{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:52:46Z","timestamp":1789102366472,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cell Commun. Signal."],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s12079-021-00607-5","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T10:03:39Z","timestamp":1614247419000},"page":"185-193","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The role of nuclear factor kappa B (NF-\u03baB) in filarial pathology"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-5099","authenticated-orcid":false,"given":"Fatima Amponsah","family":"Fordjour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer","family":"Asiedu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amma","family":"Larbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kwarteng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"issue":"46","key":"607_CR1","doi-asserted-by":"publisher","first-page":"75954","DOI":"10.18632\/oncotarget.12488","volume":"7","author":"CV Alexander-Savino","year":"2016","unstructured":"Alexander-Savino CV, Hayden MS, Richardson C, Zhao J, Poligone B (2016) Doxycycline is an NF-\u03baB inhibitor that induces apoptotic cell death in malignant T-cells. Oncotarget 7(46):75954\u201375967. https:\/\/doi.org\/10.18632\/oncotarget.12488","journal-title":"Oncotarget"},{"issue":"1","key":"607_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/s0952-7915(99)00045-x","volume":"12","author":"KV Anderson","year":"2000","unstructured":"Anderson KV (2000) Toll signalling pathways in the innate immune response. Curr Opin Immunol 12(1):13\u201319. https:\/\/doi.org\/10.1016\/s0952-7915(99)00045-x","journal-title":"Curr Opin Immunol"},{"issue":"7","key":"607_CR3","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1084\/jem.190.7.953","volume":"190","author":"D Artis","year":"1999","unstructured":"Artis D, Humphreys NE, Bancroft AJ, Rothwell NJ, Potten CS, Grencis RK (1999) Tumor necrosis factor \u03b1 Is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during Helminth Infection. J Exp Med 190(7):953\u2013962. https:\/\/doi.org\/10.1084\/jem.190.7.953","journal-title":"J Exp Med"},{"issue":"8","key":"607_CR4","doi-asserted-by":"publisher","first-page":"4481","DOI":"10.4049\/jimmunol.169.8.4481","volume":"169","author":"D Artis","year":"2002","unstructured":"Artis D, Shapira S, Mason N, Speirs KM, Goldschmidt M, Caama\u00f1o J, Liou H-C, Hunter CA, Scott P (2002) Differential requirement for NF-\u03baB family members in control of Helminth infection and intestinal inflammation. J Immunol 169(8):4481\u20134487. https:\/\/doi.org\/10.4049\/jimmunol.169.8.4481","journal-title":"J Immunol"},{"issue":"12","key":"607_CR5","doi-asserted-by":"publisher","first-page":"6723","DOI":"10.4049\/jimmunol.171.12.6723","volume":"171","author":"S Babu","year":"2003","unstructured":"Babu S, Nutman TB (2003) Proinflammatory cytokines dominate the early immune response to filarial parasites. J Immunol 171(12):6723\u20136732. https:\/\/doi.org\/10.4049\/jimmunol.171.12.6723","journal-title":"J Immunol"},{"issue":"5","key":"607_CR6","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.4049\/jimmunol.176.5.3248","volume":"176","author":"S Babu","year":"2006","unstructured":"Babu S, Blauvelt CP, Kumaraswami V, Nutman TB (2006) Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence. J Immunol 176(5):3248\u20133256. https:\/\/doi.org\/10.4049\/jimmunol.176.5.3248","journal-title":"J Immunol"},{"issue":"4","key":"607_CR7","doi-asserted-by":"publisher","first-page":"e420","DOI":"10.1371\/journal.pntd.0000420","volume":"3","author":"S Babu","year":"2009","unstructured":"Babu S, Bhat SQ, Pavan Kumar N, Lipira AB, Kumar S, Karthik C, Kumaraswami V, Nutman TB (2009) Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells. PLoS Neglect Trop Dis 3(4):e420. https:\/\/doi.org\/10.1371\/journal.pntd.0000420","journal-title":"PLoS Neglect Trop Dis"},{"issue":"11","key":"607_CR8","doi-asserted-by":"publisher","first-page":"4600","DOI":"10.1128\/IAI.05419-11","volume":"79","author":"S