{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:32:55Z","timestamp":1777653175730,"version":"3.51.4"},"reference-count":68,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,23]],"date-time":"2015-08-23T00:00:00Z","timestamp":1440288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cell Commun. Signal."],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s12079-015-0303-9","type":"journal-article","created":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T02:36:02Z","timestamp":1440210962000},"page":"361-375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nifedipine and phenytoin induce matrix synthesis, but not proliferation, in intact human gingival connective tissue ex vivo"],"prefix":"10.1002","volume":"9","author":[{"given":"Shawna S.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Michelsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendal","family":"Creber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Rieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,23]]},"reference":[{"key":"303_CR1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1902\/jop.2012.120225","volume":"84","author":"R Arancibia","year":"2013","unstructured":"Arancibia R, Oyarzun A, Silva D, Tobar N, Martinez J, Smith PC (2013) Tumor necrosis factor-alpha inhibits transforming growth factor-beta-stimulated myofibroblastic differentiation and extracellular matrix production in human gingival fibroblasts. J Periodontol 84:683\u201393","journal-title":"J Periodontol"},{"key":"303_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4:1\u20136","journal-title":"Ann Periodontol"},{"key":"303_CR3","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1242\/jcs.079509","volume":"125","author":"BM Baker","year":"2012","unstructured":"Baker BM, Chen CS (2012) Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J Cell Sci 125:3015\u201324","journal-title":"J Cell Sci"},{"key":"303_CR4","first-page":"579","volume":"11","author":"R Banthia","year":"2014","unstructured":"Banthia R, Gupta S, Banthia P, Singh P, Raje S, Kaur N (2014) Is periodontal health a predictor of drug-induced gingival overgrowth? A cross-sectional study. Dent Res J (Isfahan) 11:579\u201384","journal-title":"Dent Res J (Isfahan)"},{"issue":"24","key":"303_CR5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1034\/j.1600-0757.2000.2240103.x","volume":"2000","author":"PM Bartold","year":"2000","unstructured":"Bartold PM, Walsh LJ, Narayanan AS (2000) Molecular and cell biology of the gingiva. Periodontol 2000(24):28\u201355","journal-title":"Periodontol"},{"key":"303_CR6","doi-asserted-by":"crossref","first-page":"528","DOI":"10.2353\/ajpath.2010.090526","volume":"176","author":"K Boye","year":"2010","unstructured":"Boye K, Maelandsmo GM (2010) S100A4 and metastasis: a small actor playing many roles. Am J Pathol 176:528\u201335","journal-title":"Am J Pathol"},{"key":"303_CR7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0167-4838(99)00279-4","volume":"1477","author":"K Brew","year":"2000","unstructured":"Brew K, Dinakarpandian D, Nagase H (2000) Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta 1477:267\u2013283","journal-title":"Biochim Biophys Acta"},{"key":"303_CR8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-0714.1991.tb00419.x","volume":"20","author":"RS Brown","year":"1991","unstructured":"Brown RS, Beaver WT, Bottomley WK (1991) On the mechanism of drug-induced gingival hyperplasia. J Oral Pathol Med 20:201\u2013209","journal-title":"J Oral Pathol Med"},{"key":"303_CR9","first-page":"21","volume":"63","author":"I Darby","year":"1990","unstructured":"Darby I, Skalli O, Gabbiani G (1990) Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Invest 63:21\u20139","journal-title":"Lab Invest"},{"key":"303_CR10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1902\/jop.1997.68.4.375","volume":"68","author":"RE Dill","year":"1997","unstructured":"Dill RE, Iacopino AM (1997) Myofibroblasts in phenytoin-induced hyperplastic connective tissue in the rat and in human gingival overgrowth. J Periodontol 68:375\u2013380","journal-title":"J Periodontol"},{"key":"303_CR11","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1902\/jop.2004.75.10.1424","volume":"75","author":"A Dongari-Bagtzoglou","year":"2004","unstructured":"Dongari-Bagtzoglou