{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:03:29Z","timestamp":1792263809436,"version":"4.4.0"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cell Commun. Signal."],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s12079-022-00714-x","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T13:25:32Z","timestamp":1669901132000},"page":"1081-1088","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A network map of discoidin domain receptor 1(DDR1)-mediated signaling in pathological conditions"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-2839","authenticated-orcid":false,"given":"Shobha","family":"Dagamajalu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-3150","authenticated-orcid":false,"given":"D. A. B.","family":"Rex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-2590","authenticated-orcid":false,"given":"G. P.","family":"Suchitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-1120","authenticated-orcid":false,"given":"Akhila B.","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-5273","authenticated-orcid":false,"given":"Shreya","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9209-0397","authenticated-orcid":false,"given":"Shreya","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-121X","authenticated-orcid":false,"given":"Rajesh","family":"Raju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6206-2384","authenticated-orcid":false,"given":"T. S. Keshava","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"issue":"11","key":"714_CR1","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1158\/1535-7163.MCT-16-0834","volume":"16","author":"KY Aguilera","year":"2017","unstructured":"Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA (2017) Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma. Mol Cancer Ther 16(11):2473\u20132485","journal-title":"Mol Cancer Ther"},{"key":"714_CR2","unstructured":"Alves F, Vogel W, Mossie K, Millauer B, Ullrich A (1995) Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene 10(3): 609\u2013618"},{"issue":"3","key":"714_CR3","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/nm.4041","volume":"22","author":"C Ambrogio","year":"2016","unstructured":"Ambrogio C, Gomez-Lopez G, Falcone M, Vidal A, Nadal E, Crosetto N, Blasco RB, Fernandez-Marcos PJ, Sanchez-Cespedes M, Ren X, Wang Z, Ding K, Hidalgo M, Serrano M, Villanueva A, Santamaria D, Barbacid M (2016) Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma. Nat Med 22(3):270\u2013277","journal-title":"Nat Med"},{"issue":"3","key":"714_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116006","volume":"10","author":"D Assent","year":"2015","unstructured":"Assent D, Bourgot I, Hennuy B, Geurts P, Noel A, Foidart JM, Maquoi E (2015) A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells. PLoS ONE 10(3):e0116006","journal-title":"PLoS ONE"},{"issue":"11","key":"714_CR5","doi-asserted-by":"publisher","first-page":"19539","DOI":"10.1002\/jcp.28552","volume":"234","author":"R Azizi","year":"2019","unstructured":"Azizi R, Salemi Z, Fallahian F, Aghaei M (2019) Inhibition of didscoidin domain receptor 1 reduces epithelial-mesenchymal transition and induce cell-cycle arrest and apoptosis in prostate cancer cell lines. J Cell Physiol 234(11):19539\u201319552","journal-title":"J Cell Physiol"},{"key":"714_CR6","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.matbio.2013.12.002","volume":"34","author":"CM Borza","year":"2014","unstructured":"Borza CM, Pozzi A (2014) Discoidin domain receptors in disease. Matrix Biol 34:185\u2013192","journal-title":"Matrix Biol"},{"key":"714_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbplus.2020.100022","volume":"6\u20137","author":"S Buraschi","year":"2020","unstructured":"Buraschi S, Morcavallo A, Neill T, Stefanello M, Palladino C, Xu SQ, Belfiore A, Iozzo RV, Morrione A (2020) Discoidin domain receptor 1 functionally interacts with the IGF-I system in bladder cancer. Matrix Biol plus 6\u20137:100022","journal-title":"Matrix Biol plus"},{"issue":"11","key":"714_CR8","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.ejcb.2010.07.004","volume":"89","author":"L