{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:49:20Z","timestamp":1791319760559,"version":"4.3.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s12094-021-02596-8","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T08:03:30Z","timestamp":1617264210000},"page":"1857-1865","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Extended intraoperative peritoneal lavage as prophylactic peritoneal recurrence for locally advanced gastric cancer: a prospective randomized trial"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-9205","authenticated-orcid":false,"given":"J.","family":"Rodr\u00edguez-Santiago","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Garsot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Aldeano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Balagu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"2596_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s10120-007-0436-5","volume":"10","author":"Y Fujiwara","year":"2007","unstructured":"Fujiwara Y, Doki Y, Taniguchi H, et al. Genetic detection of free cancer cells in the peritoneal cavity of the patient with gastric cancer: present status and future perspectives. Gastric Cancer. 2007;10:197\u20132014.","journal-title":"Gastric Cancer"},{"key":"2596_CR2","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.1245\/s10434-011-1620-8","volume":"18","author":"TS Han","year":"2011","unstructured":"Han TS, Kong SH, Lee HJ, et al. Dissemination of free cancer cells from the gastric lumen and from perigastric lymphovascular pedicles during radical gastric cancer surgery. Ann Surg Oncol. 2011;18:2818\u201325.","journal-title":"Ann Surg Oncol"},{"key":"2596_CR3","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1007\/s00595-014-1005-2","volume":"45","author":"Y Okumitsu","year":"2015","unstructured":"Okumitsu Y, Yoshino S, Lida M, et al. Intraoperative dissemination during gastrectomy for gastric c\u00e1ncer associated with serosal invasion. Surg Today. 2015;45:746\u201351.","journal-title":"Surg Today"},{"key":"2596_CR4","doi-asserted-by":"crossref","unstructured":"Sobin LH, Gospodarowicz MK, Witteking Ch. TNM. In: Leslie HS, editor. Classification of malignant tumours. Wiley; 2010.","DOI":"10.1002\/9780471420194.tnmc26.pub2"},{"key":"2596_CR5","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/SLA.0b013e3181b0c80e","volume":"250","author":"M Kuramoto","year":"2009","unstructured":"Kuramoto M, Shimada S, Ikeshima S, et al. Extensive intraoperative peritoneal lavage as a standard prophylactic strategy of peritoneal recurrence in patients with gastric carcinoma. Ann Surg. 2009;250:242\u20136.","journal-title":"Ann Surg"},{"key":"2596_CR6","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/340380","author":"M Kuramoto","year":"2012","unstructured":"Kuramoto M, Shimada S, Ikeshima S, et al. A proposal of a practical and optimal prophylactic strategy for peritoneal recurrence. J Oncol. 2012. https:\/\/doi.org\/10.1155\/2012\/340380.","journal-title":"J Oncol"},{"key":"2596_CR7","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/jjco\/hyt157","volume":"44","author":"K Misawa","year":"2014","unstructured":"Misawa K, Mochizuli Y, Oshashi N, et al. A randomized phase III exploring the prognostic of extensive intraoperative lavage in addition to standard treatment for resectable advanced gastric cancer: CCOG 1102. Jpn J Clin Oncol. 2014;44:101\u20133.","journal-title":"Jpn J Clin Oncol"},{"key":"2596_CR8","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s10147-015-0892-6","volume":"21","author":"T Masuda","year":"2016","unstructured":"Masuda T, Kuramoto M, Shimada S, et al. The effect of extensive intraoperative peritoneal lavage therapy (EIPL) on stage IIIB+C and cytology-positive gastric cancer patients. Int J Clin Oncol. 2016;21:289\u201394.","journal-title":"Int J Clin Oncol"},{"key":"2596_CR9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.surg.2009.11.025","volume":"148","author":"T Makino","year":"2010","unstructured":"Makino T, Fujiwara Y, Takiguchi S, et al. The utility of pre-operative peritoneal lavage examination in serosa-invading gastric cancer patients. Surgery. 2010;148:96\u2013102.","journal-title":"Surgery"},{"issue":"Suppl 1","key":"2596_CR10","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1007\/s10120-011-0071-z","volume":"15","author":"PA Leake","year":"2012","unstructured":"Leake PA, Cardoso R, Seevaratnam R, et al. A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer. Gastric Cancer. 