A (2004) Drug-associated gingival enlargement. J Periodontol 75:1424\u201331","journal-title":"J Periodontol"},{"key":"303_CR12","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1177\/00220345980770090501","volume":"77","author":"WR Duarte","year":"1998","unstructured":"Duarte WR, Kasugai S, Iimura T, Oida S, Takenaga K, Ohya K, Ishikawa I (1998) cDNA cloning of S100 calcium-binding proteins from bovine periodontal ligament and their expression in oral tissues. J Dent Res 77:1694\u20139","journal-title":"J Dent Res"},{"key":"303_CR13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/03008200802143125","volume":"49","author":"R Elenjord","year":"2008","unstructured":"Elenjord R, Ljones H, Sundkvist E, Loennechen T, Winberg JO (2008) Dysregulation of matrix metalloproteinases and their tissue inhibitors by S100A4. Connect Tissue Res 49:185\u20138","journal-title":"Connect Tissue Res"},{"key":"303_CR14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1242\/jcs.087841","volume":"125","author":"CG Elliott","year":"2012","unstructured":"Elliott CG, Wang J, Guo X, Xu SW, Eastwood M, Guan J, Leask A, Conway SJ, Hamilton DW (2012) Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair. J Cell Sci 125:121\u201332","journal-title":"J Cell Sci"},{"key":"303_CR15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0014-2999(01)00810-X","volume":"415","author":"Y Fujimori","year":"2001","unstructured":"Fujimori Y, Maeda S, Saeki M, Morisaki I, Kamisaki Y (2001) Inhibition by nifedipine of adherence- and activated macrophage-induced death of human gingival fibroblasts. Eur J Pharmacol 415:95\u2013103","journal-title":"Eur J Pharmacol"},{"key":"303_CR16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/path.1427","volume":"200","author":"G Gabbiani","year":"2003","unstructured":"Gabbiani G (2003) The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 200:500\u20133","journal-title":"J Pathol"},{"key":"303_CR17","volume":"6","author":"F Guo","year":"2011","unstructured":"Guo F, Carter DE, Mukhopadhyay A, Leask A (2011) Gingival fibroblasts display reduced adhesion and spreading on extracellular matrix: a possible basis for scarless tissue repair? PLoS One 6, e27097","journal-title":"PLoS One"},{"key":"303_CR18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/sj.bdj.2014.905","volume":"217","author":"PA Heasman","year":"2014","unstructured":"Heasman PA, Hughes FJ (2014) Drugs, medications and periodontal disease. Br Dent J 217:411\u20139","journal-title":"Br Dent J"},{"key":"303_CR19","first-page":"1655","volume":"79","author":"HH Hong","year":"1999","unstructured":"Hong HH, Uzel MI, Duan C, Sheff MC, Trackman PC (1999) Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva. Lab Invest 79:1655\u201367","journal-title":"Lab Invest"},{"key":"303_CR20","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1359\/jbmr.1999.14.7.1239","volume":"14","author":"K Horiuchi","year":"1999","unstructured":"Horiuchi K, Amizuka N, Takeshita S, Takamatsu H, Katsuura M, Ozawa H, Toyama Y, Bonewald LF, Kudo A (1999) Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. J Bone Miner Res 14:1239\u20131249","journal-title":"J Bone Miner Res"},{"key":"303_CR21","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1902\/jop.1999.70.9.967","volume":"70","author":"T Ilgenli","year":"1999","unstructured":"Ilgenli T, Atilla G, Baylas H (1999) Effectiveness of periodontal therapy in patients with drug-induced gingival overgrowth. Long-term results. J Periodontol 70:967\u201372","journal-title":"J Periodontol"},{"key":"303_CR22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/(SICI)1097-4644(199702)64:2<295::AID-JCB12>3.0.CO;2-I","volume":"64","author":"N Jaiswal","year":"1997","unstructured":"Jaiswal N, Haynesworth SE, Caplan AI, Bruder SP (1997) Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J Cell Biochem 64:295\u2013312","journal-title":"J Cell Biochem"},{"key":"303_CR23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1902\/jop.2008.070267","volume":"79","author":"CM Kanno","year":"2008","unstructured":"Kanno CM, Oliveira JA, Garcia JF, Castro AL, Crivelini MM (2008) Effects of cyclosporin, phenytoin, and nifedipine on the synthesis and degradation of gingival collagen in tufted capuchin monkeys (Cebus apella): histochemical and MMP-1 and \u22122 and collagen I gene expression analyses. J Periodontol 79:114\u201322","journal-title":"J Periodontol"},{"key":"303_CR24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/path.2000","volume":"210","author":"A Kantarci","year":"2006","unstructured":"Kantarci A, Black SA, Xydas CE, Murawel P, Uchida Y, Yucekal-Tuncer B, Atilla G, Emingil G, Uzel MI, Lee A et al (2006) Epithelial and connective tissue cell CTGF\/CCN2 expression in gingival fibrosis. J Pathol 210:59\u201366","journal-title":"J Pathol"},{"key":"303_CR25","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1177\/154405910708600916","volume":"86","author":"A Kantarci","year":"2007","unstructured":"Kantarci A, Augustin P, Firatli E, Sheff MC, Hasturk H, Graves DT, Trackman PC (2007) Apoptosis in gingival overgrowth tissues. J Dent Res 86:888\u201392","journal-title":"J Dent Res"},{"key":"303_CR26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1755-1536-1-3","volume":"1","author":"M Kapoor","year":"2008","unstructured":"Kapoor M, Liu S, Huh K, Parapuram S, Kennedy L, Leask A (2008) Connective tissue growth factor promoter activity in normal and wounded skin. Fibrogenesis Tissue Repair 1:3","journal-title":"Fibrogenesis Tissue Repair"},{"key":"303_CR27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<351::AID-JCP5>3.0.CO;2-U","volume":"182","author":"M Kataoka","year":"2000","unstructured":"Kataoka M, Shimizu Y, Kunikiyo K, Asahara Y, Yamashita K, Ninomiya M, Morisaki I, Ohsaki Y, Kido JI, Nagata T (2000) Cyclosporin A decreases the degradation of type I collagen in rat gingival overgrowth. J Cell Physiol 182:351\u2013358","journal-title":"J Cell Physiol"},{"key":"303_CR28","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1902\/jop.2001.72.8.1078","volume":"72","author":"M Kataoka","year":"2001","unstructured":"Kataoka M, Shimizu Y, Kunikiyo K, Asahara Y, Azuma H, Sawa T, Kido J, Nagata T (2001) Nifedipine induces gingival overgrowth in rats through a reduction in collagen phagocytosis by gingival fibroblasts. J Periodontol 72:1078\u201383","journal-title":"J Periodontol"},{"key":"303_CR29","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1902\/jop.2005.76.6.941","volume":"76","author":"T Kato","year":"2005","unstructured":"Kato T, Okahashi N, Kawai S, Kato T, Inaba H, Morisaki I, Amano A (2005) Impaired degradation of matrix collagen in human gingival fibroblasts by the antiepileptic drug phenytoin. J Periodontol 76:941\u201350","journal-title":"J Periodontol"},{"key":"303_CR30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1601-0825.2005.01175.x","volume":"12","author":"T Kato","year":"2006","unstructured":"Kato T, Okahashi N, Ohno T, Inaba H, Kawai S, Amano A (2006) Effect of phenytoin on collagen accumulation by human gingival fibroblasts exposed to TNF-alpha in vitro. Oral Dis 12:156\u2013162","journal-title":"Oral Dis"},{"key":"303_CR31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1600-051X.2010.01574.x","volume":"37","author":"G Kaur","year":"2010","unstructured":"Kaur G, Verhamme KM, Dieleman JP, Vanrolleghem A, van Soest EM, Stricker BH, Sturkenboom MC (2010) Association between calcium channel blockers and gingival hyperplasia. J Clin Periodontol 37:625\u2013630","journal-title":"J Clin Periodontol"},{"key":"303_CR32","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1177\/00220345770560103301","volume":"56","author":"DA Keith","year":"1977","unstructured":"Keith DA, Paz MA, Gallop PM (1977) The effect of diphenylhydantoin on fibroblasts in vitro. J Dent Res 56:1279\u20131283","journal-title":"J Dent Res"},{"key":"303_CR33","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1177\/0022034513503659","volume":"92","author":"SS Kim","year":"2013","unstructured":"Kim SS, Jackson-Boeters L, Darling MR, Rieder MJ, Hamilton DW (2013) Nifedipine induces periostin expression in gingival fibroblasts through TGF-beta. J Dent Res 92:1022\u20138","journal-title":"J Dent Res"},{"key":"303_CR34","doi-asserted-by":"crossref","unstructured":"Kim SS, Wen W, Prowse P, Hamilton DW (2015) Regulation of matrix remodelling phenotype in gingival fibroblasts by substratum topography. J Cell Mol Med","DOI":"10.1111\/jcmm.12451"},{"key":"303_CR35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1089\/wound.2012.0363","volume":"2","author":"A