{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:58:05Z","timestamp":1790139485277,"version":"4.0.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s12094-021-02687-6","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T14:02:53Z","timestamp":1628863373000},"page":"2323-2334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["MiR-495-3p and miR-143-3p co-target CDK1 to inhibit the development of cervical cancer"],"prefix":"10.1007","volume":"23","author":[{"given":"J.","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-1982","authenticated-orcid":false,"given":"A.","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"issue":"7","key":"2687_CR1","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1002\/2211-5463.12869","volume":"10","author":"Y Dai","year":"2020","unstructured":"Dai Y, Xie F, Chen Y. Reduced levels of miR-485-5p in HPV-infected cervical cancer promote cell proliferation and enhance invasion ability. FEBS Open Bio. 2020;10(7):1348\u201361. https:\/\/doi.org\/10.1002\/2211-5463.12869.","journal-title":"FEBS Open Bio"},{"key":"2687_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-020-00290-y","author":"D Diouf","year":"2020","unstructured":"Diouf D, Diop G, Diarra CAT, Ngom AI, Niane K, Ndiaye M, et al. Systematic screening for cervical cancer in Dakar region: prevalence and correlation with biological and socio-demographic parameters. Infect Agent Cancer. 2020. https:\/\/doi.org\/10.1186\/s13027-020-00290-y.","journal-title":"Infect Agent Cancer"},{"key":"2687_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25899","author":"J Liu","year":"2020","unstructured":"Liu J, Shi Y, Wang L, Wang J, Fan D, Han S, et al. Epidemiology and persistence of cervical human papillomavirus infection among outpatient women in Heilongjiang province: A retrospective cohort study. J Med Virol. 2020. https:\/\/doi.org\/10.1002\/jmv.25899.","journal-title":"J Med Virol"},{"key":"2687_CR4","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S108094","author":"J Li","year":"2016","unstructured":"Li J, Zhou C, Zhou H, Bao T, Gao T, Jiang X, et al. The association between methylated CDKN2A and cervical carcinogenesis, and its diagnostic value in cervical cancer: a meta-analysis. Ther Clin Risk Manag. 2016. https:\/\/doi.org\/10.2147\/TCRM.S108094.","journal-title":"Ther Clin Risk Manag."},{"key":"2687_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.01.035","author":"N Yadav","year":"2020","unstructured":"Yadav N, Parveen S, Banerjee M. Potential of nano-phytochemicals in cervical cancer therapy. Clin Chim Acta. 2020. https:\/\/doi.org\/10.1016\/j.cca.2020.01.035.","journal-title":"Clin Chim Acta."},{"issue":"23","key":"2687_CR6","first-page":"4270","volume":"125","author":"D Ma","year":"2012","unstructured":"Ma D, Zhang YY, Guo YL, Li ZJ, Geng L. Profiling of microRNA-mRNA reveals roles of microRNAs in cervical cancer. Chin Med J (Engl). 2012;125(23):4270\u20136.","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"2687_CR7","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/dvdy.21047","volume":"236","author":"AE Williams","year":"2007","unstructured":"Williams AE, Moschos SA, Perry MM, Barnes PJ, Lindsay MA. Maternally imprinted microRNAs are differentially expressed during mouse and human lung development. Dev Dyn. 2007;236(2):572\u201380. https:\/\/doi.org\/10.1002\/dvdy.21047.","journal-title":"Dev Dyn"},{"issue":"1","key":"2687_CR8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/path.4994","volume":"244","author":"JW Eun","year":"2018","unstructured":"Eun JW, Kim HS, Shen Q, Yang HD, Kim SY, Yoon JH, et al. MicroRNA-495-3p functions as a tumor suppressor by regulating multiple epigenetic modifiers in gastric carcinogenesis. J Pathol. 