{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:16:18Z","timestamp":1783005378887,"version":"3.54.5"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaemia is defined by the presence of haemoglobin (Hb) levels\u2009&lt;\u200913\u00a0g\/dL in men and 12\u00a0g\/dL in women. Up to 39% of cancer patients present it at the time of diagnosis and up to 40% have iron deficiency. Anaemia causes fatigue, functional deterioration and a reduction in the quality of life; it has also been associated with a poorer response to anti-tumour treatment and lower survival. Basic diagnostic tests for anaemia are simple and should be a routine part of clinical practice. These guidelines review the available evidence on the use of different therapies for treating anaemia: erythropoiesis-stimulating agents, iron supplements, and transfusion of blood products.<\/jats:p>","DOI":"10.1007\/s12094-021-02580-2","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T22:40:18Z","timestamp":1616712018000},"page":"931-939","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["SEOM clinical guidelines for anaemia treatment in cancer patients (2020)"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5492-6739","authenticated-orcid":false,"given":"Y.","family":"Escobar \u00c1lvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-4168","authenticated-orcid":false,"given":"R.","family":"de las Pe\u00f1as Bataller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Perez Altozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ros Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sabino \u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-0382","authenticated-orcid":false,"given":"A.","family":"Blasco Cordellat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-4142","authenticated-orcid":false,"given":"E.","family":"Brozos V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4377-2871","authenticated-orcid":false,"given":"J.","family":"Corral Jaime","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-0455","authenticated-orcid":false,"given":"I.","family":"Garc\u00eda Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1349-2652","authenticated-orcid":false,"given":"C.","family":"Beato Zambrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"issue":"15","key":"2580_CR1","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1016\/j.ejca.2004.06.019","volume":"40","author":"H Ludwig","year":"2004","unstructured":"Ludwig H, Van Belle S, Barrett-Lee P, Birgegard G, Bokemeyer C, Gascon P, et al. The European Cancer Anaemia Survey (ECAS): a large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients. Eur J Cancer. 2004;40(15):2293\u2013306.","journal-title":"Eur J Cancer"},{"key":"2580_CR2","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1093\/annonc\/mdh235","volume":"15","author":"D Cella","year":"2004","unstructured":"Cella D, Kallich J, McDermott A, Xu X. The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials. Ann Oncol. 2004;15:979\u201386.","journal-title":"Ann Oncol"},{"key":"2580_CR3","unstructured":"https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed on March 09, 2018)."},{"key":"2580_CR4","unstructured":"NCCN Cancer and chemotherapy-induced anemia, versi\u00f3n 2.2019."},{"key":"2580_CR5","unstructured":"Manejo de la anemia y d\u00e9ficit de hierro en pacientes oncol\u00f3gicos. Jos\u00e9 Mu\u00f1oz Langa."},{"key":"2580_CR6","doi-asserted-by":"crossref","unstructured":"Management of cancer-associated anemia with erythropoiesis-stimulating agents: ASCO\/ASH Clinical Practice Guideline Update (Bohlius) J Clin Oncol 37:1336\u20131351","DOI":"10.1200\/JCO.18.02142"},{"key":"2580_CR7","doi-asserted-by":"publisher","first-page":"CD003407","DOI":"10.1002\/14651858.CD003407.pub5","volume":"12","author":"T Tonia","year":"2012","unstructured":"Tonia T, Mettler A, Robert N, et al. Erythropoietin or darbepoetin for patients with cancer. Cochrane Database Syst Rev. 2012;12:CD003407. https:\/\/doi.org\/10.1002\/14651858.CD003407.pub5.","journal-title":"Cochrane Database Syst Rev"},{"key":"2580_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/bjc.2014.171","volume":"111","author":"J Bohlius","year":"2014","unstructured":"Bohlius J, Tonia T, N\u00fcesch E, et al. Effects of erythropoiesis-stimulating agents on fatigue and anaemia related symptoms in cancer patients: systematic review and meta-analyses of published and unpublished data. Br J Cancer. 