{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:28:40Z","timestamp":1790764120284,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000142","name":"Arthritis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000142","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cell Commun. Signal."],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s12079-020-00596-x","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T18:02:59Z","timestamp":1609783379000},"page":"71-80","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Verteporfin inhibits the persistent fibrotic phenotype of lesional scleroderma dermal fibroblasts"],"prefix":"10.1002","volume":"15","author":[{"given":"Xu","family":"Shi-wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Racanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaisham","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amara","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Quesnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Stratton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2832-283X","authenticated-orcid":false,"given":"Andrew","family":"Leask","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"issue":"1","key":"596_CR1","doi-asserted-by":"publisher","first-page":"15002","DOI":"10.1038\/nrdp.2015.2","volume":"2015","author":"Y Allanore","year":"2015","unstructured":"Allanore Y, Simms R, Distler O, Trojanowska M, Pope J, Denton CP et al (2015) Systemic sclerosis. Nat Rev Dis Primers 2015(1):15002","journal-title":"Nat Rev Dis Primers"},{"key":"596_CR2","doi-asserted-by":"publisher","first-page":"407","DOI":"10.12968\/jowc.2013.22.8.407","volume":"22","author":"P Bainbridge","year":"2013","unstructured":"Bainbridge P (2013) Wound healing and the role of fibroblasts. J Wound Care 22:407\u201312","journal-title":"J Wound Care"},{"key":"596_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.cytogfr.2004.03.006","volume":"15","author":"JC Bonner","year":"2004","unstructured":"Bonner JC (2004) Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev 15:255\u201373","journal-title":"Cytokine Growth Factor Rev"},{"key":"596_CR4","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.bbadis.2012.09.014","volume":"1832","author":"LA Borthwick","year":"2013","unstructured":"Borthwick LA, Wynn TA, Fisher AJ (2013) Cytokine-mediated tissue fibrosis. Biochim Biophys Acta 1832:1049\u20131060","journal-title":"Biochim Biophys Acta"},{"key":"596_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s12079-019-00529-3","volume":"14","author":"B Chaqour","year":"2020","unstructured":"Chaqour B (2020) Caught between a \u201cRho\u201d and a hard place: Are CCN1\/CYR61 and CCN2\/CTGF the arbiters of microvascular stiffness? J Cell Commun Signal 14:21\u201329","journal-title":"J Cell Commun Signal"},{"key":"596_CR6","doi-asserted-by":"publisher","first-page":"5371","DOI":"10.2147\/OTT.S102733","volume":"9","author":"J Feng","year":"2016","unstructured":"Feng J, Gou J, Jia J, Yi T, Cui T, Li Z (2016) Verteporfin, a suppressor of YAP\u2013TEAD complex, presents promising antitumor properties on ovarian cancer. Onco Targets Ther 9:5371\u20135381","journal-title":"Onco Targets Ther"},{"key":"596_CR7","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.2174\/0929867323666160316125048","volume":"23","author":"F Gibault","year":"2016","unstructured":"Gibault F, Corvaisier M, Bailly F, Huet G, Melnyk P, Cotelle P (2016) Non-photoinduced biological properties of verteporfin. Curr Med Chem 23:1171\u20131184","journal-title":"Curr Med Chem"},{"key":"596_CR8","doi-asserted-by":"publisher","first-page":"e19756","DOI":"10.1371\/journal.pone.0019756","volume":"6","author":"F Guo","year":"2011","unstructured":"Guo F, Carter DE, Leask A (2011) Mechanical tension increases CCN2\/CTGF expression and proliferation in gingival fibroblasts via a TGF\u03b2-dependent mechanism. PLoS One 