{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:11:32Z","timestamp":1761156692271,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s12094-019-02118-7","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T06:16:20Z","timestamp":1559369780000},"page":"151-157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypofractionation vs. conventional radiotherapy fractionation in the conservative treatment of T1 glottic cancer: a prospective cohort study"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-4045","authenticated-orcid":false,"given":"B. G.","family":"Salas-Salas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Dom\u00ednguez-Nuez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ferrera-Alay\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lloret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. C.","family":"Lara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,1]]},"reference":[{"key":"2118_CR1","doi-asserted-by":"crossref","unstructured":"De Santis RJ, Poon I, Lee J, Karam I, Enepekides DJ, Higgins KM. Comparison of survival between radiation therapy and trans-oral laser microsurgery for early glottic cancer patients; a retrospective cohort study. J Otolaryngol Head Neck Surg. 2016;45:42. \nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4969973\/pdf\/40463_2016_Article_155.pdf\n\n.","DOI":"10.1186\/s40463-016-0155-1"},{"issue":"2","key":"2118_CR2","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1177\/0194599813512783","volume":"150","author":"H Arshad","year":"2014","unstructured":"Arshad H, Jayaprakash V, Gupta V, Cohan DM, Ambujakshan D, Rigual NR, et al. Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 2014;150(2):237\u201344. \nhttps:\/\/doi.org\/10.1177\/0194599813512783\n\n.","journal-title":"Otolaryngol Head Neck Surg."},{"key":"2118_CR3","doi-asserted-by":"crossref","unstructured":"C\u00f6mert E, Tun\u00e7el \u00dc, Dizman A, G\u00fcney YY. Comparison of early oncological results of diode laser surgery with radiotherapy for early glottic carcinoma. Otolaryngol Head Neck Surg. 2014;150(5):818\u201323. \nhttp:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/0194599814521775?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed\n\n.","DOI":"10.1177\/0194599814521775"},{"key":"2118_CR4","unstructured":"Bron L, Soldati D, Zouhair A, Ozsahin M, Brossard E, Monnier P, et al. Treatment of laryngeal cancer: cordectomy or crico-hyoido-epiglottopexy versus radiotherapy. Schweiz med Wochenschr Suppl. 2000; 116:18S\u201321S. \nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10780064\n\n."},{"issue":"8","key":"2118_CR5","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1097\/01.mlg.0000166896.67924.b7","volume":"115","author":"DG Sessions","year":"2005","unstructured":"Sessions DG, Lennox J, Spector GJ. Supraglottic laryngeal cancer: analysis of treatment results. Laryngoscope. 2005;115(8):1402\u201310. \nhttps:\/\/doi.org\/10.1097\/01.mlg.0000166896.67924.b7\n\n.","journal-title":"Laryngoscope."},{"issue":"9","key":"2118_CR6","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s004050000276","volume":"257","author":"C. Or\u00fas","year":"2000","unstructured":"Or\u00fas C, Le\u00f3n X, Vega M, Quer M. Initial treatment of the early stages (I, II) of supraglottic squamous cell carcinoma: partial laryngectomy versus radiotherapy. Eur Arch Otorhinolaryngol. 2000;257(9):512\u20136. \nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11131380\n\n.","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"issue":"12","key":"2118_CR7","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1007\/s00405-017-4736-z","volume":"274","author":"FM Gioacchini","year":"2017","unstructured":"Gioacchini FM, Tulli M, Kaleci S, Bondi S, Bussi M, Re M. Therapeutic modalities and oncologic outcomes in the treatment of T1b glottic squamous cell carcinoma: a systematic review. Eur Arch Otorhinolaryngol. 2017;274(12):4091\u2013102. \nhttps:\/\/doi.org\/10.1007\/s00405-017-4736-z\n\n.","journal-title":"Eur Arch Otorhinolaryngol."},{"issue":"1","key":"2118_CR8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/lary.21226","volume":"121","author":"KM Higgins","year":"2011","unstructured":"Higgins KM. What treatment for early-stage glottic carcinoma among adult patients: CO2 endolaryngeal laser excision versus standard fractionated external beam radiation is superior in terms of cost utility? Laryngoscope. 2011;121(1):116\u201334. \nhttps:\/\/doi.org\/10.1002\/lary.21226\n\n.","journal-title":"Laryngoscope."},{"key":"2118_CR9","unstructured":"Olsen SM, Moore FJ, Kotch CA, Price DL, Kasperbauer JL, Olsen KD. Transoral robotic surgery for supraglottica squamous cell carcinoma. Am J Otolaryngol. 2012; 33(4):379-84. \nhttps:\/\/ac.els-cdn.com\/S2095881117300501\/1-s2.0-S2095881117300501-main.pdf?