{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:52:22Z","timestamp":1793418742359,"version":"4.5.0"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100015068","name":"Universidade de Santiago de Compostela","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015068","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aim to provide an overview of the research available on indoor radon and lung cancer, with a special focus on Spanish investigations. Early studies on underground miners established the link between radon and lung cancer, which was later confirmed for the general population by residential case\u2013control studies. Spain contributed with extensive evidence, including 5 multicentric, hospital-based, case\u2013control studies in the last 30 years, exploring diverse aspects, such as radon's effect on never-smokers, molecular pathways linking radon exposure to lung cancer risk, survival rates, mortality burden, and occupational exposure. There is a well-established causal association between radon with lung cancer. Despite pioneering research performed in our country by the Galician Radon Laboratory, particularly on driver genes, the evidence on the potential molecular pathways which makes radon a carcinogen is sparse. Also, relevant questions on the potential association of radon exposure with the induction of other diseases are still pending.<\/jats:p>","DOI":"10.1007\/s12094-023-03308-0","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T11:01:48Z","timestamp":1692788508000},"page":"3357-3368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["An overview on the relationship between residential radon and lung cancer: what we know and future research"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-7453","authenticated-orcid":false,"given":"Alberto","family":"Ruano-Ravina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4641-2129","authenticated-orcid":false,"given":"Lucia","family":"Martin-Gisbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-1600","authenticated-orcid":false,"given":"Karl","family":"Kelsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4456-6631","authenticated-orcid":false,"given":"M\u00f3nica","family":"P\u00e9rez-R\u00edos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1703-3592","authenticated-orcid":false,"given":"Cristina","family":"Candal-Pedreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-8437","authenticated-orcid":false,"given":"Julia","family":"Rey-Brandariz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-7961","authenticated-orcid":false,"given":"Leonor","family":"Varela-Lema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"3308_CR1","unstructured":"World Health Organization, editor. WHO handbook on indoor radon: a public health perspective. Geneva, Switzerland: World Health Organization; 2009. p. 94."},{"key":"3308_CR2","unstructured":"Radon. In: IARC Monogr Eval Carcinog Risks Hum. Lyon, France: International Agency for Research on Cancer; 1988. p. 43: 173\u2013259. (Monographies Evaluating Carcinogenic Risks to Humans)."},{"key":"3308_CR3","unstructured":"Environmental Protection Agency. Radon Reference Manual. 1987. Report No.: EPA 520\/1-87-20."},{"issue":"4","key":"3308_CR4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/oxfordjournals.rpd.a006512","volume":"94","author":"J Porstend\u00f6rfer","year":"2001","unstructured":"Porstend\u00f6rfer J. Physical parameters and dose factors of the radon and thoron decay products. Radiat Prot Dosimetry. 2001;94(4):365\u201373.","journal-title":"Radiat Prot Dosimetry"},{"issue":"3\u20134","key":"3308_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/0146645317734963","volume":"46","author":"F Paquet","year":"2017","unstructured":"Paquet F, Bailey MR, Leggett RW, Lipsztein J, Marsh J, Fell TP, et al. ICRP publication 137: occupational intakes of radionuclides: part 3. Ann ICRP. 2017;46(3\u20134):1\u2013486.","journal-title":"Ann ICRP"},{"key":"3308_CR6","unstructured":"Environmental Protection Agency. [cited 2023 Apr 7]. Available from: https:\/\/www.epa.gov\/radiation\/radiation-sources-and-doses."