{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:07:37Z","timestamp":1766088457890,"version":"build-2065373602"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hepatol Int"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s12072-025-10839-x","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T14:58:12Z","timestamp":1747321092000},"page":"1121-1132","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel immune-related prognostic models for patients with hepatocellular carcinoma after curative resection"],"prefix":"10.1007","volume":"19","author":[{"given":"Mingnan","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5428-928X","authenticated-orcid":false,"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"issue":"3","key":"10839_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u2013263","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"10839_CR2","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1158\/0008-5472.CAN-16-2822","volume":"77","author":"DC Lin","year":"2017","unstructured":"Lin DC, Mayakonda A, Dinh HQ, Huang P, Lin L, Liu X, et al. Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma. Cancer Res. 2017;77(9):2255\u20132265","journal-title":"Cancer Res"},{"issue":"6717","key":"10839_CR3","doi-asserted-by":"publisher","first-page":"eabq7248","DOI":"10.1126\/science.abq7248","volume":"386","author":"A Hayday","year":"2024","unstructured":"Hayday A, Dechanet-Merville J, Rossjohn J, Silva-Santos B. Cancer immunotherapy by gammadelta T cells. Science. 2024;386(6717):eabq7248","journal-title":"Science"},{"issue":"5","key":"10839_CR4","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646\u2013674","journal-title":"Cell"},{"issue":"2","key":"10839_CR5","doi-asserted-by":"publisher","first-page":"886","DOI":"10.3892\/or.2017.5738","volume":"38","author":"CX Ren","year":"2017","unstructured":"Ren CX, Leng RX, Fan YG, Pan HF, Li BZ, Wu CH, et al. Intratumoral and peritumoral expression of CD68 and CD206 in hepatocellular carcinoma and their prognostic value. Oncol Rep. 2017;38(2):886\u2013898","journal-title":"Oncol Rep"},{"issue":"12","key":"10839_CR6","doi-asserted-by":"publisher","first-page":"4048","DOI":"10.1111\/cas.15437","volume":"113","author":"T Yusa","year":"2022","unstructured":"Yusa T, Yamashita YI, Okabe H, Nakao Y, Itoyama R, Kitano Y, et al. Survival impact of immune cells infiltrating peritumoral area of hepatocellular carcinoma. Cancer Sci. 2022;113(12):4048\u20134058","journal-title":"Cancer Sci"},{"issue":"1","key":"10839_CR7","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.1038\/s41467-020-18640-0","volume":"11","author":"A Taber","year":"2020","unstructured":"Taber A, Christensen E, Lamy P, Nordentoft I, Prip F, Lindskrog SV, et al. Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis. Nat Commun. 2020;11(1):4858","journal-title":"Nat Commun"},{"issue":"1","key":"10839_CR8","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1186\/s13046-019-1396-4","volume":"38","author":"Y Fu","year":"2019","unstructured":"Fu Y, Liu S, Zeng S, Shen H. From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma. J Exp Clin Cancer Res. 2019;38(1):396","journal-title":"J Exp Clin Cancer Res"},{"issue":"3","key":"10839_CR9","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1053\/j.gastro.2017.06.007","volume":"153","author":"D Sia","year":"2017","unstructured":"Sia D, Jiao Y, Martinez-Quetglas I, Kuchuk O, Villacorta-Martin C, Castro de Moura M, et al. Identification of an immune-specific class of hepatocellular carcinoma based on molecular features. Gastroenterology. 2017;153(3):812\u2013826","journal-title":"Gastroenterology"},{"issue":"5","key":"10839_CR10","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.jhep.2019.12.024","volume":"72","author":"TI Huo","year":"2020","unstructured":"Huo TI, Liu PH, Hsu CY. Nomogram to predict surgical hepatocellular carcinoma with Child-Pugh B: Feasibility and overlooked predictors. J Hepatol. 2020;72(5):1032\u20131033","journal-title":"J Hepatol"},{"issue":"12","key":"10839_CR11","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1038\/labinvest.3780204","volume":"80","author":"RL Camp","year":"2000","unstructured":"Camp RL, Charette LA, Rimm DL. Validation of tissue microarray technology in breast carcinoma. Lab Invest. 