{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:33:55Z","timestamp":1791200035688,"version":"4.2.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s12094-020-02416-5","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T05:04:05Z","timestamp":1591592645000},"page":"283-288","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The application value of PAX1 and ZNF582 gene methylation in high grade intraepithelial lesion and cervical cancer"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9245-9462","authenticated-orcid":false,"given":"H.","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"2416_CR1","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.12688\/f1000research.9701.1","volume":"6","author":"K Hellner","year":"2017","unstructured":"Hellner K, Dorrell L. Recent advances in understanding and preventing human papillomavirus-related disease. F1000Res. 2017;6:F1000.","journal-title":"F1000Res"},{"key":"2416_CR2","first-page":"2105","volume":"121","author":"C Printz","year":"2015","unstructured":"Printz C. Physicians say HPV testing alone can screen for cervical cancer. Cancer. 2015;121:2105.","journal-title":"Cancer"},{"key":"2416_CR3","first-page":"515","volume":"44","author":"D Rennie","year":"2015","unstructured":"Rennie D, Boxsell J, Pedretti K. A team care model of cervical screening in a general practice. Aust Fam Physician. 2015;44:515\u20138.","journal-title":"Aust Fam Physician"},{"key":"2416_CR4","doi-asserted-by":"publisher","first-page":"15431","DOI":"10.18632\/oncotarget.14873","volume":"8","author":"M Brait","year":"2017","unstructured":"Brait M, Banerjee M, Maldonado L, Ooki A, Loyo M, Guida E, Izumchenko E, Mangold L, Humphreys E, et al. Promoter methylation of MCAM, ERalpha and ERbeta in serum of early stage prostate cancer patients. Oncotarget. 2017;8:15431\u201340.","journal-title":"Oncotarget"},{"key":"2416_CR5","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1002\/cncr.11599","volume":"98","author":"K Uchino","year":"2003","unstructured":"Uchino K, Ito A, Wakayama T, Koma Y, Okada T, Ohbayashi C, Iseki S, Kitamura Y, Tsubota N, Okita Y, et al. Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung. Cancer. 2003;98:1002\u20137.","journal-title":"Cancer"},{"key":"2416_CR6","first-page":"1471","volume":"61","author":"LY Kong","year":"2015","unstructured":"Kong LY, Du W, Wang L, Yang Z, Zhang HS. PAX1 methylation hallmarks promising accuracy for cervical cancer screening in Asians: results from a meta-analysis. Clin Lab. 2015;61:1471\u20139.","journal-title":"Clin Lab"},{"key":"2416_CR7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1097\/IGC.0000000000000054","volume":"24","author":"CC Chang","year":"2014","unstructured":"Chang CC, Huang RL, Wang HC, Liao YP, Yu MH, Lai HC. High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma. Int J Gynecol Cancer. 2014;24:201\u20139.","journal-title":"Int J Gynecol Cancer"},{"key":"2416_CR8","doi-asserted-by":"publisher","first-page":"E216","DOI":"10.3390\/ijerph14020216","volume":"14","author":"J Huang","year":"2017","unstructured":"Huang J, Wang G, Tang J, Zhuang W, Wang LP, Liou YL, Liu YZ, Zhou HH, Zhu YS. DNA methylation status of PAX1 and ZNF582 in esophageal squamous cell carcinoma. Int J Environ Res Public Health. 2017;14:E216.","journal-title":"Int J Environ Res Public Health"},{"key":"2416_CR9","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/cncy.21839","volume":"125","author":"L Zhao","year":"2017","unstructured":"Zhao L, Dias-Santagata D, Sadow PM, Faquin WC. Cytological, molecular, and clinical features of noninvasive follicular thyroid neoplasm with papillary-like nuclear features versus invasive forms of follicular variant of papillary thyroid carcinoma. Cancer Cytopathol. 2017;125:323\u201331.","journal-title":"Cancer Cytopathol"},{"key":"2416_CR10","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s12253-016-0094-1","volume":"23","author":"N Varga","year":"2017","unstructured":"Varga N, M\u00f3zes J, Keegan H, White C, Kelly L, Pilkington L, Benczik M, Zsuzsanna S, Sobel G, Koiss R, et al. The value of a novel panel of cervical cancer biomarkers for triage of HPV positive patients and for detecting disease progression. Pathol Oncol Res. 2017;23:295\u2013305.","journal-title":"Pathol Oncol Res"},{"key":"2416_CR11","first-page":"212","volume":"27","author":"J Zhu","year":"2013","unstructured":"Zhu J, Lin Y, Ruan HB, Zhang XH, Yang Q. Value of high risk human papilloma virus detection in screening and diagnosing cervical lesion in littoral of Zhejiang province. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2013;27:212\u20134.","journal-title":"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"},{"issue":"105","key":"2416_CR12","first-page":"905","volume":"2005","author":"American College of Obstetricians and Gynecologists","year":"2005","unstructured":"American College of Obstetricians and Gynecologists. Clinical management guidelines for obstetrician-gynecologists. Number 61. Human papillomavirus. Obstet Gynecol. 