"Clin Transplant"},{"issue":"6","key":"10426_CR33","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1007\/s12072-021-10206-6","volume":"15","author":"A Choudhury","year":"2021","unstructured":"Choudhury A, Vijayaraghavan R, Maiwall R, Kumar M, Duan Z, Yu C, et al. \u201cFirst week\u201d is the crucial period for deciding living donor liver transplantation in patients with acute-on-chronic liver failure. Hepatol Int. 2021;15(6):1376\u20131388","journal-title":"Hepatol Int"},{"issue":"7","key":"10426_CR34","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","volume":"144","author":"R Moreau","year":"2013","unstructured":"Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144(7):1426\u20131437","journal-title":"Gastroenterology"},{"key":"10426_CR35","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s12072-019-09946-3","volume":"13","author":"SK Sarin","year":"2019","unstructured":"Sarin SK, Choudhury A, Sharma MK, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int. 2019;13:353\u2013390","journal-title":"Hepatol Int"},{"key":"10426_CR36","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1053\/j.gastro.2018.12.005","volume":"156","author":"S Piano","year":"2019","unstructured":"Piano S, Singh V, Caraceni P, et al. International club of ascites global study group. epidemiology and effects of bacterial infections in patients with cirrhosis worldwide. Gastroenterology. 2019;156:1368\u20131380","journal-title":"Gastroenterology"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-022-10426-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-022-10426-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-022-10426-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T08:34:56Z","timestamp":1681979696000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-022-10426-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10426"],"URL":"https:\/\/doi.org\/10.1007\/s12072-022-10426-4","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]},"assertion":[{"value":"12 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Rakhi Maiwall, Samba Siva Rao Pasupuleti, Harsh Vardhan Tevethia,Shiv Kumar Sarin declares that they have no conflict of interest..","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Taken.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from either the patient or the legal representative from the family.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors approved the final version of the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}