2000;80(12):1943\u20131949","journal-title":"Lab Invest"},{"key":"10839_CR12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m441","volume":"368","author":"RD Riley","year":"2020","unstructured":"Riley RD, Ensor J, Snell KIE, Harrell FE Jr, Martin GP, Reitsma JB, et al. Calculating the sample size required for developing a clinical prediction model. BMJ. 2020;368: m441","journal-title":"BMJ"},{"issue":"2","key":"10839_CR13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ejso.2014.11.002","volume":"41","author":"K Wang","year":"2015","unstructured":"Wang K, Liu G, Li J, Yan Z, Xia Y, Wan X, et al. Early intrahepatic recurrence of hepatocellular carcinoma after hepatectomy treated with re-hepatectomy, ablation or chemoembolization: a prospective cohort study. Eur J Surg Oncol. 2015;41(2):236\u2013242","journal-title":"Eur J Surg Oncol"},{"issue":"3","key":"10839_CR14","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1002\/hep.29904","volume":"68","author":"Y Kurebayashi","year":"2018","unstructured":"Kurebayashi Y, Ojima H, Tsujikawa H, Kubota N, Maehara J, Abe Y, et al. Landscape of immune microenvironment in hepatocellular carcinoma and its additional impact on histological and molecular classification. Hepatology. 2018;68(3):1025\u20131041","journal-title":"Hepatology"},{"issue":"4","key":"10839_CR15","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1002\/jso.24908","volume":"117","author":"SK Kamarajah","year":"2018","unstructured":"Kamarajah SK, Frankel TL, Sonnenday C, Cho CS, Nathan H. Critical evaluation of the American Joint Commission on Cancer (AJCC) 8th edition staging system for patients with Hepatocellular Carcinoma (HCC): A Surveillance, Epidemiology, End Results (SEER) analysis. J Surg Oncol. 2018;117(4):644\u2013650","journal-title":"J Surg Oncol"},{"issue":"4","key":"10839_CR16","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/hep.20636","volume":"41","author":"JA Marrero","year":"2005","unstructured":"Marrero JA, Fontana RJ, Barrat A, Askari F, Conjeevaram HS, Su GL, et al. Prognosis of hepatocellular carcinoma: comparison of 7 staging systems in an American cohort. Hepatology. 2005;41(4):707\u2013716","journal-title":"Hepatology"},{"key":"10839_CR17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2147\/JHC.S86792","volume":"5","author":"M Najjar","year":"2018","unstructured":"Najjar M, Agrawal S, Emond JC, Halazun KJ. Pretreatment neutrophil-lymphocyte ratio: useful prognostic biomarker in hepatocellular carcinoma. J Hepatocell Carcinoma. 2018;5:17\u201328","journal-title":"J Hepatocell Carcinoma"},{"issue":"13","key":"10839_CR18","doi-asserted-by":"publisher","first-page":"11411","DOI":"10.1007\/s00432-023-05017-1","volume":"149","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Yang J, Xie S, Chen H, Zhong J, Lin X, et al. A novel prognostic signature based on immunogenic cell death score predicts outcomes and response to transcatheter arterial chemoembolization and immunotherapy in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2023;149(13):11411\u201311429","journal-title":"J Cancer Res Clin Oncol"},{"issue":"1","key":"10839_CR19","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1002\/cam4.4941","volume":"12","author":"B Bahcivanci","year":"2023","unstructured":"Bahcivanci B, Shafiha R, Gkoutos GV, Acharjee A. Associating transcriptomics data with inflammatory markers to understand tumour microenvironment in hepatocellular carcinoma. Cancer Med. 2023;12(1):696\u2013711","journal-title":"Cancer Med"},{"issue":"2","key":"10839_CR20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.5306\/wjco.v15.i2.243","volume":"15","author":"MT Li","year":"2024","unstructured":"Li MT, Zheng KF, Qiu YE. Identification of immune cell-related prognostic genes characterized by a distinct microenvironment in hepatocellular carcinoma. World J Clin Oncol. 2024;15(2):243\u2013270","journal-title":"World J Clin Oncol"},{"issue":"5","key":"10839_CR21","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.jhep.2010.08.041","volume":"54","author":"DM Kuang","year":"2011","unstructured":"Kuang DM, Zhao Q, Wu Y, Peng C, Wang J, Xu Z, et al. Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J Hepatol. 