{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:37:32Z","timestamp":1773326252810,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:00:00Z","timestamp":1699660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:00:00Z","timestamp":1699660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241223"],"award-info":[{"award-number":["82241223"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20360"],"award-info":[{"award-number":["U20A20360"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s12072-023-10608-8","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T10:01:35Z","timestamp":1699696895000},"page":"517-528","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Proteome-wide Mendelian randomization highlights AIF1 and HLA-DQA2 as targets for primary sclerosing cholangitis"],"prefix":"10.1007","volume":"18","author":[{"given":"Lanlan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-4955","authenticated-orcid":false,"given":"Guoyue","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,11]]},"reference":[{"key":"10608_CR1","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1016\/S0140-6736(18)30300-3","volume":"391","author":"JK Dyson","year":"2018","unstructured":"Dyson JK, Beuers U, Jones DEJ, Lohse AW, Hudson M. Primary sclerosing cholangitis. Lancet. 2018;391:2547\u20132559","journal-title":"Lancet"},{"key":"10608_CR2","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s40265-021-01545-7","volume":"81","author":"S Hasegawa","year":"2021","unstructured":"Hasegawa S, Yoneda M, Kurita Y, Nogami A, Honda Y, Hosono K, et al. Cholestatic liver disease: current treatment strategies and new therapeutic agents. Drugs. 2021;81:1181\u20131192","journal-title":"Drugs"},{"key":"10608_CR3","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1111\/tri.13925","volume":"34","author":"T Visseren","year":"2021","unstructured":"Visseren T, Erler NS, Polak WG, Adam R, Karam V, Vondran FWR, et al. Recurrence of primary sclerosing cholangitis after liver transplantation\u2014analysing the European Liver Transplant Registry and beyond. Transpl Int. 2021;34:1455\u20131467","journal-title":"Transpl Int"},{"key":"10608_CR4","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ng.728","volume":"43","author":"E Melum","year":"2011","unstructured":"Melum E, Franke A, Schramm C, Weism\u00fcller TJ, Gotthardt DN, Offner FA, et al. Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet. 2011;43:17\u201319","journal-title":"Nat Genet"},{"key":"10608_CR5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/ng.3745","volume":"49","author":"SG Ji","year":"2017","unstructured":"Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L, Melum E, et al. Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nat Genet. 2017;49:269\u2013273","journal-title":"Nat Genet"},{"key":"10608_CR6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ajhg.2022.12.017","volume":"110","author":"S Burgess","year":"2023","unstructured":"Burgess S, Mason AM, Grant AJ, Slob EAW, Gkatzionis A, Zuber V, et al. Using genetic association data to guide drug discovery and development: review of methods and applications. Am J Hum Genet. 2023;110:195\u2013214","journal-title":"Am J Hum Genet"},{"key":"10608_CR7","doi-asserted-by":"publisher","first-page":"1052616","DOI":"10.3389\/fimmu.2023.1052616","volume":"14","author":"H Yang","year":"2023","unstructured":"Yang H, Chen L, Liu Y. A large-scale plasma proteome Mendelian randomization study identifies novel causal plasma proteins related to primary biliary cholangitis. Front Immunol. 2023;14:1052616","journal-title":"Front Immunol"},{"key":"10608_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104494","volume":"89","author":"J Chen","year":"2023","unstructured":"Chen J, Xu F, Ruan X, Sun J, Zhang Y, Zhang H, et al. Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses. EBioMedicine. 2023;89: 104494","journal-title":"EBioMedicine"},{"key":"10608_CR9","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","volume":"53","author":"E Ferkingstad","year":"2021","unstructured":"Ferkingstad E, Sulem P, Atlason BA, Sveinbjornsson G, Magnusson MI, Styrmisdottir EL, et al. Large-scale integration of the plasma proteome with genetics and disease. Nat Genet. 2021;53:1712\u20131721","journal-title":"Nat Genet"},{"key":"10608_CR10","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48:481\u2013487","journal-title":"Nat Genet"},{"key":"10608_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004383","volume":"10","author":"C Giambartolomei","year":"2014","unstructured":"Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C, et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 2014;10: e1004383","journal-title":"PLoS Genet"},{"key":"10608_CR12","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1038\/s41467-021-22338-2","volume":"12","author":"R Pazoki","year":"2021","unstructured":"Pazoki R, Vujkovic M, Elliott J, Evangelou E, Gill D, Ghanbari M, et al. Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. Nat Commun. 