{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:57:31Z","timestamp":1786982251726,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T00:00:00Z","timestamp":1574380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s12094-019-02245-1","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T11:02:31Z","timestamp":1574420551000},"page":"1180-1186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Splenic volume as a biomarker of hepatic damage after chemotherapy in patients with resected colorectal liver metastases (CRLM)"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-4884","authenticated-orcid":false,"given":"P.","family":"Saez-Carlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garc\u00eda-Botella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. I.","family":"Diez-Valladares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ortega Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C. M.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Serrano Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Avellana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Torres Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"issue":"4","key":"2245_CR1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/00000658-199610000-00009","volume":"224","author":"H Bismuth","year":"1996","unstructured":"Bismuth H, Adam R, Levi F, Farabos C, Waechter F, Castaing D, et al. Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy. Ann Surg. 1996;224(4):509\u201320.","journal-title":"Ann Surg"},{"issue":"1","key":"2245_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/jnci\/djq456","volume":"103","author":"G Masi","year":"2011","unstructured":"Masi G, Vasile E, Loupakis F, Cupini S, Fornaro L, Baldi G, et al. Randomized trial of two induction chemotherapy regimens in metastatic colorectal cancer: an updated analysis. J Natl Cancer Inst. 2011;103(1):21\u201330.","journal-title":"J Natl Cancer Inst"},{"issue":"35","key":"2245_CR3","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1200\/JCO.2008.17.7147","volume":"26","author":"HK Sanoff","year":"2008","unstructured":"Sanoff HK, Sargent DJ, Campbell ME, Morton RF, Fuchs CS, Ramanathan RK, et al. Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741. J Clin Oncol. 2008;26(35):5721\u20137.","journal-title":"J Clin Oncol"},{"issue":"11","key":"2245_CR4","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1002\/bjs.1800771115","volume":"77","author":"J Scheele","year":"1990","unstructured":"Scheele J, Stangl R, Altendorf-Hofmann A. Hepatic metastases from colorectal carcinoma: impact of surgical resection on the natural history. Br J Surg. 1990;77(11):1241\u20136.","journal-title":"Br J Surg"},{"issue":"2","key":"2245_CR5","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1200\/JCO.2004.05.113","volume":"22","author":"C Tournigand","year":"2004","unstructured":"Tournigand C, Andre T, Achille E, Lledo G, Flesh M, Mery-Mignard D, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol. 2004;22(2):229\u201337.","journal-title":"J Clin Oncol"},{"issue":"14","key":"2245_CR6","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1056\/NEJMoa0805019","volume":"360","author":"E Van Cutsem","year":"2009","unstructured":"Van Cutsem E, Kohne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. The N Engl J Med. 2009;360(14):1408\u201317.","journal-title":"The N Engl J Med"},{"issue":"9617","key":"2245_CR7","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/S0140-6736(08)60455-9","volume":"371","author":"B Nordlinger","year":"2008","unstructured":"Nordlinger B, Sorbye H, Glimelius B, Poston GJ, Schlag PM, Rougier P, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371(9617):1007\u2013166.","journal-title":"Lancet"},{"issue":"13","key":"2245_CR8","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1200\/JCO.2005.05.3074","volume":"24","author":"JN Vauthey","year":"2006","unstructured":"Vauthey JN, Pawlik TM, Ribero D, Wu TT, Zorzi D, Hoff PM, et al. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol. 2006;24(13):2065\u201372.","journal-title":"J Clin Oncol"},{"issue":"31","key":"2245_CR9","doi-asserted-by":"publisher","first-page":"4983","DOI":"10.1200\/JCO.2006.05.8156","volume":"24","author":"T Aloia","year":"2006","unstructured":"Aloia T, Sebagh M, Plasse M, Karam V, Levi F, Giacchetti S, et al. Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases. J Clin Oncol. 