{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:33:00Z","timestamp":1772119980720,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81970460"],"award-info":[{"award-number":["No. 81970460"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["No. 2023J011598"],"award-info":[{"award-number":["No. 2023J011598"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s12072-025-10813-7","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T21:32:20Z","timestamp":1743888740000},"page":"1199-1210","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mindin orchestrates the macrophage-mediated resolution of liver fibrosis in mice"],"prefix":"10.1007","volume":"19","author":[{"given":"Yong-Dong","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-Ling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-mei","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Shen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai-Ying","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ni","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Jing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Hui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amarsanaa","family":"Jazag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayasi","family":"Guleng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"issue":"Suppl 1","key":"10813_CR1","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1016\/j.clinre.2015.06.015","volume":"39","author":"M Sun","year":"2015","unstructured":"Sun M, Kisseleva T. Reversibility of liver fibrosis. Clin Res Hepatol Gastroenterol. 2015;39(Suppl 1):S60-63","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10813_CR2","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/gut.46.4.443","volume":"46","author":"RC Benyon","year":"2000","unstructured":"Benyon RC, Iredale JP. Is liver fibrosis reversible? Gut. 2000;46:443\u2013446","journal-title":"Gut"},{"key":"10813_CR3","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","volume":"6","author":"V Hernandez-Gea","year":"2011","unstructured":"Hernandez-Gea V, Friedman SL. Pathogenesis of liver fibrosis. Annu Rev Pathol. 2011;6:425\u2013456","journal-title":"Annu Rev Pathol"},{"key":"10813_CR4","first-page":"143","volume":"24","author":"M Consolo","year":"2009","unstructured":"Consolo M, Amoroso A, Spandidos DA, Mazzarino MC. Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease (Review). Int J Mol Med. 2009;24:143\u2013152","journal-title":"Int J Mol Med"},{"key":"10813_CR5","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1146\/annurev-immunol-032414-112220","volume":"33","author":"C Varol","year":"2015","unstructured":"Varol C, Mildner A, Jung S. Macrophages: development and tissue specialization. Annu Rev Immunol. 2015;33:643\u2013675","journal-title":"Annu Rev Immunol"},{"key":"10813_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","volume":"18","author":"T Kisseleva","year":"2021","unstructured":"Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021;18:151\u2013166","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10813_CR7","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/hep4.1356","volume":"3","author":"A Guillot","year":"2019","unstructured":"Guillot A, Tacke F. Liver macrophages: old dogmas and new insights. Hepatol Commun. 2019;3:730\u2013743","journal-title":"Hepatol Commun"},{"key":"10813_CR8","doi-asserted-by":"publisher","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","volume":"109","author":"P Ramachandran","year":"2012","unstructured":"Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, et al. Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Proc Natl Acad Sci U S A. 2012;109:E3186-3195","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10813_CR9","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1189\/jlb.6A0114-004RR","volume":"96","author":"M Wang","year":"2014","unstructured":"Wang M, You Q, Lor K, Chen F, Gao B, Ju C. Chronic alcohol ingestion modulates hepatic macrophage populations and functions in mice. J Leukoc Biol. 2014;96:657\u2013665","journal-title":"J Leukoc Biol"},{"key":"10813_CR10","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.4049\/jimmunol.1701247","volume":"200","author":"L Campana","year":"2018","unstructured":"Campana L, Starkey Lewis PJ, Pellicoro A, Aucott RL, Man J, O\u2019Duibhir E, et al. The STAT3-IL-10-IL-6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury. J Immunol. 2018;200:1169\u20131187","journal-title":"J Immunol"},{"key":"10813_CR11","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1080\/15548627.2015.1058473","volume":"11","author":"J Lodder","year":"2015","unstructured":"Lodder J, Dena\u00ebs T, Chobert MN, Wan J, El-Benna J, Pawlotsky JM, et al. Macrophage autophagy protects against liver fibrosis in mice. Autophagy. 2015;11:1280\u20131292","journal-title":"Autophagy"},{"key":"10813_CR12","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41580-021-00373-7","volume":"22","author":"L Campana","year":"2021","unstructured":"Campana L, Esser H, Huch M, Forbes S. Liver regeneration and inflammation: from fundamental science to clinical applications. Nat Rev Mol Cell Biol. 2021;22:608\u2013624","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10813_CR13","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.1182\/blood-2005-04-1658","volume":"106","author":"W Jia","year":"2005","unstructured":"Jia W, Li H, He YW. The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. Blood. 