{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:34:08Z","timestamp":1779258848123,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA021390"],"award-info":[{"award-number":["AA021390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL117759"],"award-info":[{"award-number":["HL117759"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400290"],"award-info":[{"award-number":["81400290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070342"],"award-info":[{"award-number":["81070342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cell Commun. Signal."],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s12079-017-0432-4","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T11:45:03Z","timestamp":1512560703000},"page":"389-399","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Myeloid deficiency of CCN3 exacerbates liver injury in a mouse model of nonalcoholic fatty liver disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Wenconghui","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingjian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A.","family":"Klenotic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"issue":"1","key":"432_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12079-012-0180-4","volume":"7","author":"T Abd El Kader","year":"2013","unstructured":"Abd El Kader T, Kubota S, Janune D, Nishida T, Hattori T, Aoyama E, Perbal B, Kuboki T, Takigawa M (2013) Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family. J Cell Commun Signal 7(1):11\u201318","journal-title":"J Cell Commun Signal"},{"issue":"6","key":"432_CR2","first-page":"1359","volume":"21","author":"SC Barreto","year":"2016","unstructured":"Barreto SC, Ray A, Ag Edgar P (2016) Biological characteristics of CCN proteins in tumor development. J BUON 21(6):1359\u20131367","journal-title":"J BUON"},{"issue":"9","key":"432_CR3","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1111\/j.1478-3231.2012.02837.x","volume":"32","author":"E Borkham-Kamphorst","year":"2012","unstructured":"Borkham-Kamphorst E, Huss S, Van de Leur E, Haas U, Weiskirchen R (2012a) Adenoviral CCN3\/NOV gene transfer fails to mitigate liver fibrosis in an experimental bile duct ligation model because of hepatocyte apoptosis. Liver Int 32(9):1342\u20131353","journal-title":"Liver Int"},{"issue":"1","key":"432_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12079-011-0141-3","volume":"6","author":"E Borkham-Kamphorst","year":"2012","unstructured":"Borkham-Kamphorst E, van Roeyen CR, Van de Leur E, Floege J, Weiskirchen R (2012b) CCN3\/NOV small interfering RNA enhances fibrogenic gene expression in primary hepatic stellate cells and cirrhotic fat storing cell line CFSC. J Cell Commun Signal 6(1):11\u201325","journal-title":"J Cell Commun Signal"},{"issue":"11","key":"432_CR5","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1016\/j.bbamcr.2016.07.006","volume":"1863","author":"E Borkham-Kamphorst","year":"2016","unstructured":"Borkham-Kamphorst E, Steffen BT, Van de Leur E, Tihaa L, Haas U, Woitok MM, Meurer SK, Weiskirchen R (2016) Adenoviral CCN gene transfers induce in vitro and in vivo endoplasmic reticulum stress and unfolded protein response. Biochim Biophys Acta 1863(11):2604\u20132612","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"432_CR6","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.3390\/ijms18081770","volume":"18","author":"X Escote","year":"2017","unstructured":"Escote X, Gomez-Zorita S, Lopez-Yoldi M, Milton-Laskibar I, Fernandez-Quintela A, Martinez JA, Moreno-Aliaga MJ, Portillo MP (2017) Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV\/CCN3 in obesity and diabetes development. Int J Mol Sci 18(8):1770. \n                    https:\/\/doi.org\/10.3390\/ijms18081770","journal-title":"Int J Mol Sci"},{"issue":"3","key":"432_CR7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s12079-016-0332-z","volume":"10","author":"PA Klenotic","year":"2016","unstructured":"Klenotic PA, Zhang C, Lin Z (2016) Emerging roles of CCN proteins in vascular development and pathology. J Cell Commun Signal 10(3):251\u2013257","journal-title":"J