{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:42:51Z","timestamp":1771231371339,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Indian J Microbiol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s12088-022-01032-x","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T17:02:51Z","timestamp":1656781371000},"page":"540-549","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Colonic Microflora Protagonist of Liver Metabolism and Gut Permeability: Study on Mice Model"],"prefix":"10.1007","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-7160","authenticated-orcid":false,"given":"Sweta","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipeeka","family":"Mandaliya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-2193","authenticated-orcid":false,"given":"Sriram","family":"Seshadri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"1032_CR1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","volume":"7","author":"DJ Morrison","year":"2016","unstructured":"Morrison DJ, Preston T (2016) Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes 7:189\u2013200. https:\/\/doi.org\/10.1080\/19490976.2015.1134082","journal-title":"Gut Microbes"},{"key":"1032_CR2","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12088-018-0746-9","volume":"58","author":"CS Kalyana","year":"2018","unstructured":"Kalyana CS, Jayasudha R, Sai PG et al (2018) Dysbiosis in the gut bacterial microbiome of patients with uveitis, an inflammatory disease of the eye. Indian J Microbiol 58:457\u2013469. https:\/\/doi.org\/10.1007\/s12088-018-0746-9","journal-title":"Indian J Microbiol"},{"key":"1032_CR3","doi-asserted-by":"crossref","unstructured":"Hu F, Zhang Y, Song Y (2013) Lipid Metabolism, Metabolic Syndrome, and Cancer. In: Valenzuela Baez R (ed) Lipid Metabolism. InTech","DOI":"10.5772\/51821"},{"key":"1032_CR4","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1097\/MIB.0000000000000750","volume":"22","author":"AK DeGruttola","year":"2016","unstructured":"DeGruttola AK, Low D, Mizoguchi A, Mizoguchi E (2016) Current understanding of dysbiosis in disease in human and animal models. Inflamm Bowel Dis 22:1137\u20131150. https:\/\/doi.org\/10.1097\/MIB.0000000000000750","journal-title":"Inflamm Bowel Dis"},{"key":"1032_CR5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12088-019-00825-x","volume":"60","author":"N Singhvi","year":"2020","unstructured":"Singhvi N, Gupta V, Gaur M et al (2020) Interplay of human gut microbiome in health and wellness. Indian J Microbiol 60:26\u201336. https:\/\/doi.org\/10.1007\/s12088-019-00825-x","journal-title":"Indian J Microbiol"},{"key":"1032_CR6","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000e115","author":"A Asif","year":"2014","unstructured":"Asif A, Khan N (2014) Tight junction integrity: need for non-invasive markers. J Clin Cellular Immunol. https:\/\/doi.org\/10.4172\/2155-9899.1000e115","journal-title":"J Clin Cellular Immunol"},{"key":"1032_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144854","author":"MV-L Tulstrup","year":"2015","unstructured":"Tulstrup MV-L, Christensen EG, Carvalho V et al (2015) Antibiotic treatment affects intestinal permeability and gut microbial composition in wistar rats dependent on antibiotic class. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0144854","journal-title":"PLoS ONE"},{"key":"1032_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/1745-7580.10000109","volume":"12","author":"PK Jena","year":"2016","unstructured":"Jena PK, Prajapati B, Mishra PK, Seshadri S (2016) Influence of gut microbiota on inflammation and pathogenesis of sugar rich diet induced diabetes. Immunome Res 12:1\u201310. https:\/\/doi.org\/10.4172\/1745-7580.10000109","journal-title":"Immunome Res"},{"key":"1032_CR9","doi-asserted-by":"publisher","first-page":"26201","DOI":"10.1039\/C8RA03774D","volume":"8","author":"B Prajapati","year":"2018","unstructured":"Prajapati B, Jena PK, Patel S, Seshadri S (2018) Divergent outcomes of gut microbiota alteration upon use of spectrum antibiotics in high sugar diet-induced diabetes in rats. RSC Adv 8:26201\u201326211. https:\/\/doi.org\/10.1039\/C8RA03774D","journal-title":"RSC