{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:51:32Z","timestamp":1789789892401,"version":"4.0.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8187101983"],"award-info":[{"award-number":["8187101983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-022-02883-y","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T21:02:34Z","timestamp":1658610154000},"page":"2222-2230","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["IL-6 secretion of CD4+ T cells stimulated by LC3-positive extracellular vesicles in human epithelial ovarian cancer"],"prefix":"10.1007","volume":"24","author":[{"given":"Xiu-Lin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Ru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Ying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-1785","authenticated-orcid":false,"given":"Yun-lang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"issue":"5","key":"2883_CR1","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359\u201386. https:\/\/doi.org\/10.1002\/ijc.29210.","journal-title":"Int J Cancer"},{"issue":"3","key":"2883_CR2","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3978\/j.issn.2227-684X.2013.10.01","volume":"3","author":"VM Vargas-Hernandez","year":"2014","unstructured":"Vargas-Hernandez VM, Moreno-Eutimio MA, Acosta-Altamirano G, Vargas-Aguilar VM. Management of recurrent epithelial ovarian cancer. Gland Surg. 2014;3(3):198\u2013202. https:\/\/doi.org\/10.3978\/j.issn.2227-684X.2013.10.01.","journal-title":"Gland Surg"},{"issue":"6","key":"2883_CR3","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394\u2013424. https:\/\/doi.org\/10.3322\/caac.21492.","journal-title":"CA Cancer J Clin"},{"issue":"32","key":"2883_CR4","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1200\/JCO.18.02238","volume":"37","author":"CJ Del","year":"2019","unstructured":"Del CJ, Matulonis UA, Malander S, Provencher D, Mahner S, Follana P, et al. Niraparib maintenance therapy in patients with recurrent ovarian cancer after a partial response to the last platinum-based chemotherapy in the ENGOT-OV16\/NOVA trial. J Clin Oncol. 2019;37(32):2968\u201373. https:\/\/doi.org\/10.1200\/JCO.18.02238.","journal-title":"J Clin Oncol"},{"issue":"5","key":"2883_CR5","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/sj.bjc.6606092","volume":"104","author":"T Van Gorp","year":"2011","unstructured":"Van Gorp T, Cadron I, Despierre E, Daemen A, Leunen K, Amant F, et al. HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the risk of ovarian malignancy algorithm. Br J Cancer. 2011;104(5):863\u201370. https:\/\/doi.org\/10.1038\/sj.bjc.6606092.","journal-title":"Br J Cancer"},{"issue":"3","key":"2883_CR6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/nri.2015.18","volume":"16","author":"M DuPage","year":"2016","unstructured":"DuPage M, Bluestone JA. Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease. Nat Rev Immunol. 2016;16(3):149\u201363. https:\/\/doi.org\/10.1038\/nri.2015.18.","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"2883_CR7","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41577-018-0044-0","volume":"18","author":"J Borst","year":"2018","unstructured":"Borst J, Ahrends T, Babala N, Melief C, Kastenmuller W. CD4(+) T cell help in cancer immunology and immunotherapy. Nat Rev Immunol. 2018;18(10):635\u201347. https:\/\/doi.org\/10.1038\/s41577-018-0044-0.","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"2883_CR8","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1159\/000346707","volume":"5","author":"S Jiang","year":"2013","unstructured":"Jiang S, Dupont N, Castillo EF, Deretic V. Secretory versus degradative autophagy: unconventional secretion of inflammatory mediators. J Innate Immun. 2013;5(5):471\u20139. https:\/\/doi.org\/10.1159\/000346707.","journal-title":"J Innate Immun"},{"issue":"12","key":"2883_CR9","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/s41422-019-0246-4","volume":"29","author":"Z Yin","year":"2019","unstructured":"Yin Z, Liu X, Ariosa A, Huang H, Jin M, Karbstein K, et al. Psp2, a novel regulator of autophagy that promotes autophagy-related protein translation. Cell Res. 2019;29(12):994\u20131008. https:\/\/doi.org\/10.1038\/s41422-019-0246-4.","journal-title":"Cell Res"},{"issue":"3","key":"2883_CR10","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3390\/v10030139","volume":"10","author":"Y Mutsafi","year":"2018","unstructured":"Mutsafi Y, Altan-Bonnet N. Enterovirus transmission by secretory autophagy. Viruses. 2018;10(3):139. https:\/\/doi.org\/10.3390\/v10030139.","journal-title":"Viruses"},{"issue":"5","key":"2883_CR11","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1080\/15548627.2016.1159375","volume":"12","author":"SM Son","year":"2016","unstructured":"Son SM, Cha MY, Choi H, Kang S, Choi H, Lee MS, et al. Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. Autophagy. 