{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:41:09Z","timestamp":1778654469784,"version":"3.51.4"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T00:00:00Z","timestamp":1550275200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s12094-019-02033-x","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T05:06:31Z","timestamp":1550466391000},"page":"1127-1134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Relationship between tumor-associated immune infiltrate and p16 staining over clinicopathological features in acral lentiginous melanoma"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-0856","authenticated-orcid":false,"given":"C. A.","family":"Castaneda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0111-3176","authenticated-orcid":false,"given":"M.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7422-0661","authenticated-orcid":false,"given":"C.","family":"Torres-Cabala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-7060","authenticated-orcid":false,"given":"L. A.","family":"Bernabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8406-739X","authenticated-orcid":false,"given":"S.","family":"Casavilca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9560-029X","authenticated-orcid":false,"given":"V.","family":"Villegas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-4180","authenticated-orcid":false,"given":"J.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-3991","authenticated-orcid":false,"given":"M.","family":"de la Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4148-6858","authenticated-orcid":false,"given":"J.","family":"Dunstan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8330-803X","authenticated-orcid":false,"given":"J. M.","family":"Cotrina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-1843","authenticated-orcid":false,"given":"H. L.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-7207","authenticated-orcid":false,"given":"C.","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-9327","authenticated-orcid":false,"given":"M. P.","family":"Landa-Baella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-3411","authenticated-orcid":false,"given":"K.","family":"Tello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3824-8285","authenticated-orcid":false,"given":"B. F.","family":"Felix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9806-0989","authenticated-orcid":false,"given":"J.","family":"Abugattas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,16]]},"reference":[{"issue":"5795","key":"2033_CR1","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1126\/science.1129139","volume":"313","author":"J Galon","year":"2006","unstructured":"Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313(5795):1960\u20134.","journal-title":"Science"},{"issue":"7","key":"2033_CR2","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1158\/1078-0432.CCR-08-2179","volume":"15","author":"BD Robinson","year":"2009","unstructured":"Robinson BD, Sica GL, Liu YF, Rohan TE, Gertler FB, Condeelis JS, et al. Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin Cancer Res. 2009;15(7):2433\u201341.","journal-title":"Clin Cancer Res."},{"issue":"12","key":"2033_CR3","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1007\/s12094-017-1685-3","volume":"19","author":"CA Castaneda","year":"2017","unstructured":"Castaneda CA, Torres-Cabala C, Castillo M, Villegas V, Casavilca S, Cano L, et al. Tumor infiltrating lymphocytes in acral lentiginous melanoma: a study of a large cohort of cases from Latin America. Clin Transl Oncol. 2017;19(12):1478\u201388.","journal-title":"Clin Transl Oncol."},{"issue":"24","key":"2033_CR4","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1093\/jnci\/81.24.1893","volume":"81","author":"WH Clark Jr.","year":"1989","unstructured":"Clark WH, Jr., Elder DE, Guerry DT, Braitman LE, Trock BJ, Schultz D, et al. Model predicting survival in stage I melanoma based on tumor progression. J Natl Cancer Inst. 1989;81(24):1893-904.","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"2033_CR5","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5","volume":"77","author":"CG Clemente","year":"1996","unstructured":"Clemente CG, Mihm MC Jr, Bufalino R, Zurrida S, Collini P, Cascinelli N. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer. 1996;77(7):1303\u201310.","journal-title":"Cancer"},{"issue":"4","key":"2033_CR6","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1309\/WBF7-N8KH-71KT-RVQ9","volume":"118","author":"RJ Tuthill","year":"2002","unstructured":"Tuthill RJ, Unger JM, Liu PY, Flaherty LE, Sondak VK, Southwest Oncology G. Risk assessment in localized primary cutaneous melanoma: a Southwest Oncology Group study evaluating nine factors and a test of the Clark logistic regression prediction model. Am J Clin Pathol. 2002;118(4):504\u201311.","journal-title":"Am J Clin Pathol."},{"issue":"21","key":"2033_CR7","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1200\/JCO.2011.37.8539","volume":"30","author":"F Azimi","year":"2012","unstructured":"Azimi F, Scolyer RA, Rumcheva P, Moncrieff M, Murali R, McCarthy SW, et al. Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma. J Clin Oncol. 2012;30(21):2678\u201383.","journal-title":"J Clin Oncol."},{"issue":"1","key":"2033_CR8","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1158\/0008-5472.CAN-06-3388","volume":"67","author":"SJ Piersma","year":"2007","unstructured":"Piersma SJ, Jordanova ES, van Poelgeest MI, Kwappenberg KM, van der Hulst JM, Drijfhout JW, et al. High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer. Cancer Res. 2007;67(1):354\u201361.","journal-title":"Cancer Res."},{"issue":"51","key":"2033_CR9","doi-asserted-by":"publisher","first-page":"18538","DOI":"10.1073\/pnas.0509182102","volume":"102","author":"E Sato","year":"2005","unstructured":"Sato E, Olson SH, Ahn J, Bundy B, Nishikawa H, Qian F, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+\/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A. 2005;102(51):18538\u201343.","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"2033_CR10","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1158\/0008-5472.CAN-11-3218","volume":"72","author":"G Erdag","year":"2012","unstructured":"Erdag G, Schaefer JT, Smolkin ME, Deacon DH, Shea SM, Dengel LT, et al. Immunotype and immunohistologic characteristics of tumor-infiltrating immune cells are associated with clinical outcome in metastatic melanoma. Cancer Res. 2012;72(5):1070\u201380.","journal-title":"Cancer Res."},{"issue":"18","key":"2033_CR11","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1038\/onc.2010.614","volume":"30","author":"C Romagosa","year":"2011","unstructured":"Romagosa C, Simonetti S, Lopez-Vicente L, Mazo A, Lleonart ME, Castellvi J, et al. p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors. Oncogene. 2011;30(18):2087\u201397.","journal-title":"Oncogene"},{"issue":"9","key":"2033_CR12","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1002\/ijc.21608","volume":"118","author":"D Mihic-Probst","year":"2006","unstructured":"Mihic-Probst D, Mnich CD, Oberholzer PA, Seifert B, Sasse B, Moch H, et al. p16 expression in primary malignant melanoma is associated with prognosis and lymph node status. Int J Cancer. 2006;118(9):2262\u20138.","journal-title":"Int J Cancer."},{"issue":"36","key":"2033_CR13","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","volume":"27","author":"CM Balch","year":"2009","unstructured":"Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009;27(36):6199\u2013206.","journal-title":"J Clin Oncol."},{"issue":"6","key":"2033_CR14","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1002\/cncr.21283","volume":"104","author":"F Piras","year":"2005","unstructured":"Piras F, Colombari R, Minerba L, Murtas D, Floris C, Maxia C, et al. The predictive value of CD8, CD4, CD68, and human leukocyte antigen-D-related cells in the prognosis of cutaneous malignant melanoma with vertical growth phase. Cancer. 2005;104(6):1246\u201354.","journal-title":"Cancer"},{"issue":"9","key":"2033_CR15","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1002\/cncr.26511","volume":"118","author":"TO Jensen","year":"2012","unstructured":"Jensen TO, Schmidt H, Moller HJ, Donskov F, Hoyer M, Sjoegren P, et al. Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I\/II melanoma. Cancer. 2012;118(9):2476\u201385.","journal-title":"Cancer"},{"issue":"4","key":"2033_CR16","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/modpathol.2011.182","volume":"25","author":"SJ Storr","year":"2012","unstructured":"Storr SJ, Safuan S, Mitra A, Elliott F, Walker C, Vasko MJ, et al. Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma. Mod Pathol. 2012;25(4):493\u2013504.","journal-title":"Mod Pathol."},{"issue":"20","key":"2033_CR17","doi-asserted-by":"publisher","first-page":"3330","DOI":"10.1200\/JCO.2008.19.9919","volume":"27","author":"TO Jensen","year":"2009","unstructured":"Jensen TO, Schmidt H, Moller HJ, Hoyer M, Maniecki MB, Sjoegren P, et al. Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I\/II melanoma. J Clin Oncol. 2009;27(20):3330\u20137.","journal-title":"J Clin Oncol."}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12094-019-02033-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-019-02033-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-019-02033-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T19:12:08Z","timestamp":1581793928000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12094-019-02033-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,16]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["2033"],"URL":"https:\/\/doi.org\/10.1007\/s12094-019-02033-x","relation":{},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"value":"1699-048X","type":"print"},{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,16]]},"assertion":[{"value":"30 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No potential conflicts of interest are disclosed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethics committee approved this study, and exonerated it of using informed consent in June 2015.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this study, no informed consent was required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}