Leask","year":"2013","unstructured":"Leask A (2013) Focal adhesion kinase: a key mediator of transforming growth factor beta signaling in fibroblasts. Adv Wound Care (New Rochelle) 2:247\u20139","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"303_CR36","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1681\/ASN.2013060664","volume":"25","author":"M Mael-Ainin","year":"2014","unstructured":"Mael-Ainin M, Abed A, Conway SJ, Dussaule JC, Chatziantoniou C (2014) Inhibition of periostin expression protects against the development of renal inflammation and fibrosis. J Am Soc Nephrol 25:1724\u201336","journal-title":"J Am Soc Nephrol"},{"key":"303_CR37","first-page":"143","volume":"59","author":"H Martelli Jr","year":"2010","unstructured":"Martelli H Jr, Santos SM, Guimaraes AL, Paranaiba LM, Laranjeira AL, Coletta RD, Bonan PR (2010) Idiopathic gingival fibromatosis: description of two cases. Minerva Stomatol 59:143\u20138","journal-title":"Minerva Stomatol"},{"key":"303_CR38","doi-asserted-by":"crossref","first-page":"L709","DOI":"10.1152\/ajplung.00418.2012","volume":"304","author":"W McKleroy","year":"2013","unstructured":"McKleroy W, Lee TH, Atabai K (2013) Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis. Am J Physiol Lung Cell Mol Physiol 304:L709\u201321","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"303_CR39","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1902\/jop.2001.72.5.605","volume":"72","author":"J Miranda","year":"2001","unstructured":"Miranda J, Brunet L, Roset P, Berini L, Farre M, Mendieta C (2001) Prevalence and risk of gingival enlargement in patients treated with nifedipine. J Periodontol 72:605\u201311","journal-title":"J Periodontol"},{"key":"303_CR40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0019-5359.103971","volume":"65","author":"MB Mishra","year":"2011","unstructured":"Mishra MB, Khan ZY, Mishra S (2011) Gingival overgrowth and drug association: a review. Indian J Med Sci 65:73\u201382","journal-title":"Indian J Med Sci"},{"key":"303_CR41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1001\/archderm.1985.01660010083024","volume":"121","author":"LS Moy","year":"1985","unstructured":"Moy LS, Tan EM, Holness R, Uitto J (1985) Phenytoin modulates connective tissue metabolism and cell proliferation in human skin fibroblast cultures. Arch Dermatol 121:79\u201383","journal-title":"Arch Dermatol"},{"key":"303_CR42","doi-asserted-by":"crossref","first-page":"L1046","DOI":"10.1152\/ajplung.00139.2012","volume":"303","author":"PK Naik","year":"2012","unstructured":"Naik PK, Bozyk PD, Bentley JK, Popova AP, Birch CM, Wilke CA, Fry CD, White ES, Sisson TH, Tayob N et al (2012) Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 303:L1046\u201356","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"303_CR43","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1902\/jop.1996.67.5.463","volume":"67","author":"S Nishikawa","year":"1996","unstructured":"Nishikawa S, Nagata T, Morisaki I, Oka T, Ishida H (1996) Pathogenesis of drug-induced gingival overgrowth. A review of studies in the rat model. J Periodontol 67:463\u201371","journal-title":"J Periodontol"},{"key":"303_CR44","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jcb.21224","volume":"101","author":"RA Norris","year":"2007","unstructured":"Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T, Potts JD, Goodwin RL, Davis J et al (2007) Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem 101:695\u2013711","journal-title":"J Cell Biochem"},{"key":"303_CR45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12185-008-0095-2","volume":"88","author":"E Oku","year":"2008","unstructured":"Oku E, Kanaji T, Takata Y, Oshima K, Seki R, Morishige S, Imamura R, Ohtsubo K, Hashiguchi M, Osaki K et al (2008) Periostin and bone marrow fibrosis. Int J Hematol 88:57\u201363","journal-title":"Int J Hematol"},{"key":"303_CR46","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1073\/pnas.1017547108","volume":"108","author":"CH Osterreicher","year":"2011","unstructured":"Osterreicher CH, Penz-Osterreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA (2011) Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 108:308\u201313","journal-title":"Proc Natl Acad Sci U S