{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:24:26Z","timestamp":1778700266688,"version":"3.51.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s12094-012-0773-7","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T19:49:15Z","timestamp":1329421755000},"page":"138-142","source":"Crossref","is-referenced-by-count":10,"title":["Examination of Smad2 and Smad4 copy-number variations in skin cancers"],"prefix":"10.1007","volume":"14","author":[{"given":"Yong","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,2,17]]},"reference":[{"key":"773_CR1","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.febslet.2006.04.033","volume":"580","author":"J. Massague","year":"2006","unstructured":"Massague J, Gomis RR (2006) The logic of TGFbeta signaling. FEBS Lett 580:2811\u20132820","journal-title":"FEBS Lett"},{"key":"773_CR2","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","volume":"19","author":"J. Massague","year":"2005","unstructured":"Massague J, Seoane J, Wotton D (2005) Smad transcription factors. Genes Dev 19:2783\u20132810","journal-title":"Genes Dev"},{"key":"773_CR3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cytogfr.2005.09.006","volume":"17","author":"B. Bierie","year":"2006","unstructured":"Bierie B, Moses HL (2006) TGF-beta and cancer. Cytokine Growth Factor Rev 17:29\u201340","journal-title":"Cytokine Growth Factor Rev"},{"key":"773_CR4","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1172\/JCI24399","volume":"115","author":"G. Han","year":"2005","unstructured":"Han G, Lu SL, Li AG et al (2005) Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis. J Clin Invest 115:1714\u20131723","journal-title":"J Clin Invest"},{"key":"773_CR5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/sj.onc.1209029","volume":"25","author":"W. Qiao","year":"2006","unstructured":"Qiao W, Li AG, Owens P et al (2006) Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Oncogene 25:207\u2013217","journal-title":"Oncogene"},{"key":"773_CR6","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.1158\/0008-5472.CAN-05-0800","volume":"65","author":"L. Yang","year":"2005","unstructured":"Yang L, Mao C, Teng Y et al (2005) Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors. Cancer Res 65:8671\u20138678","journal-title":"Cancer Res"},{"key":"773_CR7","doi-asserted-by":"crossref","first-page":"e8879","DOI":"10.1371\/journal.pone.0008879","volume":"5","author":"H. Ashktorab","year":"2010","unstructured":"Ashktorab H, Schaffer AA, Daremipouran M et al (2010) Distinct genetic alterations in colorectal cancer. PLoS One 5:e8879","journal-title":"PLoS One"},{"key":"773_CR8","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1182\/blood-2008-07-172106","volume":"113","author":"D. French","year":"2009","unstructured":"French D, Yang W, Cheng C et al (2009) Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia. Blood 113:4512\u20134520","journal-title":"Blood"},{"key":"773_CR9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature06862","volume":"453","author":"J.M. Kidd","year":"2008","unstructured":"Kidd JM, Cooper GM, Donahue WF et al (2008) Mapping and sequencing of structural variation from eight human genomes. Nature 453:56\u201364","journal-title":"Nature"},{"key":"773_CR10","doi-asserted-by":"crossref","first-page":"10110","DOI":"10.1073\/pnas.0703834104","volume":"104","author":"J.O. Korbel","year":"2007","unstructured":"Korbel JO, Urban AE, Grubert F et al (2007) Systematic prediction and validation of breakpoints associated with copy-number variants in the human genome. Proc Natl Acad Sci U S A 104:10110\u201310115","journal-title":"Proc Natl Acad Sci U S A"},{"key":"773_CR11","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1158\/0008-5472.CAN-08-3151","volume":"69","author":"W. Liu","year":"2009","unstructured":"Liu W, Sun J, Li G et al (2009) Association of a germ-line copy number variation at 2p24.3 and risk for aggressive prostate cancer. Cancer Res 69:2176\u20132179","journal-title":"Cancer Res"},{"key":"773_CR12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1755-148X.2008.00497.x","volume":"21","author":"R.D. Kim","year":"2008","unstructured":"Kim RD, Curtin JA, Bastian BC (2008) Lack of somatic alterations of MC1R in primary melanoma. Pigment Cell Melanoma Res 21:579\u2013582","journal-title":"Pigment Cell Melanoma Res"},{"key":"773_CR13","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/gcc.20447","volume":"46","author":"K.J. Purdie","year":"2007","unstructured":"Purdie KJ, Lambert SR, Teh MT et al (2007) Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer 46:661\u2013669","journal-title":"Genes Chromosomes Cancer"},{"key":"773_CR14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/1471-2164-6-180","volume":"6","author":"R. Weksberg","year":"2005","unstructured":"Weksberg R, Hughes S, Moldovan L et al (2005) A method for accurate detection of genomic microdeletions using real-time quantitative PCR. BMC Genomics 6:180","journal-title":"BMC Genomics"},{"key":"773_CR15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"K.J. Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"773_CR16","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.tibtech.2009.05.003","volume":"27","author":"P.H. Dear","year":"2009","unstructured":"Dear PH (2009) Copy-number variation: the end of the human genome? Trends Biotechnol 27:448\u2013454","journal-title":"Trends Biotechnol"},{"key":"773_CR17","doi-asserted-by":"crossref","first-page":"11264","DOI":"10.1073\/pnas.0802970105","volume":"105","author":"A. Shlien","year":"2008","unstructured":"Shlien A, Tabori U, Marshall CR et al (2008) Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome. Proc Natl Acad Sci U S A 105:11264\u201311269","journal-title":"Proc Natl Acad Sci U S A"},{"key":"773_CR18","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1354\/vp.41-3-278","volume":"41","author":"S.H. Tannehill-Gregg","year":"2004","unstructured":"Tannehill-Gregg SH, Kusewitt DF, Rosol TJ et al (2004) The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice. Vet Pathol 41:278\u2013282","journal-title":"Vet Pathol"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-012-0773-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12094-012-0773-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-012-0773-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T20:54:38Z","timestamp":1561323278000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12094-012-0773-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["773"],"URL":"https:\/\/doi.org\/10.1007\/s12094-012-0773-7","relation":{},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"value":"1699-048X","type":"print"},{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}