{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:53:13Z","timestamp":1790787193133,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100006952","name":"Louisiana Board of Regents","doi-asserted-by":"publisher","award":["LEQSF(2019-22)-RD-A-26"],"award-info":[{"award-number":["LEQSF(2019-22)-RD-A-26"]}],"id":[{"id":"10.13039\/100006952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5 P20 GM103424-15"],"award-info":[{"award-number":["5 P20 GM103424-15"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cell Commun. Signal."],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s12079-020-00593-0","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T08:03:50Z","timestamp":1605254630000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs"],"prefix":"10.1002","volume":"15","author":[{"given":"Mohammad S.","family":"Akhter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Uddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew V.","family":"Schally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadeja-Tul","family":"Kubra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8366-5099","authenticated-orcid":false,"given":"Nektarios","family":"Barabutis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"593_CR1","doi-asserted-by":"publisher","first-page":"e22380","DOI":"10.1002\/jbt.22380","volume":"33","author":"MS Akhter","year":"2019","unstructured":"Akhter MS, Uddin MA, Barabutis N (2019) Unfolded protein response regulates P53 expression in the pulmonary endothelium. J Biochem Mol Toxicol 33:e22380. https:\/\/doi.org\/10.1002\/jbt.22380","journal-title":"J Biochem Mol Toxicol"},{"key":"593_CR2","doi-asserted-by":"publisher","first-page":"104051","DOI":"10.1016\/j.mvr.2020.104051","volume":"132","author":"MS Akhter","year":"2020","unstructured":"Akhter MS, Kubra KT, Uddin MA, Barabutis N (2020a) Kifunensine compromises lung endothelial barrier function. Microvasc Res 132:104051. https:\/\/doi.org\/10.1016\/j.mvr.2020.104051","journal-title":"Microvasc Res"},{"key":"593_CR3","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s10753-019-01150-7","volume":"43","author":"MS Akhter","year":"2020","unstructured":"Akhter MS, Uddin MA, Barabutis N (2020b) P53 regulates the redox status of lung endothelial cells. Inflammation 43:686\u2013691. https:\/\/doi.org\/10.1007\/s10753-019-01150-7","journal-title":"Inflammation"},{"key":"593_CR4","doi-asserted-by":"publisher","unstructured":"Akhter MS, Uddin MA, Kubra KT, Barabutis N (2020c) Autophagy, unfolded protein response and lung disease. Curr Res Cell Biol 1:100003. https:\/\/doi.org\/10.1016\/j.crcbio.2020.100003","DOI":"10.1016\/j.crcbio.2020.100003"},{"key":"593_CR5","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1111\/1440-1681.13324","volume":"47","author":"N Barabutis","year":"2020","unstructured":"Barabutis N (2020a) A glimpse at growth hormone-releasing hormone cosmos. Clin Exp Pharmacol Physiol 47:1632\u20131634. https:\/\/doi.org\/10.1111\/1440-1681.13324","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"593_CR6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s12020-020-02205-8","volume":"67","author":"N Barabutis","year":"2020","unstructured":"Barabutis N (2020b) Growth hormone releasing hormone in the unfolded protein response context. Endocrine 67:291\u2013293. https:\/\/doi.org\/10.1007\/s12020-020-02205-8","journal-title":"Endocrine"},{"key":"593_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03629-1","author":"N Barabutis","year":"2020","unstructured":"Barabutis N (2020c) P53 in acute respiratory distress syndrome. Cell Mol Life Sci. https:\/\/doi.org\/10.1007\/s00018-020-03629-1","journal-title":"Cell Mol Life Sci"},{"key":"593_CR8","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3389\/fmed.2020.00344","volume":"7","author":"N Barabutis","year":"2020","unstructured":"Barabutis N (2020d) Unfolded protein response in lung health and disease. Front Med (Lausanne) 7:344. https:\/\/doi.org\/10.3389\/fmed.2020.00344","journal-title":"Front Med (Lausanne)"},{"key":"593_CR9","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1038\/sj.bjc.6604386","volume":"98","author":"N