A"},{"key":"303_CR47","doi-asserted-by":"crossref","first-page":"9064","DOI":"10.1073\/pnas.89.19.9064","volume":"89","author":"OW Petersen","year":"1992","unstructured":"Petersen OW, Ronnov-Jessen L, Howlett AR, Bissell MJ (1992) Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci U S A 89:9064\u20138","journal-title":"Proc Natl Acad Sci U S A"},{"key":"303_CR48","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"BL Pihlstrom","year":"2005","unstructured":"Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. Lancet 366:1809\u201320","journal-title":"Lancet"},{"key":"303_CR49","first-page":"285","volume":"55","author":"CG Pisoschi","year":"2014","unstructured":"Pisoschi CG, Stanciulescu CE, Andrei AM, Berbecaru-Iovan A, Munteanu C, Popescu F, Banita IM (2014) Role of transforming growth factor beta-connective tissue growth factor pathway in dihydropyridine calcium channel blockers-induced gingival overgrowth. Rom J Morphol Embryol 55:285\u201390","journal-title":"Rom J Morphol Embryol"},{"key":"303_CR50","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s007950200029","volume":"35","author":"R Sakamoto","year":"2002","unstructured":"Sakamoto R, Nitta T, Kamikawa Y, Kono S, Kamikawa Y, Sugihara K, Tsuyama S, Murata F (2002) Histochemical, immunohistochemical, and ultrastructural studies of gingival fibromatosis: a case report. Med Electron Microsc 35:248\u201354","journal-title":"Med Electron Microsc"},{"key":"303_CR51","first-page":"741402","volume":"2014","author":"G Sam","year":"2014","unstructured":"Sam G, Sebastian SC (2014) Nonsurgical management of nifedipine induced gingival overgrowth. Case Rep Dent 2014:741402","journal-title":"Case Rep Dent"},{"key":"303_CR52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-5793(93)81681-O","volume":"334","author":"H Shikata","year":"1993","unstructured":"Shikata H, Utsumi N, Shimojima T, Oda Y, Okada Y (1993) Increased expression of type VI collagen genes in drug-induced gingival enlargement. FEBS Lett 334:65\u20138","journal-title":"FEBS Lett"},{"key":"303_CR53","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1590\/S1806-83242010000200010","volume":"24","author":"LM Sobral","year":"2010","unstructured":"Sobral LM, Kellermann MG, Graner E, Martelli-Junior H, Coletta RD (2010) Cyclosporin A-induced gingival overgrowth is not associated with myofibroblast transdifferentiation. Braz Oral Res 24:182\u20138","journal-title":"Braz Oral Res"},{"key":"303_CR54","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1034\/j.1600-051X.1999.260606.x","volume":"26","author":"S Steinsvoll","year":"1999","unstructured":"Steinsvoll S, Halstensen TS, Schenck K (1999) Extensive expression of TGF-beta1 in chronically-inflamed periodontal tissue. J Clin Periodontol 26:366\u2013373","journal-title":"J Clin Periodontol"},{"key":"303_CR55","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1126\/science.3933111","volume":"230","author":"BJ Sugarman","year":"1985","unstructured":"Sugarman BJ, Aggarwal BB, Hass PE, Figari IS, Palladino MA Jr, Shepard HM (1985) Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science 230:943\u20135","journal-title":"Science"},{"key":"303_CR56","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1002\/1097-0142(19911115)68:10<2202::AID-CNCR2820681019>3.0.CO;2-O","volume":"68","author":"M Takagi","year":"1991","unstructured":"Takagi M, Yamamoto H, Mega H, Hsieh KJ, Shioda S, Enomoto S (1991) Heterogeneity in the gingival fibromatoses. Cancer 68:2202\u201312","journal-title":"Cancer"},{"key":"303_CR57","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1902\/jop.1998.69.2.108","volume":"69","author":"S Tavassoli","year":"1998","unstructured":"Tavassoli S, Yamalik N, Caglayan F, Caglayan G, Eratalay K (1998) The clinical effects of nifedipine on periodontal status. J Periodontol 69:108\u201312","journal-title":"J Periodontol"},{"key":"303_CR58","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-0765.1994.tb01241.x","volume":"29","author":"DA Tipton","year":"1994","unstructured":"Tipton DA, Fry HR, Dabbous MK (1994) Altered collagen metabolism in nifedipine-induced gingival overgrowth. J Periodontal Res 29:401\u2013409","journal-title":"J Periodontal Res"},{"key":"303_CR59","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/0022034515571265","volume":"94","author":"PC Trackman","year":"2015","unstructured":"Trackman