},{"issue":"2","key":"3308_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/EDE.0000000000001148","volume":"31","author":"A Ruano-Ravina","year":"2020","unstructured":"Ruano-Ravina A, Wakeford R. The increasing exposure of the global population to ionizing radiation. Epidemiol Camb Mass. 2020;31(2):155\u20139.","journal-title":"Epidemiol Camb Mass"},{"key":"3308_CR8","unstructured":"Different Scientific Societies. Image Gently [Internet]. [cited 2023 Jul 16]. Available from: http:\/\/www.imagegently.org\/."},{"issue":"3","key":"3308_CR9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"3308_CR10","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.recesp.2020.10.018","volume":"75","author":"J Rey","year":"2022","unstructured":"Rey J, P\u00e9rez-R\u00edos M, Santiago-P\u00e9rez MI, Gal\u00e1n I, Schiaffino A, Varela-Lema L, et al. Smoking-attributable mortality in the autonomous communities of Spain, 2017. Rev Espanola Cardiol Engl Ed. 2022;75(2):150\u20138.","journal-title":"Rev Espanola Cardiol Engl Ed"},{"issue":"6","key":"3308_CR11","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1093\/eurpub\/ckac165","volume":"32","author":"J Rey-Brandariz","year":"2022","unstructured":"Rey-Brandariz J, P\u00e9rez-R\u00edos M, Santiago-P\u00e9rez MI, Gal\u00e1n I, Schiaffino A, Varela-Lema L, et al. Trends in smoking-attributable mortality in Spain: 1990\u20132018. Eur J Public Health. 2022;32(6):919\u201325.","journal-title":"Eur J Public Health"},{"issue":"1\u20132","key":"3308_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/rpd\/ncu281","volume":"164","author":"L Walsh","year":"2015","unstructured":"Walsh L, Grosche B, Schnelzer M, Tschense A, Sogl M, Kreuzer M. A review of the results from the German Wismut uranium miners cohort. Radiat Prot Dosimetry. 2015;164(1\u20132):147\u201353.","journal-title":"Radiat Prot Dosimetry"},{"issue":"6","key":"3308_CR13","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1093\/aje\/kwn406","volume":"169","author":"MK Schubauer-Berigan","year":"2009","unstructured":"Schubauer-Berigan MK, Daniels RD, Pinkerton LE. Radon exposure and mortality among white and American Indian uranium miners: an update of the Colorado Plateau cohort. Am J Epidemiol. 2009;169(6):718\u201330.","journal-title":"Am J Epidemiol"},{"issue":"2","key":"3308_CR14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/oemed-2021-107392","volume":"79","author":"K Kelly-Reif","year":"2022","unstructured":"Kelly-Reif K, Sandler DP, Shore D, Schubauer-Berigan M, Troester M, Nylander-French L, et al. Lung and extrathoracic cancer incidence among underground uranium miners exposed to radon progeny in the P\u0159\u00edbram region of the Czech Republic: a case-cohort study. Occup Environ Med. 2022;79(2):102\u20138.","journal-title":"Occup Environ Med"},{"key":"3308_CR15","unstructured":"National Research Council. Health Effects of Exposure to Radon (BEIR VI). 1999."},{"issue":"11","key":"3308_CR16","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1093\/oxfordjournals.aje.a010153","volume":"151","author":"RW Field","year":"2000","unstructured":"Field RW, Steck DJ, Smith BJ, Brus CP, Fisher EL, Neuberger JS, et al. Residential radon gas exposure and lung cancer: the Iowa Radon Lung Cancer Study. Am J Epidemiol. 2000;151(11):1091\u2013102.","journal-title":"Am J Epidemiol"},{"issue":"4","key":"3308_CR17","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1093\/oxfordjournals.aje.a117253","volume":"140","author":"EG L\u00e9tourneau","year":"1994","unstructured":"L\u00e9tourneau EG, Krewski D, Choi NW, Goddard MJ, McGregor RG, Zielinski JM, et al. Case\u2013control study of residential radon and lung cancer in Winnipeg, Manitoba, Canada. Am J Epidemiol. 