2016;12(5):784\u2013800.","journal-title":"Autophagy"},{"issue":"7","key":"2883_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180892","volume":"12","author":"Y Yang","year":"2017","unstructured":"Yang Y, Qin M, Bao P, Xu W, Xu J. Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of alpha-synuclein via exosome. PLoS ONE. 2017;12(7): e180892. https:\/\/doi.org\/10.1371\/journal.pone.0180892.","journal-title":"PLoS ONE"},{"key":"2883_CR13","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3389\/fendo.2020.00266","volume":"11","author":"CD Gonzalez","year":"2020","unstructured":"Gonzalez CD, Resnik R, Vaccaro MI. Secretory autophagy and its relevance in metabolic and degenerative disease. Front Endocrinol (Lausanne). 2020;11:266. https:\/\/doi.org\/10.3389\/fendo.2020.00266.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2883_CR14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13024-015-0054-3","volume":"10","author":"SM Son","year":"2015","unstructured":"Son SM, Kang S, Choi H, Mook-Jung I. Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Mol Neurodegener. 2015;10:56. https:\/\/doi.org\/10.1186\/s13024-015-0054-3.","journal-title":"Mol Neurodegener"},{"key":"2883_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.586483","volume":"7","author":"S Padmanabhan","year":"2020","unstructured":"Padmanabhan S, Manjithaya R. Facets of autophagy based unconventional protein secretion-the road less traveled. Front Mol Biosci. 2020;7: 586483. https:\/\/doi.org\/10.3389\/fmolb.2020.586483.","journal-title":"Front Mol Biosci"},{"issue":"22","key":"2883_CR16","doi-asserted-by":"publisher","first-page":"7047","DOI":"10.1158\/1078-0432.CCR-11-0951","volume":"17","author":"Y Li","year":"2011","unstructured":"Li Y, Wang LX, Pang P, Cui Z, Aung S, Haley D, et al. Tumor-derived autophagosome vaccine: mechanism of cross-presentation and therapeutic efficacy. Clin Cancer Res. 2011;17(22):7047\u201357. https:\/\/doi.org\/10.1158\/1078-0432.CCR-11-0951.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"2883_CR17","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1180485","volume":"5","author":"M Zhou","year":"2016","unstructured":"Zhou M, Wen Z, Cheng F, Ma J, Li W, Ren H, et al. Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-kappaB signal pathway. Oncoimmunology. 2016;5(7): e1180485. https:\/\/doi.org\/10.1080\/2162402X.2016.1180485.","journal-title":"Oncoimmunology"},{"issue":"1","key":"2883_CR18","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s40425-019-0646-5","volume":"7","author":"YQ Chen","year":"2019","unstructured":"Chen YQ, Li PC, Pan N, Gao R, Wen ZF, Zhang TY, et al. Tumor-released autophagosomes induces CD4(+) T cell-mediated immunosuppression via a TLR2-IL-6 cascade. J Immunother Cancer. 2019;7(1):178. https:\/\/doi.org\/10.1186\/s40425-019-0646-5.","journal-title":"J Immunother Cancer"},{"issue":"6","key":"2883_CR19","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13309","volume":"84","author":"P Crispim","year":"2020","unstructured":"Crispim P, Jammal MP, Antao P, Micheli DC, Tavares-Murta BM, Murta E, et al. IL6, IL8, and IL10 in the distinction of malignant ovarian neoplasms and endometriomas. Am J Reprod Immunol. 2020;84(6): e13309. https:\/\/doi.org\/10.1111\/aji.13309.","journal-title":"Am J Reprod Immunol"},{"issue":"21","key":"2883_CR20","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1016\/j.jacc.2020.03.067","volume":"75","author":"V Narayan","year":"2020","unstructured":"Narayan V, Thompson EW, Demissei B, Ho JE, Januzzi JJ, Ky B. Mechanistic biomarkers informative of both cancer and cardiovascular disease: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75(21):2726\u201337. https:\/\/doi.org\/10.1016\/j.jacc.2020.03.067.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"2883_CR21","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","volume":"15","author":"DE Johnson","year":"2018","unstructured":"Johnson DE, O\u2019Keefe RA, Grandis JR. Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15(4):234\u201348. https:\/\/doi.org\/10.1038\/nrclinonc.2018.8.","journal-title":"Nat Rev Clin Oncol"},{"key":"2883_CR22","doi-asserted-by":"publisher","first-page":"8026494","DOI":"10.1155\/2016\/8026494","volume":"2016","author":"ZY Wang","year":"2016","unstructured":"Wang ZY, Zhang JA, Wu XJ, Liang YF, Lu YB, Gao YC, et al. IL-6 Inhibition reduces stat3 activation and enhances the antitumor effect of carboplatin. Mediators Inflamm. 2016;2016:8026494. https:\/\/doi.org\/10.1155\/2016\/8026494.","journal-title":"Mediators Inflamm"},{"key":"2883_CR23","doi-asserted-by":"publisher","first-page":"6685","DOI":"10.2147\/CMAR.S179189","volume":"10","author":"L Browning","year":"2018","unstructured":"Browning L, Patel MR, Horvath EB, Tawara K, Jorcyk CL. IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis. Cancer Manag Res. 2018;10:6685\u201393. https:\/\/doi.org\/10.2147\/CMAR.S179189.","journal-title":"Cancer Manag Res"},{"issue":"3","key":"2883_CR24","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1080\/01443615.2019.1633516","volume":"40","author":"CA de Lima","year":"2020","unstructured":"de Lima CA, Silva RI, Martins-Filho A, Cobo MD, Martins TB, Candido ME, et al. Cytokines in peritoneal fluid of ovarian neoplasms. J Obstet Gynaecol. 