2005;2005(105):905\u201318.","journal-title":"Obstet Gynecol"},{"key":"2416_CR13","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.brachy.2011.07.002","volume":"11","author":"AN Viswanathan","year":"2012","unstructured":"Viswanathan AN, Beriwal S, De Los Santos JF, Demanes DJ, Gaffney D, Hansen J, Jones E, Kirisits C, Thomadsen B, Erickson B, et al. American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. Part II: high-dose-rate brachytherapy. Brachytherapy. 2012;11:47\u201352.","journal-title":"Brachytherapy"},{"key":"2416_CR14","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13148-016-0232-3","volume":"8","author":"YL Liou","year":"2016","unstructured":"Liou YL, Zhang TL, Yan T, Yeh CT, Kang YN, Cao L, Wu N, Chang CF, Wang HJ, Yen C, et al. Combined clinical and genetic testing algorithm for cervical cancer diagnosis. Clin Epigenetics. 2016;8:66.","journal-title":"Clin Epigenetics"},{"key":"2416_CR15","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1007\/s00439-013-1337-9","volume":"132","author":"E Pohl","year":"2013","unstructured":"Pohl E, Aykut A, Beleggia F, Karaca E, Durmaz B, Keupp K, Arslan E, Palamar M, Yigit G, \u00d6zkinay F, et al. A hypofunctional PAX1 mutation causes autosomal recessively inherited otofaciocervical syndrome. Hum Genet. 2013;132:1311\u201320.","journal-title":"Hum Genet"},{"key":"2416_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrc3184","volume":"12","author":"LV Nguyen","year":"2012","unstructured":"Nguyen LV, Vanner R, Dirks P, Eaves CJ. Cancer stem cells: an evolving concept. Nat Rev Cancer. 2012;12:133\u201343.","journal-title":"Nat Rev Cancer"},{"key":"2416_CR17","first-page":"403","volume":"142","author":"F Smedts","year":"1993","unstructured":"Smedts F, Ramaekers F, Leube RE, Keijser K, Link M, Vooijs P. Expression of keratins 1, 6, 15, 16, and 20 in normal cervical epithelium, squamous metaplasia, cervical intraepithelial neoplasia, and cervical carcinoma. Am J Pathol. 1993;142:403\u201312.","journal-title":"Am J Pathol"},{"key":"2416_CR18","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/hed.24958","volume":"40","author":"SJ Cheng","year":"2018","unstructured":"Cheng SJ, Chang CF, Ko HH, Lee JJ, Chen HM, Wang HJ, Lin HS, Chiang CP. Hypermethylated ZNF582 and PAX1 genes in mouth rinse samples as biomarkers for oral dysplasia and oral cancer detection. Head Neck. 2018;40:355\u201368.","journal-title":"Head Neck"},{"key":"2416_CR19","doi-asserted-by":"publisher","first-page":"62274","DOI":"10.18632\/oncotarget.19459","volume":"8","author":"Y Tian","year":"2017","unstructured":"Tian Y, Yuan Wu NY, Liou YL, Yeh CT, Cao L, Kang YN, Wang HJ, Li Y, Chu TY, Li W, et al. Utility of gene methylation analysis, cytological examination, and HPV-16\/18 genotyping in triage of high-risk human papilloma virus-positive women. Oncotarget. 2017;8:62274\u201385.","journal-title":"Oncotarget"},{"key":"2416_CR20","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ygyno.2014.08.012","volume":"135","author":"H Lin","year":"2014","unstructured":"Lin H, Chen TC, Chang TC, Cheng YM, Chen CH, Chu TY, Hsu ST, Liu CB, Yeh LS, Wen KC, et al. Methylated ZNF582 gene as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions\u2014a Taiwanese Gynecologic Oncology Group (TGOG) study. Gynecol Oncol. 2014;135:64\u20138.","journal-title":"Gynecol Oncol"},{"key":"2416_CR21","doi-asserted-by":"publisher","first-page":"e0172719","DOI":"10.1371\/journal.pone.0172719","volume":"12","author":"S Navet","year":"2017","unstructured":"Navet S, Buresi A, Baratte S, Andouche A, Bonnaud-Ponticelli L, Bassaglia Y. The Pax gene family: highlights from cephalopods. PLoS ONE. 2017;12:e0172719.","journal-title":"PLoS ONE"},{"key":"2416_CR22","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s00239-008-9113-5","volume":"66","author":"S Short","year":"2008","unstructured":"Short S, Holland LZ. The evolution of alternative splicing in the Pax family: the view from the Basal chordate amphioxus. J Mol Evol. 2008;66:605\u201320.","journal-title":"J Mol Evol"},{"key":"2416_CR23","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/IGC.0b013e3181c7fe6e","volume":"20","author":"TH Huang","year":"2010","unstructured":"Huang TH, Lai HC, Liu HW, Lin CJ, Wang KH, Ding DC, Chu TY. Quantitative analysis of methylation status of the PAX1 gene for detection of cervical cancer. Int J Gynecol Cancer. 2010;20:513\u20139.","journal-title":"Int J Gynecol Cancer"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-020-02416-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-020-02416-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-020-02416-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:24:48Z","timestamp":1623111888000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-020-02416-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["2416"],"URL":"https:\/\/doi.org\/10.1007\/s12094-020-02416-5","relation":{},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"value":"1699-048X","type":"print"},{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]},"assertion":[{"value":"8 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by Ethical Committee of Xuzhou Maternity and Child Health Care Hospital and conducted in accordance with the ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Yes.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}