2018;244(1):107\u201319. https:\/\/doi.org\/10.1002\/path.4994.","journal-title":"J Pathol"},{"key":"2687_CR9","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S193937","author":"G Zhao","year":"2019","unstructured":"Zhao G, Zhang L, Qian D, Sun Y, Liu W. miR-495\u20133p inhibits the cell proliferation, invasion and migration of osteosarcoma by targeting C1q\/TNF-related protein 3. Onco Targets Ther. 2019. https:\/\/doi.org\/10.2147\/OTT.S193937.","journal-title":"Onco Targets Ther"},{"key":"2687_CR10","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.2147\/CMAR.S226409","volume":"12","author":"X Gang","year":"2020","unstructured":"Gang X, Yuan M, Zhang J. Long Non-Coding RNA TMPO-AS1 Promotes cervical cancer cell proliferation, migration, and invasion by regulating miR-143\u20133p\/ZEB1 axis. Cancer Manag Res. 2020;12:1587\u201399. https:\/\/doi.org\/10.2147\/CMAR.S226409.","journal-title":"Cancer Manag Res"},{"issue":"5","key":"2687_CR11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1080\/15384047.2018.1423921","volume":"19","author":"M Liu","year":"2018","unstructured":"Liu M, Jia J, Wang X, Liu Y, Wang C, Fan R. Long non-coding RNA HOTAIR promotes cervical cancer progression through regulating BCL2 via targeting miR-143-3p. Cancer Biol Ther. 2018;19(5):391\u20139. https:\/\/doi.org\/10.1080\/15384047.2018.1423921.","journal-title":"Cancer Biol Ther"},{"issue":"10","key":"2687_CR12","doi-asserted-by":"publisher","first-page":"3826","DOI":"10.1073\/pnas.1115201109","volume":"109","author":"MK Diril","year":"2012","unstructured":"Diril MK, Ratnacaram CK, Padmakumar VC, Du T, Wasser M, Coppola V, et al. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci USA. 2012;109(10):3826\u201331. https:\/\/doi.org\/10.1073\/pnas.1115201109.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2687_CR13","doi-asserted-by":"publisher","first-page":"5835","DOI":"10.2147\/CMAR.S200907","volume":"11","author":"YR Deng","year":"2019","unstructured":"Deng YR, Chen XJ, Chen W, Wu LF, Jiang HP, Lin D, et al. Sp1 contributes to radioresistance of cervical cancer through targeting G2\/M cell cycle checkpoint CDK1. Cancer Manag Res. 2019;11:5835\u201344. https:\/\/doi.org\/10.2147\/CMAR.S200907.","journal-title":"Cancer Manag Res"},{"key":"2687_CR14","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.ijbiomac.2020.01.223","volume":"148","author":"L Li","year":"2020","unstructured":"Li L, Thakur K, Cao YY, Liao BY, Zhang JG, Wei ZJ. Anticancerous potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua in human cervical cancer hela cells. Int J Biol Macromol. 2020;148:843\u201350. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.01.223.","journal-title":"Int J Biol Macromol."},{"key":"2687_CR15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.gene.2017.07.046","volume":"628","author":"C Huang","year":"2017","unstructured":"Huang C, Huang J, Ma P, Yu G. microRNA-143 acts as a suppressor of hemangioma growth by targeting Bcl-2. Gene. 2017;628:211\u20137. https:\/\/doi.org\/10.1016\/j.gene.2017.07.046.","journal-title":"Gene"},{"issue":"11","key":"2687_CR16","doi-asserted-by":"publisher","first-page":"19582","DOI":"10.1002\/jcp.28557","volume":"234","author":"Z He","year":"2019","unstructured":"He Z, Dang J, Song A, Cui X, Ma Z, Zhang Z. NEAT1 promotes colon cancer progression through sponging miR-495-3p and activating CDK6 in vitro and in vivo. J Cell Physiol. 2019;234(11):19582\u201391. https:\/\/doi.org\/10.1002\/jcp.28557.","journal-title":"J Cell Physiol"},{"issue":"7","key":"2687_CR17","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1080\/15548627.2018.1458173","volume":"14","author":"B Han","year":"2018","unstructured":"Han B, Zhang Y, Zhang Y, Bai Y, Chen X, Huang R, et al. Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke. Autophagy. 2018;14(7):1164\u201384. https:\/\/doi.org\/10.1080\/15548627.2018.1458173.","journal-title":"Autophagy"},{"issue":"1","key":"2687_CR18","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s11845-015-1283-8","volume":"185","author":"Y Luo","year":"2016","unstructured":"Luo Y, Wu Y, Peng Y, Liu X, Bie J, Li S. Systematic analysis to identify a key role of CDK1 in mediating gene interaction networks in cervical cancer development. Ir J Med Sci. 2016;185(1):231\u20139. https:\/\/doi.org\/10.1007\/s11845-015-1283-8.","journal-title":"Ir J Med Sci"},{"issue":"10","key":"2687_CR19","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1080\/15384047.2016.1219818","volume":"17","author":"YF Chen","year":"2016","unstructured":"Chen YF, Cho JJ, Huang TH, Tseng