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Moreover, association between Child\u2013Pugh classes\u00a0and post-TIPS hepatic encephalopathy (HE) has indicated that tolerance of PPG reduction depends on liver function. This study aimed to investigate the optimal PPG for covered TIPS and explore the optimal threshold tailored to the Child\u2013Pugh classes to find individualized PPG to balance rebleeding and overt HE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective study analyzed rebleeding, OHE, and mortality of patients associated with post-TIPS PPGs (8, 10, 12, and 14\u00a0mmHg) in the entire cohort and among different Child\u2013Pugh classes. Propensity score matching (PSM) and competing risk analyses were performed for sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 2100 consecutively screened patients undergoing TIPS. In all patients, PPG\u2009&lt;\u200912\u00a0mmHg reduced rebleeding after TIPS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). In Child\u2013Pugh class A, none of the PPG thresholds were discriminative of clinical outcomes. In Child\u2013Pugh class B, 12\u00a0mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) and 14\u00a0mmHg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037) discriminated rebleeding, but 12\u00a0mmHg showed a higher net benefit. In Child\u2013Pugh class C, PPG\u2009&lt;\u200914\u00a0mmHg had a lower rebleeding incidence (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), and exhibited more net benefit than 12\u00a0mmHg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Different PPG standards may be required for patients with different liver function categories. A PPG threshold\u2009&lt;\u200912\u00a0mmHg might be suitable for patients in Child\u2013Pugh class B, while\u2009&lt;\u200914\u00a0mmHg might be optimal for patients in Child\u2013Pugh class C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s12072-023-10489-x","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T17:19:12Z","timestamp":1676654352000},"page":"967-978","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Individualized portal pressure gradient threshold based on liver function categories in preventing rebleeding after TIPS"],"prefix":"10.1007","volume":"17","author":[{"given":"Yifu","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzheng","family":"Zhuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"issue":"4","key":"10489_CR1","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","volume":"76","author":"R de Franchis","year":"2022","unstructured":"de Franchis R, Bosch J, Garcia-Tsao G, et al. 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