{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:35:44Z","timestamp":1792798544701,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant number 81301328"],"award-info":[{"award-number":["Grant number 81301328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific and Technological Research Project of Department of Science and Technology of Henan province","award":["Grant number 192102310063"],"award-info":[{"award-number":["Grant number 192102310063"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Cell Commun. Signal."],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s12079-023-00737-y","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T10:06:14Z","timestamp":1679479574000},"page":"897-914","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["METTL3\u2013METTL14 complex induces necroptosis and inflammation of vascular smooth muscle cells via promoting N6 methyladenosine mRNA methylation of receptor-interacting protein 3 in abdominal aortic aneurysms"],"prefix":"10.1002","volume":"17","author":[{"given":"Kun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiting","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"issue":"2","key":"737_CR1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/ejhg.2009.141","volume":"18","author":"AF Baas","year":"2010","unstructured":"Baas AF, Medic J (2010) Association of the TGF-beta receptor genes with abdominal aortic aneurysm. Eur J Human Genet EJHG 18(2):240\u2013244","journal-title":"Eur J Human Genet EJHG"},{"issue":"7","key":"737_CR2","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.3390\/cells11071221","volume":"11","author":"GL Beretta","year":"2022","unstructured":"Beretta GL, Zaffaroni N (2022) Necroptosis and prostate cancer: molecular mechanisms and therapeutic potential. Cells 11(7):1221","journal-title":"Cells"},{"issue":"7695","key":"737_CR3","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nature25784","volume":"555","author":"A Bertero","year":"2018","unstructured":"Bertero A, Brown S, Madrigal P, Osnato A, Ortmann D, Yiangou L, Kadiwala J, Hubner NC, de Los Mozos IR, Sad\u00e9e C, Lenaerts AS, Nakanoh S, Grandy R, Farnell E, Ule J, Stunnenberg HG, Mendjan S, Vallier L (2018) The SMAD2\/3 interactome reveals that TGF\u03b2 controls m(6)A mRNA methylation in pluripotency. Nature 555(7695):256\u2013259","journal-title":"Nature"},{"issue":"1","key":"737_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/ejhf.1672","volume":"22","author":"T Berulava","year":"2020","unstructured":"Berulava T, Buchholz E, Elerdashvili V, Pena T, Islam MR, Lbik D, Mohamed BA, Renner A, von Lewinski D, Sacherer M, Bohnsack KE, Bohnsack MT, Jain G, Capece V, Cleve N, Burkhardt S, Hasenfuss G, Fischer A, Toischer K (2020) Changes in m6A RNA methylation contribute to heart failure progression by modulating translation. Eur J Heart Fail 22(1):54\u201366","journal-title":"Eur J Heart Fail"},{"key":"737_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117034","volume":"239","author":"J Chen","year":"2019","unstructured":"Chen J, Ning Y, Zhang H, Song N, Gu Y, Shi Y, Cai J, Ding X, Zhang X (2019) METTL14-dependent m6A regulates vascular calcification induced by indoxyl sulfate. Life Sci 239:117034","journal-title":"Life Sci"},{"issue":"3","key":"737_CR6","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.bbagrm.2018.12.002","volume":"1862","author":"H Coker","year":"2019","unstructured":"Coker H, Wei G, Brockdorff N (2019) m6A modification of non-coding RNA and the control of mammalian gene expression. Biochim Biophys Acta 1862(3):310\u2013318","journal-title":"Biochim Biophys Acta"},{"key":"737_CR7","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1007\/s12264-022-00861-6","volume":"38","author":"X Dang","year":"2022","unstructured":"Dang X, Huan X, Du X, Chen X, Bi M, Yan C, Jiao Q, Jiang H (2022) Correlation of ferroptosis and other types of cell death in neurodegenerative diseases. Neurosci Bull 38:938","journal-title":"Neurosci Bull"},{"issue":"4","key":"737_CR8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.3390\/biom12040509","volume":"12","author":"E