{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:27:25Z","timestamp":1776068845796,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800192"],"award-info":[{"award-number":["81800192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200887"],"award-info":[{"award-number":["82200887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008868","name":"Science and Technology Department of Jiangsu Province","doi-asserted-by":"crossref","award":["BK20220716"],"award-info":[{"award-number":["BK20220716"]}],"id":[{"id":"10.13039\/501100008868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M711404"],"award-info":[{"award-number":["2022M711404"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-023-03280-9","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T02:02:15Z","timestamp":1689645735000},"page":"613-622","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low T3 syndrome as a predictor of poor prognosis in peripheral T-cell lymphomas"],"prefix":"10.1007","volume":"26","author":[{"given":"Wenyi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiazhu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haorui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-7477","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"issue":"20","key":"3280_CR1","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms [J]. Blood. 2016;127(20):2375\u201390.","journal-title":"Blood"},{"issue":"6","key":"3280_CR2","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41568-020-0247-0","volume":"20","author":"D Fiore","year":"2020","unstructured":"Fiore D, Cappelli LV, Broccoli A, Zinzani PL, Chan WC, Inghirami G. Peripheral T cell lymphomas: from the bench to the clinic [J]. Nat Rev Cancer. 2020;20(6):323\u201342.","journal-title":"Nat Rev Cancer"},{"issue":"8","key":"3280_CR3","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s40618-020-01482-4","volume":"44","author":"E Fliers","year":"2021","unstructured":"Fliers E, Boelen A. An update on non-thyroidal illness syndrome [J]. J Endocrinol Investig. 2021;44(8):1597\u2013607.","journal-title":"J Endocrinol Investig"},{"issue":"10","key":"3280_CR4","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/S2213-8587(15)00225-9","volume":"3","author":"E Fliers","year":"2015","unstructured":"Fliers E, Bianco AC, Langouche L, Boelen A. Thyroid function in critically ill patients [J]. Lancet Diabetes Endocrinol. 2015;3(10):816\u201325.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"3280_CR5","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1210\/er.2011-0007","volume":"32","author":"A Boelen","year":"2011","unstructured":"Boelen A, Kwakkel J, Fliers E. Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection [J]. Endocr Rev. 2011;32(5):670\u201393.","journal-title":"Endocr Rev"},{"key":"3280_CR6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ijsu.2018.02.001","volume":"51","author":"H Ren","year":"2018","unstructured":"Ren H, Ren J, Wang G, Hong Z, Gu G, Chen J, et al. The non-thyroidal illness syndrome is associated with postoperative surgical site infections in enterocutaneous fistulae [J]. Int J Surg. 2018;51:213\u20137.","journal-title":"Int J Surg"},{"issue":"16","key":"3280_CR7","doi-asserted-by":"publisher","first-page":"6385","DOI":"10.18632\/aging.102195","volume":"11","author":"GQ Huang","year":"2019","unstructured":"Huang GQ, Zeng YY, Cheng QQ, Cheng HR, Ruan YT, Yuan CX, et al. Low triiodothyronine syndrome is associated with hemorrhagic transformation in patients with acute ischaemic stroke [J]. Aging (Albany NY). 2019;11(16):6385\u201397.","journal-title":"Aging (Albany NY)"},{"key":"3280_CR8","doi-asserted-by":"publisher","unstructured":"Chen H, Xu M, Huang Y, He J, Ren W. Low triiodothyronine syndrome is associated with stroke-associated pneumonia [J]. Eur J Clin Invest. 2022;52(11):e13840. https:\/\/doi.org\/10.1111\/eci.13840.","DOI":"10.1111\/eci.13840"},{"key":"3280_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.571765","volume":"12","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Wang W, Zhang K, Tang YD. Association between low T3 syndrome and poor prognosis in adult patients with acute myocarditis [J]. Front Endocrinol (Lausanne). 2021;12: 571765.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"3280_CR10","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jjcc.2018.02.013","volume":"72","author":"W Su","year":"2018","unstructured":"Su W, Zhao XQ, Wang M, Chen H, Li HW. Low T3 syndrome improves risk prediction of in-hospital cardiovascular death in patients with acute myocardial infarction [J]. J Cardiol. 