Babu","year":"2011","unstructured":"Babu S, Anuradha R, Kumar NP, George PJ, Kumaraswami V, Nutman TB (2011) Filarial lymphatic pathology reflects augmented toll-like receptor-mediated, mitogen-activated protein kinase-mediated proinflammatory cytokine production. Infect Immun 79(11):4600\u20134608. https:\/\/doi.org\/10.1128\/IAI.05419-11","journal-title":"Infect Immun"},{"issue":"7","key":"607_CR9","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1128\/IAI.06179-11","volume":"80","author":"S Babu","year":"2012","unstructured":"Babu S, Anuradha R, Kumar NP, George PJ, Kumaraswami V, Nutman TB (2012) Toll-like receptor- and filarial antigen-mediated, mitogen-activated protein kinase- and NF-\u03baB-dependent regulation of angiogenic growth factors in filarial lymphatic pathology. Infect Immun 80(7):2509\u20132518. https:\/\/doi.org\/10.1128\/IAI.06179-11","journal-title":"Infect Immun"},{"issue":"12","key":"607_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.ppat.1000688","volume":"5","author":"S Bennuru","year":"2009","unstructured":"Bennuru S, Nutman TB (2009) Lymphangiogenesis and lymphatic remodeling induced by filarial parasites: implications for pathogenesis. PLOS Pathogens 5(12):1\u201312. https:\/\/doi.org\/10.1371\/journal.ppat.1000688","journal-title":"PLOS Pathogens"},{"issue":"1","key":"607_CR11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.4049\/jimmunol.173.1.437","volume":"173","author":"NW Brattig","year":"2004","unstructured":"Brattig NW, Bazzocchi C, Kirschning CJ, Reiling N, B\u00fcttner DW, Ceciliani F, Geisinger F, Hochrein H, Ernst M, Wagner H, Bandi C, Hoerauf A (2004) The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4. J Immunol 173(1):437\u2013445. https:\/\/doi.org\/10.4049\/jimmunol.173.1.437","journal-title":"J Immunol"},{"key":"607_CR12","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s41182-019-0141-1","volume":"47","author":"CN Carlingford","year":"2019","unstructured":"Carlingford CN, Melrose W, Mokoia G, Graves PM, Ichimori K, Capuano C, Kim SH, Aratchige P, Nosa M (2019) Elimination of lymphatic filariasis as a public health problem in Niue under PacELF, 1999\u20132016. Trop Med Health 47:20. https:\/\/doi.org\/10.1186\/s41182-019-0141-1","journal-title":"Trop Med Health"},{"issue":"5838","key":"607_CR13","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1126\/science.1142953","volume":"317","author":"RJ Carmody","year":"2007","unstructured":"Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH (2007) Negative regulation of toll-like receptor signalling by NF-kappaB p50 ubiquitination blockade. Science 317(5838):675\u2013678. https:\/\/doi.org\/10.1126\/science.1142953","journal-title":"Science"},{"issue":"8","key":"607_CR14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1046\/j.1365-3024.1996.d01-126.x","volume":"18","author":"BK Das","year":"1996","unstructured":"Das BK, Sahoo PK, Ravindran B (1996) A role for tumour necrosis factor-\u03b1 in acute lymphatic filariasis. Parasite Immunol 18(8):421\u2013424. https:\/\/doi.org\/10.1046\/j.1365-3024.1996.d01-126.x","journal-title":"Parasite Immunol"},{"issue":"9","key":"607_CR15","doi-asserted-by":"publisher","first-page":"e92","DOI":"10.1371\/journal.ppat.0020092","volume":"2","author":"AY Debrah","year":"2006","unstructured":"Debrah AY, Mand S, Specht S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Larbi J, Lawson B, Taylor M, Adjei O, Hoerauf A (2006) Doxycycline reduces plasma VEGF-C\/sVEGFR-3 and improves pathology in lymphatic filariasis. PLoS Pathog 2(9):e92. https:\/\/doi.org\/10.1371\/journal.ppat.0020092","journal-title":"PLoS Pathog"},{"key":"607_CR101","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1111\/j.1365-3156.2007.01949.x","volume":"12","author":"AY Debrah","year":"2007","unstructured":"Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Buttner M, Adjei O, Buttner D, Hoerauf A (2007) Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti. Trop Med Int Health 12:1433\u20131441. https:\/\/doi.org\/10.1111\/j.1365-3156.2007.01949.x","journal-title":"Trop Med Intl Health"},{"issue":"6","key":"607_CR16","doi-asserted-by":"publisher","first-page":"956","DOI":"10.4269\/ajtmh.2009.80.956","volume":"80","author":"AY Debrah","year":"2009","unstructured":"Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Pfarr K, Lawson B, Taylor M, Adjei O, Hoerauf A (2009) Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline. Am J Trop Med Hyg 80(6):956\u2013963. https:\/\/doi.org\/10.4269\/ajtmh.2009.80.956","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"607_CR17","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40246-017-0121-7","volume":"11","author":"LB Debrah","year":"2017","unstructured":"Debrah LB, Albers A, Debrah AY, Brockschmidt FF, Becker T, Herold C, Hofmann A, Osei-Mensah J, Mubarik Y, Fr\u00f6hlich H, Hoerauf A, Pfarr K (2017) Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti. Hum Genomics 11(1):26. https:\/\/doi.org\/10.1186\/s40246-017-0121-7","journal-title":"Hum Genomics"},{"issue":"1","key":"607_CR18","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/1756-3305-5-240","volume":"5","author":"K Deribe","year":"2012","unstructured":"Deribe K, Meribo K, Gebre T, Hailu A, Ali A, Aseffa A, Davey G (2012) The burden of neglected tropical diseases in Ethiopia, and opportunities for integrated control and elimination. Parasites Vectors 5(1):240. https:\/\/doi.org\/10.1186\/1756-3305-5-240","journal-title":"Parasites Vectors"},{"issue":"12","key":"607_CR19","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/s0169-4758(00)01778-6","volume":"16","author":"G Dreyer","year":"2000","unstructured":"Dreyer G, Nor\u00f5es J, Figueredo-Silva J, Piessens WF (2000) Pathogenesis of lymphatic disease in bancroftian filariasis: a clinical perspective. Parasitol Today 16(12):544\u2013548. https:\/\/doi.org\/10.1016\/s0169-4758(00)01778-6","journal-title":"Parasitol Today"},{"key":"607_CR20","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/bs.apcsb.2016.11.006","volume":"107","author":"JK Durand","year":"2017","unstructured":"Durand JK, Baldwin AS (2017) Targeting IKK and NF-\u03baB for therapy. Adv Protein Chem Struct Biol 107:77\u2013115. https:\/\/doi.org\/10.1016\/bs.apcsb.2016.11.006","journal-title":"Adv Protein Chem Struct Biol"},{"issue":"2","key":"607_CR21","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/s1097-2765(00)80426-8","volume":"5","author":"S Erg\u00fcn","year":"2000","unstructured":"Erg\u00fcn S, Kilic N, Ziegeler G, Hansen A, Nollau P, G\u00f6tze J, Wurmbach J-H, Horst A, Weil J, Fernando M, Wagener C (2000) CEA-related cell Adhesion molecule 1. Mol Cell 5(2):311\u2013320. https:\/\/doi.org\/10.1016\/s1097-2765(00)80426-8","journal-title":"Mol Cell"},{"issue":"6","key":"607_CR22","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1179\/000349802125001348","volume":"96","author":"J Figueredo-Silva","year":"2002","unstructured":"Figueredo-Silva J, Nor\u00f5es J, Cedenho A, Dreyer G (2002) The histopathology of bancroftian filariasis revisited: the role of the adult worm in the lymphatic-vessel disease. Ann Trop Med Parasitol 96(6):531\u2013541. https:\/\/doi.org\/10.1179\/000349802125001348","journal-title":"Ann Trop Med Parasitol"},{"key":"607_CR23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.immunol.16.1.225","volume":"16","author":"S Ghosh","year":"1998","unstructured":"Ghosh S, May MJ, Kopp EB (1998) NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225\u2013260. https:\/\/doi.org\/10.1146\/annurev.immunol.16.1.225","journal-title":"Annu Rev Immunol"},{"issue":"10","key":"607_CR24","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/j.yexcr.2009.02.026","volume":"315","author":"A Gu","year":"2009","unstructured":"Gu A, Tsark W, Holmes KV, Shively JE (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res 315(10):1668\u20131682. https:\/\/doi.org\/10.1016\/j.yexcr.2009.02.026","journal-title":"Exp