1994;140(4):310\u201322.","journal-title":"Am J Epidemiol"},{"issue":"14","key":"3308_CR18","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1093\/jnci\/88.14.966","volume":"88","author":"A Auvinen","year":"1996","unstructured":"Auvinen A, M\u00e4kel\u00e4inen I, Hakama M, Castr\u00e9n O, Pukkala E, Reisbacka H, et al. Indoor radon exposure and risk of lung cancer: a nested case\u2013control study in Finland. J Natl Cancer Inst. 1996;88(14):966\u201372.","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"3308_CR19","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1093\/aje\/kwf070","volume":"156","author":"JM Barros-Dios","year":"2002","unstructured":"Barros-Dios JM, Barreiro MA, Ruano-Ravina A, Figueiras A. Exposure to residential radon and lung cancer in Spain: a population-based case\u2013control study. Am J Epidemiol. 2002;156(6):548\u201355.","journal-title":"Am J Epidemiol"},{"issue":"7485","key":"3308_CR20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1136\/bmj.38308.477650.63","volume":"330","author":"S Darby","year":"2005","unstructured":"Darby S, Hill D, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, et al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case\u2013control studies. BMJ. 2005;330(7485):223.","journal-title":"BMJ"},{"issue":"Suppl 1","key":"3308_CR21","first-page":"1","volume":"32","author":"S Darby","year":"2006","unstructured":"Darby S, Hill D, Deo H, Auvinen A, Barros-Dios JM, Baysson H, et al. Residential radon and lung cancer\u2013detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 persons without lung cancer from 13 epidemiologic studies in Europe. Scand J Work Environ Health. 2006;32(Suppl 1):1\u201383.","journal-title":"Scand J Work Environ Health"},{"key":"3308_CR22","unstructured":"Uni\u00f3n Europea. Council Directive 2013\/59\/Euratom laying down basic safety standards for protection against the dangers arising from exposure to ionising radiation [Internet]. Jan 17, 2014. Available from: https:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2014:013:0001:0073:EN:PDF."},{"issue":"2","key":"3308_CR23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/01.ede.0000152522.80261.e3","volume":"16","author":"D Krewski","year":"2005","unstructured":"Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS, Field RW, et al. Residential radon and risk of lung cancer: a combined analysis of 7 North American case\u2013control studies. Epidemiol Camb Mass. 2005;16(2):137\u201345.","journal-title":"Epidemiol Camb Mass"},{"key":"3308_CR24","doi-asserted-by":"crossref","unstructured":"Barros-Dios JM, Ruano-Ravina A, P\u00e9rez-R\u00edos M, Castro-Bern\u00e1rdez M, Abal-Arca J, Tojo-Castro M. Residential radon exposure, histologic types, and lung cancer risk. A case\u2013control study in Galicia, Spain. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 2012;21(6):951\u20138.","DOI":"10.1158\/1055-9965.EPI-12-0146-T"},{"issue":"4","key":"3308_CR25","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1183\/09031936.00017114","volume":"44","author":"M Torres-Dur\u00e1n","year":"2014","unstructured":"Torres-Dur\u00e1n M, Ruano-Ravina A, Parente-Lamelas I, Leiro-Fern\u00e1ndez V, Abal-Arca J, Montero-Mart\u00ednez C, et al. Lung cancer in never-smokers: a case\u2013control study in a radon-prone area (Galicia, Spain). Eur Respir J. 2014;44(4):994\u20131001.","journal-title":"Eur Respir J"},{"key":"3308_CR26","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.envres.2019.03.011","volume":"172","author":"M Lorenzo-Gonz\u00e1lez","year":"2019","unstructured":"Lorenzo-Gonz\u00e1lez M, Ruano-Ravina A, Torres-Dur\u00e1n M, Kelsey KT, Provencio M, Parente-Lamelas I, et