2021;12:2579","journal-title":"Nat Commun"},{"key":"10608_CR13","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/s41467-023-36678-8","volume":"14","author":"Y Han","year":"2023","unstructured":"Han Y, Byun J, Zhu C, Sun R, Roh JY, Cordell HJ, et al. Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis. Nat Commun. 2023;14:1069","journal-title":"Nat Commun"},{"key":"10608_CR14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/s41588-017-0009-4","volume":"50","author":"P Turley","year":"2018","unstructured":"Turley P, Walters RK, Maghzian O, Okbay A, Lee JJ, Fontana MA, et al. Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat Genet. 2018;50:229\u2013237","journal-title":"Nat Genet"},{"key":"10608_CR15","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1136\/gutjnl-2012-302865","volume":"62","author":"A Juli\u00e0","year":"2013","unstructured":"Juli\u00e0 A, Dom\u00e8nech E, Ricart E, Tortosa R, Garc\u00eda-S\u00e1nchez V, Gisbert JP, et al. A genome-wide association study on a southern European population identifies a new Crohn\u2019s disease susceptibility locus at RBX1-EP300. Gut. 2013;62:1440\u20131445","journal-title":"Gut"},{"key":"10608_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/1354750X.2016.1252950","volume":"22","author":"ID Rom\u00e1n","year":"2017","unstructured":"Rom\u00e1n ID, Cano-Mart\u00ednez D, Lobo MV, Fern\u00e1ndez-Moreno MD, Hern\u00e1ndez-Breijo B, Sacrist\u00e1n S, et al. Infliximab therapy reverses the increase of allograft inflammatory factor-1 in serum and colonic mucosa of rats with inflammatory bowel disease. Biomarkers. 2017;22:133\u2013144","journal-title":"Biomarkers"},{"key":"10608_CR17","doi-asserted-by":"crossref","unstructured":"Elizondo DM, Brandy NZ, da Silva RL, de Moura TR, Lipscomb MW. Allograft inflammatory factor-1 in myeloid cells drives autoimmunity in type 1 diabetes. JCI Insight. 2020;5(10):e136092","DOI":"10.1172\/jci.insight.136092"},{"key":"10608_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.2119\/molmed.2014.00264","volume":"21","author":"P Chinnasamy","year":"2015","unstructured":"Chinnasamy P, Lutz SE, Riascos-Bernal DF, Jeganathan V, Casimiro I, Brosnan CF, et al. Loss of allograft inflammatory factor-1 ameliorates experimental autoimmune encephalomyelitis by limiting encephalitogenic CD4 T-cell expansion. Mol Med. 2015;21:233\u2013241","journal-title":"Mol Med"},{"key":"10608_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainresbull.2021.07.011","volume":"175","author":"DS Peres","year":"2021","unstructured":"Peres DS, Theisen MC, Fialho MFP, Dalenogare DP, Rodrigues P, Kudsi SQ, et al. TRPA1 involvement in depression- and anxiety-like behaviors in a progressive multiple sclerosis model in mice. Brain Res Bull. 2021;175:1\u201315","journal-title":"Brain Res Bull"},{"key":"10608_CR20","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.neuroscience.2019.06.006","volume":"414","author":"MJ Churchill","year":"2019","unstructured":"Churchill MJ, Cantu MA, Kasanga EA, Moore C, Salvatore MF, Meshul CK. Glatiramer acetate reverses motor dysfunction and the decrease in tyrosine hydroxylase levels in a mouse model of Parkinson\u2019s disease. Neuroscience. 2019;414:8\u201327","journal-title":"Neuroscience"},{"key":"10608_CR21","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3389\/fgene.2018.00701","volume":"9","author":"F Cao","year":"2018","unstructured":"Cao F, Souders Ii CL, Perez-Rodriguez V, Martyniuk CJ. Elucidating conserved transcriptional networks underlying pesticide exposure and Parkinson\u2019s disease: a focus on chemicals of epidemiological relevance. Front Genet. 2018;9:701","journal-title":"Front Genet"},{"key":"10608_CR22","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3233\/JAD-2009-0995","volume":"16","author":"M Tong","year":"2009","unstructured":"Tong M, Dong M, de la Monte SM. Brain insulin-like growth factor and neurotrophin resistance in Parkinson\u2019s disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. J Alzheimers Dis. 2009;16:585\u2013599","journal-title":"J Alzheimers Dis"},{"key":"10608_CR23","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/ng.2616","volume":"45","author":"JZ Liu","year":"2013","unstructured":"Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, et al. Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nat Genet. 2013;45:670\u2013675","journal-title":"Nat Genet"},{"key":"10608_CR24","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1136\/gutjnl-2014-308617","volume":"65","author":"SN Hong","year":"2016","unstructured":"Hong SN, Park C, Park SJ, Lee CK, Ye BD, Kim YS, et al. Deep resequencing of 131 Crohn\u2019s disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants. Gut. 2016;65:788\u2013796","journal-title":"Gut"},{"key":"10608_CR25","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1002\/art.39504","volume":"68","author":"ME Alarc\u00f3n-Riquelme","year":"2016","unstructured":"Alarc\u00f3n-Riquelme ME, Ziegler JT, Molineros J, Howard TD, Moreno-Estrada A, S\u00e1nchez-Rodr\u00edguez E, et al. Genome-wide association study in an amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of european admixture. Arthritis Rheumatol. 