{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:32:40Z","timestamp":1793831560050,"version":"4.6.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Talent Plan of Shanghai Municipal Health Commission for Academic Leader","award":["2022XD028"],"award-info":[{"award-number":["2022XD028"]}]},{"name":"the Medical Innovation Research Project of Shanghai Science and Technology Commission","award":["22Y11908400"],"award-info":[{"award-number":["22Y11908400"]}]},{"name":"the Outstanding Youth Medical Talents Project of Shanghai \u201cRising Stars of Medical Talent\u201d Youth Development Program","award":["SHWJRS2021-99"],"award-info":[{"award-number":["SHWJRS2021-99"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070616"],"award-info":[{"award-number":["82070616"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81870416"],"award-info":[{"award-number":["81870416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Pilot Talent Plan of Shanghai East Hospital","award":["2019lhrcjh"],"award-info":[{"award-number":["2019lhrcjh"]}]},{"name":"he Medical discipline Construction Project of Pudong Health Committee of Shanghai","award":["PWYgf2021-02"],"award-info":[{"award-number":["PWYgf2021-02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s12072-023-10497-x","type":"journal-article","created":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T13:01:22Z","timestamp":1687093282000},"page":"673-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Skeletal muscle alterations indicate poor prognosis in cirrhotic patients: a multicenter cohort study in China"],"prefix":"10.1007","volume":"18","author":[{"given":"Xin","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Wen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Mei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7137-112X","authenticated-orcid":false,"given":"Wei-Fen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,18]]},"reference":[{"issue":"10308","key":"10497_CR1","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","volume":"398","author":"P Gin\u00e8s","year":"2021","unstructured":"Gin\u00e8s P, Krag A, Abraldes JG, Sol\u00e0 E, Fabrellas N, Kamath PS. Liver cirrhosis. Lancet 2021;398(10308):1359\u20131376","journal-title":"Lancet"},{"issue":"1","key":"10497_CR2","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jhep.2019.03.004","volume":"71","author":"J Xiao","year":"2019","unstructured":"Xiao J, Wang F, Wong NK, He J, Zhang R, Sun R, et al. Global liver disease burdens and research trends: analysis from a Chinese perspective. J Hepatol 2019;71(1):212\u2013221","journal-title":"J Hepatol"},{"issue":"1","key":"10497_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruy\u00e8re O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019;48(1):16\u201331","journal-title":"Age Ageing"},{"issue":"5","key":"10497_CR4","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1002\/hep.30692","volume":"70","author":"S Nardelli","year":"2019","unstructured":"Nardelli S, Lattanzi B, Merli M, Farcomeni A, Gioia S, Ridola L, et al. Muscle alterations are associated with minimal and overt hepatic encephalopathy in patients with liver cirrhosis. Hepatology 2019;70(5):1704\u20131713","journal-title":"Hepatology"},{"issue":"15","key":"10497_CR5","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.3390\/nu14153154","volume":"14","author":"APT Fayh","year":"2022","unstructured":"Fayh APT, Guedes FFO, Calado GCF, Queiroz SA, Anselmo MGGB, Sousa IM. SARC-F is a predictor of longer LOS and hospital readmission in hospitalized patients after a cardiovascular event. Nutrients 2022;14(15):3154","journal-title":"Nutrients"},{"key":"10497_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2022.111704","volume":"101","author":"Q Gao","year":"2022","unstructured":"Gao Q, Hu K, Gao J, Shang Y, Mei F, Zhao L, et al. Prevalence and prognostic value of sarcopenic obesity in patients with cancer: a systematic review and meta-analysis. Nutrition 2022;101: 