Adv"},{"key":"1032_CR10","doi-asserted-by":"publisher","first-page":"349","DOI":"10.2174\/1871530319666181224122115","volume":"19","author":"S Patel","year":"2018","unstructured":"Patel S, Mandaliya D, Prajapati B et al (2018) Cefdinir Microsphere modulated microflora and liver immunological response to diet induced diabetes in mice. Endocr Metab Immune Disord Drug Targets 19:349\u2013347. https:\/\/doi.org\/10.2174\/1871530319666181224122115","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"1032_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12088-019-00852-8","volume":"60","author":"V Gupta","year":"2020","unstructured":"Gupta V, Sood U, Kumar R et al (2020) Microbiome: a new lease to microbiology. Indian J Microbiol 60:1. https:\/\/doi.org\/10.1007\/s12088-019-00852-8","journal-title":"Indian J Microbiol"},{"key":"1032_CR12","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.2174\/1567201813666160512145625","volume":"13","author":"B Prajapati","year":"2016","unstructured":"Prajapati B, Kumar Jena P, Mehta T, Seshadri S (2016) Preparation and optimization of moxifloxacin microspheres for colon targeted delivery using quality by design approach. In vitro and in vivo study. Curr Drug Deliv 13:1021\u20131033. https:\/\/doi.org\/10.2174\/1567201813666160512145625","journal-title":"Curr Drug Deliv"},{"key":"1032_CR13","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","volume":"10","author":"R Edgar","year":"2013","unstructured":"Edgar R (2013) UPARSE: highly accurate OTU sequences from microbial amplicon reads | Nature Methods. Nat Methods 10:996\u2013998","journal-title":"Nat Methods"},{"key":"1032_CR14","doi-asserted-by":"publisher","first-page":"W180","DOI":"10.1093\/nar\/gkx295","volume":"45","author":"A Dhariwal","year":"2017","unstructured":"Dhariwal A, Chong J, Habib S et al (2017) MicrobiomeAnalyst: a web-based tool for comprehensive statistical, visual and meta-analysis of microbiome data. Nucleic Acids Res 45:W180\u2013W188. https:\/\/doi.org\/10.1093\/nar\/gkx295","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"1032_CR15","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1016\/j.molmet.2017.07.006","volume":"6","author":"T Jois","year":"2017","unstructured":"Jois T, Chen W, Howard V et al (2017) Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice. Mol Metab 6(11):1381\u20131394. https:\/\/doi.org\/10.1016\/j.molmet.2017.07.006","journal-title":"Mol Metab"},{"key":"1032_CR16","doi-asserted-by":"publisher","DOI":"10.5808\/GI.2019.17.1.e6","volume":"17","author":"ML Calle","year":"2019","unstructured":"Calle ML (2019) Statistical analysis of metagenomics data. Genomics Inform 17:e6. https:\/\/doi.org\/10.5808\/GI.2019.17.1.e6","journal-title":"Genomics Inform"},{"key":"1032_CR17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.gpb.2015.02.005","volume":"13","author":"RS Mandal","year":"2015","unstructured":"Mandal RS, Saha S, Das S (2015) Metagenomic surveys of gut microbiota. Genom Proteom Bioinform 13:148\u2013158. https:\/\/doi.org\/10.1016\/j.gpb.2015.02.005","journal-title":"Genom Proteom Bioinform"},{"key":"1032_CR18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1172\/JCI88881","volume":"127","author":"Y Koyama","year":"2017","unstructured":"Koyama Y, Brenner DA (2017) Liver inflammation and fibrosis. J Clin Invest 127:55\u201364. https:\/\/doi.org\/10.1172\/JCI88881","journal-title":"J Clin Invest"},{"key":"1032_CR19","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.pan.2019.04.013","volume":"19","author":"DK Mandaliya","year":"2019","unstructured":"Mandaliya DK, Seshadri S (2019) Short chain fatty acids, pancreatic dysfunction and type 2 diabetes. Pancreatology 19:617\u2013622. https:\/\/doi.org\/10.1016\/j.pan.2019.04.013","journal-title":"Pancreatology"},{"key":"1032_CR20","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12944-016-0278-4","volume":"15","author":"OA Baothman","year":"2016","unstructured":"Baothman OA, Zamzami MA, Taher I et al (2016) The role of Gut Microbiota in the development of obesity and Diabetes. Lipids Health Dis 15:108. https:\/\/doi.org\/10.1186\/s12944-016-0278-4","journal-title":"Lipids Health Dis"},{"key":"1032_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature11450","volume":"490","author":"J