DeRoo","year":"2022","unstructured":"DeRoo E, Stranz A, Yang H, Hsieh M, Se C, Zhou T (2022) Endothelial dysfunction in the pathogenesis of abdominal aortic aneurysm. Biomolecules 12(4):509","journal-title":"Biomolecules"},{"issue":"24","key":"737_CR9","doi-asserted-by":"publisher","first-page":"797","DOI":"10.21037\/atm.2019.12.65","volume":"7","author":"Y He","year":"2019","unstructured":"He Y, Xing J, Wang S, Xin S, Han Y, Zhang J (2019) Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm. Ann Transl Med 7(24):797","journal-title":"Ann Transl Med"},{"issue":"20","key":"737_CR10","doi-asserted-by":"publisher","first-page":"8939","DOI":"10.7150\/thno.45178","volume":"10","author":"D Jian","year":"2020","unstructured":"Jian D, Wang Y, Jian L, Tang H, Rao L, Chen K, Jia Z, Zhang W, Liu Y, Chen X, Shen X, Gao C, Wang S, Li M (2020) METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications. Theranostics 10(20):8939\u20138956","journal-title":"Theranostics"},{"issue":"2","key":"737_CR11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000151766","volume":"46","author":"JA Jones","year":"2009","unstructured":"Jones JA, Spinale FG, Ikonomidis JS (2009) Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis. J Vasc Res 46(2):119\u2013137","journal-title":"J Vasc Res"},{"issue":"7338","key":"737_CR12","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nature09857","volume":"471","author":"WJ Kaiser","year":"2011","unstructured":"Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES (2011) RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471(7338):368\u2013372","journal-title":"Nature"},{"issue":"2","key":"737_CR13","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1093\/cvr\/cvr080","volume":"91","author":"H Kaneko","year":"2011","unstructured":"Kaneko H, Anzai T, Takahashi T, Kohno T, Shimoda M, Sasaki A, Shimizu H, Nagai T, Maekawa Y, Yoshimura K, Aoki H, Yoshikawa T, Okada Y, Yozu R, Ogawa S, Fukuda K (2011) Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm. Cardiovasc Res 91(2):358\u2013367","journal-title":"Cardiovasc Res"},{"issue":"2","key":"737_CR14","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.neuron.2018.06.007","volume":"99","author":"JL Koranda","year":"2018","unstructured":"Koranda JL, Dore L, Shi H, Patel MJ, Vaasjo LO, Rao MN, Chen K, Lu Z, Yi Y, Chi W, He C, Zhuang X (2018) Mettl14 Is essential for epitranscriptomic regulation of striatal function and learning. Neuron 99(2):283-292.e285","journal-title":"Neuron"},{"issue":"9","key":"737_CR15","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1080\/15384101.2020.1743915","volume":"19","author":"K Li","year":"2020","unstructured":"Li K, Cui M, Zhang K, Wang G, Zhai S (2020) LncRNA CRNDE affects the proliferation and apoptosis of vascular smooth muscle cells in abdominal aortic aneurysms by regulating the expression of Smad3 by Bcl-3. Cell Cycle 19(9):1036\u20131047","journal-title":"Cell Cycle"},{"issue":"2","key":"737_CR16","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio.1432","volume":"10","author":"J Liu","year":"2014","unstructured":"Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C (2014) A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol 10(2):93\u201395","journal-title":"Nat Chem Biol"},{"key":"737_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.847345","volume":"13","author":"J Liu","year":"2022","unstructured":"Liu J, Hong M, Li Y, Chen D, Wu Y, Hu Y (2022) Programmed cell death tunes tumor immunity. Front Immunol 13:847345","journal-title":"Front Immunol"},{"issue":"2","key":"737_CR18","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3390\/biom12020172","volume":"12","author":"K Mangum","year":"2022","unstructured":"Mangum K, Gallagher K, Davis FM (2022) The role of epigenetic modifications in abdominal aortic aneurysm pathogenesis. Biomolecules 12(2):172","journal-title":"Biomolecules"},{"issue":"1","key":"737_CR19","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1096\/fj.201800719R","volume":"33","author":"TG Meng","year":"2019","unstructured":"Meng TG, Lu X, Guo L, Hou GM, Ma XS, Li QN, Huang L, Fan LH, Zhao ZH, Ou XH, OuYang