111704","journal-title":"Nutrition"},{"issue":"6","key":"10497_CR7","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1002\/jcsm.12834","volume":"12","author":"J Linge","year":"2021","unstructured":"Linge J, Petersson M, Forsgren MF, Sanyal AJ, Dahlqvist LO. Adverse muscle composition predicts all-cause mortality in the UK Biobank imaging study. J Cachexia Sarcopenia Muscle 2021;12(6):1513\u20131526","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10497_CR8","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1002\/hep.32049","volume":"74","author":"JC Lai","year":"2021","unstructured":"Lai JC, Tandon P, Bernal W, Tapper EB, Ekong U, Dasarathy S, et al. Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology 2021;74(3):1611\u20131644","journal-title":"Hepatology"},{"issue":"Suppl 1","key":"10497_CR9","doi-asserted-by":"publisher","first-page":"S147","DOI":"10.1016\/j.jhep.2021.01.025","volume":"75","author":"P Tandon","year":"2021","unstructured":"Tandon P, Montano-Loza AJ, Lai JC, Dasarathy S, Merli M. Sarcopenia and frailty in decompensated cirrhosis. J Hepatol 2021;75(Suppl 1):S147\u2013S162","journal-title":"J Hepatol"},{"issue":"4","key":"10497_CR10","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s12072-018-9875-9","volume":"12","author":"RA Bhanji","year":"2018","unstructured":"Bhanji RA, Moctezuma-Velazquez C, Duarte-Rojo A, Ebadi M, Ghosh S, Rose C, et al. Myosteatosis and sarcopenia are associated with hepatic encephalopathy in patients with cirrhosis. Hepatol Int 2018;12(4):377\u2013386","journal-title":"Hepatol Int"},{"issue":"3","key":"10497_CR11","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.aohep.2019.06.007","volume":"19","author":"K Wijarnpreecha","year":"2020","unstructured":"Wijarnpreecha K, Werlang M, Panjawatanan P, Kroner PT, Cheungpasitporn W, Lukens FJ, et al. Association between sarcopenia and hepatic encephalopathy: a systematic review and meta-analysis. Ann Hepatol 2020;19(3):245\u2013250","journal-title":"Ann Hepatol"},{"issue":"11","key":"10497_CR12","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.cgh.2010.06.024","volume":"8","author":"M Merli","year":"2010","unstructured":"Merli M, Lucidi C, Giannelli V, Giusto M, Riggio O, Falcone M, et al. Cirrhotic patients are at risk for health care-associated bacterial infections. Clin Gastroenterol Hepatol 2010;8(11):979\u2013985","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"7","key":"10497_CR13","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00535-021-01788-x","volume":"56","author":"H Yoshiji","year":"2021","unstructured":"Yoshiji H, Nagoshi S, Akahane T, Asaoka Y, Ueno Y, Ogawa K, et al. Evidence-based clinical practice guidelines for liver cirrhosis 2020. J Gastroenterol 2021;56(7):593\u2013619","journal-title":"J Gastroenterol"},{"issue":"1","key":"10497_CR14","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jhep.2018.06.024","volume":"70","author":"European Association for the Study of the Liver","year":"2019","unstructured":"European Association for the Study of the Liver. EASL Clinical Practice Guidelines on nutrition in chronic liver disease. J Hepatol 2019;70(1):172\u2013193","journal-title":"J Hepatol"},{"issue":"2","key":"10497_CR15","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/jcsm.12039","volume":"7","author":"AJ Montano-Loza","year":"2016","unstructured":"Montano-Loza AJ, Angulo P, Meza-Junco J, Prado CM, Sawyer MB, Beaumont C, et al. Sarcopenic obesity and myosteatosis are associated with higher mortality in patients with cirrhosis. J Cachexia Sarcopenia Muscle 2016;7(2):126\u2013135","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"11","key":"10497_CR16","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/j.dld.2019.09.004","volume":"51","author":"B Lattanzi","year":"2019","unstructured":"Lattanzi B, Nardelli S, Pigliacelli A, Di Cola S, Farcomeni A, D\u2019Ambrosio D, et al. The additive value of sarcopenia, myosteatosis and hepatic encephalopathy in the predictivity of model for end-stage liver disease. Dig Liver Dis 