{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:37:28Z","timestamp":1775734648724,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81371658"],"award-info":[{"award-number":["81371658"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LZ18H180001"],"award-info":[{"award-number":["LZ18H180001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s12094-018-1902-8","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T10:51:32Z","timestamp":1531392692000},"page":"167-177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["CalliSpheres\u00ae drug-eluting beads (DEB) transarterial chemoembolization (TACE) is equally efficient and safe in liver cancer patients with different times of previous conventional TACE treatments: a result from CTILC study"],"prefix":"10.1007","volume":"21","author":[{"given":"X.","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.-D.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-H.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.-F.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-S.","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.-C.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.-M.","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.-Y.","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.-Q.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-S.","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.-J.","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.-H.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.-X","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.-H.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.-H.","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.-H.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-H.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.-H.","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.-H.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.-B.","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-P.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.-T.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.-Y.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-J.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-J.","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8896","authenticated-orcid":false,"given":"G.-L.","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"1902_CR1","unstructured":"Recio-Boiles A, Babiker HM. Cancer, Liver. StatPearls. Treasure Island (FL)2017."},{"issue":"2","key":"1902_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"LA Torre","year":"2015","unstructured":"Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87\u2013108. \n                    https:\/\/doi.org\/10.3322\/caac.21262\n                    \n                  .","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"1902_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.clinre.2016.05.013","volume":"41","author":"P Chen","year":"2017","unstructured":"Chen P, Yuan P, Chen B, Sun J, Shen H, Qian Y. Evaluation of drug-eluting beads versus conventional transcatheter arterial chemoembolization in patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. 2017;41(1):75\u201385. \n                    https:\/\/doi.org\/10.1016\/j.clinre.2016.05.013\n                    \n                  .","journal-title":"Clin Res Hepatol Gastroenterol."},{"issue":"4","key":"1902_CR4","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.jhep.2011.12.001","volume":"56","author":"European Association For The Study Of The","year":"2012","unstructured":"European Association For The Study Of The. L, European Organisation For R, Treatment Of C. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2012;56(4):908\u201343. \n                    https:\/\/doi.org\/10.1016\/j.jhep.2011.12.001\n                    \n                  .","journal-title":"J Hepatol"},{"issue":"3","key":"1902_CR5","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/hep.24199","volume":"53","author":"J Bruix","year":"2011","unstructured":"Bruix J, Sherman M. American Association for the Study of Liver D. Management of hepatocellular carcinoma: an update. Hepatology. 2011;53(3):1020\u20132. \n                    https:\/\/doi.org\/10.1002\/hep.24199\n                    \n                  .","journal-title":"Hepatology"},{"issue":"5","key":"1902_CR6","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1007\/s00330-016-4548-3","volume":"27","author":"JM Ludwig","year":"2017","unstructured":"Ludwig JM, Zhang D, Xing M, Kim HS. Meta-analysis: adjusted indirect comparison of drug-eluting bead transarterial chemoembolization versus 90Y-radioembolization for hepatocellular carcinoma. Eur Radiol. 2017;27(5):2031\u201341. \n                    https:\/\/doi.org\/10.1007\/s00330-016-4548-3\n                    \n                  .","journal-title":"Eur Radiol"},{"issue":"45","key":"1902_CR7","doi-asserted-by":"publisher","first-page":"17206","DOI":"10.3748\/wjg.v20.i45.17206","volume":"20","author":"JY Ni","year":"2014","unstructured":"Ni JY, Xu LF, Wang WD, Sun HL, Chen YT. Conventional transarterial chemoembolization vs microsphere embolization in hepatocellular carcinoma: a meta-analysis. World J Gastroenterol. 2014;20(45):17206\u201317. \n                    https:\/\/doi.org\/10.3748\/wjg.v20.i45.17206\n                    \n                  .","journal-title":"World J Gastroenterol"},{"issue":"2","key":"1902_CR8","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/hepr.12450","volume":"45","author":"ZB Xie","year":"2015","unstructured":"Xie ZB, Wang XB, Peng YC, Zhu SL, Ma L, Xiang BD, et al. Systematic review comparing the safety and efficacy of conventional and drug-eluting bead transarterial chemoembolization for inoperable hepatocellular carcinoma. Hepatol Res. 2015;45(2):190\u2013200. \n                    https:\/\/doi.org\/10.1111\/hepr.12450\n                    \n                  .","journal-title":"Hepatol Res."},{"issue":"1","key":"1902_CR9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1055\/s-0030-1247132","volume":"30","author":"R Lencioni","year":"2010","unstructured":"Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis. 2010;30(1):52\u201360. \n                    https:\/\/doi.org\/10.1055\/s-0030-1247132\n                    \n                  .","journal-title":"Semin Liver Dis"},{"issue":"6","key":"1902_CR10","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1016\/j.jhep.2012.07.025","volume":"57","author":"E Terzi","year":"2012","unstructured":"Terzi E, Golfieri R, Piscaglia F, Galassi M, Dazzi A, Leoni S, et al. Response rate and clinical outcome of HCC after first and repeated cTACE performed \u201con demand\u201d. J Hepatol. 