_tid=dc92717c-6d88-4f96-85b5-82564a129a95&acdnat=1549121401_d6abb9d798791437586faab507fbb827\n\n."},{"issue":"7","key":"2118_CR10","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1007\/s00405-013-2460-x","volume":"270","author":"AJ Remmelts","year":"2013","unstructured":"Remmelts AJ, Hoebers FJ, Klop WM, Balm AJ, Hamming-Vrieze O, van den Brekel MW. Evaluation of lasersurgery and radiotherapy as treatment modalities in early stage laryngeal carcinoma: tumour outcome and quality of voice. Eur Arch Otorhinolaryngol. 2013;270(7):2079\u201387. \nhttps:\/\/doi.org\/10.1007\/s00405-013-2460-x\n\n.","journal-title":"Eur Arch Otorhinolaryngol."},{"issue":"3","key":"2118_CR11","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/hed.23603","volume":"37","author":"F Arias","year":"2015","unstructured":"Arias F, Arraras JI, Asin G, Uzcanga MI, Marav\u00ed E, Chicata V, et al. Quality of life and voice assessment in patients with early-stage glottic cancer. Head Neck. 2015;37(3):340\u20136. \nhttps:\/\/doi.org\/10.1002\/hed.23603\n\n.","journal-title":"Head Neck."},{"issue":"2","key":"2118_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.radonc.2008.09.016","volume":"90","author":"JP Agarwal","year":"2009","unstructured":"Agarwal JP, Baccher GK, Waghmare CM, Mallick I, Ghosh-Laskar S, Budrukkar A, et al. Factors affecting the quality of voice in the early glottic cancer treated with radiotherapy. Radiother Oncol. 2009;90(2):177\u201382. \nhttps:\/\/doi.org\/10.1016\/j.radonc.2008.09.016\n\n.","journal-title":"Radiother Oncol."},{"issue":"12","key":"2118_CR13","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/hed.10323","volume":"25","author":"SJ Stoeckli","year":"2003","unstructured":"Stoeckli SJ, Schnieper I, Huguenin P, Schmid S. Early glottic carcinoma: treatment according patient\u2019s preference? Head Neck. 2003;25(12):1051\u20136. \nhttps:\/\/doi.org\/10.1002\/hed.10323\n\n(Disponible).","journal-title":"Head Neck."},{"issue":"5","key":"2118_CR14","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.ijrobp.2017.03.050","volume":"98","author":"AW Stokes","year":"2017","unstructured":"Stokes AW, Abbott D, Phan A, Raben D, Lanning RM, Karam SD. Patterns of care for patients with early-stage glottic cancer undergoing deffinitive radiation therapy: a national cancer database analysis. Int J Radiat Oncol Biol Phys. 2017;98(5):1014\u201321. \nhttps:\/\/doi.org\/10.1016\/j.ijrobp.2017.03.050\n\n.","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2118_CR15","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","volume":"45","author":"EA Eisenhauer","year":"2009","unstructured":"Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45:228\u201347. \nhttps:\/\/doi.org\/10.1016\/j.ejca.2008.10.026\n\n.","journal-title":"Eur J Cancer."},{"issue":"5","key":"2118_CR16","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","volume":"31","author":"JD Cox","year":"1995","unstructured":"Cox JD, Stetz J, Pajak TF. Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC). Int J Radiat Oncol Biol Phys. 1995;31(5):1341\u20136.","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"5","key":"2118_CR17","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.canrad.2004.08.003","volume":"8","author":"J Thariat","year":"2004","unstructured":"Thariat J, Bruchon Y, Bonnetain F, Barillot I, Truc G, Peignaux K, et al. Conservative treatment of early glottic carcinomas with exclusive radiotherapy. Cancer Radiother. 2004;8(5):288\u201396. \nhttps:\/\/doi.org\/10.1016\/j.canrad.2004.08.003\n\n.","journal-title":"Cancer Radiother."},{"key":"2118_CR18","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1200\/jco.2001.19.20.4029","volume":"19","author":"WM Mendenhall","year":"2001","unstructured":"Mendenhall WM, Amdur RJ, Morris CG, Hinerman RW. T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol. 2001;19:4029\u201336. \nhttps:\/\/doi.org\/10.1200\/jco.2001.19.20.4029\n\n.","journal-title":"J Clin Oncol"},{"issue":"2","key":"2118_CR19","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ijrobp.2009.08.066","volume":"78","author":"Bhishamjit S. Chera","year":"2010","unstructured":"Chera BS, Amdur RJ, Morris CG, Kirwan JM, Mendenhall WM. T1N0 to T2N0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy. Int J Radiat Oncol Biol Phys 2010; 78:461-466. \nhttps:\/\/www.redjournal.org\/article\/S0360-3016(09)03022-3\/fulltext\n\n. \nhttps:\/\/doi.org\/10.1016\/j.ijrobp.2009.08.066\n\n.","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"issue":"1","key":"2118_CR20","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/COC.0b013e3181a3194f","volume":"33","author":"Neil Sengupta","year":"2010","unstructured":"Sengupta N, Morris CG, Kirwan J, Amdur RJ, Mendenhall WM. Definitive radiotherapy for carcinoma in situ of the true vocal cords. Am J Clin Oncol 2010; 33:94. \nhttps:\/\/insights.ovid.com\/crossref?an=00000421-201002000-00019\n\n. \nhttps:\/\/doi.org\/10.1097\/coc.0b013e3181a3194f\n\n.","journal-title":"American Journal of Clinical Oncology"},{"issue":"1","key":"2118_CR21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ijrobp.2005.06.014","volume":"64","author":"Hideya Yamazaki","year":"2006","unstructured":"Yamazaki H, Nishiyama K, Tanaka E, Koizumi M, Chatani M. Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys 2006; 64:77-82. \nhttps:\/\/www.redjournal.org\/article\/S0360-3016(05)01123-5\/fulltext\n\n. \nhttps:\/\/doi.org\/10.1016\/j.ijrobp.2005.06.014\n\n.","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"key":"2118_CR22","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.radonc.2013.09.016","volume":"110","author":"SH Moon","year":"2014","unstructured":"Moon SH, Cho KH, Chung EJ, Lee CG, Lee KC, Chai GY, et al. A prospective randomized trial comparing hypofractionation with conventional fractionation radio- therapy for T1\u20132 glottic squamous cell carcinomas: results of a Korean Radiation Oncology Group (KROG-0201) study. Radiother Oncol. 2014;110:98\u2013103. \nhttps:\/\/doi.org\/10.1016\/j.radonc.2013.09.016\n\n.","journal-title":"Radiother Oncol"},{"key":"2118_CR23","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0360-3016(93)90250-Y","volume":"27","author":"DA Fein","year":"1993","unstructured":"Fein DA, Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Million RR. Carcinoma in situ of the glottic larynx: the role of radiotherapy. Int J Radiat Oncol Biol Phys. 1993;27:379\u201384. \nhttps:\/\/doi.org\/10.1016\/0360-3016(93)90250-Y\n\n.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"2118_CR24","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/hed.10071","volume":"24","author":"Allie Garcia-Serra","year":"2002","unstructured":"Garcia-Serra A, Hinerman RW, Amdur RJ, Morris CG, Mendenhall WM. Radiotherapy for carcinoma in situ of the true vocal cords. Head Neck. 2002; 24: 390\u2013394 \nhttps:\/\/www.sciencedirect.com\/science\/refhub\/S0360-3016(17)30771-X\/sref16\n\n. \nhttps:\/\/doi.org\/10.1002\/hed.10071\n\n.","journal-title":"Head & Neck"},{"key":"2118_CR25","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/S0360-3016(00)01517-0","volume":"49","author":"JA Spayne","year":"2001","unstructured":"Spayne JA, Warde P, O\u2019Sullivan B, Payne D, Liu FF, Waldron J, et al. Carcinoma-in-situ of the glottic larynx: Results of treatment with radiation therapy. Int J Radiat Oncol Biol Phys. 2001;49:1235\u20138. \nhttps:\/\/doi.org\/10.1016\/S0360-3016(00)01517-0\n\n.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2118_CR26","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0360-3016(97)00284-8","volume":"39","author":"QT Le","year":"1997","unstructured":"Le QT, Fu KK, Kroll S, Ryu JK, Quivey JM, Meyler TS, et al. Influence of fraction size, total dose, and overall time on local control of T1-T2 glottic carcinoma. Int J Radiat Oncol Biol Phys. 1997;39:115\u201326. \nhttps:\/\/doi.org\/10.1016\/S0360-3016(97)00284-8\n\n.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2118_CR27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0360-3016(82)90517-x","volume":"8","author":"HD Thames Jr","year":"1982","unstructured":"Thames HD Jr, Withers HR, Peters LJ, Fletcher GH. Changes in early and late radiation responses with altered dose fractionation: implications for dose- survival relationships. Int J Radiat Oncol Biol Phys. 1982;8:219\u201326. \nhttps:\/\/doi.org\/10.1016\/0360-3016(82)90517-x\n\n.","journal-title":"Int J Radiat Oncol Biol Phys."}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-019-02118-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12094-019-02118-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-019-02118-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T23:23:02Z","timestamp":1590880982000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12094-019-02118-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["2118"],"URL":"https:\/\/doi.org\/10.1007\/s12094-019-02118-7","relation":{},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"type":"print","value":"1699-048X"},{"type":"electronic","value":"1699-3055"}],"subject":[],"published":{"date-parts":[[2019,6,1]]},"assertion":[{"value":"6 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethic Committee in medical research of the HUGCDN, following the General Health Law 14\/86, the Organic Law of data protection 15\/99 and the Royal Decree 1090\/2015, and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study. Patients were followed prospectively under the Spanish RD 1566\/1998 regulation for Radiotherapy Quality Assurance.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}