2019;51(11):1508\u20131512","journal-title":"Dig Liver Dis"},{"issue":"1","key":"10497_CR17","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.hpb.2019.06.006","volume":"22","author":"SD Shenvi","year":"2020","unstructured":"Shenvi SD, Taber DJ, Hardie AD, Botstein JO, McGillicuddy JW. Assessment of magnetic resonance imaging derived fat fraction as a sensitive and reliable predictor of myosteatosis in liver transplant recipients. HPB (Oxford) 2020;22(1):102\u2013108","journal-title":"HPB (Oxford)"},{"issue":"9","key":"10497_CR18","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.4254\/wjh.v14.i9.1694","volume":"14","author":"S Haj Ali","year":"2022","unstructured":"Haj Ali S, Abu Sneineh A, Hasweh R. Nutritional assessment in patients with liver cirrhosis. World J Hepatol 2022;14(9):1694\u20131703","journal-title":"World J Hepatol"},{"issue":"6","key":"10497_CR19","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1002\/jcsm.12831","volume":"12","author":"J McGovern","year":"2021","unstructured":"McGovern J, Dolan RD, Horgan PG, Laird BJ, McMillan DC. Computed tomography-defined low skeletal muscle index and density in cancer patients: observations from a systematic review. J Cachexia Sarcopenia Muscle 2021;12(6):1408\u20131417","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10497_CR20","first-page":"349","volume":"11","author":"SW Son","year":"2021","unstructured":"Son SW, Song DS, Chang UI, Yang JM. Definition of sarcopenia in chronic liver disease. Life (Basel) 2021;11(4):349","journal-title":"Life (Basel)"},{"issue":"6","key":"10497_CR21","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1002\/jcsm.12797","volume":"12","author":"X Zeng","year":"2021","unstructured":"Zeng X, Shi ZW, Yu JJ, Wang LF, Luo YY, Jin SM, et al. Sarcopenia as a prognostic predictor of liver cirrhosis: a multicenter study in China. J Cachexia Sarcopenia Muscle 2021;12(6):1948\u20131958","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"10497_CR22","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","volume":"69","author":"European Association for the Study of the Liver","year":"2018","unstructured":"European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol 2018;69(2):406\u2013460","journal-title":"J Hepatol"},{"issue":"11","key":"10497_CR23","first-page":"846","volume":"27","author":"Chinese Society of Hepatology","year":"2019","unstructured":"Chinese Society of Hepatology, Chinese Medical Association. Chinese guidelines on the management of liver cirrhosis. Zhonghua Gan Zang Bing Za Zhi 2019;27(11):846\u2013865","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"issue":"10","key":"10497_CR24","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrgastro.2009.149","volume":"6","author":"J Bosch","year":"2009","unstructured":"Bosch J, Abraldes JG, Berzigotti A, Garc\u00eda-Pagan JC. The clinical use of HVPG measurements in chronic liver disease. Nat Rev Gastroenterol Hepatol 2009;6(10):573\u2013582","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"4","key":"10497_CR25","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3348\/kjr.2020.0914","volume":"22","author":"DW Kim","year":"2021","unstructured":"Kim DW, Ha J, Ko Y, Kim KW, Park T, Lee J, et al. Reliability of skeletal muscle area measurement on CT with different parameters: a phantom study. Korean J Radiol 2021;22(4):624\u2013633","journal-title":"Korean J Radiol"},{"issue":"20","key":"10497_CR26","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1002\/sim.2177","volume":"24","author":"C Jennen-Steinmetz","year":"2005","unstructured":"Jennen-Steinmetz C, Wellek S. A new approach to sample size calculation for reference interval studies. Stat Med 2005;24(20):3199\u20133212","journal-title":"Stat Med"},{"issue":"12","key":"10497_CR27","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1111\/liv.15060","volume":"41","author":"S Gioia","year":"2021","unstructured":"Gioia S, Ridola L, Cristofaro L, Merli M, Faccioli J, Riggio O, et al. The improvement in body composition including