2012;15(Suppl 1):S27\u201337.","journal-title":"Gastric Cancer"},{"key":"2596_CR11","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1177\/0300891618792485","volume":"104","author":"U Ronellenfitsch","year":"2018","unstructured":"Ronellenfitsch U, Ernst K, Mertens C, et al. Extensive intraperitoneal lavage to eliminate intraperitoneal tumor cells in gastrectomy with D2 lymphadenectomy for gastric cancer. Tumori J. 2018;104:361\u20138.","journal-title":"Tumori J"},{"key":"2596_CR12","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jss.2018.10.049","volume":"235","author":"N Yepuri","year":"2018","unstructured":"Yepuri N, Bahary N, Jain A, et al. Review and update on the role of peritoneal cytology in the treatment of gastric cancer. J Surg Res. 2018;235:607\u201314.","journal-title":"J Surg Res"},{"key":"2596_CR13","doi-asserted-by":"crossref","unstructured":"Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2014 (ver. 4). Gastric Cancer 20(1): 1\u20139. 1 Jan 2017","DOI":"10.1007\/s10120-016-0622-4"},{"issue":"3","key":"2596_CR14","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s101200200029","volume":"5","author":"S Shimada","year":"2002","unstructured":"Shimada S, Tanaka E, Maratsuka T, et al. Extensive intraperative lavage and chemotherapy for gastric cancer patients with peritoneal free cancer cells. Gastric Cancer. 2002;5(3):168\u201372.","journal-title":"Gastric Cancer"},{"key":"2596_CR15","first-page":"678","volume":"9","author":"T Marutsuka","year":"2003","unstructured":"Marutsuka T, Shimada S, Shimori K, et al. Mechanisms of peritoneal metastasis after operation for non-serosa-invasive gastric cancer: an ultrarapid detection system for intraperitoneal free cancer cell and a prophylactic strategy for peritoneal metastasis. Clin Cancer Res. 2003;9:678\u201385.","journal-title":"Clin Cancer Res"},{"key":"2596_CR16","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/jjco\/hyw153","volume":"47","author":"G Kim","year":"2017","unstructured":"Kim G, Chen E, Tay AY, et al. Extensive peritoneal lavage after curative gastrectomy for gastric cancer (EXPEL): study protocol of an international multicenter randomized controlled trial. Jpn J Clin Oncol. 2017;47:179\u201384.","journal-title":"Jpn J Clin Oncol"},{"key":"2596_CR17","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1001\/jamasurg.2019.0153","volume":"154","author":"J Guo","year":"2019","unstructured":"Guo J, Xu A, Sun X, et al. Combined surgery and extensive intraoperative peritoneal lavage vs surgery alone for treatment of locally gastric cancer. The SEIPLUS randomized clinical trial. JAMA Surg. 2019;154:610\u20136.","journal-title":"JAMA Surg"},{"key":"2596_CR18","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1002\/bjs.11303","volume":"106","author":"K Misawa","year":"2019","unstructured":"Misawa K, Mochizuki Y, Sakai M, et al. Randomized clinical trial of extensive intraoperative peritoneal lavage versus standard treatment for resecable advanced gastric cancer (CCOG 1102 trial). BJS. 2019;106:1602\u201310.","journal-title":"BJS"},{"issue":"2","key":"2596_CR19","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/S2468-1253(20)30315-0","volume":"6","author":"HK Yang","year":"2021","unstructured":"Yang HK, Han SU, Terashima M, et al. Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicenter randomized controlled trial. Lancet Gastroenterol Hepatol. 2021;6(2):120\u20137.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2596_CR20","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.21873\/anticanres.12892","volume":"38","author":"E Virgilio","year":"2018","unstructured":"Virgilio E, Giarnieri E, Giovagnoli M, et al. Gastric Cancer cells in peritoneal lavage fluid: a systematic review comparing cytological with molecular detection for diagnosis of peritoneal metastases and prediction of peritoneal recurrences. Anticancer Res. 2018;38:1255\u201362.","journal-title":"Anticancer Res"},{"key":"2596_CR21","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.4103\/0973-1482.184518","volume":"14","author":"M Hasbahceci","year":"2018","unstructured":"Hasbahceci M, Akcakaya A, Guler B, et al. Use of peritoneal washing cytology for the detection of free peritoneal cancer cells before and after surgical treatment of gastric adenocarcinoma. J Can Res Ther. 2018;14:1225\u20139.","journal-title":"J Can Res Ther"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-021-02596-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-021-02596-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-021-02596-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T12:48:38Z","timestamp":1698842918000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-021-02596-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["2596"],"URL":"https:\/\/doi.org\/10.1007\/s12094-021-02596-8","relation":{},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"value":"1699-048X","type":"print"},{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"28 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors have any conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Clinical Trial Commitee of the the reference hospital (Hospital Universitary Mutua de Terrassa) and the ethics committees of each participating hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All candidates accepted to participate provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}