2005;106:3854\u20133859","journal-title":"Blood"},{"key":"10813_CR14","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00109-012-0883-2","volume":"90","author":"ZY Bian","year":"2012","unstructured":"Bian ZY, Wei X, Deng S, Tang QZ, Feng J, Zhang Y, et al. Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. J Mol Med (Berl). 2012;90:895\u2013910","journal-title":"J Mol Med (Berl)"},{"key":"10813_CR15","doi-asserted-by":"publisher","first-page":"5740","DOI":"10.1111\/jcmm.15236","volume":"24","author":"K Yang","year":"2020","unstructured":"Yang K, Li W, Bai T, Xiao Y, Yu W, Luo P, et al. Mindin deficiency alleviates renal fibrosis through inhibiting NF-\u03baB and TGF-\u03b2\/Smad pathways. J Cell Mol Med. 2020;24:5740\u20135750","journal-title":"J Cell Mol Med"},{"key":"10813_CR16","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.jid.2022.10.011","volume":"143","author":"I Rana","year":"2023","unstructured":"Rana I, Kataria S, Tan TL, Hajam EY, Kashyap DK, Saha D, et al. Mindin (SPON2) is essential for cutaneous fibrogenesis in a mouse model of systemic sclerosis. J Invest Dermatol. 2023;143:699-710.e610","journal-title":"J Invest Dermatol"},{"key":"10813_CR17","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.jhep.2015.06.033","volume":"63","author":"P Sun","year":"2015","unstructured":"Sun P, Zhang P, Wang PX, Zhu LH, Du Y, Tian S, et al. Mindin deficiency protects the liver against ischemia\/reperfusion injury. J Hepatol. 2015;63:1198\u20131211","journal-title":"J Hepatol"},{"key":"10813_CR18","doi-asserted-by":"publisher","first-page":"8391","DOI":"10.1111\/jcmm.15332","volume":"24","author":"XS Cheng","year":"2020","unstructured":"Cheng XS, Huo YN, Fan YY, Xiao CX, Ouyang XM, Liang LY, et al. Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK\/ERK signalling pathway in mice. J Cell Mol Med. 2020;24:8391\u20138404","journal-title":"J Cell Mol Med"},{"key":"10813_CR19","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41575-023-00807-x","volume":"20","author":"L Hammerich","year":"2023","unstructured":"Hammerich L, Tacke F. Hepatic inflammatory responses in liver fibrosis. Nat Rev Gastroenterol Hepatol. 2023;20:633\u2013646","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10813_CR20","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/hep.26429","volume":"58","author":"JP Pradere","year":"2013","unstructured":"Pradere JP, Kluwe J, De Minicis S, Jiao JJ, Gwak GY, Dapito DH, et al. Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology. 2013;58:1461\u20131473","journal-title":"Hepatology"},{"key":"10813_CR21","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","volume":"66","author":"F Tacke","year":"2017","unstructured":"Tacke F. Targeting hepatic macrophages to treat liver diseases. J Hepatol. 2017;66:1300\u20131312","journal-title":"J Hepatol"},{"key":"10813_CR22","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/ni1021","volume":"5","author":"YW He","year":"2004","unstructured":"He YW, Li H, Zhang J, Hsu CL, Lin E, Zhang N, et al. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol. 2004;5:88\u201397","journal-title":"Nat Immunol"},{"key":"10813_CR23","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1111\/jcmm.14236","volume":"23","author":"YS Liu","year":"2019","unstructured":"Liu YS, Wang LF, Cheng XS, Huo YN, Ouyang XM, Liang LY, et al. The pattern-recognition molecule mindin binds integrin Mac-1 to promote macrophage phagocytosis via Syk activation and NF-\u03baB p65 translocation. J Cell Mol Med. 2019;23:3402\u20133416","journal-title":"J Cell Mol Med"},{"key":"10813_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.662164","volume":"12","author":"C Lamers","year":"2021","unstructured":"Lamers C, Pl\u00fcss CJ, Ricklin D. The promiscuous profile of complement receptor 3 in ligand binding, immune modulation, and pathophysiology. Front Immunol. 2021;12: 662164","journal-title":"Front Immunol"},{"key":"10813_CR25","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jim.2015.08.012","volume":"426","author":"K Lim","year":"2015","unstructured":"Lim K, Hyun YM, Lambert-Emo K, Topham DJ, Kim M. Visualization of integrin Mac-1 in vivo. J Immunol Methods. 2015;426:120\u2013127","journal-title":"J Immunol Methods"},{"key":"10813_CR26","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/cmi.2015.104","volume":"13","author":"C Ju","year":"2016","unstructured":"Ju C, Tacke F. Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell Mol Immunol. 2016;13:316\u2013327","journal-title":"Cell Mol Immunol"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-025-10813-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-025-10813-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-025-10813-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T18:48:54Z","timestamp":1759949334000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-025-10813-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10813"],"URL":"https:\/\/doi.org\/10.1007\/s12072-025-10813-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5155041\/v1","asserted-by":"object"}]},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"value":"1936-0533","type":"print"},{"value":"1936-0541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,5]]},"assertion":[{"value":"26 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors has a conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"All the protocols used in the animal experiments were approved by the Committee for Animal Research of Xiamen University (No. XMULAC20190127).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}