{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:19:34Z","timestamp":1777565974733,"version":"3.51.4"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Fundaci\u00f3n ECO"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s12094-017-1682-6","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T11:22:48Z","timestamp":1497352968000},"page":"1293-1302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Supportive care in pancreatic ductal adenocarcinoma"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7219-7354","authenticated-orcid":false,"given":"B.","family":"Laquente","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Calsina-Berna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Carmona-Bayonas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Jim\u00e9nez-Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Peir\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Carrato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"key":"1682_CR1","unstructured":"http:\/\/globocan.iarc.fr . GLOBOCAN. European age-standardised rates calculated by the statistical information team at cancer research UK, 2011 using data from GLOBOCAN 2008 v1.2, IARC, Accessed February 2016."},{"key":"1682_CR2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1086\/321805","volume":"33","author":"CA Dykewicz","year":"2001","unstructured":"Dykewicz CA. Summary of the guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. Clin Infect Dis. 2001;33:139\u201344.","journal-title":"Clin Infect Dis"},{"key":"1682_CR3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1053\/j.seminoncol.2014.12.014","volume":"42","author":"A Stark","year":"2015","unstructured":"Stark A, Hines OJ. Endoscopic and operative palliation strategies for pancreatic ductal adenocarcinoma. Semin Oncol. 2015;42:163\u201376.","journal-title":"Semin Oncol"},{"key":"1682_CR4","first-page":"342","volume":"19","author":"M Huguier","year":"1993","unstructured":"Huguier M, Baumel H. Surgical palliation for unresected cancer of the exocrine pancreas. Eur J Surg Oncol. 1993;19:342\u20137.","journal-title":"Eur J Surg Oncol"},{"key":"1682_CR5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jpainsymman.2013.03.013","volume":"47","author":"ES Glazer","year":"2014","unstructured":"Glazer ES, Hornbrook MC. A metaanalysis of randomized trials: immediate stent replacement vs surgical bypass in the palliative management of malignant biliary obstruction. J Pain Symptom Manag. 2014;47:307\u201314.","journal-title":"J Pain Symptom Manag"},{"key":"1682_CR6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1148\/radiol.2243011517","volume":"225","author":"V Pinol","year":"2002","unstructured":"Pinol V, Castells A. Percutaneous self-expanding metal stents versus endoscopic polyethylene endoprotheses for treating malignant biliary obstruction: randomized clinical trial. Radiology. 2002;225:27\u201334.","journal-title":"Radiology"},{"key":"1682_CR7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ctrv.2006.10.006","volume":"33","author":"AC Moss","year":"2007","unstructured":"Moss AC, Morris E, Leyden J, MacMathuna P. Malignant distal biliary obstruction: a systematic review and meta-analysis of endoscopic and surgical bypass results. Cancer Treat Rev. 2007;33:213\u201321.","journal-title":"Cancer Treat Rev"},{"key":"1682_CR8","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/ajg.2013.305","volume":"108","author":"M Kitano","year":"2013","unstructured":"Kitano M, Yamashita Y, Tanaka K, Konishe H, Yazui S, Nakai Y, et al. Covered self-expandable metal stents with an anti-migration system improve patency duration without increased complications compared with uncovered stents for distal biliary obstruction caused by pancreatic carcinoma: a randomized multicenter trial. Am J Gastroenterol. 