Barabutis","year":"2008","unstructured":"Barabutis N, Schally AV (2008) Knocking down gene expression for growth hormone-releasing hormone inhibits proliferation of human cancer cell lines. Br J Cancer 98:1790\u20131796. https:\/\/doi.org\/10.1038\/sj.bjc.6604386","journal-title":"Br J Cancer"},{"key":"593_CR10","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1002\/cbin.11356","volume":"44","author":"N Barabutis","year":"2020","unstructured":"Barabutis N, Siejka A (2020) The highly interrelated GHRH, p53, and Hsp90 universe. Cell Biol Int 44:1558\u20131563. https:\/\/doi.org\/10.1002\/cbin.11356","journal-title":"Cell Biol Int"},{"key":"593_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1677\/JME-09-0121","volume":"44","author":"N Barabutis","year":"2010","unstructured":"Barabutis N, Siejka A, Schally AV, Block NL, Cai R, Varga JL (2010) Activation of mitogen-activated protein kinases by a splice variant of GHRH receptor. J Mol Endocrinol 44:127\u2013134. https:\/\/doi.org\/10.1677\/JME-09-0121","journal-title":"J Mol Endocrinol"},{"key":"593_CR12","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1111\/j.1582-4934.2010.01096.x","volume":"15","author":"N Barabutis","year":"2011","unstructured":"Barabutis N, Siejka A, Schally AV (2011) Growth hormone releasing hormone induces the expression of nitric oxide synthase. J Cell Mol Med 15:1148\u20131155. https:\/\/doi.org\/10.1111\/j.1582-4934.2010.01096.x","journal-title":"J Cell Mol Med"},{"key":"593_CR13","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1111\/jcmm.13460","volume":"22","author":"N Barabutis","year":"2018","unstructured":"Barabutis N, Dimitropoulou C, Gregory B, Catravas JD (2018) Wild-type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibition. J Cell Mol Med 22:1792\u20131804. https:\/\/doi.org\/10.1111\/jcmm.13460","journal-title":"J Cell Mol Med"},{"key":"593_CR14","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1055\/a-1149-9347","volume":"52","author":"N Barabutis","year":"2020","unstructured":"Barabutis N, Akhter MS, Uddin MA, Kubra KT, Schally AV (2020) GHRH antagonists protect against hydrogen peroxide-induced breakdown of brain microvascular endothelium integrity. Horm Metab Res 52:336\u2013339. https:\/\/doi.org\/10.1055\/a-1149-9347","journal-title":"Horm Metab Res"},{"key":"593_CR15","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1056\/NEJMe2018629","volume":"383","author":"L Hariri","year":"2020","unstructured":"Hariri L, Hardin CC (2020) Covid-19, angiogenesis, and ARDS endotypes. N Engl J Med 383:182\u2013183. https:\/\/doi.org\/10.1056\/NEJMe2018629","journal-title":"N Engl J Med"},{"key":"593_CR16","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/s41589-019-0326-2","volume":"15","author":"C Hetz","year":"2019","unstructured":"Hetz C, Axten JM, Patterson JB (2019) Pharmacological targeting of the unfolded protein response for disease intervention. Nat Chem Biol 15:764\u2013775. https:\/\/doi.org\/10.1038\/s41589-019-0326-2","journal-title":"Nat Chem Biol"},{"key":"593_CR17","doi-asserted-by":"publisher","first-page":"109699","DOI":"10.1016\/j.cellsig.2020.109699","volume":"73","author":"KT Kubra","year":"2020","unstructured":"Kubra KT, Akhter MS, Uddin MA, Barabutis N (2020a) Unfolded protein response in cardiovascular disease. Cell Signal 73:109699. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109699","journal-title":"Cell Signal"},{"key":"593_CR18","doi-asserted-by":"publisher","first-page":"109500","DOI":"10.1016\/j.cellsig.2019.109500","volume":"67","author":"KT Kubra","year":"2020","unstructured":"Kubra KT, Uddin MA, Akhter MS, Barabutis N (2020b) Hsp90 inhibitors induce the unfolded protein response in bovine and mice lung cells. Cell Signal 67:109500. https:\/\/doi.org\/10.1016\/j.cellsig.2019.109500","journal-title":"Cell Signal"},{"key":"593_CR19","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.crtox.2020.09.003","volume":"1","author":"KT Kubra","year":"2020","unstructured":"Kubra KT, Uddin MA, Akhter MS, Barabutis N (2020c) Luminespib counteracts the kifunensine-induced lung endothelial barrier dysfunction. Curr Res Toxicol 1:111\u2013115. https:\/\/doi.org\/10.1016\/j.crtox.2020.09.003","journal-title":"Curr Res Toxicol"},{"key":"593_CR20","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1161\/HYPERTENSIONAHA.114.03811","volume":"64","author":"X Liu","year":"2014","unstructured":"Liu X et al (2014) Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling. Hypertension 64:738\u2013744. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.114.03811","journal-title":"Hypertension"},{"key":"593_CR21","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1038\/sj.cdd.4402151","volume":"14","author":"N Mimura","year":"2007","unstructured":"Mimura N et al (2007) Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP. Cell Death Differ 14:1475\u20131485. https:\/\/doi.org\/10.1038\/sj.cdd.4402151","journal-title":"Cell Death Differ"},{"key":"593_CR22","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1152\/physrev.00020.2020","volume":"100","author":"S Romagnoli","year":"2020","unstructured":"Romagnoli S, Peris A, De Gaudio AR, Geppetti P (2020) SARS-CoV-2 and COVID-19: from the bench to the bedside. Physiol Rev 100:1455\u20131466. https:\/\/doi.org\/10.1152\/physrev.00020.2020","journal-title":"Physiol Rev"},{"key":"593_CR23","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1210\/en.2019-00111","volume":"160","author":"AV Schally","year":"2019","unstructured":"Schally AV, Zhang X, Cai R, Hare JM, Granata R, Bartoli M (2019) Actions and potential therapeutic applications of growth hormone-releasing hormone agonists. Endocrinology 160:1600\u20131612. https:\/\/doi.org\/10.1210\/en.2019-00111","journal-title":"Endocrinology"},{"key":"593_CR24","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s00018-009-0224-y","volume":"67","author":"A Siejka","year":"2010","unstructured":"Siejka A, Schally AV, Barabutis N (2010) Activation of Janus kinase\/signal transducer and activator of transcription 3 pathway by growth hormone-releasing hormone. Cell Mol Life Sci 67:959\u2013964. https:\/\/doi.org\/10.1007\/s00018-009-0224-y","journal-title":"Cell Mol Life Sci"},{"key":"593_CR25","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.imbio.2019.04.008","volume":"224","author":"MA Uddin","year":"2019","unstructured":"Uddin MA, Akhter MS, Siejka A, Catravas JD, Barabutis N (2019a) P53 supports endothelial barrier function via APE1\/Ref1 suppression. Immunobiology 224:532\u2013538. https:\/\/doi.org\/10.1016\/j.imbio.2019.04.008","journal-title":"Immunobiology"},{"key":"593_CR26","doi-asserted-by":"publisher","first-page":"1669989","DOI":"10.1080\/21688370.2019.1669989","volume":"7","author":"MA Uddin","year":"2019","unstructured":"Uddin MA, Akhter MS, Singh SS, Kubra KT, Schally AV, Jois S, Barabutis N (2019b) GHRH antagonists support lung endothelial barrier function. Tissue Barriers 7:1669989. https:\/\/doi.org\/10.1080\/21688370.2019.1669989","journal-title":"Tissue Barriers"},{"key":"593_CR27","doi-asserted-by":"publisher","first-page":"100046","DOI":"10.1016\/j.medidd.2020.100046","volume":"6","author":"MA Uddin","year":"2020","unstructured":"Uddin MA, Kubra KT, Sonju JJ, Akhter MS, Seetharama J, Barabutis N (2020) Effects of heat shock protein 90 inhibition in the lungs. Med Drug Discov 6:100046. https:\/\/doi.org\/10.1016\/j.medidd.2020.100046","journal-title":"Med Drug Discov"}],"container-title":["Journal of Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-020-00593-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12079-020-00593-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-020-00593-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:04:35Z","timestamp":1702667075000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12079-020-00593-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["593"],"URL":"https:\/\/doi.org\/10.1007\/s12079-020-00593-0","relation":{},"ISSN":["1873-9601","1873-961X"],"issn-type":[{"value":"1873-9601","type":"print"},{"value":"1873-961X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,13]]},"assertion":[{"value":"27 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}