2014;111:33\u201345.","journal-title":"Br J Cancer"},{"issue":"15","key":"2580_CR9","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1200\/JCO.18.02142","volume":"37","author":"J Bohlius","year":"2019","unstructured":"Bohlius J, Bohlke K, Castelli R, et al. Management of cancer-associated anemia with erythropoiesis-stimulating agents: ASCO\/ASH Clinical Practice Guideline Update. J Clin Oncol. 2019;37(15):1336\u201351.","journal-title":"J Clin Oncol"},{"key":"2580_CR10","doi-asserted-by":"crossref","unstructured":"Aapro M, Beguin Y, N\u00fcesch E, et al. Management of Anaemia and Iron Deficiency in Patients With Cancer: ESMO Clinical Practice Guidelines. Ann Oncol. 2018; 29 (4): iv96\u2013iv110.","DOI":"10.1093\/annonc\/mdx758"},{"key":"2580_CR11","doi-asserted-by":"publisher","first-page":"5960","DOI":"10.1200\/JCO.2005.06.150","volume":"23","author":"B Leyland-jones","year":"2005","unstructured":"Leyland-jones B, Semiglazov V, Pawlicki M, et al. Maintaining normal hemoglobin le- vels with epoetin alfa in mainly nonanemi patients with metastatic breast cancer re- ceiving first-line chemotherapy: asurvival study. J Clin Oncol. 2005;23:5960\u201372.","journal-title":"J Clin Oncol"},{"key":"2580_CR12","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/sj.bjc.6605498","volume":"102","author":"J Glaspy","year":"2010","unstructured":"Glaspy J, Crawford J, Vansteenkiste J, et al. Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes. Br J Cancer. 2010;102:301\u201315.","journal-title":"Br J Cancer"},{"issue":"2","key":"2580_CR13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s12094-019-02263-z","volume":"22","author":"AJ Mu\u00f1oz Mart\u00edn","year":"2020","unstructured":"Mu\u00f1oz Mart\u00edn AJ, Gallardo D\u00edaz E, Garc\u00eda Escobar I, et al. SEOM clinical guideline of venous thromboembolism (VTE) and cancer (2019). Clin Transl Oncol. 2020;22(2):171\u201386.","journal-title":"Clin Transl Oncol"},{"key":"2580_CR14","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/S0140-6736(03)14567-9","volume":"362","author":"M Henke","year":"2003","unstructured":"Henke M, Laszig R, R\u00fcbe C, et al. Erythropoietin to treat head and neck cancer patients with anemia undergoing radiotherapy: a randomized, double-blind, placebo-controlled trial. Lancet. 2003;362:1255.","journal-title":"Lancet"},{"key":"2580_CR15","first-page":"3","volume":"33","author":"L Cabrera Garc\u00eda","year":"2009","unstructured":"Cabrera Garc\u00eda L, Ru\u00edz Antor\u00e1n B, Sancho LA. Eritropoyetina: revisi\u00f3n de sus indicaciones. Inf Ter Nac Salud. 2009;33:3\u20139.","journal-title":"Inf Ter Nac Salud"},{"key":"2580_CR16","unstructured":"Consenso sobre el uso de agentes eritropoy\u00e9ticos en pacientes an\u00e9micos con c\u00e1ncer. Esquemas de administraci\u00f3n. C\u00e9sar-Augusto Rodr\u00edguez S\u00e1nchez. Prodrug Multimedia 2007, SL. ISBN: 978-84-95972-43-9."},{"key":"2580_CR17","unstructured":"Eprex, Binocrit, Abseamed, Hexal, Neorecormon, Eporatio, Biopoin, Retacrit, Silapo, Aranesp. Ficha t\u00e9cnica del medicamento. The European Agency for the Evaluation of Medicinal Products (EMEA). Committee for Propietary Medicinal Products (CPMP). European Public Assessment Report (EPAR): Binocrit (2009), Abseamed (2009), Hexal (2009), Neorecormon (2004), Eporatio (2009), Biopoin (2009), Retacrit (2008), Silapo (2007), Aranesp (2004). Disponibles en: http:\/\/www.emea.europa.es\/."},{"issue":"15","key":"2580_CR18","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1016\/j.ejca.2004.06.019","volume":"40","author":"H Ludwig","year":"2004","unstructured":"Ludwig H, Van Belle S, Barrett-Lee P, Birgeg\u00e5rd G, Bokemeyer C, Gasc\u00f3n P, et al. The European Cancer Anaemia Survey (ECAS): a large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients. Eur J Cancer. 