2006;24(31):4983\u201390.","journal-title":"J Clin Oncol"},{"issue":"7","key":"2245_CR10","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1007\/s11605-007-0149-4","volume":"11","author":"TM Pawlik","year":"2007","unstructured":"Pawlik TM, Olino K, Gleisner AL, Torbenson M, Schulick R, Choti MA. Preoperative chemotherapy for colorectal liver metastases: impact on hepatic histology and postoperative outcome. J Gastrointest Surg. 2007;11(7):860\u20138.","journal-title":"J Gastrointest Surg"},{"issue":"13","key":"2245_CR11","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.1245\/s10434-012-2438-8","volume":"19","author":"SM Robinson","year":"2012","unstructured":"Robinson SM, Wilson CH, Burt AD, Manas DM, White SA. Chemotherapy- associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis. Ann Surg Oncol. 2012;19(13):4287\u201399.","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"2245_CR12","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.cld.2010.07.009","volume":"14","author":"L Rubbia-Brandt","year":"2010","unstructured":"Rubbia-Brandt L. Sinusoidal obstruction syndrome. Clin Liver Dis. 2010;14(4):651\u201368.","journal-title":"Clin Liver Dis"},{"issue":"2","key":"2245_CR13","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.surg.2009.01.004","volume":"147","author":"C Hubert","year":"2010","unstructured":"Hubert C, Fervaille C, Sempoux C, Horsmans Y, Humblet Y, Machiels JP, et al. Prevalence and clinical relevance of pathological hepatic changes occurring after neoadjuvant chemotherapy for colorectal liver metastases. Surgery. 2010;147(2):185\u201394.","journal-title":"Surgery."},{"issue":"15","key":"2245_CR14","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1200\/JCO.2009.27.5701","volume":"28","author":"MJ Overman","year":"2010","unstructured":"Overman MJ, Maru DM, Charnsangavej C, Loyer EM, Wang H, Pathak P, et al. Oxaliplatin-mediated increase in spleen size as a biomarker for the development of 152 hepatic sinusoidal injury. J Clin Oncol. 2010;28(15):2549\u201355.","journal-title":"J Clin Oncol"},{"issue":"5","key":"2245_CR15","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ejso.2013.12.009","volume":"40","author":"K Imai","year":"2014","unstructured":"Imai K, Emi Y, Iyama KI, Beppu T, Ogata Y, Kakeji Y, et al. Splenic volume may be a useful indicator of the protective effect of bevacizumab against oxaliplatin-induced hepatic sinusoidal obstruction syndrome. Eur J Surg Oncol. 2014;40(5):559\u201366.","journal-title":"Eur J Surg Oncol"},{"issue":"3","key":"2245_CR16","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jamcollsurg.2014.12.008","volume":"220","author":"AL Simpson","year":"2015","unstructured":"Simpson AL, Leal JN, Pugalenthi A, Allen PJ, DeMatteo RP, Fong Y, et al. Chemotherapy-induced splenic volume increase is independently associated with major complications after hepatic resection for metastatic colorectal cancer. J Am Coll Surg. 2015;220(3):271\u201380.","journal-title":"J Am Coll Surg"},{"issue":"2","key":"2245_CR17","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien\u2013Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250(2):187\u201396.","journal-title":"Ann Surg"},{"issue":"6","key":"2245_CR18","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","volume":"41","author":"DE Kleiner","year":"2005","unstructured":"Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313\u201321.","journal-title":"Hepatology"},{"issue":"3","key":"2245_CR19","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1093\/annonc\/mdh095","volume":"15","author":"L. Rubbia-Brandt","year":"2004","unstructured":"Rubbia-Brandt L, Audard V, Sartoretti P, et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Ann Oncol 2004;15:460e466.","journal-title":"Annals of Oncology"},{"issue":"1","key":"2245_CR20","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1097\/SLA.0b013e3181ad85b5","volume":"250","author":"M Stockmann","year":"2009","unstructured":"Stockmann M, Lock JF, Riecke B, Heyne K, Martus P, Fricke M, et al. Prediction of postoperative outcome after hepatectomy with a new bedside test for maximal liver function capacity. Ann Surg. 2009;250(1):119\u201325.","journal-title":"Ann Surg"},{"issue":"6","key":"2245_CR21","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1245\/s10434-010-1494-1","volume":"18","author":"PM Krieger","year":"2011","unstructured":"Krieger PM, Tamandl D, Herberger B, Faybik P, Fleischmann E, Maresch J, et al. Evaluation of chemotherapy-associated liver injury in patients with colorectal cancer liver metastases using indocyanine green clearance testing. Ann Surg Oncol. 2011;18(6):1644\u201350.","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"2245_CR22","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1097\/SLA.0b013e31815774de","volume":"247","author":"H Nakano","year":"2008","unstructured":"Nakano H, Oussoultzoglou E, Rosso E, Casnedi S, Chenard-Neu MP, Dufour P, et al. Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy. Ann Surg. 2008;247(1):118\u201324.","journal-title":"Ann Surg"},{"issue":"6","key":"2245_CR23","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jamcollsurg.2005.01.024","volume":"200","author":"FG Fernandez","year":"2005","unstructured":"Fernandez FG, Ritter J, Goodwin JW, Linehan DC, Hawkins WG, Strasberg SM. Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases. J Am Coll Surg. 2005;200(6):845\u201353.","journal-title":"J Am Coll Surg"},{"issue":"1","key":"2245_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jamcollsurg.2005.09.010","volume":"202","author":"L Rubbia-Brandt","year":"2006","unstructured":"Rubbia-Brandt L, Mentha G, Terris B. Sinusoidal obstruction syndrome is a major feature of hepatic lesions associated with oxaliplatin neoadjuvant chemotherapy for liver colorectal metastases. J Am Coll Surg. 2006;202(1):199\u2013200.","journal-title":"J Am Coll Surg"},{"issue":"36","key":"2245_CR25","doi-asserted-by":"publisher","first-page":"9073","DOI":"10.1200\/JCO.2005.03.2334","volume":"23","author":"AJ Bilchik","year":"2005","unstructured":"Bilchik AJ, Poston G, Curley SA, Strasberg S, Saltz L, Adam R, et al. Neoadjuvant chemotherapy for metastatic colon cancer: a cautionary note. J Clin Oncol. 2005;23(36):9073\u20138.","journal-title":"J Clin Oncol"},{"issue":"4","key":"2245_CR26","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3816\/CCC.2009.n.038","volume":"8","author":"JH Slade","year":"2009","unstructured":"Slade JH, Alattar ML, Fogelman DR, Overman MJ, Agarwal A, Maru DM, et al. Portal hypertension associated with oxaliplatin administration: clinical manifestations of hepatic sinusoidal injury. Clin Colorect Cancer. 2009;8(4):225\u201330.","journal-title":"Clin Colorect Cancer"},{"issue":"5","key":"2245_CR27","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1159\/000210025","volume":"76","author":"R Angitapalli","year":"2009","unstructured":"Angitapalli R, Litwin AM, Kumar PR, Nasser E, Lombardo J, Mashtare T, et al. Adjuvant FOLFOX chemotherapy and splenomegaly in patients with stages II\u2013III colorectal cancer. Oncology. 2009;76(5):363\u20138.","journal-title":"Oncology"},{"issue":"126","key":"2245_CR28","first-page":"1420","volume":"60","author":"M Katayama","year":"2013","unstructured":"Katayama M, Nakano H, Kishi S, Kobayashi S, Koizumi S, Fukunaga T, et al. A splenic volume increase due to preoperative chemotherapy may impair the long-term outcome after hepatectomy in patients with initially non-optimally resectable colorectal cancer liver metastases. Hepatogastroenterology. 2013;60(126):1420\u20135.","journal-title":"Hepatogastroenterology"},{"issue":"3","key":"2245_CR29","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/bjs.5719","volume":"94","author":"D Zorzi","year":"2007","unstructured":"Zorzi D, Laurent A, Pawlik TM, Lauwers GY, Vauthey JN, Abdalla EK. Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg. 2007;94(3):274\u201386.","journal-title":"Br J Surg"},{"issue":"31","key":"2245_CR30","doi-asserted-by":"publisher","first-page":"4954","DOI":"10.1200\/JCO.2006.07.9244","volume":"24","author":"B Nordlinger","year":"2006","unstructured":"Nordlinger B, Benoist S. Benefits and risks of neoadjuvant therapy for liver metastases. J Clin Oncol. 2006;24(31):4954\u20135.","journal-title":"J Clin Oncol"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-019-02245-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12094-019-02245-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-019-02245-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T19:16:58Z","timestamp":1605899818000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12094-019-02245-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,22]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["2245"],"URL":"https:\/\/doi.org\/10.1007\/s12094-019-02245-1","relation":{},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"value":"1699-048X","type":"print"},{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,22]]},"assertion":[{"value":"18 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Institutional Review Board at Hospital Cl\u00ednico San Carlos approved this study (Ethical Committee Code: 16\/485-E_Tesis).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The retrospective study design was approved by the Hospital's ethics committee and written patients' consent was not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}