2013;108:1713\u201322.","journal-title":"Am J Gastroenterol"},{"key":"1682_CR9","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/bjs.1800780909","volume":"78","author":"PD Rooij de","year":"1991","unstructured":"de Rooij PD, Rogatko A, Brennan MF. Evaluation of palliative surgical procedures in unresectable pancreatic cancer. Br J Surg. 1991;78:1053\u20138.","journal-title":"Br J Surg"},{"key":"1682_CR10","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/01.sla.0000184190.20289.4b","volume":"242","author":"Y Fong","year":"2005","unstructured":"Fong Y, Gonen M, Rubin D, Radzyner M, Brennan MF. Long-term survival is superior after resection for cancer in high-volume centres. Ann Surg. 2005;242:540\u20137.","journal-title":"Ann Surg"},{"key":"1682_CR11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1055\/s-0030-1256383","volume":"43","author":"JE vanHooft","year":"2011","unstructured":"vanHooft JE, van Montfoort ML, Jeurnink SM, Bruno MJ, Dijkgraaf MG, Siersema PD, Fockens P. Safety and efficacy of a new non-foreshortening nitinol stent in malignant gastric outlet obstruction (DUONITI study): a prospective, multicenter study. Endoscopy. 2011;43:671\u20135.","journal-title":"Endoscopy"},{"key":"1682_CR12","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.gie.2008.07.026","volume":"69","author":"JE Hooft van","year":"2009","unstructured":"van Hooft JE, Uitdehaag MJ, Bruno MJ, Timmer R, Siersema PD, Dijkgraaf MGW, Fockens P. Efficacy and safety of the new WallFlex enteral stent in palliative treatment of malignant gastric outlet obstruction (DUOFLEX study): a prospective multicenter study. Gastrointest Endosc. 2009;69:1059\u201366.","journal-title":"Gastrointest Endosc"},{"key":"1682_CR13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00535-006-2003-y","volume":"42","author":"S Hosono","year":"2007","unstructured":"Hosono S, Ohtani H, Arimoto Y, Kanamiya Y. Endoscopic stenting versus surgical gastroenterostomy for palliation of malignant gastroduodenal obstruction: a meta-analysis. J Gastroenterol. 2007;42:283\u201390.","journal-title":"J Gastroenterol"},{"key":"1682_CR14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/104990910502200611","volume":"22","author":"M Davis","year":"2005","unstructured":"Davis M. Integrating palliative care into oncology practice. Am J Hosp Palliat Care. 2005;22:447\u201356.","journal-title":"Am J Hosp Palliat Care."},{"key":"1682_CR15","first-page":"CD007519","volume":"3","author":"PG Arcidiacono","year":"2011","unstructured":"Arcidiacono PG, Calori G, Carrara S, McNicol ED, Testoni PA. Celiac plexus block (CPB) is thought to be a safe and effective technique for reducing the severity of pain. Cochrane Database Syst Rev. 2011;3:CD007519.","journal-title":"Cochrane Database Syst Rev"},{"key":"1682_CR16","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1572-0241.2006.00967.x","volume":"102","author":"BM Yan","year":"2007","unstructured":"Yan BM, Myers RP. Neurolytic celiac plexus block for pain control in unresectable pancreatic cancer. Am J Gastroenterol. 2007;102:430\u201343.","journal-title":"Am J Gastroenterol"},{"key":"1682_CR17","unstructured":"http:\/\/www.who.int\/cancer\/palliative\/painladder\/en . Accessed Feb 2016."},{"key":"1682_CR18","unstructured":"http:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/pain.pgf , National Comprehensive Cancer Network, Adult Cancer Pain Guidelines. http:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/pain.pgf . Accessed Feb 2016."},{"key":"1682_CR19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0885-3924(88)90028-0","volume":"3","author":"K Foley","year":"1988","unstructured":"Foley K. Pain syndromes and pharmacological management of pancreatic cancer pain. J Pain Symptom Manag. 1988;3:176\u201387.","journal-title":"J Pain Symptom Manag"},{"key":"1682_CR20","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1097\/AJP.0b013e3181ecd895","volume":"26","author":"S Mercadante","year":"2010","unstructured":"Mercadante S, Tirelli W, David F, Arcara C, Fulfaro F, Casuccio A, et al. Morphine versus oxycodone in pancreatic cancer pain. A randomized controlled study. Clin J Pain. 2010;26:794\u20137.","journal-title":"Clin J Pain"},{"key":"1682_CR21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.currproblcancer.2013.10.003","volume":"37","author":"MA Erdek","year":"2013","unstructured":"Erdek MA, King LM, Ellsworth SG. Pain management and palliative care in pancreatic cancer. Curr Probl Cancer. 2013;37:266\u201372.","journal-title":"Curr Probl Cancer"},{"key":"1682_CR22","first-page":"399","volume":"3","author":"L Stearns","year":"2005","unstructured":"Stearns L, Boortz-Marx R, Du Pen S, Friechs G, Gordon M, Halyard M, et al. Intratecal drug delivery for the management of cancer pain: a multidisciplinary consensus of best clinical practices. J Support Oncol. 