Cell Res"},{"key":"607_CR67","unstructured":"Global Programme to Eliminate Lymphatic Filariasis: Progress Report (2016) (2017). Releve epidemiologique hebdomadaire, 92(40):594\u2013607"},{"issue":"357","key":"607_CR25","doi-asserted-by":"publisher","first-page":"re13","DOI":"10.1126\/stke.3572006re13","volume":"2006","author":"H H\u00e4cker","year":"2006","unstructured":"H\u00e4cker H, Karin M (2006) Regulation and function of IKK and IKK-related kinases. Science\u2019s STKE Signal Trans Knowl Environ 2006(357):re13. https:\/\/doi.org\/10.1126\/stke.3572006re13","journal-title":"Science\u2019s STKE Signal Trans Knowl Environ"},{"issue":"3","key":"607_CR26","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","volume":"132","author":"MS Hayden","year":"2008","unstructured":"Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signalling. Cell 132(3):344\u2013362. https:\/\/doi.org\/10.1016\/j.cell.2008.01.020","journal-title":"Cell"},{"issue":"51","key":"607_CR27","doi-asserted-by":"publisher","first-page":"6758","DOI":"10.1038\/sj.onc.1209943","volume":"25","author":"MS Hayden","year":"2006","unstructured":"Hayden MS, West AP, Ghosh S (2006) NF-kappaB and the immune response. Oncogene 25(51):6758\u20136780. https:\/\/doi.org\/10.1038\/sj.onc.1209943","journal-title":"Oncogene"},{"issue":"2","key":"607_CR28","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.4049\/jimmunol.178.2.1068","volume":"178","author":"AG Hise","year":"2007","unstructured":"Hise AG, Daehnel K, Gillette-Ferguson I, Cho E, McGarry HF, Taylor MJ, Golenbock DT, Fitzgerald KA, Kazura JW, Pearlman E (2007) Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM. J Immunol 178(2):1068\u20131076. https:\/\/doi.org\/10.4049\/jimmunol.178.2.1068","journal-title":"J Immunol"},{"issue":"8","key":"607_CR29","doi-asserted-by":"publisher","first-page":"e412","DOI":"10.1371\/journal.pntd.0000412","volume":"3","author":"PJ Hotez","year":"2009","unstructured":"Hotez PJ, Kamath A (2009) Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Neglect Trop Dis 3(8):e412. https:\/\/doi.org\/10.1371\/journal.pntd.0000412","journal-title":"PLoS Neglect Trop Dis"},{"key":"607_CR30","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","volume":"18","author":"M Karin","year":"2000","unstructured":"Karin M, Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18:621\u2013663. https:\/\/doi.org\/10.1146\/annurev.immunol.18.1.621","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"607_CR31","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","volume":"13","author":"T Kawai","year":"2007","unstructured":"Kawai T, Akira S (2007) Signalling to NF-\u03baB by toll-like receptors. Trends Mol Med 13(11):460\u2013469. https:\/\/doi.org\/10.1016\/j.molmed.2007.09.002","journal-title":"Trends Mol Med"},{"issue":"1","key":"607_CR32","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.expneurol.2006.01.032","volume":"200","author":"MA Kelly","year":"2006","unstructured":"Kelly MA, Shuaib A, Todd KG (2006) Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis. Exp Neurol 200(1):38\u201349. https:\/\/doi.org\/10.1016\/j.expneurol.2006.01.032","journal-title":"Exp Neurol"},{"issue":"3","key":"607_CR33","doi-asserted-by":"publisher","first-page":"A54","DOI":"10.1016\/S0167-5699(05)80016-7","volume":"12","author":"CL King","year":"1991","unstructured":"King CL, Nutman TB (1991) Regulation of the immune response in lymphatic filariasis and onchocerciasis. Immunol Today 12(3):A54\u2013A58. https:\/\/doi.org\/10.1016\/S0167-5699(05)80016-7","journal-title":"Immunol Today"},{"issue":"4","key":"607_CR34","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1242\/jcs.00286","volume":"116","author":"S Kiriakidis","year":"2003","unstructured":"Kiriakidis S, Andreakos E, Monaco C, Foxwell B, Feldmann M, Paleolog E (2003) VEGF expression in human macrophages is NF-\u03baB-dependent: studies using adenoviruses expressing the endogenous NF-\u03baB