Castro-Sanchez","year":"2010","unstructured":"Castro-Sanchez L, Soto-Guzman A, Navarro-Tito N, Martinez-Orozco R, Salazar EP (2010) Native type IV collagen induces cell migration through a CD9 and DDR1-dependent pathway in MDA-MB-231 breast cancer cells. Eur J Cell Biol 89(11):843\u2013852","journal-title":"Eur J Cell Biol"},{"issue":"5","key":"714_CR9","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1039\/C5MB00911A","volume":"12","author":"C Chen","year":"2016","unstructured":"Chen C, Deng J, Yu X, Wu F, Men K, Yang Q, Zhu Y, Liu X, Jiang Q (2016) Identification of novel inhibitors of DDR1 against idiopathic pulmonary fibrosis by integrative transcriptome meta-analysis, computational and experimental screening. Mol Biosyst 12(5):1540\u20131551","journal-title":"Mol Biosyst"},{"issue":"9","key":"714_CR10","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1681\/ASN.2018111160","volume":"30","author":"M Chiusa","year":"2019","unstructured":"Chiusa M, Hu W, Liao HJ, Su Y, Borza CM, de Caestecker MP, Skrypnyk NI, Fogo AB, Pedchenko V, Li X, Zhang MZ, Hudson BG, Basak T, Vanacore RM, Zent R, Pozzi A (2019) The extracellular matrix receptor discoidin domain receptor 1 regulates collagen transcription by translocating to the nucleus. J Am Soc Nephrol 30(9):1605\u20131624","journal-title":"J Am Soc Nephrol"},{"issue":"16","key":"714_CR11","doi-asserted-by":"publisher","first-page":"8123","DOI":"10.1158\/0008-5472.CAN-06-1215","volume":"66","author":"S Das","year":"2006","unstructured":"Das S, Ongusaha PP, Yang YS, Park JM, Aaronson SA, Lee SW (2006) Discoidin domain receptor 1 receptor tyrosine kinase induces cyclooxygenase-2 and promotes chemoresistance through nuclear factor-kappaB pathway activation. Cancer Res 66(16):8123\u20138130","journal-title":"Cancer Res"},{"issue":"4","key":"714_CR12","first-page":"299","volume":"12","author":"A Dorison","year":"2018","unstructured":"Dorison A, Chantziantoniou C (2018) DDR1: a major player in renal diseases. Cell Adh Migr 12(4):299\u2013304","journal-title":"Cell Adh Migr"},{"issue":"3","key":"714_CR13","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1159\/000479119","volume":"137","author":"A Dorison","year":"2017","unstructured":"Dorison A, Dussaule JC, Chatziantoniou C (2017) The role of discoidin domain receptor 1 in inflammation, fibrosis and renal disease. Nephron 137(3):212\u2013220","journal-title":"Nephron"},{"issue":"12","key":"714_CR14","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1681\/ASN.2006060677","volume":"17","author":"M Flamant","year":"2006","unstructured":"Flamant M, Placier S, Rodenas A, Curat CA, Vogel WF, Chatziantoniou C, Dussaule JC (2006) Discoidin domain receptor 1 null mice are protected against hypertension-induced renal disease. J Am Soc Nephrol 17(12):3374\u20133381","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"714_CR15","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1161\/CIRCRESAHA.109.207357","volume":"105","author":"C Franco","year":"2009","unstructured":"Franco C, Britto K, Wong E, Hou G, Zhu SN, Chen M, Cybulsky MI, Bendeck MP (2009) Discoidin domain receptor 1 on bone marrow-derived cells promotes macrophage accumulation during atherogenesis. Circ Res 105(11):1141\u20131148","journal-title":"Circ Res"},{"issue":"1","key":"714_CR16","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1523-1755.2004.00712.x","volume":"66","author":"O Gross","year":"2004","unstructured":"Gross O, Beirowski B, Harvey SJ, McFadden C, Chen D, Tam S, Thorner PS, Smyth N, Addicks K, Bloch W, Ninomiya Y, Sado Y, Weber M, Vogel WF (2004) DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria. Kidney Int 66(1):102\u2013111","journal-title":"Kidney Int"},{"issue":"1","key":"714_CR17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ajpath.2011.03.023","volume":"179","author":"D Guerrot","year":"2011","unstructured":"Guerrot D, Kerroch M, Placier S, Vandermeersch S, Trivin C, Mael-Ainin M, Chatziantoniou C, Dussaule JC (2011) Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy. Am J Pathol 179(1):83\u201391","journal-title":"Am J Pathol"},{"issue":"20","key":"714_CR18","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1016\/j.yexcr.2006.09.003","volume":"312","author":"C Hansen","year":"2006","unstructured":"Hansen C, Greengard P, Nairn AC, Andersson T, Vogel WF (2006) Phosphorylation of DARPP-32 regulates breast cancer cell migration downstream of the receptor tyrosine kinase DDR1. Exp Cell Res 312(20):4011\u20134018","journal-title":"Exp Cell Res"},{"issue":"13","key":"714_CR19","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.1158\/1078-0432.CCR-04-0073","volume":"10","author":"VA Heinzelmann-Schwarz","year":"2004","unstructured":"Heinzelmann-Schwarz VA, Gardiner-Garden M, Henshall SM, Scurry J, Scolyer RA, Davies MJ, Heinzelmann M, Kalish LH, Bali A, Kench JG, Edwards LS, Vanden Bergh PM, Hacker NF, Sutherland RL, O\u2019Brien PM (2004) Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. Clin Cancer Res 10(13):4427\u20134436","journal-title":"Clin Cancer Res"},{"issue":"1","key":"714_CR20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/ncb2133","volume":"13","author":"C Hidalgo-Carcedo","year":"2011","unstructured":"Hidalgo-Carcedo C, Hooper S, Chaudhry SI, Williamson P, Harrington K, Leitinger B, Sahai E (2011) Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol 13(1):49\u201358","journal-title":"Nat Cell Biol"},{"issue":"6","key":"714_CR21","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1172\/JCI10720","volume":"107","author":"G Hou","year":"2001","unstructured":"Hou G, Vogel W, Bendeck MP (2001) The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest 107(6):727\u2013735","journal-title":"J Clin Invest"},{"issue":"44","key":"714_CR22","doi-asserted-by":"publisher","first-page":"23208","DOI":"10.1074\/jbc.M116.740605","volume":"291","author":"H Huang","year":"2016","unstructured":"Huang H, Svoboda RA, Lazenby AJ, Saowapa J, Chaika N, Ding K, Wheelock MJ, Johnson KR (2016) Up-regulation of N-cadherin by collagen i-activated discoidin domain receptor 1 in pancreatic cancer requires the adaptor molecule Shc1. J Biol Chem 291(44):23208\u201323223","journal-title":"J Biol Chem"},{"issue":"1","key":"714_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12885-017-3051-9","volume":"17","author":"H Hur","year":"2017","unstructured":"Hur H, Ham IH, Lee D, Jin H, Aguilera KY, Oh HJ, Han SU, Kwon JE, Kim YB, Ding K, Brekken RA (2017) Discoidin domain receptor 1 activity drives an aggressive phenotype in gastric carcinoma. BMC Cancer 17(1):87","journal-title":"BMC Cancer"},{"issue":"4","key":"714_CR24","doi-asserted-by":"publisher","first-page":"e7918","DOI":"10.15252\/emmm.201707918","volume":"10","author":"M Jeitany","year":"2018","unstructured":"Jeitany M, Leroy C, Tosti P, Lafitte M, Le Guet J, Simon V, Bonenfant D, Robert B, Grillet F, Mollevi C, El Messaoudi S, Otandault A, Canterel-Thouennon L, Busson M, Thierry AR, Martineau P, Pannequin J, Roche S, Sirvent A (2018) Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer. EMBO Mol Med 10(4):e7918","journal-title":"EMBO Mol Med"},{"issue":"10","key":"714_CR25","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1158\/1541-7786.MCR-17-0710","volume":"16","author":"H Jin","year":"2018","unstructured":"Jin H, Ham IH, Oh HJ, Bae CA, Lee D, Kim YB, Son SY, Chwae YJ, Han SU, Brekken RA, Hur H (2018) Inhibition of discoidin domain receptor 1 prevents stroma-induced peritoneal metastasis in gastric carcinoma. Mol Cancer Res 16(10):1590\u20131600","journal-title":"Mol Cancer Res"},{"issue":"12","key":"714_CR26","doi-asserted-by":"publisher","first-page":"5677","DOI":"10.1073\/pnas.90.12.5677","volume":"90","author":"JD Johnson","year":"1993","unstructured":"Johnson JD, Edman JC, Rutter WJ (1993) A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. Proc Natl Acad Sci U S A 90(12):5677\u20135681","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"714_CR27","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1093\/bioinformatics\/btp453","volume":"25","author":"K