2005;3:399\u2013408.","journal-title":"J Support Oncol"},{"key":"1682_CR23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cryobiol.2012.12.002","volume":"66","author":"L Niu","year":"2013","unstructured":"Niu L, Wang Y, Yao F, Wei C, Chen Y, Zhang L, et al. Alleviating visceral cancer pain in patients with pancreatic cancer using cryoablation and celiac plexus block. Cryobiology. 2013;66:105\u201311.","journal-title":"Cryobiology"},{"key":"1682_CR24","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.pan.2013.10.007","volume":"13","author":"H Chen","year":"2013","unstructured":"Chen H, Liu TY, Kuai L, Zhu J, Wu CJ, Liu LM. Electroacupuncture treatment for pancreatic cancer pain: a randomized controlled trial. Pancreatology. 2013;13:594\u20137.","journal-title":"Pancreatology"},{"key":"1682_CR25","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s11916-012-0310-y","volume":"17","author":"BM Bahn","year":"2013","unstructured":"Bahn BM, Erdek MA. Celiac plexus block and neurolysis for pancreatic cancer. Curr Pain Headache Rep. 2013;17:310\u20133.","journal-title":"Curr Pain Headache Rep"},{"key":"1682_CR26","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1200\/JCO.2010.32.2750","volume":"26","author":"JM Wyse","year":"2011","unstructured":"Wyse JM, Carone M, Paquin SC. Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer. J Clin Oncol. 2011;26:3541\u20136.","journal-title":"J Clin Oncol"},{"key":"1682_CR27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.critrevonc.2015.07.014","volume":"96","author":"S Mercadante","year":"2015","unstructured":"Mercadante S, Klepstad P, Kurita GP, Sjogren P, Giarratano A, Euopean Palliative Care Research Collaborative (EPCRC). Sympathetic blocks for visceral cancer pain management: a systematic review and EAPC recommendations. Crit Rev Oncol Hematol. 2015;96:577\u201383.","journal-title":"Crit Rev Oncol Hematol"},{"key":"1682_CR28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1200\/JCO.2011.38.5161","volume":"30","author":"T Smith","year":"2012","unstructured":"Smith T, Temin S, Alesi E. American Society of Clinical Oncology provisional clinical opinion: the integration of palliative care into standard oncology care. J Clin Oncol. 2012;30:880\u20137.","journal-title":"J Clin Oncol"},{"key":"1682_CR29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0885-3924(88)90031-0","volume":"3","author":"BD Minsky","year":"1988","unstructured":"Minsky BD, Hilaris B, Fuks Z. The role of radiation therapy in the control of pain from pancreatic carcinoma. J Pain Symptom Manag. 1988;3:199\u2013205.","journal-title":"J Pain Symptom Manag"},{"key":"1682_CR30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1017\/S0007114512001067","volume":"109","author":"KM Sebastiano Di","year":"2013","unstructured":"Di Sebastiano KM, Yang L, Zbuk K, Wong RK, Chow T, Koff D, Moran GR, Mourtzakis M. Accelerated muscle and adipose tissue loss may predict survival in pancreatic cancer patients: the relationship with diabetes and anaemia. Br J Nutr. 2013;109:302\u201312.","journal-title":"Br J Nutr"},{"key":"1682_CR31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.clnu.2006.01.020","volume":"25","author":"J Arends","year":"2006","unstructured":"Arends J, Bodoky G, Bozzetti F, Fearon K, Muscaritoli M, Selga G, et al. ESPEN guidelines on enteral nutrition: non-surgical oncology. Clin Nutr. 2006;25:245\u201359.","journal-title":"Clin Nutr"},{"key":"1682_CR32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1177\/0148607109341804","volume":"33","author":"DA August","year":"2009","unstructured":"August DA, Huhmann MB. ASPEN clinical guidelines: nutrition support therapy during adult anticancer treatment and in hematopoietic cell transplantation. JPEN. 2009;33:472\u2013500.","journal-title":"JPEN"},{"key":"1682_CR33","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1136\/gut.2010.228254","volume":"60","author":"WH Allum","year":"2011","unstructured":"Allum WH, Blazeby JM, Griffin SM, Cunningham D, Jankowski JA, Wong R. Guidelines for the management of oesophageal and gastric cancer. Gut. 2011;60:1449\u201372.","journal-title":"Gut"},{"key":"1682_CR34","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/sj.ejcn.1601412","volume":"56","author":"J