2018;72(3):215\u20139.","journal-title":"J Cardiol"},{"issue":"3","key":"3280_CR11","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.cardfail.2019.01.007","volume":"25","author":"Y Sato","year":"2019","unstructured":"Sato Y, Yoshihisa A, Kimishima Y, Kiko T, Kanno Y, Yokokawa T, et al. Low T3 syndrome is associated with high mortality in hospitalized patients with heart failure [J]. J Card Fail. 2019;25(3):195\u2013203.","journal-title":"J Card Fail"},{"key":"3280_CR12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ijsu.2019.08.019","volume":"70","author":"H Xiong","year":"2019","unstructured":"Xiong H, Yan P, Huang Q, Shuai T, Liu J, Zhu L, et al. A prognostic role for non-thyroidal illness syndrome in chronic renal failure: a systematic review and meta-analysis [J]. Int J Surg. 2019;70:44\u201352.","journal-title":"Int J Surg"},{"key":"3280_CR13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fendo.2018.00097","volume":"9","author":"B Ruiz-Nunez","year":"2018","unstructured":"Ruiz-Nunez B, Tarasse R, Vogelaar EF, Janneke Dijck-Brouwer DA, Muskiet FAJ. Higher prevalence of \u201cLow T3 Syndrome\u201d in patients with chronic fatigue syndrome: a case\u2013control study [J]. Front Endocrinol (Lausanne). 2018;9:97.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3280_CR14","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3389\/fendo.2019.00541","volume":"10","author":"J Xu","year":"2019","unstructured":"Xu J, Wang L. Low T3 syndrome as a predictor of poor prognosis in patients with pyogenic liver abscess [J]. Front Endocrinol (Lausanne). 2019;10:541.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"3280_CR15","doi-asserted-by":"publisher","first-page":"22271","DOI":"10.1038\/srep22271","volume":"6","author":"J Liu","year":"2016","unstructured":"Liu J, Wu X, Lu F, Zhao L, Shi L, Xu F. Low T3 syndrome is a strong predictor of poor outcomes in patients with community-acquired pneumonia [J]. Sci Rep. 2016;6:22271.","journal-title":"Sci Rep"},{"issue":"5","key":"3280_CR16","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1530\/eje.0.1510557","volume":"151","author":"E Scoscia","year":"2004","unstructured":"Scoscia E, Baglioni S, Eslami A, Iervasi G, Monti S, Todisco T. Low triiodothyronine (T3) state: a predictor of outcome in respiratory failure? Results of a clinical pilot study [J]. Eur J Endocrinol. 2004;151(5):557\u201360.","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"3280_CR17","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1007\/s40618-021-01599-0","volume":"44","author":"R Baldelli","year":"2021","unstructured":"Baldelli R, Nicastri E, Petrosillo N, Marchioni L, Gubbiotti A, Sperduti I, et al. Thyroid dysfunction in COVID-19 patients [J]. J Endocrinol Investig. 2021;44(12):2735\u20139.","journal-title":"J Endocrinol Investig"},{"issue":"4","key":"3280_CR18","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s40618-021-01714-1","volume":"45","author":"C Sparano","year":"2022","unstructured":"Sparano C, Zago E, Morettini A, Nozzoli C, Yannas D, Adornato V, et al. Euthyroid sick syndrome as an early surrogate marker of poor outcome in mild SARS-CoV-2 disease [J]. J Endocrinol Investig. 2022;45(4):837\u201347.","journal-title":"J Endocrinol Investig"},{"issue":"12","key":"3280_CR19","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1515\/cclm-2021-0805","volume":"59","author":"M Llamas","year":"2021","unstructured":"Llamas M, Garo ML, Giovanella L. Low free-T3 serum levels and prognosis of COVID-19: systematic review and meta-analysis [J]. Clin Chem Lab Med. 2021;59(12):1906\u201313.","journal-title":"Clin Chem Lab Med"},{"key":"3280_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.566439","volume":"11","author":"R Zou","year":"2020","unstructured":"Zou R, Wu C, Zhang S, Wang G, Zhang Q, Yu B, et al. Euthyroid sick syndrome in patients with COVID-19 [J]. Front Endocrinol (Lausanne). 2020;11: 566439.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"3280_CR21","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s12967-021-02805-6","volume":"19","author":"S Sciacchitano","year":"2021","unstructured":"Sciacchitano S, De Vitis C, D\u2019Ascanio M, Giovagnoli S, De Dominicis C, Laghi A, et al. Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting low T3 syndrome and coexistent hematological malignancies [J]. J Transl Med. 2021;19(1):139.","journal-title":"J Transl Med"},{"issue":"5","key":"3280_CR22","doi-asserted-by":"publisher","first-page":"8648","DOI":"10.18632\/oncotarget.14376","volume":"8","author":"A Bunevicius","year":"2017","unstructured":"Bunevicius A, Deltuva VP, Tamasauskas S, Smith T, Laws ER, Bunevicius R, et al. Preoperative low tri-iodothyronine concentration is associated with worse health status and shorter five year survival of primary brain tumor patients [J]. Oncotarget. 2017;8(5):8648\u201356.","journal-title":"Oncotarget"},{"issue":"4","key":"3280_CR23","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/s12672-014-0183-0","volume":"5","author":"ZA Yasar","year":"2014","unstructured":"Yasar ZA, Kirakli C, Yilmaz U, Ucar ZZ, Talay F. Can non-thyroid illness syndrome predict mortality in lung cancer patients? A prospective cohort study [J]. Horm Cancer. 2014;5(4):240\u20136.","journal-title":"Horm Cancer"},{"issue":"1","key":"3280_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/bjh.14528","volume":"177","author":"R Gao","year":"2017","unstructured":"Gao R, Liang JH, Wang L, Zhu HY, Wu W, Wu JZ, et al. Low T3 syndrome is a strong prognostic predictor in diffuse large B cell lymphoma [J]. Br J Haematol. 2017;177(1):95\u2013105.","journal-title":"Br J Haematol"},{"issue":"3","key":"3280_CR25","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/ijc.31327","volume":"143","author":"R Gao","year":"2018","unstructured":"Gao R, Chen RZ, Xia Y, Liang JH, Wang L, Zhu HY, et al. Low T3 syndrome as a predictor of poor prognosis in chronic lymphocytic leukemia [J]. Int J Cancer. 2018;143(3):466\u201377.","journal-title":"Int J Cancer"},{"issue":"7","key":"3280_CR26","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms [J]. Leukemia. 2022;36(7):1720\u201348.","journal-title":"Leukemia"},{"issue":"12","key":"3280_CR27","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.jagp.2018.07.007","volume":"26","author":"H Chen","year":"2018","unstructured":"Chen H, Wu Y, Huang G, He W, Lin S, Zhang X, et al. Low tri-iodothyronine syndrome is associated with cognitive impairment in patients with acute ischemic stroke: a prospective cohort study [J]. Am J Geriatr Psychiatry. 2018;26(12):1222\u201330.","journal-title":"Am J Geriatr Psychiatry"},{"key":"3280_CR28","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1186\/1471-2407-13-334","volume":"13","author":"J Huang","year":"2013","unstructured":"Huang J, Jin L, Ji G, Xing L, Xu C, Xiong X, et al. Implication from thyroid function decreasing during chemotherapy in breast cancer patients: chemosensitization role of triiodothyronine [J]. BMC Cancer. 2013;13:334.","journal-title":"BMC Cancer"},{"key":"3280_CR29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.pharmthera.2017.02.012","volume":"173","author":"A Mendoza","year":"2017","unstructured":"Mendoza A, Hollenberg AN. New insights into thyroid hormone action [J]. Pharmacol Ther. 2017;173:135\u201345.","journal-title":"Pharmacol Ther"},{"key":"3280_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.850328","volume":"13","author":"S Sciacchitano","year":"2022","unstructured":"Sciacchitano S, Capalbo C, Napoli C, Anibaldi P, Salvati V, De Vitis C, et al. Nonthyroidal illness syndrome: to treat or not to treat? have we answered the question? A review of metanalyses [J]. Front Endocrinol (Lausanne). 2022;13: 850328.","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-023-03280-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-023-03280-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-023-03280-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T09:16:13Z","timestamp":1707988573000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-023-03280-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,18]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["3280"],"URL":"https:\/\/doi.org\/10.1007\/s12094-023-03280-9","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,18]]},"assertion":[{"value":"18 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University. All aspects of this study, including the measurement of serum thyroid hormone levels such as serum free T3 (FT3), free T4 (FT4) and TSH, and other clinical and laboratorial checkups, were performed in accordance with the principles of the Declaration of Helsinki (64th, 2013).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"All persons gave their informed consent prior to their inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}