Kandasamy","year":"2009","unstructured":"Kandasamy K, Keerthikumar S, Raju R, Keshava Prasad TS, Ramachandra YL, Mohan S, Pandey A (2009) PathBuilder\u2013open source software for annotating and developing pathway resources. Bioinformatics 25(21):2860\u20132862","journal-title":"Bioinformatics"},{"issue":"1","key":"714_CR28","doi-asserted-by":"publisher","first-page":"R3","DOI":"10.1186\/gb-2010-11-1-r3","volume":"11","author":"K Kandasamy","year":"2010","unstructured":"Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A (2010) NetPath: a public resource of curated signal transduction pathways. Genome Biol 11(1):R3","journal-title":"Genome Biol"},{"issue":"3","key":"714_CR29","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.freeradbiomed.2006.10.052","volume":"42","author":"SH Kim","year":"2007","unstructured":"Kim SH, Lee S, Suk K, Bark H, Jun CD, Kim DK, Choi CH, Yoshimura T (2007) Discoidin domain receptor 1 mediates collagen-induced nitric oxide production in J774A.1 murine macrophages. Free Radic Biol Med 42(3):343\u2013352","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"714_CR30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.febslet.2005.11.035","volume":"580","author":"DH Koo","year":"2006","unstructured":"Koo DH, McFadden C, Huang Y, Abdulhussein R, Friese-Hamim M, Vogel WF (2006) Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1. FEBS Lett 580(1):15\u201322","journal-title":"FEBS Lett"},{"issue":"2","key":"714_CR31","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.drudis.2014.09.025","volume":"20","author":"S Kothiwale","year":"2015","unstructured":"Kothiwale S, Borza CM, Lowe EW Jr, Pozzi A, Meiler J (2015) Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery. Drug Discov Today 20(2):255\u2013261","journal-title":"Drug Discov Today"},{"issue":"2","key":"714_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004085","volume":"11","author":"M Kutmon","year":"2015","unstructured":"Kutmon M, van Iersel MP, Bohler A, Kelder T, Nunes N, Pico AR, Evelo CT (2015) PathVisio 3: an extendable pathway analysis toolbox. PLoS Comput Biol 11(2):e1004085","journal-title":"PLoS Comput Biol"},{"issue":"18","key":"714_CR33","doi-asserted-by":"publisher","first-page":"16084","DOI":"10.18632\/oncotarget.3177","volume":"6","author":"R Malaguarnera","year":"2015","unstructured":"Malaguarnera R, Nicolosi ML, Sacco A, Morcavallo A, Vella V, Voci C, Spatuzza M, Xu SQ, Iozzo RV, Vigneri R, Morrione A, Belfiore A (2015) Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. Oncotarget 6(18):16084\u201316105","journal-title":"Oncotarget"},{"issue":"7","key":"714_CR34","doi-asserted-by":"publisher","first-page":"7683","DOI":"10.18632\/oncotarget.6524","volume":"7","author":"R Mata","year":"2016","unstructured":"Mata R, Palladino C, Nicolosi ML, Lo Presti AR, Malaguarnera R, Ragusa M, Sciortino D, Morrione A, Maggiolini M, Vella V, Belfiore A (2016) IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K\/AKT pathway. Oncotarget 7(7):7683\u20137700","journal-title":"Oncotarget"},{"issue":"3","key":"714_CR35","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00044-020-02694-2","volume":"30","author":"GSP Matada","year":"2021","unstructured":"Matada GSP, Das A, Dhiwar PS, Ghara A (2021) DDR1 and DDR2: a review on signaling pathway and small molecule inhibitors as an anticancer agent. J Med Chem Res 30(3):535\u2013551","journal-title":"J Med Chem Res"},{"issue":"4","key":"714_CR36","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.4049\/jimmunol.172.4.2332","volume":"172","author":"W Matsuyama","year":"2004","unstructured":"Matsuyama W, Wang L, Farrar WL, Faure M, Yoshimura T (2004) Activation of discoidin domain receptor 1 isoform b with collagen up-regulates chemokine production in human macrophages: role of p38 mitogen-activated protein kinase and NF-kappa B. J Immunol 172(4):2332\u20132340","journal-title":"J Immunol"},{"issue":"3","key":"714_CR37","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s12032-013-0626-4","volume":"30","author":"L Miao","year":"2013","unstructured":"Miao