Bauer","year":"2002","unstructured":"Bauer J, Capra S, Fergunson M. Use of the scored Patient-Generated Subjective Global Assessment (PG-SGA) as a nutrition assessment tool in patients with cancer. Eur J Clin Nutr. 2002;56:779\u201385.","journal-title":"Eur J Clin Nutr"},{"key":"1682_CR35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clnu.2016.07.015","volume":"36","author":"J Arends","year":"2017","unstructured":"Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017;36:11\u201348.","journal-title":"Clin Nutr"},{"key":"1682_CR36","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.clnu.2013.04.020","volume":"32","author":"F Bozzetti","year":"2013","unstructured":"Bozzetti F. Perioperative nutritional support in the ERAS approach. Clin Nutr. 2013;32:872\u20133.","journal-title":"Clin Nutr"},{"key":"1682_CR37","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.dld.2015.06.015","volume":"47","author":"MJ Bartel","year":"2015","unstructured":"Bartel MJ, Asbun H, Stauffer J, Raimondo M. Pancreatic exocrine insufficiency in pancreatic cancer: a review of the literature. Dig Liver Dis. 2015;47:1013\u201320.","journal-title":"Dig Liver Dis"},{"key":"1682_CR38","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"K Fearon","year":"2011","unstructured":"Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12:489\u201395.","journal-title":"Lancet Oncol"},{"key":"1682_CR39","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/jso.23862","volume":"111","author":"S Joglekar","year":"2015","unstructured":"Joglekar S, Asghar A, Mott SL. Sarcopenia is an independent predictor of complications following pancreatectomy for adenocarcinoma. J Surg Oncol. 2015;111:771\u20135.","journal-title":"J Surg Oncol"},{"key":"1682_CR40","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1245\/s10434-014-4285-2","volume":"22","author":"AB Cooper","year":"2015","unstructured":"Cooper AB, Slack R, Fogelman D, Holmes HM, Petzel M, Parker N, et al. Characterization of anthropometric changes that occur during neoadjuvant therapy for potentially resectable pancreatic cancer. Ann Surg Oncol. 2015;22:2416\u201323.","journal-title":"Ann Surg Oncol"},{"key":"1682_CR41","doi-asserted-by":"crossref","first-page":"6973","DOI":"10.1158\/1078-0432.CCR-09-1525","volume":"15","author":"BH Tan","year":"2009","unstructured":"Tan BH, Birdsell LA, Martin L, Baracos VE, Fearon KCH, et al. Sarcopenia in an overweight or obese patient is an adverse prognostic factor in pancreatic cancer. Clin Cancer Res. 2009;15:6973\u20139.","journal-title":"Clin Cancer Res"},{"key":"1682_CR42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pan.2014.11.006","volume":"15","author":"IO Zalite","year":"2015","unstructured":"Zalite IO, Zykus R, Gonz\u00e1lez MF, Saygili F, Pukitis A, Gaujoux S, et al. Influence of cachexia and sarcopenia on survival in pancreatic ductal adenocarcinoma: a systematic review. Pancreatology. 2015;15:19\u201324.","journal-title":"Pancreatology"},{"key":"1682_CR43","first-page":"CD004310","volume":"3","author":"V Ruiz Garc\u00eda","year":"2013","unstructured":"Ruiz Garc\u00eda V, L\u00f3pez-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2013;3:CD004310.","journal-title":"Cochrane Database Syst Rev"},{"key":"1682_CR44","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1160\/TH10-12-0789","volume":"106","author":"LA Menapace","year":"2011","unstructured":"Menapace LA, Peterson DR, Berry A, Sousou T, Khorana AA. Symptomatic and incidental thromboembolism are both associated with mortality in pancreatic cancer. Thromb Haemost. 2011;106:371\u20138.","journal-title":"Thromb Haemost"},{"key":"1682_CR45","first-page":"4261","volume":"30","author":"W Shaib","year":"2010","unstructured":"Shaib W, Deng Y, Zilterman D, Lundberg B, Saif MW. Assessing risk and mortality of venous thromboembolism in pancreatic cancer patients. Anticancer Res. 2010;30:4261\u20134.","journal-title":"Anticancer Res"},{"key":"1682_CR46","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s12094-014-1165-y","volume":"10","author":"AJ Mu\u00f1oz Mart\u00edn","year":"2014","unstructured":"Mu\u00f1oz Mart\u00edn AJ, Garc\u00eda Alfonso P, Rup\u00e9rez Blanco AB, et al. Incidence of venous thromboembolism (VTE) in ambulatory pancreatic cancer patients receiving chemotherapy and analysis of Khorana\u2019s predictive model. Clin Trans Oncol. 