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Late vaginal complications were evaluated using objective LENT-SOMA criteria. Statistics: descriptive analysis, Chi-square, Fisher and Student tests were applied. Univariate and multivariate analyses were performed with the Baptista\u2013Pike exact method and multiple logistic regression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean age was 65\u00a0years (SD\u2009\u00b1\u200910), and median follow-up was 66\u00a0months (8\u2013104). 19\/126 patients (15%) showed G2-late vaginal complications, and 107\/126 (85%) G0\u2013G1. Univariate analysis showed: CTV\u2009\u2264\u20099\u00a0cm<jats:sup>3<\/jats:sup> (<jats:italic>p<\/jats:italic>\u2009=\u20090.036), use of dilators\u2009&lt;\u20099\u00a0months (<jats:italic>p<\/jats:italic>\u2009=\u20090.015), and total\u2009\u2265\u200968\u00a0Gy EQD2 received by 2\u00a0cm<jats:sup>3<\/jats:sup> of CTV (<jats:italic>p<\/jats:italic>\u2009=\u20090.039) were associated with G2-late vaginal toxicity. Multivariate analysis showed the use of dilators\u2009&lt;\u20099\u00a0months as an independent prognostic factor for G2-late vaginal toxicity (<jats:italic>p<\/jats:italic>\u2009=\u20090.043, OR 8.59, CI 1.59\u2013159.9).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The use of dilators\u2009&lt;\u20099\u00a0months in VBT\u2009\u00b1\u2009EBRT for PEC was an independent prognostic factor for G2-late vaginal toxicity. The use of vaginal dilators\u2009\u2265\u20099\u00a0months requires further analysis in studies evaluating late vaginal toxicity.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s12094-023-03099-4","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T23:36:03Z","timestamp":1675899363000},"page":"1748-1755","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vaginal dilator use more than 9 months is a main prognostic factor for reducing G2\u2011late vaginal complications in 3D\u2011vaginal\u2011cuff brachytherapy (interventional radiotherapy)?"],"prefix":"10.1007","volume":"25","author":[{"given":"Yaowen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faegheh","family":"Noorian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Abellana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Rochera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Herreros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Antelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Lancellotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Tagliaferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aureli","family":"Torne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-334X","authenticated-orcid":false,"given":"Angeles","family":"Rovirosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"3099_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/annonc\/mdv484","volume":"27","author":"N Colombo","year":"2016","unstructured":"Colombo N, Creutzberg C, Amant F, Bosse T, Gonz\u00e1lez-Mart\u00edn A, Ledermann J, et al. 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