Qin","year":"2012","unstructured":"Qin J, Li Y, Cai Z et al (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490:55\u201360. https:\/\/doi.org\/10.1038\/nature11450","journal-title":"Nature"},{"key":"1032_CR22","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.1007\/s10620-012-2259-4","volume":"57","author":"H-B Wang","year":"2012","unstructured":"Wang H-B, Wang P-Y, Wang X et al (2012) Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein Claudin-1 transcription. Dig Dis Sci 57:3126\u20133135. https:\/\/doi.org\/10.1007\/s10620-012-2259-4","journal-title":"Dig Dis Sci"},{"key":"1032_CR23","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ebiom.2018.12.034","volume":"40","author":"X Liu","year":"2018","unstructured":"Liu X, Shao L, Liu X et al (2018) Alterations of gastric mucosal microbiota across different stomach microhabitats in a cohort of 276 patients with gastric cancer. EBioMedicine 40:336\u2013348. https:\/\/doi.org\/10.1016\/j.ebiom.2018.12.034","journal-title":"EBioMedicine"},{"key":"1032_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039242","volume":"7","author":"E Papa","year":"2012","unstructured":"Papa E, Docktor M, Smillie C et al (2012) Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease. PLoS ONE 7:e39242. https:\/\/doi.org\/10.1371\/journal.pone.0039242","journal-title":"PLoS ONE"},{"key":"1032_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.humic.2016.09.001","volume":"1","author":"M Tidjani Alou","year":"2016","unstructured":"Tidjani Alou M, Lagier JC, Raoult D (2016) Diet influence on the gut microbiota and dysbiosis related to nutritional disorders. Hum Microbiome J 1:3\u201311. https:\/\/doi.org\/10.1016\/j.humic.2016.09.001","journal-title":"Hum Microbiome J"},{"issue":"6","key":"1032_CR26","doi-asserted-by":"publisher","first-page":"7567","DOI":"10.3892\/mmr.2018.8833","volume":"17","author":"C Zhu","year":"2018","unstructured":"Zhu C, Song K, Shen Z et al (2018) Roseburia intestinalis inhibits interleukin-17 excretion and promotes regulatory T cells differentiation in colitis. Mol Med Rep 17(6):7567\u20137574. https:\/\/doi.org\/10.3892\/mmr.2018.8833","journal-title":"Mol Med Rep"},{"key":"1032_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2016.00979","volume":"7","author":"A Rivi\u00e8re","year":"2016","unstructured":"Rivi\u00e8re A, Selak M, Lantin D et al (2016) Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut. Front Microbiol 7:1\u201321. https:\/\/doi.org\/10.3389\/fmicb.2016.00979","journal-title":"Front Microbiol"},{"key":"1032_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.5217\/ir.2015.13.1.11","volume":"13","author":"SH Lee","year":"2015","unstructured":"Lee SH (2015) Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases. Intest Res 13:11\u201318. https:\/\/doi.org\/10.5217\/ir.2015.13.1.11","journal-title":"Intest Res"}],"container-title":["Indian Journal of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12088-022-01032-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12088-022-01032-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12088-022-01032-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T21:16:41Z","timestamp":1669670201000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12088-022-01032-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["1032"],"URL":"https:\/\/doi.org\/10.1007\/s12088-022-01032-x","relation":{},"ISSN":["0046-8991","0973-7715"],"issn-type":[{"value":"0046-8991","type":"print"},{"value":"0973-7715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,2]]},"assertion":[{"value":"23 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All The authors also declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal-associated protocol was sanctioned by the \u2018Institutional Animal Care and Use Committee\u2019, Nirma University, Ahmedabad under the CPCSEA guidelines of Ministry of Environment and Forest, New Delhi (Protocol No: IS\/PHD\/18\/024).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All the authors have gone through the manuscript and have consented to proceed with publication in this journal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}