Cell Commun Signal"},{"issue":"4","key":"432_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094912","volume":"9","author":"J Liu","year":"2014","unstructured":"Liu J, Ren Y, Kang L, Zhang L (2014) Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice. PLoS One 9(4):e94912","journal-title":"PLoS One"},{"issue":"9","key":"432_CR9","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.2337\/db15-0617","volume":"65","author":"C Martinerie","year":"2016","unstructured":"Martinerie C, Garcia M, Do TT, Antoine B, Moldes M, Dorothee G, Kazazian C, Auclair M, Buyse M, Ledent T, Marchal PO, Fesatidou M, Beisseiche A, Koseki H, Hiraoka S, Chadjichristos CE, Blondeau B, Denis RG, Luquet S, Feve B (2016) NOV\/CCN3: a new Adipocytokine involved in obesity-associated insulin resistance. Diabetes 65(9):2502\u20132515","journal-title":"Diabetes"},{"issue":"2","key":"432_CR10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s12079-012-0161-7","volume":"6","author":"V Ouellet","year":"2012","unstructured":"Ouellet V, Siegel PM (2012) CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis. J Cell Commun Signal 6(2):73\u201385","journal-title":"J Cell Commun Signal"},{"issue":"6","key":"432_CR11","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.ajpath.2017.01.020","volume":"187","author":"H Shi","year":"2017","unstructured":"Shi H, Zhang C, Pasupuleti V, Hu X, Prosdocimo DA, Wu W, Qing Y, Wu S, Mohammad H, Gerson SL, Perbal B, Klenotic PA, Dong N, Lin Z (2017) CCN3 regulates macrophage foam cell formation and atherosclerosis. Am J Pathol 187(6):1230\u20131237","journal-title":"Am J Pathol"},{"issue":"5","key":"432_CR12","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1016\/j.ajpath.2012.01.031","volume":"180","author":"CR van Roeyen","year":"2012","unstructured":"van Roeyen CR, Boor P, Borkham-Kamphorst E, Rong S, Kunter U, Martin IV, Kaitovic A, Fleckenstein S, Perbal B, Trautwein C, Weiskirchen R, Ostendorf T, Floege J (2012) A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects. Am J Pathol 180(5):1979\u20131990","journal-title":"Am J Pathol"},{"issue":"3\u20134","key":"432_CR13","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s12079-008-0022-6","volume":"1","author":"H Yeger","year":"2007","unstructured":"Yeger H, Perbal B (2007) The CCN family of genes: a perspective on CCN biology and therapeutic potential. J Cell Commun Signal 1(3\u20134):159\u2013164","journal-title":"J Cell Commun Signal"},{"issue":"3","key":"432_CR14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s12079-016-0346-6","volume":"10","author":"H Yeger","year":"2016","unstructured":"Yeger H, Perbal B (2016) CCN family of proteins: critical modulators of the tumor cell microenvironment. J Cell Commun Signal 10(3):229\u2013240","journal-title":"J Cell Commun Signal"},{"issue":"4","key":"432_CR15","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1172\/JCI82337","volume":"126","author":"C Zhang","year":"2016","unstructured":"Zhang C, van der Voort D, Shi H, Zhang R, Qing Y, Hiraoka S, Takemoto M, Yokote K, Moxon JV, Norman P, Rittie L, Kuivaniemi H, Atkins GB, Gerson SL, Shi GP, Golledge J, Dong N, Perbal B, Prosdocimo DA, Lin Z (2016) Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J Clin Invest 126(4):1282\u20131299","journal-title":"J Clin Invest"}],"container-title":["Journal of Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12079-017-0432-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-017-0432-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-017-0432-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:06:47Z","timestamp":1702667207000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12079-017-0432-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,6]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["432"],"URL":"https:\/\/doi.org\/10.1007\/s12079-017-0432-4","relation":{},"ISSN":["1873-9601","1873-961X"],"issn-type":[{"value":"1873-9601","type":"print"},{"value":"1873-961X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,6]]},"assertion":[{"value":"15 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}