CN, Huang EY, Cho CL. Downregulation of a novel human gene, ROGDI, increases radiosensitivity in cervical cancer cells. Cancer Biol Ther. 2016;17(10):1070\u20138. https:\/\/doi.org\/10.1080\/15384047.2016.1219818.","journal-title":"Cancer Biol Ther"},{"issue":"1","key":"2687_CR20","doi-asserted-by":"publisher","first-page":"e8883","DOI":"10.1590\/1414-431X20198883","volume":"53","author":"L Song","year":"2020","unstructured":"Song L, Wang L, Pan X, Yang C. lncRNA OIP5-AS1 targets ROCK1 to promote cell proliferation and inhibit cell apoptosis through a mechanism involving miR-143-3p in cervical cancer. Braz J Med Biol Res. 2020;53(1):e8883. https:\/\/doi.org\/10.1590\/1414-431X20198883.","journal-title":"Braz J Med Biol Res"},{"issue":"1","key":"2687_CR21","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1002\/jcb.27454","volume":"120","author":"J Yang","year":"2019","unstructured":"Yang J, Jiang B, Hai J, Duan S, Dong X, Chen C. Long noncoding RNA opa-interacting protein 5 antisense transcript 1 promotes proliferation and invasion through elevating integrin alpha6 expression by sponging miR-143-3p in cervical cancer. J Cell Biochem. 2019;120(1):907\u201316. https:\/\/doi.org\/10.1002\/jcb.27454.","journal-title":"J Cell Biochem"},{"issue":"3","key":"2687_CR22","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1002\/jcb.27539","volume":"120","author":"N Cui","year":"2019","unstructured":"Cui N, Liu J, Xia H, Xu D. LncRNA SNHG20 contributes to cell proliferation and invasion by upregulating ZFX expression sponging miR-495-3p in gastric cancer. J Cell Biochem. 2019;120(3):3114\u201323. https:\/\/doi.org\/10.1002\/jcb.27539.","journal-title":"J Cell Biochem"},{"key":"2687_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1477-7819-11-87","volume":"11","author":"SM Chen","year":"2013","unstructured":"Chen SM, Chen HC, Chen SJ, Huang CY, Chen PY, Wu TW, et al. MicroRNA-495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin-dependent kinase 6. World J Surg Oncol. 2013;11:87. https:\/\/doi.org\/10.1186\/1477-7819-11-87.","journal-title":"World J Surg Oncol."},{"key":"2687_CR24","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.molimm.2016.09.004","volume":"78","author":"W Cheng","year":"2016","unstructured":"Cheng W, Yan K, Xie LY, Chen F, Yu HC, Huang YX, et al. MiR-143\u20133p controls TGF-beta1-induced cell proliferation and extracellular matrix production in airway smooth muscle via negative regulation of the nuclear factor of activated T cells 1. Mol Immunol. 2016;78:133\u20139. https:\/\/doi.org\/10.1016\/j.molimm.2016.09.004.","journal-title":"Mol Immunol."},{"key":"2687_CR25","doi-asserted-by":"crossref","unstructured":"Zhu H DU, Mustafi R, et al. 679 Putative Tumor Suppressors miR-143 and miR-145 Inhibit HCT116 Colon Cancer Cell Growth in Tumor Xenografts, Roles of K-RAS, MYC, Ccnd2 and Cdk6. Gastroenterology. 2010;138(5-supp-S1):S\u201393.","DOI":"10.1016\/S0016-5085(10)60424-6"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-021-02687-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-021-02687-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-021-02687-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T13:42:25Z","timestamp":1632231745000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-021-02687-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["2687"],"URL":"https:\/\/doi.org\/10.1007\/s12094-021-02687-6","relation":{},"ISSN":["1699-048X","1699-3055"],"issn-type":[{"value":"1699-048X","type":"print"},{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]},"assertion":[{"value":"5 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have reported that no potential conflicts of interest exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study, under approval of Ethics Committee of Huzhou Central Hospital, was conducted with informed consent provided by all participants, strictly following the <i>Declaration of Helsinki<\/i>. The animal experiments was approved by the Animal Ethics Committee of Huzhou Central Hospital.<b>Informed consent<\/b> This study was conducted with informed consent from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}