2011;54(5):948\u2013955","journal-title":"J Hepatol"},{"issue":"8","key":"10839_CR22","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nri3024","volume":"11","author":"A Mantovani","year":"2011","unstructured":"Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 2011;11(8):519\u2013531","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10839_CR23","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12943-019-1047-6","volume":"18","author":"C Lu","year":"2019","unstructured":"Lu C, Rong D, Zhang B, Zheng W, Wang X, Chen Z, et al. Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities. Mol Cancer. 2019;18(1):130","journal-title":"Mol Cancer"},{"issue":"1","key":"10839_CR24","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12885-024-11904-8","volume":"24","author":"E Ali","year":"2024","unstructured":"Ali E, Cervenkova L, Palek R, Ambrozkiewicz F, Hosek P, Daum O, et al. Prognostic role of macrophages and mast cells in the microenvironment of hepatocellular carcinoma after resection. BMC Cancer. 2024;24(1):142","journal-title":"BMC Cancer"},{"key":"10839_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154919","volume":"252","author":"YQ Qi","year":"2023","unstructured":"Qi YQ, Xiong F, Chen YJ. The correlation between tumor-associated macrophages and the prognosis of east Asian hepatocellular carcinoma patients: A systematic review and meta-analysis. Pathol Res Pract. 2023;252: 154919","journal-title":"Pathol Res Pract"},{"issue":"3","key":"10839_CR26","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.ctrv.2011.06.010","volume":"38","author":"SD Wu","year":"2012","unstructured":"Wu SD, Ma YS, Fang Y, Liu LL, Fu D, Shen XZ. Role of the microenvironment in hepatocellular carcinoma development and progression. Cancer Treat Rev. 2012;38(3):218\u2013225","journal-title":"Cancer Treat Rev"},{"key":"10839_CR27","doi-asserted-by":"publisher","first-page":"7819520","DOI":"10.1155\/2018\/7819520","volume":"2018","author":"H Degroote","year":"2018","unstructured":"Degroote H, Van Dierendonck A, Geerts A, Van Vlierberghe H, Devisscher L. Preclinical and Clinical Therapeutic Strategies Affecting Tumor-Associated Macrophages in Hepatocellular Carcinoma. J Immunol Res. 2018;2018:7819520","journal-title":"J Immunol Res"},{"issue":"2","key":"10839_CR28","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","volume":"184","author":"Y Sun","year":"2021","unstructured":"Sun Y, Wu L, Zhong Y, Zhou K, Hou Y, Wang Z, et al. Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma. Cell. 2021;184(2):404-421 e416","journal-title":"Cell"},{"issue":"7938","key":"10839_CR29","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41586-022-05400-x","volume":"612","author":"R Xue","year":"2022","unstructured":"Xue R, Zhang Q, Cao Q, Kong R, Xiang X, Liu H, et al. Liver tumour immune microenvironment subtypes and neutrophil heterogeneity. Nature. 2022;612(7938):141\u2013147","journal-title":"Nature"},{"issue":"18","key":"10839_CR30","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1200\/JCO.2006.09.4565","volume":"25","author":"Q Gao","year":"2007","unstructured":"Gao Q, Qiu SJ, Fan J, Zhou J, Wang XY, Xiao YS, et al. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol. 2007;25(18):2586\u20132593","journal-title":"J Clin Oncol"}],"container-title":["Hepatology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-025-10839-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12072-025-10839-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12072-025-10839-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T18:48:59Z","timestamp":1759949339000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12072-025-10839-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10839"],"URL":"https:\/\/doi.org\/10.1007\/s12072-025-10839-x","relation":{},"ISSN":["1936-0533","1936-0541"],"issn-type":[{"type":"print","value":"1936-0533"},{"type":"electronic","value":"1936-0541"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"assertion":[{"value":"15 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Mingnan Cao, Chen Pan, Zhigang Zhao, Sisi Ye, Li Bai, Tingting Zhang these authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of the Chinese PLA General Hospital and Beijing Tiantan Hospital. Informed consent was obtained before surgery.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}