6:e19756","journal-title":"PLoS One"},{"key":"596_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.yexcr.2019.03.027","volume":"379","author":"B Hinz","year":"2019","unstructured":"Hinz B, McCulloch CA, Coelho NM (2019) Mechanical regulation of myofibroblast phenoconversion and collagen contraction. Exp Cell Res 379:119\u2013128","journal-title":"Exp Cell Res"},{"key":"596_CR13","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1002\/art.33482","volume":"64","author":"D Lagares","year":"2012","unstructured":"Lagares D, Busnadiego O, Garc\u00eda-Fern\u00e1ndez RA, Kapoor M, Liu S, Carter DE et al (2012) Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation. Arthritis Rheum 64:1653\u20131664","journal-title":"Arthritis Rheum"},{"key":"596_CR10","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1089\/wound.2012.0365","volume":"2","author":"A Leask","year":"2013","unstructured":"Leask A (2013) Integrin beta1: a mechanosignaling sensor essential for connective tissue deposition by fibroblasts. Adv Wound Care 2:160\u2013166","journal-title":"Adv Wound Care"},{"issue":"6","key":"596_CR11","doi-asserted-by":"publisher","first-page":"C1046","DOI":"10.1152\/ajpcell.00028.2020","volume":"318","author":"A Leask","year":"2020","unstructured":"Leask A (2020) Conjunction junction, what\u2019s the function? CCN proteins as targets in fibrosis and cancers. Am J Physiol Cell Physiol 318(6):C1046\u2013C1054","journal-title":"Am J Physiol Cell Physiol"},{"key":"596_CR12","doi-asserted-by":"publisher","first-page":"13008","DOI":"10.1074\/jbc.M210366200","volume":"278","author":"A Leask","year":"2003","unstructured":"Leask A, Holmes A, Black CM, Abraham DJ (2003) Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J Biol Chem 278:13008\u201313015","journal-title":"J Biol Chem"},{"key":"596_CR14","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/cas.13888","volume":"110","author":"Y Li","year":"2019","unstructured":"Li Y, Wang S, Wei X, Zhang S, Song Z, Chen X et al (2019) Role of inhibitor of yes-associated protein 1 in triple-negative breast cancer with taxol-based chemoresistance. Cancer Sci 110:561\u2013567","journal-title":"Cancer Sci"},{"key":"596_CR15","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1091\/mbc.e06-12-1121","volume":"18","author":"S Liu","year":"2007","unstructured":"Liu S, Xu SW, Kennedy L, Pala D, Chen Y, Eastwood M, Carter DE, Black CM, Abraham DJ, Leask A (2007) FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype. Mol Biol Cell 18:2169\u20132178","journal-title":"Mol Biol Cell"},{"key":"596_CR16","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1002\/art.24801","volume":"60","author":"S Liu","year":"2009","unstructured":"Liu S, Kapoor M, Denton CP, Abraham DJ, Leask A (2009) Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model. Arthritis Rheum 60:2817\u201321","journal-title":"Arthritis Rheum"},{"key":"596_CR17","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1002\/art.38121","volume":"65","author":"S Liu","year":"2013","unstructured":"Liu S, Parapuram SK, Leask A (2013) Brief report: Fibrosis caused by Loss of pten expression in mouse fibroblasts is crucially dependent on CCN2. Arthritis Rheum 65:2940\u20132944","journal-title":"Arthritis Rheum"},{"key":"596_CR18","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/wrr.12131","volume":"22","author":"S Liu","year":"2014","unstructured":"Liu S, Thompson K, Leask A (2014) CCN2 expression by fibroblasts is not required for cutaneous tissue repair. Wound Repair Regen 22:119\u2013124","journal-title":"Wound Repair Regen"},{"key":"596_CR19","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1101\/gad.192856.112","volume":"26","author":"Y Liu-Chittenden","year":"2012","unstructured":"Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee SJ, Anders RA, Liu JO, Pan D (2012) Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev 26:1300\u20131305","journal-title":"Genes Dev"},{"key":"596_CR20","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s13075-017-1356-3","volume":"19","author":"K Makino","year":"2017","unstructured":"Makino K, Makino T, Stawski L, Lipson KE, Leask A, Trojanowska M (2017) Anti-connective tissue growth factor (CTGF\/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis. Arthritis Res Ther 19:134","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"596_CR21","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1093\/humrep\/dey384","volume":"34","author":"CL Mulder","year":"2019","unstructured":"Mulder CL, Eijkenboom LL, Beerendonk CCM, Braat DDM, Peek R (2019) Enhancing the safety of ovarian cortex autotransplantation: cancer cells are purged completely from human ovarian tissue fragments by pharmacological inhibition of YAP\/TAZ oncoproteins. Hum Reprod 34(3):506\u2013518","journal-title":"Hum Reprod"},{"key":"596_CR22","doi-asserted-by":"publisher","first-page":"e0186740","DOI":"10.1371\/journal.pone.0186740","volume":"12","author":"H Murphy-Marshman","year":"2017","unstructured":"Murphy-Marshman H, Quesnel K, Shi-Wen X, Barnfield R, Kelly J, Peidl A et al (2017) Antioxidants and NOX1\/NOX4 inhibition blocks TGF\u03b21-induced CCN2 and \u03b1-SMA expression in dermal and gingival fibroblasts. PLoS One 12:e0186740","journal-title":"PLoS One"},{"key":"596_CR23","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1038\/jid.2011.156","volume":"131","author":"SK Parapuram","year":"2011","unstructured":"Parapuram SK, Shi-wen X, Elliott C, Welch ID, Jones H, Baron M, Denton CP, Abraham DJ, Leask A (2011) Loss of PTEN expression by dermal fibroblasts causes skin fibrosis. J Investig Dermatol 131:1996\u20132003","journal-title":"J Investig Dermatol"},{"key":"596_CR25","doi-asserted-by":"publisher","first-page":"e0218178","DOI":"10.1371\/journal.pone.0218178","volume":"14","author":"A Peidl","year":"2019","unstructured":"Peidl A, Perbal B, Leask A (2019) Yin\/Yang expression of CCN family members: transforming growth factor beta 1, via ALK5\/FAK\/MEK, induces CCN1 and CCN2, yet suppresses CCN3, expression in human dermal fibroblasts. PLoS One 14:e0218178","journal-title":"PLoS One"},{"key":"596_CR24","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1021\/acs.molpharmaceut.8b01001","volume":"16","author":"DS Pellosi","year":"2019","unstructured":"Pellosi DS, Paula LB, de Melo MT, Tedesco AC (2019) Targeted and synergic glioblastoma treatment: multifunctional nanoparticle delivering verteporfin as adjuvant therapy for temozolomide chemotherapy. Mol Pharm 16:1009\u20131024","journal-title":"Mol Pharm"},{"key":"596_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmed.2015.00059","volume":"2","author":"B Piersma","year":"2015","unstructured":"Piersma B, Bank RA, Boersema M (2015) Signaling in fibrosis: TGF-\u03b2, WNT, and YAP\/TAZ converge. Front Med 2:1\u201314","journal-title":"Front Med"},{"key":"596_CR27","doi-asserted-by":"publisher","first-page":"100009","DOI":"10.1016\/j.mbplus.2019.100009","volume":"3","author":"K Quesnel","year":"2019","unstructured":"Quesnel K, Shiwen X, Hutchenreuther J, Xiao Z, Liu S, Peidl A et al (2019) CCN1 expression by fibroblasts is required for bleomycin-induced skin fibrosis. Matrix Biol Plus 3:100009","journal-title":"Matrix Biol Plus"},{"key":"596_CR28","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.matbio.2018.01.025","volume":"68\u201369","author":"JN Schulz","year":"2018","unstructured":"Schulz JN, Plomann JM, Sengle G, Gullberg D, Krieg T, Eckes B (2018) New developments on skin fibrosis - essential signals emanating from the extracellular matrix for the control of myofibroblasts. Matrix Biol 68\u201369:522\u2013532","journal-title":"Matrix Biol"},{"key":"596_CR29","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1093\/rheumatology\/kes234","volume":"51","author":"X