L, Zhu S, Wang Y, Li Y, Ding J, Dai J, Cai H, Zhang D, Song Y (2013) Discoidin domain receptor 1 is associated with poor prognosis of non-small cell lung cancer and promotes cell invasion via epithelial-to-mesenchymal transition. Med Oncol 30(3):626","journal-title":"Med Oncol"},{"key":"714_CR38","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/978-94-007-4719-7_8","volume":"986","author":"M Nakada","year":"2013","unstructured":"Nakada M, Kita D, Teng L, Pyko IV, Watanabe T, Hayashi Y, Hamada J (2013) Receptor tyrosine kinases: principles and functions in glioma invasion. Adv Exp Med Biol 986:143\u2013170","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"714_CR39","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000164123","volume":"65","author":"T Nemoto","year":"1997","unstructured":"Nemoto T, Ohashi K, Akashi T, Johnson JD, Hirokawa K (1997) Overexpression of protein tyrosine kinases in human esophageal cancer. Pathobiology 65(4):195\u2013203","journal-title":"Pathobiology"},{"issue":"6","key":"714_CR40","first-page":"1435","volume":"18","author":"HS Park","year":"2007","unstructured":"Park HS, Kim KR, Lee HJ, Choi HN, Kim DK, Kim BT, Moon WS (2007) Overexpression of discoidin domain receptor 1 increases the migration and invasion of hepatocellular carcinoma cells in association with matrix metalloproteinase. Oncol Rep 18(6):1435\u20131441","journal-title":"Oncol Rep"},{"issue":"2","key":"714_CR41","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3390\/ijms12020971","volume":"12","author":"J Quan","year":"2011","unstructured":"Quan J, Yahata T, Adachi S, Yoshihara K, Tanaka K (2011) Identification of receptor tyrosine kinase, discoidin domain receptor 1 (DDR1), as a potential biomarker for serous ovarian cancer. Int J Mol Sci 12(2):971\u2013982","journal-title":"Int J Mol Sci"},{"issue":"1","key":"714_CR42","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1080\/19336918.2020.1733892","volume":"14","author":"I Romayor","year":"2020","unstructured":"Romayor I, Badiola I, Olaso E (2020) Inhibition of DDR1 reduces invasive features of human A375 melanoma, HT29 colon carcinoma and SK-HEP hepatoma cells. Cell Adh Migr 14(1):69\u201381","journal-title":"Cell Adh Migr"},{"issue":"5","key":"714_CR43","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/jnr.21552","volume":"86","author":"MC Seo","year":"2008","unstructured":"Seo MC, Kim S, Kim SH, Zheng LT, Park EK, Lee WH, Suk K (2008) Discoidin domain receptor 1 mediates collagen-induced inflammatory activation of microglia in culture. J Neurosci Res 86(5):1087\u20131095","journal-title":"J Neurosci Res"},{"key":"714_CR44","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/1476-4598-9-227","volume":"9","author":"Q Shen","year":"2010","unstructured":"Shen Q, Cicinnati VR, Zhang X, Iacob S, Weber F, Sotiropoulos GC, Radtke A, Lu M, Paul A, Gerken G, Beckebaum S (2010) Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion. Mol Cancer 9:227","journal-title":"Mol Cancer"},{"issue":"1","key":"714_CR45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1349-7006.2007.00655.x","volume":"99","author":"K Shimada","year":"2008","unstructured":"Shimada K, Nakamura M, Ishida E, Higuchi T, Yamamoto H, Tsujikawa K, Konishi N (2008) Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer. Cancer Sci 99(1):39\u201345","journal-title":"Cancer Sci"},{"issue":"6","key":"714_CR46","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1083\/jcb.200708137","volume":"180","author":"Y Shintani","year":"2008","unstructured":"Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR (2008) Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol 180(6):1277\u20131289","journal-title":"J Cell Biol"},{"issue":"1","key":"714_CR47","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S1097-2765(00)80004-0","volume":"1","author":"A Shrivastava","year":"1997","unstructured":"Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, Davis S, Goldfarb MP, Glass DJ, Lemke G, Yancopoulos GD (1997) An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell 1(1):25\u201334","journal-title":"Mol Cell"},{"issue":"8","key":"714_CR48","doi-asserted-by":"publisher","first-page":"11509","DOI":"10.1007\/s13277-016-5021-2","volume":"37","author":"J Song","year":"2016","unstructured":"Song J, Chen X, Bai J, Liu Q, Li H, Xie J, Jing H, Zheng J (2016) Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumour Biol 37(8):11509\u201311521","journal-title":"Tumour Biol"},{"issue":"9","key":"714_CR49","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1002\/1878-0261.12520","volume":"13","author":"Y Tao","year":"2019","unstructured":"Tao Y, Wang R, Lai Q, Wu M, Wang Y, Jiang X, Zeng L, Zhou S, Li Z, Yang T, Yao Y, Wu Y, Yu L, Fu Y, Lai W, Peng Y, Lu Y, Zhang Z, Guo C, Zhang G, Gou L, Yang J (2019) Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma. Mol Oncol 13(9):1855\u20131873","journal-title":"Mol Oncol"},{"issue":"1","key":"714_CR50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s10549-015-3285-7","volume":"150","author":"KA Toy","year":"2015","unstructured":"Toy KA, Valiathan RR, Nunez F, Kidwell KM, Gonzalez ME, Fridman R, Kleer CG (2015) Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer. Breast Cancer Res Treat 150(1):9\u201318","journal-title":"Breast Cancer Res Treat"},{"issue":"1\u20132","key":"714_CR51","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s10555-012-9346-z","volume":"31","author":"RR Valiathan","year":"2012","unstructured":"Valiathan RR, Marco M, Leitinger B, Kleer CG, Fridman R (2012) Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev 31(1\u20132):295\u2013321","journal-title":"Cancer Metastasis Rev"},{"issue":"13","key":"714_CR52","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1016\/j.celrep.2019.02.096","volume":"26","author":"A Vehlow","year":"2019","unstructured":"Vehlow A, Klapproth E, Jin S, Hannen R, Hauswald M, Bartsch JW, Nimsky C, Temme A, Leitinger B, Cordes N (2019) Interaction of discoidin domain receptor 1 with a 14\u20133\u20133-Beclin-1-Akt1 complex modulates glioblastoma therapy sensitivity. Cell Rep 26(13):3672\u20133683","journal-title":"Cell Rep"},{"issue":"26","key":"714_CR53","doi-asserted-by":"publisher","first-page":"43248","DOI":"10.18632\/oncotarget.18020","volume":"8","author":"V Vella","year":"2017","unstructured":"Vella V, Malaguarnera R, Nicolosi ML, Palladino C, Spoleti C, Massimino M, Vigneri P, Purrello M, Ragusa M, Morrione A, Belfiore A (2017) Discoidin domain receptor 1 modulates insulin receptor signaling and biological responses in breast cancer cells. Oncotarget 8(26):43248\u201343270","journal-title":"Oncotarget"},{"issue":"1","key":"714_CR54","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1530\/ERC-18-0310","volume":"26","author":"V Vella","year":"2019","unstructured":"Vella V, Nicolosi ML, Cantafio P, Massimino M, Lappano R, Vigneri P, Ciuni R, Gangemi P, Morrione A, Malaguarnera R, Belfiore A (2019) DDR1 regulates thyroid cancer cell differentiation via IGF-2\/IR-A autocrine signaling loop. Endocr Relat Cancer 26(1):197\u2013214","journal-title":"Endocr Relat Cancer"},{"issue":"1","key":"714_CR55","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S1097-2765(00)80003-9","volume":"1","author":"W Vogel","year":"1997","unstructured":"Vogel W, Gish GD, Alves F, Pawson T (1997) The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1(1):13\u201323","journal-title":"Mol Cell"},{"issue":"8","key":"714_CR56","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.cellsig.2006.02.012","volume":"18","author":"WF Vogel","year":"2006","unstructured":"Vogel WF, Abdulhussein R, Ford CE (2006) Sensing extracellular matrix: an update on discoidin domain receptor function. Cell Signal 18(8):1108\u20131116","journal-title":"Cell Signal"},{"issue":"6","key":"714_CR57","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1097\/00006123-200012000-00028","volume":"47","author":"HL Weiner","year":"2000","unstructured":"Weiner HL, Huang H, Zagzag D, Boyce H, Lichtenbaum R, Ziff EB (2000) Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors. Neurosurgery 