2014;10:927\u201330.","journal-title":"Clin Trans Oncol"},{"key":"1682_CR47","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1002\/cncr.26600","volume":"118","author":"AS Epstein","year":"2012","unstructured":"Epstein AS, Soff GA, Capanu M, et al. Analysis of incidence and clinical outcomes in patients with thromboembolic events and invasive exocrine pancreatic cancer. Cancer. 2012;118:3053\u201361.","journal-title":"Cancer"},{"key":"1682_CR48","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1160\/TH05-10-0694","volume":"95","author":"M \u00d6gren","year":"2006","unstructured":"\u00d6gren M, Bergqvist D, W\u00e5hlander K, Eriksson H, Sternby NH. Trousseau\u2019s syndrome\u2014what is the evidence? A population-based autopsy study. Thromb Haemost. 2006;95:541\u20135.","journal-title":"Thromb Haemost"},{"key":"1682_CR49","first-page":"566","volume":"34","author":"EE Sproul","year":"1938","unstructured":"Sproul EE. Carcinoma and venous thrombosis: the frequency of association of carcinoma in the body or tail of the pancreas with multiple venous thrombosis. Am J Cancer. 1938;34:566\u201385.","journal-title":"Am J Cancer"},{"key":"1682_CR50","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1182\/blood-2012-01-402156","volume":"119","author":"JG Wang","year":"2012","unstructured":"Wang JG, Geddings JE, Aleman MM, Cardena JC, Ghantratahmmachart P, Williams JC, et al. Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. Blood. 2012;119:5543\u201352.","journal-title":"Blood"},{"key":"1682_CR51","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.thromres.2013.06.026","volume":"132","author":"A Bharthuar","year":"2013","unstructured":"Bharthuar A, Khorana AA, Hutson A, Wang JG, Key NS, Mackman N, et al. Circulating microparticle tissue factor, thromboembolism and survival in pancreaticobiliary cancers. Thromb Res. 2013;132:180\u20134.","journal-title":"Thromb Res"},{"key":"1682_CR52","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1182\/blood-2013-04-460147","volume":"122","author":"I Pabinger","year":"2013","unstructured":"Pabinger I, Thaler J, Ay C. Biomarkers for prediction of venous thromboembolism in cancer. Blood. 2013;122:2011\u20138.","journal-title":"Blood"},{"key":"1682_CR53","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1538-7836.2007.02369.x","volume":"5","author":"MET Tesselaar","year":"2007","unstructured":"Tesselaar MET, Romijn FPHTM, Van Der Linden IK, Prins FA, Bertina RM, Osanto S. Microparticle-associated tissue factor activity: a link between cancer and thrombosis? J Thromb Haemost. 2007;5:520\u20137.","journal-title":"J Thromb Haemost"},{"key":"1682_CR54","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1158\/1078-0432.CCR-06-2351","volume":"13","author":"AA Khorana","year":"2007","unstructured":"Khorana AA, Ahrendt SA, Ryan CK, Francis CW, Hruban RH, Hu YC, et al. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res. 2007;13:2870\u20135.","journal-title":"Clin Cancer Res"},{"key":"1682_CR55","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1080\/00365520600575720","volume":"41","author":"W Nakchbandi","year":"2006","unstructured":"Nakchbandi W, M\u00fcller H, Singer MV, L\u00f6hr M, Nakchbandi IA. Effects of low-dose warfarin and regional chemotherapy on survival in patients with pancreatic carcinoma. Scand J Gastroenterol. 2006;41:1095\u2013104.","journal-title":"Scand J Gastroenterol"},{"key":"1682_CR56","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1200\/JCO.2010.31.9293","volume":"29","author":"FF Doormaal Van","year":"2011","unstructured":"Van Doormaal FF, Di Nisio M, Otten H-M, Richel DJ, Prins M, Buller HR. Randomized trial of the effect of the low molecular weight heparin nadroparin on survival in patients with cancer. J Clin Oncol. 2011;29:2071\u20136.","journal-title":"J Clin Oncol"},{"key":"1682_CR57","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/02841860701687267","volume":"47","author":"J Sgouros","year":"2008","unstructured":"Sgouros J, Maraveyas A. Excess premature (3-month) mortality in advanced pancreatic cancer could be related to fatal vascular thromboembolic events. A hypothesis based on a systematic review of phase III chemotherapy studies in advanced pancreatic cancer. Acta Oncol. 