Shi-wen","year":"2012","unstructured":"Shi-wen X, Thompson K, Khan K, Liu S, Murphy-Marshman H, Baron M, Denton CP, Leask A, Abraham DJ (2012) Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts. Rheumatology 51:2146\u20132154","journal-title":"Rheumatology"},{"key":"596_CR30","doi-asserted-by":"publisher","first-page":"12384","DOI":"10.1074\/jbc.M208544200","volume":"278","author":"VJ Thannickal","year":"2003","unstructured":"Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R et al (2003) Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem 278:12384\u201312389","journal-title":"J Biol Chem"},{"key":"596_CR31","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrm809","volume":"3","author":"JJ Tomasek","year":"2002","unstructured":"Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechanoregulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3:349\u2013336","journal-title":"Nat Rev Mol Cell Biol"},{"key":"596_CR32","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jid.2017.08.024","volume":"138","author":"T Toyama","year":"2018","unstructured":"Toyama T, Looney AP, Baker BM, Stawski L, Haines P, Simms R et al (2018) Therapeutic targeting of TAZ and YAP by dimethyl fumarate in systemic sclerosis fibrosis. J Investig Dermatol 138:78\u201388","journal-title":"J Investig Dermatol"},{"key":"596_CR33","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.ajpath.2019.09.006","volume":"190","author":"M Tsang","year":"2020","unstructured":"Tsang M, Quesnel K, Vincent K, Hutchenreuther J, Postovit LM, Leask A (2020) Insights into fibroblast plasticity: cellular communication network 2 is required for activation of cancer-associated fibroblasts in a murine model of melanoma. Am J Pathol 190:206\u2013221","journal-title":"Am J Pathol"},{"key":"596_CR34","doi-asserted-by":"crossref","unstructured":"van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A et al (2013) Classification criteria forsystemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative.\u00a0 Arthritis Rheum\u00a065:2737-2774","DOI":"10.1002\/art.38098"},{"key":"596_CR35","first-page":"27","volume":"6","author":"C Wang","year":"2015","unstructured":"Wang C, Zhu X, Feng W, Yu Y, Jeong K, Guo W, Lu Y, Mills GB (2015) Verteporfin inhibits YAP function through up-regulating 14-3-3\u03c3 sequestering YAP in the cytoplasm. Am J Cancer Res 6:27\u201337","journal-title":"Am J Cancer Res"},{"key":"596_CR36","doi-asserted-by":"publisher","first-page":"e7438","DOI":"10.1371\/annotation\/654a1794-3ca1-45ac-bbf6-20ae9d33c016","volume":"4","author":"SW Xu","year":"2009","unstructured":"Xu SW, Liu S, Eastwood M, Sonnylal S, Denton CP, Abraham DJ, Leask A (2009) Rac inhibition reverses the phenotype of fibrotic fibroblasts. PLoS One 4:e7438","journal-title":"PLoS One"},{"key":"596_CR37","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.coph.2016.05.002","volume":"29","author":"F Zanconato","year":"2016","unstructured":"Zanconato F, Battilana G, Cordenonsi M, Piccolo S (2016) YAP\/TAZ as therapeutic targets in cancer. Curr Opin Pharmacol 29:26\u201333","journal-title":"Curr Opin Pharmacol"}],"container-title":["Journal of Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-020-00596-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12079-020-00596-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-020-00596-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:04:36Z","timestamp":1702667076000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12079-020-00596-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,4]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["596"],"URL":"https:\/\/doi.org\/10.1007\/s12079-020-00596-x","relation":{},"ISSN":["1873-9601","1873-961X"],"issn-type":[{"value":"1873-9601","type":"print"},{"value":"1873-961X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,4]]},"assertion":[{"value":"16 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}