2004;40(15):2293\u2013306.","journal-title":"Eur J Cancer"},{"issue":"4","key":"2580_CR19","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/annonc\/mdx758","volume":"29","author":"M Aapro","year":"2018","unstructured":"Aapro M, Beguin C, Bokemeyer M, et al. Management of anemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines. Ann Oncol. 2018;29(4):96\u2013101.","journal-title":"Ann Oncol."},{"issue":"9","key":"2580_CR20","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s12094-013-1155-5","volume":"16","author":"J De Castro","year":"2014","unstructured":"De Castro J, Gasc\u00f3n P, Casas A, Mu\u00f1oz-Langa J, Alberola V, Cucala M, et al. Iron deficiency in patients with solid tumours: prevalence and management in clinical practice. Clin Transl Oncol. 2014;16(9):823\u20138.","journal-title":"Clin Transl Oncol"},{"key":"2580_CR21","unstructured":"Sue Becker P, Griffiths EA, Alwan L, et al. Cancer and Chemotherapy-Induced Anemia. In Hematopoietic Growth Factors NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) v2.2020."},{"key":"2580_CR22","unstructured":"European Medicines Agency. New recommendations to manage risk of allergic reactions with intravenous iron-containing medicines 2013; http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Press_release\/2013\/06\/WC500144874.pdf."},{"key":"2580_CR23","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1191\/0960327105ht544oa","volume":"24","author":"H Rezazadeh","year":"2005","unstructured":"Rezazadeh H, Nayebi AR, Garjani A, et al. Evidence that iron overload plus croton oil induce skin tumours in mice. Hum Exp Toxicol. 2005;24:409\u201313.","journal-title":"Hum Exp Toxicol"},{"key":"2580_CR24","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1177\/0897190008318916","volume":"21","author":"SB Silverstein","year":"2008","unstructured":"Silverstein SB, Gilreath JA, Rodgers GM. Intravenous iron therapy: a summary of treatment options and review of guidelines. J Pharm Pract. 2008;21:431\u201343.","journal-title":"J Pharm Pract"},{"key":"2580_CR25","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1200\/JCO.2004.08.119","volume":"22","author":"M Auerbach","year":"2004","unstructured":"Auerbach M, Ballard H, Trout JR, et al. Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia: a multicenter, open-label, randomized trial. J Clin Oncol. 2004;22:1301\u20137.","journal-title":"J Clin Oncol"},{"key":"2580_CR26","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1200\/JCO.2006.10.4620","volume":"26","author":"L Bastit","year":"2008","unstructured":"Bastit L, Vandebroek A, Altintas S, et al. Randomized, multicenter, controlled trial comparing the efficacy and safety of darbepoetin alpha administered every 3 weeks with or without intravenous iron in patients with chemotherapy-induced anemia. J Clin Oncol. 2008;26:1611\u20138.","journal-title":"J Clin Oncol"},{"key":"2580_CR27","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/ajh.20056","volume":"76","author":"SB Silverstein","year":"2004","unstructured":"Silverstein SB, Rodgers GM. Parenteral iron therapy options. Am J Hematol. 2004;76:74\u20138.","journal-title":"Am J Hematol"},{"issue":"344\u2013354","key":"2580_CR28","first-page":"114","volume":"152","author":"WB Al-Refaie","year":"2012","unstructured":"Al-Refaie WB, Parsons HM, Markin A, et al. Blood transfusion and cancer surgery outcomes: a continued reason for concern. Surgery. 2012;152(344\u2013354):114.","journal-title":"Surgery"},{"issue":"CD005033","key":"2580_CR29","first-page":"115","volume":"1","author":"A Amato","year":"2006","unstructured":"Amato A, Pescatori M. Perioperative blood transfusions for the recurrence of colorectal cancer. Cochrane Database Syst Rev. 2006;1(CD005033):115.","journal-title":"Cochrane Database Syst Rev"},{"issue":"100\u2013106","key":"2580_CR30","first-page":"116","volume":"130","author":"JN Bakkum-Gamez","year":"2013","unstructured":"Bakkum-Gamez JN, Dowdy SC, Borah BJ, et al. Predictors and costs of surgical site infections in patients with endometrial cancer. Gynecol Oncol. 