YC, Schatten H, Li L, Wang ZB, Sun QY (2019) Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB J\u202f: off Pub Federation Am Soc Exp Biol 33(1):1179\u20131187","journal-title":"FASEB J : off Pub Federation Am Soc Exp Biol"},{"issue":"8","key":"737_CR20","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1161\/ATVBAHA.114.303913","volume":"34","author":"S Michineau","year":"2014","unstructured":"Michineau S, Franck G, Wagner-Ballon O, Dai J, Allaire E, Gervais M (2014) Chemokine (C-X-C motif) receptor 4 blockade by AMD3100 inhibits experimental abdominal aortic aneurysm expansion through anti-inflammatory effects. Arterioscler Thromb Vasc Biol 34(8):1747\u20131755","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"737_CR21","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1161\/CIRCULATIONAHA.105.537340","volume":"112","author":"H Pannu","year":"2005","unstructured":"Pannu H, Fadulu VT, Chang J, Lafont A, Hasham SN, Sparks E, Giampietro PF, Zaleski C, Estrera AL, Safi HJ, Shete S, Willing MC, Raman CS, Milewicz DM (2005) Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections. Circulation 112(4):513\u2013520","journal-title":"Circulation"},{"issue":"9","key":"737_CR22","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.7150\/jca.38179","volume":"11","author":"F Qin","year":"2020","unstructured":"Qin F, Liu X, Chen J, Huang S, Wei W, Zou Y, Liu X, Deng K, Mo S, Chen J, Chen X, Huang Y, Liang W (2020) Anti-TGF-\u03b2 attenuates tumor growth via polarization of tumor associated neutrophils towards an anti-tumor phenotype in colorectal cancer. J Cancer 11(9):2580\u20132592","journal-title":"J Cancer"},{"issue":"31","key":"737_CR23","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.1038\/s41388-020-1338-9","volume":"39","author":"T Sun","year":"2020","unstructured":"Sun T, Wu Z, Wang X, Wang Y, Hu X, Qin W, Lu S, Xu D, Wu Y, Chen Q, Ding X, Guo H, Li Y, Wang Y, Fu B, Yao W, Wei M, Wu H (2020) LNC942 promoting METTL14-mediated m(6)A methylation in breast cancer cell proliferation and progression. Oncogene 39(31):5358\u20135372","journal-title":"Oncogene"},{"issue":"2","key":"737_CR24","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3390\/biom12020206","volume":"12","author":"W Sun","year":"2022","unstructured":"Sun W, Zheng J, Gao Y (2022) Targeting platelet activation in abdominal aortic aneurysm: current knowledge and perspectives. Biomolecules 12(2):206","journal-title":"Biomolecules"},{"key":"737_CR25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1196\/annals.1383.029","volume":"1085","author":"RW Thompson","year":"2006","unstructured":"Thompson RW, Curci JA, Ennis TL, Mao D, Pagano MB, Pham CT (2006) Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds. Ann N Y Acad Sci 1085:59\u201373","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"737_CR26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12943-021-01447-y","volume":"21","author":"W Wan","year":"2022","unstructured":"Wan W, Ao X, Chen Q, Yu Y, Ao L, Xing W, Guo W, Wu X, Pu C, Hu X, Li Z, Yao M, Luo D, Xu X (2022) METTL3\/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N(6)-methyladenosine modification of PD-L1 mRNA in breast cancer. Mol Cancer 21(1):60","journal-title":"Mol Cancer"},{"issue":"4","key":"737_CR27","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1161\/CIRCRESAHA.116.304899","volume":"116","author":"Q Wang","year":"2015","unstructured":"Wang Q, Liu Z, Ren J, Morgan S, Assa C, Liu B (2015) Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation. Circ Res 116(4):600\u2013611","journal-title":"Circ Res"},{"key":"737_CR28","doi-asserted-by":"publisher","first-page":"42159","DOI":"10.1038\/srep42159","volume":"7","author":"Q Wang","year":"2017","unstructured":"Wang Q, Zhou T, Liu Z, Ren J, Phan N, Gupta K, Stewart DM, Morgan S, Assa C, Kent KC, Liu B (2017) Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Sci Rep 7:42159","journal-title":"Sci Rep"},{"issue":"2","key":"737_CR29","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/bph.14515","volume":"176","author":"Y Wang","year":"2019","unstructured":"Wang Y, Chen C, Wang Q, Cao