2016;68:932\u2013943","journal-title":"Arthritis Rheumatol"},{"key":"10608_CR26","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/art.41758","volume":"73","author":"C Schutt","year":"2021","unstructured":"Schutt C, Mirizio E, Salgado C, Reyes-Mugica M, Wang X, Chen W, et al. Transcriptomic evaluation of juvenile localized scleroderma skin with histologic and clinical correlation. Arthritis Rheumatol. 2021;73:1921\u20131930","journal-title":"Arthritis Rheumatol"},{"key":"10608_CR27","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12864-023-09227-2","volume":"24","author":"M Wang","year":"2023","unstructured":"Wang M, Wu J, Lei S, Mo X. Genome-wide identification of RNA modification-related single nucleotide polymorphisms associated with rheumatoid arthritis. BMC Genomics. 2023;24:153","journal-title":"BMC Genomics"},{"key":"10608_CR28","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1056\/NEJMoa073493","volume":"357","author":"DA Hafler","year":"2007","unstructured":"Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med. 2007;357:851\u2013862","journal-title":"N Engl J Med"},{"key":"10608_CR29","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12876-021-01741-5","volume":"21","author":"S Punia","year":"2021","unstructured":"Punia S, Juran BD, Ali AH, Schlicht EM, Moore RM, Sun Z, et al. Evaluation of circulating cell-free DNA in cholestatic liver disease using liver-specific methylation markers. BMC Gastroenterol. 2021;21:149","journal-title":"BMC Gastroenterol"},{"key":"10608_CR30","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1046\/j.1365-2249.2002.01861.x","volume":"128","author":"EM Ponnuraj","year":"2002","unstructured":"Ponnuraj EM, Hayward AR. Requirement for TNF-Tnfrsf1 signalling for sclerosing cholangitis in mice chronically infected by Cryptosporidium parvum. Clin Exp Immunol. 2002;128:416\u2013420","journal-title":"Clin Exp Immunol"},{"key":"10608_CR31","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.immuni.2014.04.011","volume":"40","author":"M Hedl","year":"2014","unstructured":"Hedl M, Lahiri A, Ning K, Cho JH, Abraham C. Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn\u2019s disease ICOSLG risk allele. Immunity. 2014;40:734\u2013746","journal-title":"Immunity"},{"key":"10608_CR32","doi-asserted-by":"crossref","unstructured":"Arthur B, Fouad L (2023) Risk factors of primary liver cancer initiation associated with tumour initiating cell emergence: novel targets for promising preventive therapies. eGastroenterology 1:e100010","DOI":"10.1136\/egastro-2023-100010"},{"key":"10608_CR33","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/j.ajpath.2012.06.043","volume":"181","author":"MG Coulthard","year":"2012","unstructured":"Coulthard MG, Morgan M, Woodruff TM, Arumugam TV, Taylor SM, Carpenter TC, et al. Eph\/Ephrin signaling in injury and inflammation. Am J Pathol. 2012;181:1493\u20131503","journal-title":"Am J Pathol"},{"key":"10608_CR34","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1093\/ecco-jcc\/jjv114","volume":"9","author":"G Can","year":"2015","unstructured":"Can G, Ayvaz S, Can H, Demirtas S, Aksit H, Yilmaz B, et al. The Syk inhibitor fostamatinib decreases the severity of colonic mucosal damage in a rodent model of colitis. J Crohns Colitis. 2015;9:907\u2013917","journal-title":"J Crohns Colitis"},{"key":"10608_CR35","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/labinvest.2015.32","volume":"95","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Brenner M, Yang WL, Wang P. Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice. Lab Invest. 2015;95:480\u2013490","journal-title":"Lab Invest"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-023-10608-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-023-10608-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-023-10608-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T19:11:24Z","timestamp":1712949084000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-023-10608-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,11]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10608"],"URL":"https:\/\/doi.org\/10.1007\/s12072-023-10608-8","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,11]]},"assertion":[{"value":"18 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Lanlan Chen, Yuexuan Zhao, Mingyue Li, Guoyue Lv declared that no potential conflicts of interest should be disclosed in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Each study has been approved by its corresponding Ethical Review Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The public data can be accessed without restriction if not attempting to identify individual-level information.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Each author has given his\/her consent to publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}