47(6):1400\u20131409","journal-title":"Neurosurgery"},{"issue":"5","key":"714_CR58","first-page":"596","volume":"91","author":"K Willenbrock","year":"2006","unstructured":"Willenbrock K, Kuppers R, Renne C, Brune V, Eckerle S, Weidmann E, Brauninger A, Hansmann ML (2006) Common features and differences in the transcriptome of large cell anaplastic lymphoma and classical Hodgkin\u2019s lymphoma. Haematologica 91(5):596\u2013604","journal-title":"Haematologica"},{"key":"714_CR59","doi-asserted-by":"publisher","first-page":"153303382097327","DOI":"10.1177\/1533033820973277","volume":"19","author":"X Xie","year":"2020","unstructured":"Xie X, He H, Zhang N, Wang X, Rui W, Xu D, Zhu Y (2020) Overexpression of DDR1 promotes migration, invasion, though EMT-related molecule expression and COL4A1\/DDR1\/MMP-2 signaling axis. Technol Cancer Res Treat 19:1533033820973277","journal-title":"Technol Cancer Res Treat"},{"issue":"44","key":"714_CR60","doi-asserted-by":"publisher","first-page":"5994","DOI":"10.1038\/sj.onc.1209585","volume":"25","author":"R Yamanaka","year":"2006","unstructured":"Yamanaka R, Arao T, Yajima N, Tsuchiya N, Homma J, Tanaka R, Sano M, Oide A, Sekijima M, Nishio K (2006) Identification of expressed genes characterizing long-term survival in malignant glioma patients. Oncogene 25(44):5994\u20136002","journal-title":"Oncogene"},{"issue":"2","key":"714_CR61","first-page":"311","volume":"24","author":"SH Yang","year":"2010","unstructured":"Yang SH, Baek HA, Lee HJ, Park HS, Jang KY, Kang MJ, Lee DG, Lee YC, Moon WS, Chung MJ (2010) Discoidin domain receptor 1 is associated with poor prognosis of non-small cell lung carcinomas. Oncol Rep 24(2):311\u2013319","journal-title":"Oncol Rep"},{"issue":"1","key":"714_CR62","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s12931-019-1071-5","volume":"20","author":"L Ye","year":"2019","unstructured":"Ye L, Pu C, Tang J, Wang Y, Wang C, Qiu Z, Xiang T, Zhang Y, Peng W (2019) Transmembrane-4 L-six family member-1 (TM4SF1) promotes non-small cell lung cancer proliferation, invasion and chemo-resistance through regulating the DDR1\/Akt\/ERK-mTOR axis. Respir Res 20(1):106","journal-title":"Respir Res"},{"issue":"1","key":"714_CR63","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11060-006-9246-6","volume":"82","author":"D Yoshida","year":"2007","unstructured":"Yoshida D, Teramoto A (2007a) Enhancement of pituitary adenoma cell invasion and adhesion is mediated by discoidin domain receptor-1. J Neurooncol 82(1):29\u201340","journal-title":"J Neurooncol"},{"issue":"2","key":"714_CR64","doi-asserted-by":"publisher","first-page":"92","DOI":"10.4161\/cam.1.2.4618","volume":"1","author":"D Yoshida","year":"2007","unstructured":"Yoshida D, Teramoto A (2007b) The use of 3-D culture in peptide hydrogel for analysis of discoidin domain receptor 1-collagen interaction. Cell Adh Migr 1(2):92\u201398","journal-title":"Cell Adh Migr"},{"issue":"5","key":"714_CR65","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1038\/s41416-020-01187-8","volume":"124","author":"Z Zhao","year":"2021","unstructured":"Zhao Z, Zhao S, Luo L, Xiang Q, Zhu Z, Wang J, Liu Y, Luo J (2021) miR-199b-5p-DDR1-ERK signalling axis suppresses prostate cancer metastasis via inhibiting epithelial-mesenchymal transition. Br J Cancer 124(5):982\u2013994","journal-title":"Br J Cancer"}],"container-title":["Journal of Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-022-00714-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12079-022-00714-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-022-00714-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T14:07:13Z","timestamp":1702649233000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12079-022-00714-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["714"],"URL":"https:\/\/doi.org\/10.1007\/s12079-022-00714-x","relation":{},"ISSN":["1873-9601","1873-961X"],"issn-type":[{"value":"1873-9601","type":"print"},{"value":"1873-961X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]},"assertion":[{"value":"11 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}