Y, Xu L, Qi R (2019) Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms. Br J Pharmacol 176(2):282\u2013296","journal-title":"Br J Pharmacol"},{"issue":"2","key":"737_CR30","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.bbrc.2019.02.051","volume":"511","author":"M Wortmann","year":"2019","unstructured":"Wortmann M, Skorubskaya E, Peters AS, Hakimi M, B\u00f6ckler D, Dihlmann S (2019) Necrotic cell debris induces a NF-\u03baB-driven inflammasome response in vascular smooth muscle cells derived from abdominal aortic aneurysms (AAA-SMC). Biochem Biophys Res Commun 511(2):343\u2013349","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"737_CR31","doi-asserted-by":"publisher","first-page":"4772","DOI":"10.1038\/s41467-018-06898-4","volume":"9","author":"Y Wu","year":"2018","unstructured":"Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R, Jiang Y, Ye L, Chen Q, Zhou X, Lin S, Yuan Q (2018) Mettl3-mediated m(6)A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. Nat Commun 9(1):4772","journal-title":"Nat Commun"},{"issue":"9","key":"737_CR32","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/s41422-018-0062-2","volume":"28","author":"QJ Yao","year":"2018","unstructured":"Yao QJ, Sang L, Lin M, Yin X, Dong W, Gong Y, Zhou BO (2018) Mettl3-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells. Cell Res 28(9):952\u2013954","journal-title":"Cell Res"},{"issue":"5","key":"737_CR33","first-page":"628","volume":"57","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Guo F, Zhao R (2016) Hepatic expression of FTO and fatty acid metabolic genes changes in response to lipopolysaccharide with alterations in m(6)A modification of relevant mRNAs in the chicken. Br Poult Sci 57(5):628\u2013635","journal-title":"Br Poult Sci"},{"issue":"4","key":"737_CR34","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ccell.2017.02.013","volume":"31","author":"S Zhang","year":"2017","unstructured":"Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, B\u00f6gler O, Majumder S, He C, Huang S (2017) m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. Cancer Cell 31(4):591-606.e596","journal-title":"Cancer Cell"},{"key":"737_CR35","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.omtn.2020.06.005","volume":"21","author":"L Zhong","year":"2020","unstructured":"Zhong L, He X, Song H, Sun Y, Chen G, Si X, Sun J, Chen X, Liao W, Liao Y, Bin J (2020) METTL3 Induces AAA development and progression by modulating N6-methyladenosine-dependent primary miR34a processing. Mol Ther Nucleic Acids 21:394\u2013411","journal-title":"Mol Ther Nucleic Acids"},{"issue":"3","key":"737_CR36","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/s41419-019-1468-6","volume":"10","author":"T Zhou","year":"2019","unstructured":"Zhou T, Wang Q, Phan N, Ren J, Yang H, Feldman CC, Feltenberger JB, Ye Z, Wildman SA, Tang W, Liu B (2019) Identification of a novel class of RIP1\/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models. Cell Death Dis 10(3):226","journal-title":"Cell Death Dis"}],"container-title":["Journal of Cell Communication and Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-023-00737-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12079-023-00737-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12079-023-00737-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T14:07:22Z","timestamp":1702649242000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12079-023-00737-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["737"],"URL":"https:\/\/doi.org\/10.1007\/s12079-023-00737-y","relation":{},"ISSN":["1873-9601","1873-961X"],"issn-type":[{"value":"1873-9601","type":"print"},{"value":"1873-961X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,22]]},"assertion":[{"value":"9 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Institute Research Medical Ethics Committee of Henan Provincial People\u2019s Hospital. All animal experiments complied with the ARRIVE guidelines and were carried out following the U.S. Public Health Service Policy on Humane Care and Use of Laboratory Animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}