al. Lung cancer and residential radon in never-smokers: a pooling study in the Northwest of Spain. Environ Res. 2019;172:713\u20138.","journal-title":"Environ Res"},{"issue":"8","key":"3308_CR27","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3109\/09553002.2015.1047985","volume":"91","author":"M Torres-Dur\u00e1n","year":"2015","unstructured":"Torres-Dur\u00e1n M, Ruano-Ravina A, Parente-Lamelas I, Leiro-Fern\u00e1ndez V, Abal-Arca J, Montero-Mart\u00ednez C, et al. Residential radon and lung cancer characteristics in never smokers. Int J Radiat Biol. 2015;91(8):605\u201310.","journal-title":"Int J Radiat Biol"},{"issue":"4","key":"3308_CR28","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.arbres.2021.07.006","volume":"58","author":"JR Enjo-Barreiro","year":"2022","unstructured":"Enjo-Barreiro JR, Ruano-Ravina A, P\u00e9rez-R\u00edos M, Kelsey K, Varela-Lema L, Torres-Dur\u00e1n M, et al. Radon, tobacco exposure and non-small cell lung cancer risk related to BER and NER genetic polymorphisms. Arch Bronconeumol. 2022;58(4):311\u201322.","journal-title":"Arch Bronconeumol"},{"key":"3308_CR29","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Mart\u00ednez \u00c1, Ruano-Ravina A, Torres-Dur\u00e1n M, Provencio M, Parente-Lamelas I, Vidal-Garc\u00eda I, et al. Residential Radon and Small Cell Lung Cancer. Final Results of the Small Cell Study. Arch Bronconeumol. 2021 Feb 13;","DOI":"10.1016\/j.arbres.2021.01.027"},{"issue":"3","key":"3308_CR30","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1183\/13993003.01524-2015","volume":"47","author":"M Torres-Dur\u00e1n","year":"2016","unstructured":"Torres-Dur\u00e1n M, Ruano-Ravina A, Kelsey KT, Parente-Lamelas I, Provencio M, Leiro-Fern\u00e1ndez V, et al. Small cell lung cancer in never-smokers. Eur Respir J. 2016;47(3):947\u201353.","journal-title":"Eur Respir J"},{"issue":"2","key":"3308_CR31","doi-asserted-by":"publisher","first-page":"100059","DOI":"10.1016\/j.esmoop.2021.100059","volume":"6","author":"M Torres-Dur\u00e1n","year":"2021","unstructured":"Torres-Dur\u00e1n M, Curiel-Garc\u00eda MT, Ruano-Ravina A, Provencio M, Parente-Lamelas I, Hern\u00e1ndez-Hern\u00e1ndez J, et al. Small-cell lung cancer in never-smokers. ESMO Open. 2021;6(2):100059.","journal-title":"ESMO Open"},{"issue":"3","key":"3308_CR32","doi-asserted-by":"publisher","first-page":"e224837","DOI":"10.1001\/jamanetworkopen.2022.4837","volume":"5","author":"A Ruano-Ravi\u00f1a","year":"2022","unstructured":"Ruano-Ravi\u00f1a A, Provencio-Pulla M, P\u00e9rez-R\u00edos M. Small cell lung cancer\u2014a neglected disease with more data needed. JAMA Netw Open. 2022;5(3):e224837.","journal-title":"JAMA Netw Open"},{"issue":"1","key":"3308_CR33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/annonc\/mdm395","volume":"19","author":"A Ruano-Ravina","year":"2008","unstructured":"Ruano-Ravina A, P\u00e9rez-Becerra R, Fraga M, Kelsey KT, Barros-Dios JM. Analysis of the relationship between p53 immunohistochemical expression and risk factors for lung cancer, with special emphasis on residential radon exposure. Ann Oncol Off J Eur Soc Med Oncol. 2008;19(1):109\u201314.","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"issue":"12","key":"3308_CR34","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1157\/13112970","volume":"43","author":"J Llorca","year":"2007","unstructured":"Llorca J, Bringas-Bollada M, Quind\u00f3s-Poncela LS. No evidence of a link between household radon concentrations and lung cancer in Cantabria, Spain. Arch Bronconeumol. 