subcutaneous and visceral fat reduces ammonia and hepatic encephalopathy after transjugular intrahepatic portosystemic shunt. Liver Int 2021;41(12):2965\u20132973","journal-title":"Liver Int"},{"issue":"11","key":"10497_CR28","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.dld.2019.05.034","volume":"51","author":"M Ebadi","year":"2019","unstructured":"Ebadi M, Montano-Loza AJ. Clinical relevance of skeletal muscle abnormalities in patients with cirrhosis. Dig Liver Dis 2019;51(11):1493\u20131499","journal-title":"Dig Liver Dis"},{"issue":"10","key":"10497_CR29","doi-asserted-by":"publisher","DOI":"10.2196\/23049","volume":"8","author":"DW Kim","year":"2020","unstructured":"Kim DW, Kim KW, Ko Y, Park T, Khang S, Jeong H, et al. Assessment of myosteatosis on computed tomography by automatic generation of a muscle quality map using a web-based toolkit: feasibility study. JMIR Med Inform 2020;8(10): e23049","journal-title":"JMIR Med Inform"},{"issue":"4","key":"10497_CR30","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/liv.14758","volume":"41","author":"R Paternostro","year":"2021","unstructured":"Paternostro R, Bardach C, Hofer BS, Scheiner B, Schwabl P, Asenbaum U, et al. Prognostic impact of sarcopenia in cirrhotic patients stratified by different severity of portal hypertension. Liver Int 2021;41(4):799\u2013809","journal-title":"Liver Int"},{"issue":"5","key":"10497_CR31","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/jcsm.12333","volume":"9","author":"SH Kang","year":"2018","unstructured":"Kang SH, Jeong WK, Baik SK, Cha SH, Kim MY. Impact of sarcopenia on prognostic value of cirrhosis: going beyond the hepatic venous pressure gradient and MELD score. J Cachexia Sarcopenia Muscle 2018;9(5):860\u2013870","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"7","key":"10497_CR32","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.3390\/cells11071216","volume":"11","author":"M Ebadi","year":"2022","unstructured":"Ebadi M, Tsien C, Bhanji RA, Dunichand-Hoedl AR, Rider E, Motamedrad M, et al. Myosteatosis in cirrhosis: a review of diagnosis, pathophysiological mechanisms and potential interventions. Cells 2022;11(7):1216","journal-title":"Cells"},{"issue":"4","key":"10497_CR33","doi-asserted-by":"publisher","first-page":"482","DOI":"10.4093\/dmj.2020.0277","volume":"45","author":"I Miljkovic","year":"2021","unstructured":"Miljkovic I, Vella CA, Allison M. Computed tomography-derived myosteatosis and metabolic disorders. Diabetes Metab J 2021;45(4):482\u2013491","journal-title":"Diabetes Metab J"},{"key":"10497_CR34","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.jhep.2017.11.030","volume":"68","author":"JLA van Vugt","year":"2018","unstructured":"van Vugt JLA, Alferink LJM, Buettner S, Gaspersz MP, Bot D, Darwish Murad S, et al. A model including sarcopenia surpasses the MELD score in predicting waiting list mortality in cirrhotic liver transplant candidates: a competing risk analysis in a national cohort. J Hepatol 2018;68:707\u2013714","journal-title":"J Hepatol"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-023-10497-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-023-10497-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-023-10497-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T15:10:34Z","timestamp":1712934634000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-023-10497-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,18]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10497"],"URL":"https:\/\/doi.org\/10.1007\/s12072-023-10497-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2289988\/v1","asserted-by":"object"}]},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,18]]},"assertion":[{"value":"18 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Xin Zeng, Zhi-Wen Shi, Jia-Jun Yu, Li-Fen Wang, Chun-Yan Sun, Yuan-Yuan Luo, Pei-Mei Shi, Yong Lin, Yue-Xiang Chen, Jia Guo, Chun-Qing Zhang, Wei-Fen Xie have not disclosed any competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}