inhibitor I\u03baB\u03b1 and a kinase-defective form of the I\u03baB kinase 2. J Cell Sci 116(4):665\u2013674. https:\/\/doi.org\/10.1242\/jcs.00286","journal-title":"J Cell Sci"},{"issue":"5","key":"607_CR100","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pt.2012.03.001","volume":"28","author":"E Litt","year":"2012","unstructured":"Litt E, Baker MC, Molyneux D (2012) Neglected tropical diseases and mental health: a perspective on comorbidity. Trends Parasitol 28(5):195\u2013201. https:\/\/doi.org\/10.1016\/j.pt.2012.03.001","journal-title":"Trends Parasitol"},{"key":"607_CR35","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, Sun S-C (2017) NF-\u03baB signalling in inflammation. Signal Trans Target Ther 2:17023. https:\/\/doi.org\/10.1038\/sigtrans.2017.23","journal-title":"Signal Trans Target Ther"},{"issue":"5","key":"607_CR36","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1093\/infdis\/170.5.1339","volume":"170","author":"S Mahanty","year":"1994","unstructured":"Mahanty S, Day KP, Alpers MP, Kazura JW (1994) Antifilarial IgG4 antibodies in children from filaria-endemic areas correlate with duration of infection and are dissociated from antifilarial IgE antibodies. J Infect Dis 170(5):1339\u20131343. https:\/\/doi.org\/10.1093\/infdis\/170.5.1339","journal-title":"J Infect Dis"},{"issue":"2","key":"607_CR37","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/0169-4758(95)80116-2","volume":"11","author":"RM Maizels","year":"1995","unstructured":"Maizels RM, Sartono E, Kurniawan A, Partono F, Selkirk ME, Yazdanbakhsh M (1995) T-cell activation and the balance of antibody isotypes in human lymphatic filariasis. Parasitol Today 11(2):50\u201356. https:\/\/doi.org\/10.1016\/0169-4758(95)80116-2","journal-title":"Parasitol Today"},{"issue":"2","key":"607_CR38","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/s0167-5699(97)01197-3","volume":"19","author":"MJ May","year":"1998","unstructured":"May MJ, Ghosh S (1998) Signal transduction through NF-kappa B. Immunol Today 19(2):80\u201388. https:\/\/doi.org\/10.1016\/s0167-5699(97)01197-3","journal-title":"Immunol Today"},{"issue":"4","key":"607_CR39","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1128\/CMR.05040-11","volume":"25","author":"HJ McSorley","year":"2012","unstructured":"McSorley HJ, Maizels RM (2012) Helminth infections and host immune regulation. Clin Microbiol Rev 25(4):585\u2013608. https:\/\/doi.org\/10.1128\/CMR.05040-11","journal-title":"Clin Microbiol Rev"},{"issue":"9","key":"607_CR40","doi-asserted-by":"publisher","first-page":"7438","DOI":"10.1074\/jbc.M108135200","volume":"277","author":"P Muenzner","year":"2002","unstructured":"Muenzner P, Billker O, Meyer TF, Naumann M (2002) Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells. J Biol Chem 277(9):7438\u20137446. https:\/\/doi.org\/10.1074\/jbc.M108135200","journal-title":"J Biol Chem"},{"issue":"2","key":"607_CR41","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bjid.2015.10.011","volume":"20","author":"S Mukherjee","year":"2016","unstructured":"Mukherjee S, Karmakar S, Babu SPS (2016) TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review. Braz J Infect Dis 20(2):193\u2013204. https:\/\/doi.org\/10.1016\/j.bjid.2015.10.011","journal-title":"Braz J Infect Dis"},{"issue":"6","key":"607_CR42","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1093\/infdis\/jix067","volume":"215","author":"S Mukherjee","year":"2017","unstructured":"Mukherjee S, Mukherjee S, Maiti TK, Bhattacharya S, Sinha Babu SP (2017) A novel ligand of toll-like receptor 4 from the sheath of Wuchereria bancrofti microfilaria induces proinflammatory response in macrophages. J Infect Dis 215(6):954\u2013965. https:\/\/doi.org\/10.1093\/infdis\/jix067","journal-title":"J Infect Dis"},{"issue":"1","key":"607_CR43","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s42003-019-0392-8","volume":"2","author":"S Mukherjee","year":"2019","unstructured":"Mukherjee S, Karnam A, Das M, Babu