2008;47:337\u201346.","journal-title":"Acta Oncol"},{"key":"1682_CR58","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1200\/JCO.2014.55.1481","volume":"33","author":"U Pelzer","year":"2015","unstructured":"Pelzer U, Opitz B, Deutschinoff G, Stauch M, Reitzig PC, Hahnfeld S, et al. Efficacy of prophylactic low-molecular weight heparin for ambulatory patients with advanced pancreatic cancer: outcomes from the CONKO-004 trial. J Clin Oncol. 2015;33:2028\u201334.","journal-title":"J Clin Oncol"},{"key":"1682_CR59","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1182\/blood-2007-10-116327","volume":"111","author":"AA Khorana","year":"2008","unstructured":"Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW. Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood. 2008;111:4902\u20137.","journal-title":"Blood"},{"key":"1682_CR60","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1182\/blood.V114.22.490.490","volume":"114","author":"NM Kuderer","year":"2009","unstructured":"Kuderer NM, Ortel TL, Khorana AA, Francis CW, Lyman GH. Low molecular weight heparin thromboprophylaxis in ambulatory cancer patients: a systematic review and meta-analysis of randomized controlled trials. Blood. 2009;114:203\u20136.","journal-title":"Blood"},{"key":"1682_CR61","doi-asserted-by":"crossref","unstructured":"Riess H, Pelzer U, Opitz B, Stauch M, Reitzig P, Hanhnfeld S, M\u00fcller HL, et al. A prospective, randomized trial of simultaneous pancreatic cancer treatment with enoxaparin and chemotherapy: Final results of the CONKO-004 trial. In: ASCO Annual Meeting Proceedings. 2010;28:15s.","DOI":"10.1200\/jco.2010.28.15_suppl.4033"},{"key":"1682_CR62","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.ejca.2011.10.017","volume":"48","author":"A Maraveyas","year":"2012","unstructured":"Maraveyas A, Waters J, Roy R, Fyfe D, Prooper D, Lofts F, et al. Gemcitabine versus gemcitabine plus dalteparin thromboprophylaxis in pancreatic cancer. Eur J Cancer. 2012;48:1283\u201392.","journal-title":"Eur J Cancer"},{"key":"1682_CR63","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s12094-014-1238-y","volume":"16","author":"AJ Mu\u00f1oz Mart\u00edn","year":"2014","unstructured":"Mu\u00f1oz Mart\u00edn AJ, Font Puig C, Navarro Mart\u00edn LM, Borrega Garcia P, Mart\u00cdn Jimenez M. Clinical guide SEOM on venous thromboembolism in cancer patients. Clin Transl Oncol. 2014;16:1079\u201390.","journal-title":"Clin Transl Oncol"},{"key":"1682_CR64","doi-asserted-by":"crossref","first-page":"370","DOI":"10.6004\/jnccn.2017.0036","volume":"15","author":"AB Benson","year":"2017","unstructured":"Benson AB, Venook AP, Cederquist L, Chan E, Chen YJ, Cooper HS, et al. NCCN clinical practice guidelines in oncology: colon cancer. J Natl Compr Cancer Netw. 2017;15:370\u201398.","journal-title":"J Natl Compr Cancer Netw"},{"key":"1682_CR65","doi-asserted-by":"crossref","first-page":"vi85","DOI":"10.1093\/annonc\/mdr392","volume":"22","author":"M Mandala","year":"2011","unstructured":"Mandala M, Falanga A, Roila F. Management of venous thromboembolism (VTE) in cancer patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2011;22:vi85\u201392.","journal-title":"Ann Oncol"},{"key":"1682_CR66","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1200\/JOP.2015.004473","volume":"11","author":"GH Lyman","year":"2015","unstructured":"Lyman GH, Bohlke K, Falanga A. Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update. J Oncol Pract. 2015;11:e442\u20134.","journal-title":"J Oncol Pract"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12094-017-1682-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-017-1682-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-017-1682-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T16:17:44Z","timestamp":1659111464000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12094-017-1682-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,13]]},"references-count":66,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["1682"],"URL":"https:\/\/doi.org\/10.1007\/s12094-017-1682-6","relation":{},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"value":"1699-048X","type":"print"},{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,13]]}}}