2020;40(3):401\u20135. https:\/\/doi.org\/10.1080\/01443615.2019.1633516.","journal-title":"J Obstet Gynaecol"},{"issue":"5","key":"2883_CR25","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1080\/08820139.2019.1691222","volume":"49","author":"I Rodrigues","year":"2020","unstructured":"Rodrigues I, Martins-Filho A, Micheli DC, Lima CA, Tavares-Murta BM, Murta E, et al. IL-6 and IL-8 as Prognostic Factors in Peritoneal Fluid of Ovarian Cancer. Immunol Invest. 2020;49(5):510\u201321. https:\/\/doi.org\/10.1080\/08820139.2019.1691222.","journal-title":"Immunol Invest"},{"issue":"1","key":"2883_CR26","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1038\/s41598-020-59009-z","volume":"10","author":"NC Kampan","year":"2020","unstructured":"Kampan NC, Madondo MT, Reynolds J, Hallo J, McNally OM, Jobling TW, et al. Pre-operative sera interleukin-6 in the diagnosis of high-grade serous ovarian cancer. Sci Rep. 2020;10(1):2213. https:\/\/doi.org\/10.1038\/s41598-020-59009-z.","journal-title":"Sci Rep"},{"issue":"1","key":"2883_CR27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s40425-018-0452-5","volume":"6","author":"ZF Wen","year":"2018","unstructured":"Wen ZF, Liu H, Gao R, Zhou M, Ma J, Zhang Y, et al. Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1. J Immunother Cancer. 2018;6(1):151. https:\/\/doi.org\/10.1186\/s40425-018-0452-5.","journal-title":"J Immunother Cancer"},{"issue":"1","key":"2883_CR28","doi-asserted-by":"publisher","first-page":"3996","DOI":"10.1038\/s41467-018-06178-1","volume":"9","author":"YC Wang","year":"2018","unstructured":"Wang YC, Wu YS, Hung CY, Wang SA, Young MJ, Hsu TI, et al. USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and beta-TrCP and promotes cancer malignancy. Nat Commun. 2018;9(1):3996. https:\/\/doi.org\/10.1038\/s41467-018-06178-1.","journal-title":"Nat Commun"},{"issue":"8","key":"2883_CR29","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1073\/pnas.1819728116","volume":"116","author":"Z Wu","year":"2019","unstructured":"Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, et al. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proc Natl Acad Sci U S A. 2019;116(8):2996\u20133005. https:\/\/doi.org\/10.1073\/pnas.1819728116.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2883_CR30","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1424612","volume":"7","author":"CC Chen","year":"2018","unstructured":"Chen CC, Chen LL, Li CP, Hsu YT, Jiang SS, Fan CS, et al. Myeloid-derived macrophages and secreted HSP90alpha induce pancreatic ductal adenocarcinoma development. Oncoimmunology. 2018;7(5): e1424612. https:\/\/doi.org\/10.1080\/2162402X.2018.1424612.","journal-title":"Oncoimmunology"},{"issue":"13","key":"2883_CR31","doi-asserted-by":"publisher","first-page":"9001","DOI":"10.1074\/jbc.M112.437897","volume":"288","author":"WS Chen","year":"2013","unstructured":"Chen WS, Chen CC, Chen LL, Lee CC, Huang TS. Secreted heat shock protein 90alpha (HSP90alpha) induces nuclear factor-kappaB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion. J Biol Chem. 2013;288(13):9001\u201310. https:\/\/doi.org\/10.1074\/jbc.M112.437897.","journal-title":"J Biol Chem"},{"issue":"6","key":"2883_CR32","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1438108","volume":"7","author":"R Gao","year":"2018","unstructured":"Gao R, Ma J, Wen Z, Yang P, Zhao J, Xue M, et al. Tumor cell-released autophagosomes (TRAP) enhance apoptosis and immunosuppressive functions of neutrophils. Oncoimmunology. 2018;7(6): e1438108. https:\/\/doi.org\/10.1080\/2162402X.2018.1438108.","journal-title":"Oncoimmunology"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-022-02883-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-022-02883-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-022-02883-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T20:00:03Z","timestamp":1664481603000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-022-02883-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,23]]},"references-count":32,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["2883"],"URL":"https:\/\/doi.org\/10.1007\/s12094-022-02883-y","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,23]]},"assertion":[{"value":"4 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the human experiments were approved by the Ethics Committee for Human Studies of Southeast University and performed under protocol 2019ZDSYLL021.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all the patients","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}