PC, Kantarci A (2015) Molecular and clinical aspects of drug-induced gingival overgrowth. J Dent Res 94:540\u20136","journal-title":"J Dent Res"},{"key":"303_CR60","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s001090050216","volume":"76","author":"M Trojanowska","year":"1998","unstructured":"Trojanowska M, LeRoy EC, Eckes B, Krieg T (1998) Pathogenesis of fibrosis: type 1 collagen and the skin. J Mol Med (Berl) 76:266\u201374","journal-title":"J Mol Med (Berl)"},{"key":"303_CR61","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1902\/jop.2001.72.7.921","volume":"72","author":"MI Uzel","year":"2001","unstructured":"Uzel MI, Kantarci A, Hong HH, Uygur C, Sheff MC, Firatli E, Trackman PC (2001) Connective tissue growth factor in drug-induced gingival overgrowth. J Periodontol 72:921\u2013931","journal-title":"J Periodontol"},{"key":"303_CR62","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1016\/j.yexcr.2009.07.015","volume":"315","author":"L Vi","year":"2009","unstructured":"Vi L, Feng L, Zhu RD, Wu Y, Satish L, Gan BS, O'Gorman DB (2009) Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren\u2019s disease and adjacent palmar fascia cells. Exp Cell Res 315:3574\u201386","journal-title":"Exp Cell Res"},{"key":"303_CR63","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1177\/0022034510378684","volume":"89","author":"W Wen","year":"2010","unstructured":"Wen W, Chau E, Jackson-Boeters L, Elliott C, Daley TD, Hamilton DW (2010b) TGF-beta1 and FAK regulate periostin expression in PDL fibroblasts. J Dent Res 89:1439\u201343","journal-title":"J Dent Res"},{"key":"303_CR64","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1902\/jop.2000.71.6.955","volume":"71","author":"H Yamada","year":"2000","unstructured":"Yamada H, Nishimura F, Naruishi K, Chou HH, Takashiba S, Albright GM, Nares S, Iacopino AM, Murayama Y (2000) Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts. J Periodontol 71:955\u2013960","journal-title":"J Periodontol"},{"key":"303_CR65","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/bjd.12117","volume":"168","author":"Y Yamaguchi","year":"2012","unstructured":"Yamaguchi Y, Ono J, Masuoka M, Ohta S, Izuhara K, Ikezawa Z, Aihara M, Takahashi K (2012) Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis. Br J Dermatol 168:717\u2013725","journal-title":"Br J Dermatol"},{"key":"303_CR66","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-0714.1987.tb01479.x","volume":"16","author":"A Yamasaki","year":"1987","unstructured":"Yamasaki A, Rose GG, Pinero GJ, Mahan CJ (1987) Ultrastructure of fibroblasts in cyclosporin A-induced gingival hyperplasia. J Oral Pathol 16:129\u201334","journal-title":"J Oral Pathol"},{"key":"303_CR67","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/eb3485a7-612b-4244-8d2a-43a80cdd15eb","volume":"7","author":"L Yang","year":"2012","unstructured":"Yang L, Serada S, Fujimoto M, Terao M, Kotobuki Y, Kitaba S, Matsui S, Kudo A, Naka T, Murota H et al (2012) Periostin facilitates skin sclerosis via PI3K\/Akt dependent mechanism in a mouse model of scleroderma. PLoS One 7, e41994","journal-title":"PLoS One"},{"key":"303_CR68","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12079-010-0090-2","volume":"4","author":"HM Zhou","year":"2010","unstructured":"Zhou HM, Wang J, Elliott C, Wen W, Hamilton DW, Conway SJ (2010) Spatiotemporal expression of periostin during skin development and incisional wound healing: lessons for human fibrotic scar formation. J Cell Commun Signal 4:99\u2013107","journal-title":"J Cell Commun Signal"}],"container-title":["Journal of Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-015-0303-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12079-015-0303-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-015-0303-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:04:26Z","timestamp":1702667066000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12079-015-0303-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,23]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["303"],"URL":"https:\/\/doi.org\/10.1007\/s12079-015-0303-9","relation":{},"ISSN":["1873-9601","1873-961X"],"issn-type":[{"value":"1873-9601","type":"print"},{"value":"1873-961X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,23]]}}}