2013;130(100\u2013106):116.","journal-title":"Gynecol Oncol"},{"key":"2580_CR31","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.amjsurg.2013.10.001","volume":"206","author":"WJ Halabi","year":"2013","unstructured":"Halabi WJ, Jafari MD, Nguyen VQ, et al. Blood transfusions in colorectal cancer surgery: incidence, outcomes, and predictive factors: an American College of Surgeons National Surgical Quality Improvement Program analysis. Am J Surg. 2013;206:1024-1032.1.","journal-title":"Am J Surg"},{"issue":"266\u2013272","key":"2580_CR32","first-page":"106","volume":"36","author":"H Link","year":"2013","unstructured":"Link H, Schmitz S. Treatment of cancer-associated anaemia: results from a two-day cross-sectional survey in Germany. Onkologie. 2013;36(266\u2013272):106.","journal-title":"Onkologie"},{"key":"2580_CR33","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1007\/s00520-014-2189-0","volume":"22","author":"H Ludwig","year":"2014","unstructured":"Ludwig H, Aapro M, Bokemeyer C, et al. A European patient record study on diagnosis and treatment of chemotherapy-induced anaemia. Support Care Cancer. 2014;22:2197\u2013206.","journal-title":"Support Care Cancer"},{"key":"2580_CR34","unstructured":"National Comprehensive Cancer Network. NCCN Practice Guidelines in Oncology; Cancer and Chemotherapy-Induced Anemia\u2014v.1.2018, 2017; http:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/anemia."},{"key":"2580_CR35","doi-asserted-by":"publisher","first-page":"4045","DOI":"10.1182\/blood-2010-08-300541","volume":"116","author":"JD Rizzo","year":"2010","unstructured":"Rizzo JD, Brouwers M, Hurley P, et al. American Society of Hematology\/American Society of Clinical Oncology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer. Blood. 2010;116:4045\u201359.","journal-title":"Blood"},{"issue":"2344\u20132352","key":"2580_CR36","first-page":"123","volume":"54","author":"JL Callum","year":"2014","unstructured":"Callum JL, Waters JH, Shaz BH, et al. The AABB recommendations for the choosing wisely campaign of the American Board of Internal Medicine. Transfusion. 2014;54(2344\u20132352):123.","journal-title":"Transfusion"},{"key":"2580_CR37","doi-asserted-by":"publisher","first-page":"49","DOI":"10.7326\/0003-4819-157-1-201206190-00429","volume":"157","author":"JL Carson","year":"2012","unstructured":"Carson JL, Grossman BJ, Kleinman S, et al. Red blood cell transfusion: a clinical practice guideline from the AABB. Ann Intern Med. 2012;157:49\u201358.","journal-title":"Ann Intern Med"}],"updated-by":[{"DOI":"10.1007\/s12094-021-02681-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000}}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-021-02580-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-021-02580-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-021-02580-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T17:08:09Z","timestamp":1626887289000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-021-02580-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,25]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["2580"],"URL":"https:\/\/doi.org\/10.1007\/s12094-021-02580-2","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12094-021-02681-y","asserted-by":"object"}]},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"value":"1699-048X","type":"print"},{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,25]]},"assertion":[{"value":"2 March 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2021","order":3,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":4,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":5,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12094-021-02681-y","URL":"https:\/\/doi.org\/10.1007\/s12094-021-02681-y","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"YE, RdP, JPA, SR, AS, AB, EB, JC, IGE have nothing to disclose. CB reports education Grants from Leo Pharma and Vifor.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The current study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}