{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T12:22:02Z","timestamp":1772886122886,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12072-025-10804-8","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T15:42:51Z","timestamp":1741448571000},"page":"302-303","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimizing non-invasive monitoring of the therapeutic response to NSBBs in portal hypertension: is machine learning the answer?"],"prefix":"10.1007","volume":"19","author":[{"given":"Annalisa","family":"Berzigotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"issue":"3","key":"10804_CR1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","volume":"63","author":"R de Franchis","year":"2015","unstructured":"de Franchis R, Baveno VI Faculty. Expanding consensus in portal hypertension: report of the Baveno VI Consensus Workshop: stratifying risk and individualizing care for portal hypertension. J Hepatol. 2015;63(3):743\u2013752","journal-title":"J Hepatol"},{"issue":"4","key":"10804_CR2","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","volume":"76","author":"R de Franchis","year":"2022","unstructured":"de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C, Baveno VII Faculty. Baveno VII\u2014renewing consensus in portal hypertension. J Hepatol. 2022;76(4):959\u2013974","journal-title":"J Hepatol"},{"issue":"1","key":"10804_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.12.001","volume":"2","author":"SG Rodrigues","year":"2019","unstructured":"Rodrigues SG, Mendoza YP, Bosch J. Beta-blockers in cirrhosis: evidence-based indications and limitations. JHEP Rep. 2019;2(1): 100063","journal-title":"JHEP Rep"},{"issue":"5","key":"10804_CR4","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1053\/j.gastro.2006.09.013","volume":"131","author":"G D'Amico","year":"2006","unstructured":"D\u2019Amico G, Garcia-Pagan JC, Luca A, Bosch J. Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review. Gastroenterology. 2006;131(5):1611\u20131624","journal-title":"Gastroenterology"},{"issue":"3","key":"10804_CR5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.cld.2024.03.009","volume":"28","author":"SG Rodrigues","year":"2024","unstructured":"Rodrigues SG, Delgado MG, Stirnimann G, Berzigotti A, Bosch J. Hepatic venous pressure gradient. Clin Liver Dis. 2024;28(3):383\u2013400","journal-title":"Clin Liver Dis"},{"issue":"8","key":"10804_CR6","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.ultrasmedbio.2024.03.013","volume":"50","author":"G Ferraioli","year":"2024","unstructured":"Ferraioli G, Barr RG, Berzigotti A, Sporea I, Wong VW, Reiberger T, et al. WFUMB guideline\/guidance on liver multiparametric ultrasound: part 1. Update to 2018 guidelines on liver ultrasound elastography. Ultrasound Med Biol. 2024;50(8):1071\u20131087","journal-title":"Ultrasound Med Biol"},{"key":"10804_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-024-10649-7","author":"M Giuffr\u00e8","year":"2025","unstructured":"Giuffr\u00e8 M, Dupont J, Visintin A, Masutti F, Monica F, You K, et al. Predicting response to non-selective beta-blockers with liver\u2013spleen stiffness and heart rate in patients with liver cirrhosis and high-risk varices. Hepatol Int. 2025. https:\/\/doi.org\/10.1007\/s12072-024-10649-7","journal-title":"Hepatol Int"},{"issue":"3","key":"10804_CR8","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/hep.1840110302","volume":"11","author":"F Bendtsen","year":"1990","unstructured":"Bendtsen F, Skovgaard LT, Sorensen TI, Matzen P. Agreement among multiple observers on endoscopic diagnosis of esophageal varices before bleeding. Hepatology. 1990;11(3):341\u2013347","journal-title":"Hepatology"},{"issue":"4","key":"10804_CR9","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.jhep.2022.05.021","volume":"77","author":"C Villanueva","year":"2022","unstructured":"Villanueva C, Torres F, Sarin SK, Shah HA, Tripathi D, Brujats A, et al. Carvedilol reduces the risk of decompensation and mortality in patients with compensated cirrhosis in a competing-risk meta-analysis. J Hepatol. 2022;77(4):1014\u20131025","journal-title":"J Hepatol"},{"issue":"1","key":"10804_CR10","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/hep.510300124","volume":"30","author":"R Banares","year":"1999","unstructured":"Banares R, Moitinho E, Piqueras B, Casado M, Garcia-Pagan JC, de Diego A, et al. Carvedilol, a new nonselective beta-blocker with intrinsic anti- Alpha1-adrenergic activity, has a greater portal hypotensive effect than propranolol in patients with cirrhosis. Hepatology. 1999;30(1):79\u201383","journal-title":"Hepatology"},{"issue":"3","key":"10804_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100563","volume":"3","author":"Q Yu","year":"2022","unstructured":"Yu Q, Huang Y, Li X, Pavlides M, Liu D, Luo H, et al. An imaging-based artificial intelligence model for non-invasive grading of hepatic venous pressure gradient in cirrhotic portal hypertension. Cell Rep Med. 2022;3(3): 100563","journal-title":"Cell Rep Med"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-025-10804-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-025-10804-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-025-10804-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T05:35:58Z","timestamp":1744781758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-025-10804-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,8]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10804"],"URL":"https:\/\/doi.org\/10.1007\/s12072-025-10804-8","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,8]]},"assertion":[{"value":"12 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"AB has been consultant to Boehringer-Ingelheim and received speakers\u2019 fees from GE Healthcare and Hologic.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}