SPS, Bayry J (2019) Wuchereria bancrofti filaria activates human dendritic cells and polarizes T helper 1 and regulatory T cells via toll-like receptor 4. Commun Biol 2(1):169. https:\/\/doi.org\/10.1038\/s42003-019-0392-8","journal-title":"Commun Biol"},{"issue":"1","key":"607_CR44","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s41182-019-0169-2","volume":"47","author":"R Ofanoa","year":"2019","unstructured":"Ofanoa R, Ofa T, Padmasiri EA, Kapa DR (2019) Elimination of lymphatic filariasis as a public health problem from Tonga. Trop Med Health 47(1):2\u20133. https:\/\/doi.org\/10.1186\/s41182-019-0169-2","journal-title":"Trop Med Health"},{"issue":"24","key":"607_CR45","doi-asserted-by":"publisher","first-page":"8932","DOI":"10.1158\/0008-5472.CAN-04-0505","volume":"64","author":"L Oliveira-Ferrer","year":"2004","unstructured":"Oliveira-Ferrer L, Tilki D, Ziegeler G, Hauschild J, Loges S, Irmak S, Kilic E, Huland H, Friedrich M, Erg\u00fcn S (2004) Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer. Can Res 64(24):8932\u20138938. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-0505","journal-title":"Can Res"},{"issue":"6","key":"607_CR46","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1002\/jlb.63.6.650","volume":"63","author":"LA O\u2019Neill","year":"1998","unstructured":"O\u2019Neill LA, Greene C (1998) Signal transduction pathways activated by the IL-1 receptor family: ancient signalling machinery in mammals, insects, and plants. J Leukoc Biol 63(6):650\u2013657","journal-title":"J Leukoc Biol"},{"issue":"2","key":"607_CR47","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1093\/infdis\/jir258","volume":"204","author":"AK Panda","year":"2011","unstructured":"Panda AK, Sahoo PK, Kerketta AS, Kar SK, Ravindran B, Satapathy AK (2011) Human lymphatic filariasis: genetic polymorphism of endothelin-1 and tumor necrosis factor receptor II correlates with development of chronic disease. J Infect Dis 204(2):315\u2013322. https:\/\/doi.org\/10.1093\/infdis\/jir258","journal-title":"J Infect Dis"},{"key":"607_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/9780470513446.ch3","volume":"127","author":"F Partono","year":"1987","unstructured":"Partono F (1987) The spectrum of disease in lymphatic filariasis. Ciba Found Symp 127:15\u201331. https:\/\/doi.org\/10.1002\/9780470513446.ch3","journal-title":"Ciba Found Symp"},{"issue":"11","key":"607_CR49","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/j.1365-3024.2009.01133.x","volume":"31","author":"KM Pfarr","year":"2009","unstructured":"Pfarr KM, Debrah AY, Specht S, Hoerauf A (2009) Filariasis and lymphoedema. Parasite Immunol 31(11):664\u2013672. https:\/\/doi.org\/10.1111\/j.1365-3024.2009.01133.x","journal-title":"Parasite Immunol"},{"issue":"1","key":"607_CR103","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12974-020-01809-1","volume":"17","author":"I Plastira","year":"2020","unstructured":"Plastira I, Bernhart E, Joshi L, Koyani CN, Strohmaier H, Reicher H, Malle E, Sattler W (2020) MAPK signaling determineslysophosphatidic acid (LPA)-induced inflammation in microglia. J neuroinflamm 17(1):127. https:\/\/doi.org\/10.1186\/s12974-020-01809-1","journal-title":"J neuroinflamm"},{"issue":"12","key":"607_CR50","doi-asserted-by":"publisher","first-page":"6257","DOI":"10.4049\/jimmunol.170.12.6257","volume":"170","author":"ME Poynter","year":"2003","unstructured":"Poynter ME, Irvin CG, Janssen-Heininger YMW (2003) A prominent role for airway epithelial NF-\u03baB activation in lipopolysaccharide-induced airway Inflammation. J Immunol 170(12):6257\u20136265. https:\/\/doi.org\/10.4049\/jimmunol.170.12.6257","journal-title":"J Immunol"},{"key":"607_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123890","author":"KC Pramanik","year":"2018","unstructured":"Pramanik KC, Makena MR, Bhowmick K, Pandey MK (2018) Advancement of NF-\u03baB signalling pathway: a novel target in pancreatic cancer. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms19123890","journal-title":"Int J Mol Sci"},{"issue":"4","key":"607_CR52","first-page":"164","volume":"50","author":"S Rajasekaram","year":"2017","unstructured":"Rajasekaram S, Anuradha R, Manokaran G, Bethunaickan R (2017) An overview of lymphatic filariasis lymphedema. Lymphology 50(4):164\u2013182","journal-title":"Lymphology"},{"issue":"7","key":"607_CR53","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1084\/jem.187.7.1069","volume":"187","author":"K Ruckdeschel","year":"1998","unstructured":"Ruckdeschel K, Harb S, Roggenkamp A, Hornef M, Zumbihl R, K\u00f6hler S, Heesemann J, Rouot B (1998) Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production. J Exp Med 187(7):1069\u20131079. https:\/\/doi.org\/10.1084\/jem.187.7.1069","journal-title":"J Exp Med"},{"issue":"5561","key":"607_CR54","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1126\/science.1068732","volume":"295","author":"A Saint Andr\u00e9","year":"2002","unstructured":"Saint Andr\u00e9 A, Blackwell NM, Hall LR, Hoerauf A, Brattig NW, Volkmann L, Taylor MJ, Ford L, Hise AG, Lass JH, Diaconu E, Pearlman E (2002) The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Science 295(5561):1892\u20131895. https:\/\/doi.org\/10.1126\/science.1068732","journal-title":"Science"},{"key":"607_CR55","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.0105-2896.2004.00196.x","volume":"201","author":"RT Semnani","year":"2004","unstructured":"Semnani RT, Nutman TB (2004) Toward an understanding of the interaction between filarial parasites and host antigen-presenting cells. Immunol Rev 201:127\u2013138. https:\/\/doi.org\/10.1111\/j.0105-2896.2004.00196.x","journal-title":"Immunol Rev"},{"key":"607_CR56","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/3-211-30714-1_29","volume":"96","author":"Y Shigemori","year":"2006","unstructured":"Shigemori Y, Katayama Y, Mori T, Maeda T, Kawamata T (2006) Matrix metalloproteinase-9 is associated with blood-brain barrier opening and brain edema formation after cortical contusion in rats. Acta Neurochirurgica Suppl 96:130\u2013133. https:\/\/doi.org\/10.1007\/3-211-30714-1_29","journal-title":"Acta Neurochirurgica Suppl"},{"issue":"6","key":"607_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0000696","volume":"4","author":"PE Simonsen","year":"2010","unstructured":"Simonsen PE, Pedersen EM, Rwegoshora RT, Malecela MN, Derua YA, Magesa SM (2010) Lymphatic filariasis control in Tanzania: effect of repeated mass drug administration with ivermectin and albendazole on infection and transmission. PLOS Neglect Trop Dis 4(6):1\u201310. https:\/\/doi.org\/10.1371\/journal.pntd.0000696","journal-title":"PLOS Neglect Trop Dis"},{"issue":"1","key":"607_CR58","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s10456-008-9094-4","volume":"11","author":"SP Tabruyn","year":"2008","unstructured":"Tabruyn SP, Griffioen AW (2008) NF-kappa B: a new player in angiostatic therapy. Angiogenesis 11(1):101\u2013106. https:\/\/doi.org\/10.1007\/s10456-008-9094-4","journal-title":"Angiogenesis"},{"issue":"7","key":"607_CR102","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","volume":"4","author":"K Takeda","year":"2004","unstructured":"Takeda K, Akira S (2004) Toll-like receptor signalling. Nat Rev Immunol 4(7):499\u2013511. https:\/\/doi.org\/10.1038\/nri1391","journal-title":"Nat Rev Immunol"},{"issue":"9747","key":"607_CR59","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/S0140-6736(10)60586-7","volume":"376","author":"MJ Taylor","year":"2010","unstructured":"Taylor MJ, Hoerauf A, Bockarie M (2010) Lymphatic filariasis and onchocerciasis. Lancet 376(9747):1175\u20131185. https:\/\/doi.org\/10.1016\/S0140-6736(10)60586-7","journal-title":"Lancet"},{"issue":"5","key":"607_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0001655","volume":"6","author":"LJ Wammes","year":"2012","unstructured":"Wammes LJ, Hamid F, Wiria AE, Wibowo H, Sartono E, Maizels RM, Smits HH, Supali T, Yazdanbakhsh M (2012) Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics. PLOS Neglect Trop Dis 6(5):1\u20139. https:\/\/doi.org\/10.1371\/journal.pntd.0001655","journal-title":"PLOS Neglect Trop Dis"},{"issue":"8","key":"607_CR61","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1046\/j.1365-3156.2001.00765.x","volume":"6","author":"C Witt","year":"2001","unstructured":"Witt C, Ottesen EA (2001) Lymphatic filariasis: an infection of childhood. Trop Med Int Health 6(8):582\u2013606. https:\/\/doi.org\/10.1046\/j.1365-3156.2001.00765.x","journal-title":"Trop Med Int Health"},{"key":"607_CR68","unstructured":"World Health Organization (2000) Operational guidelines for rapid mapping of Bancroftian filariasis in Africa (p. Revised during an inter-country workshop held in Ouagadougou, 8\u201312 March 2000). World Health Organization"},{"key":"607_CR62","unstructured":"World Health Organization (2013) Lymphatic filariasis (Elephantiasis)---Global. https:\/\/www.who.int\/health-topics\/lymphatic-filariasis#tab=tab_1"},{"issue":"4","key":"607_CR63","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/sj.jcbfm.9600375","volume":"27","author":"Y Yang","year":"2007","unstructured":"Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg GA (2007) Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cerebral Blood Flow Metab Off J Int Soc Cerebral Blood Flow Metab 27(4):697\u2013709. https:\/\/doi.org\/10.1038\/sj.jcbfm.9600375","journal-title":"J Cerebral Blood Flow Metab Off J Int Soc Cerebral Blood Flow Metab"},{"issue":"1\u20132","key":"607_CR200","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11010-016-2804-0","volume":"422","author":"B Yang","year":"2016","unstructured":"Yang B, Zhou Z, Li X,  Niu J (2016) The effect of lysophosphatidic acid on toll-like receptor 4 expression and the nuclear factor-\u039aB signaling pathway in THP-1 cells. Mol Cell Biochem 422(1\u20132):41\u201349","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"607_CR64","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.blre.2016.10.001","volume":"31","author":"L Yu","year":"2017","unstructured":"Yu L, Li L, Medeiros LJ, Young KH (2017) NF-\u03baB signalling pathway and its potential as a target for therapy in lymphoid neoplasms. Blood Rev 31(2):77\u201392. https:\/\/doi.org\/10.1016\/j.blre.2016.10.001","journal-title":"Blood Rev"},{"issue":"5","key":"607_CR65","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1046\/j.1365-2958.2000.01785.x","volume":"35","author":"MH Yuk","year":"2000","unstructured":"Yuk MH, Harvill ET, Cotter PA, Miller JF (2000) Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella type III secretion system. Mol Microbiol 35(5):991\u20131004. https:\/\/doi.org\/10.1046\/j.1365-2958.2000.01785.x","journal-title":"Mol Microbiol"},{"issue":"1","key":"607_CR66","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1172\/JCI11837","volume":"107","author":"G Zhang","year":"2001","unstructured":"Zhang G, Ghosh S (2001) Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Investig 107(1):13\u201319. https:\/\/doi.org\/10.1172\/JCI11837","journal-title":"J Clin Investig"}],"container-title":["Journal of Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-021-00607-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12079-021-00607-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-021-00607-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:04:39Z","timestamp":1702667079000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12079-021-00607-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,25]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["607"],"URL":"https:\/\/doi.org\/10.1007\/s12079-021-00607-5","relation":{},"ISSN":["1873-9601","1873-961X"],"issn-type":[{"value":"1873-9601","type":"print"},{"value":"1873-961X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,25]]},"assertion":[{"value":"28 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare they have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}