2012;57(6):1258\u201367. \n                    https:\/\/doi.org\/10.1016\/j.jhep.2012.07.025\n                    \n                  .","journal-title":"J Hepatol"},{"issue":"7","key":"1902_CR11","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1517\/14656566.2011.545346","volume":"12","author":"B Sangro","year":"2011","unstructured":"Sangro B, D\u2019Avola D, Inarrairaegui M, Prieto J. Transarterial therapies for hepatocellular carcinoma. Expert Opin Pharmacother. 2011;12(7):1057\u201373. \n                    https:\/\/doi.org\/10.1517\/14656566.2011.545346\n                    \n                  .","journal-title":"Expert Opin Pharmacother"},{"issue":"Suppl 1","key":"1902_CR12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000368142","volume":"87","author":"M Kudo","year":"2014","unstructured":"Kudo M, Matsui O, Izumi N, Kadoya M, Okusaka T, Miyayama S, et al. Transarterial chemoembolization failure\/refractoriness: JSH-LCSGJ criteria 2014 update. Oncology. 2014;87(Suppl 1):22\u201331. \n                    https:\/\/doi.org\/10.1159\/000368142\n                    \n                  .","journal-title":"Oncology"},{"issue":"6","key":"1902_CR13","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.dld.2016.02.005","volume":"48","author":"A Facciorusso","year":"2016","unstructured":"Facciorusso A, Di Maso M, Muscatiello N. Drug-eluting beads versus conventional chemoembolization for the treatment of unresectable hepatocellular carcinoma: a meta-analysis. Dig Liver Dis. 2016;48(6):571\u20137. \n                    https:\/\/doi.org\/10.1016\/j.dld.2016.02.005\n                    \n                  .","journal-title":"Dig Liver Dis"},{"issue":"6","key":"1902_CR14","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.jhep.2012.07.017","volume":"57","author":"MJ Song","year":"2012","unstructured":"Song MJ, Chun HJ, Song DS, Kim HY, Yoo SH, Park CH, et al. Comparative study between doxorubicin-eluting beads and conventional transarterial chemoembolization for treatment of hepatocellular carcinoma. J Hepatol. 2012;57(6):1244\u201350. \n                    https:\/\/doi.org\/10.1016\/j.jhep.2012.07.017\n                    \n                  .","journal-title":"J Hepatol"},{"issue":"1","key":"1902_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00270-009-9711-7","volume":"33","author":"J Lammer","year":"2010","unstructured":"Lammer J, Malagari K, Vogl T, Pilleul F, Denys A, Watkinson A, et al. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study. Cardiovasc Intervent Radiol. 2010;33(1):41\u201352. \n                    https:\/\/doi.org\/10.1007\/s00270-009-9711-7\n                    \n                  .","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"1","key":"1902_CR16","doi-asserted-by":"publisher","first-page":"89","DOI":"10.5009\/gnl.2013.7.1.89","volume":"7","author":"DS Song","year":"2013","unstructured":"Song DS, Choi JY, Yoo SH, Kim HY, Song MJ, Bae SH, et al. DC bead transarterial chemoembolization is effective in hepatocellular carcinoma refractory to conventional transarteral chemoembolization: a pilot study. Gut Liver. 2013;7(1):89\u201395. \n                    https:\/\/doi.org\/10.5009\/gnl.2013.7.1.89\n                    \n                  .","journal-title":"Gut Liver"},{"issue":"5","key":"1902_CR17","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1111\/jgh.12439","volume":"29","author":"K Huang","year":"2014","unstructured":"Huang K, Zhou Q, Wang R, Cheng D, Ma Y. Doxorubicin-eluting beads versus conventional transarterial chemoembolization for the treatment of hepatocellular carcinoma. J Gastroenterol Hepatol. 2014;29(5):920\u20135. \n                    https:\/\/doi.org\/10.1111\/jgh.12439\n                    \n                  .","journal-title":"J Gastroenterol Hepatol"},{"issue":"8","key":"1902_CR18","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/1751-2980.12380","volume":"17","author":"JH Zou","year":"2016","unstructured":"Zou JH, Zhang L, Ren ZG, Ye SL. Efficacy and safety of cTACE versus DEB-TACE in patients with hepatocellular carcinoma: a meta-analysis. J Dig Dis. 2016;17(8):510\u20137. \n                    https:\/\/doi.org\/10.1111\/1751-2980.12380\n                    \n                  .","journal-title":"J Dig Dis"},{"key":"1902_CR19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2147\/JHC.S44380","volume":"2","author":"JH Jang","year":"2015","unstructured":"Jang JH, Lee JW, Hong JT, Jin YJ. Transarterial chemoembolization for hepatocellular carcinoma: an evidence-based review of its place in therapy. J Hepatocell Carcinoma. 2015;2:123\u20139. \n                    https:\/\/doi.org\/10.2147\/JHC.S44380\n                    \n                  .","journal-title":"J Hepatocell Carcinoma"},{"key":"1902_CR20","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","volume":"27","author":"IN Crispe","year":"2009","unstructured":"Crispe IN. The liver as a lymphoid organ. Annu Rev Immunol. 2009;27:147\u201363. \n                    https:\/\/doi.org\/10.1146\/annurev.immunol.021908.132629\n                    \n                  .","journal-title":"Annu Rev Immunol"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12094-018-1902-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-018-1902-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-018-1902-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T11:06:27Z","timestamp":1568027187000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12094-018-1902-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,12]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["1902"],"URL":"https:\/\/doi.org\/10.1007\/s12094-018-1902-8","relation":{},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"value":"1699-048X","type":"print"},{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,12]]},"assertion":[{"value":"4 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study were in accordance with the ethical standards of the institutional ethics committee and with the 1964 Helsinki declaration and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}