2007;43(12):696.","journal-title":"Arch Bronconeumol"},{"issue":"7","key":"3308_CR35","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1080\/09553000902954504","volume":"85","author":"A Ruano-Ravina","year":"2009","unstructured":"Ruano-Ravina A, Faraldo-Valles MJ, Barros-Dios JM. Is there a specific mutation of p53 gene due to radon exposure? A systematic review. Int J Radiat Biol. 2009;85(7):614\u201321.","journal-title":"Int J Radiat Biol"},{"issue":"8","key":"3308_CR36","first-page":"1073","volume":"9","author":"A Ruano-Ravina","year":"2014","unstructured":"Ruano-Ravina A, Pereyra MF, Castro MT, P\u00e9rez-R\u00edos M, Abal-Arca J, Barros-Dios JM. Genetic susceptibility, residential radon, and lung cancer in a radon prone area. J Thorac Oncol Off Publ Int Assoc Study Lung Cancer. 2014;9(8):1073\u201380.","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"issue":"4","key":"3308_CR37","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3109\/09553002.2014.886792","volume":"90","author":"A Ruano-Ravina","year":"2014","unstructured":"Ruano-Ravina A, Aragon\u00e9s N, P\u00e9rez-R\u00edos M, L\u00f3pez-Abente G, Barros-Dios JM. Residential radon exposure and esophageal cancer. An ecological study from an area with high indoor radon concentration (Galicia, Spain). Int J Radiat Biol. 2014;90(4):299\u2013305.","journal-title":"Int J Radiat Biol"},{"issue":"5","key":"3308_CR38","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1183\/13993003.00407-2016","volume":"48","author":"A Ruano-Ravina","year":"2016","unstructured":"Ruano-Ravina A, Torres-Dur\u00e1n M, Kelsey KT, Parente-Lamelas I, Leiro-Fern\u00e1ndez V, Abdulkader I, et al. Residential radon, EGFR mutations and ALK alterations in never-smoking lung cancer cases. Eur Respir J. 2016;48(5):1462\u201370.","journal-title":"Eur Respir J"},{"issue":"2","key":"3308_CR39","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/ije\/dyx011","volume":"46","author":"R Barbosa-Lorenzo","year":"2017","unstructured":"Barbosa-Lorenzo R, Barros-Dios JM, Ruano-Ravina A. Radon and stomach cancer. Int J Epidemiol. 2017;46(2):767\u20138.","journal-title":"Int J Epidemiol"},{"issue":"3","key":"3308_CR40","first-page":"728","volume":"37","author":"M Lorenzo-Gonz\u00e1lez","year":"2017","unstructured":"Lorenzo-Gonz\u00e1lez M, Ruano-Ravina A, Pe\u00f3n J, Pi\u00f1eiro M, Barros-Dios JM. Residential radon in Galicia: a cross-sectional study in a radon-prone area. J Radiol Prot Off J Soc Radiol Prot. 2017;37(3):728\u201341.","journal-title":"J Radiol Prot Off J Soc Radiol Prot"},{"issue":"1","key":"3308_CR41","doi-asserted-by":"publisher","first-page":"3595","DOI":"10.1038\/s41598-017-03938-9","volume":"7","author":"A Ruano-Ravina","year":"2017","unstructured":"Ruano-Ravina A, Aragon\u00e9s N, Kelsey KT, P\u00e9rez-R\u00edos M, Pi\u00f1eiro-Lamas M, L\u00f3pez-Abente G, et al. Residential radon exposure and brain cancer: an ecological study in a radon prone area (Galicia, Spain). Sci Rep. 2017;7(1):3595.","journal-title":"Sci Rep"},{"issue":"610\u2013611","key":"3308_CR42","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.scitotenv.2017.08.144","volume":"1","author":"G L\u00f3pez-Abente","year":"2018","unstructured":"L\u00f3pez-Abente G, N\u00fa\u00f1ez O, Fern\u00e1ndez-Navarro P, Barros-Dios JM, Mart\u00edn-M\u00e9ndez I, Bel-Lan A, et al. Residential radon and cancer mortality in Galicia. Spain Sci Total Environ. 2018;1(610\u2013611):1125\u201332.","journal-title":"Spain Sci Total Environ"},{"issue":"4","key":"3308_CR43","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.cllc.2019.04.009","volume":"20","author":"L Mezquita","year":"2019","unstructured":"Mezquita L, Benito A, Ruano-Ravi\u00f1a A, Zamora J, Olmedo ME, Reguera P, et al. Indoor radon in EGFR- and BRAF-mutated and ALK-rearranged non-small-cell lung cancer patients. Clin Lung Cancer. 2019;20(4):305-312.e3.","journal-title":"Clin Lung Cancer"},{"key":"3308_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.lungcan.2019.07.003","volume":"135","author":"M Lorenzo-Gonz\u00e1lez","year":"2019","unstructured":"Lorenzo-Gonz\u00e1lez M, Ruano-Ravina A, Torres-Dur\u00e1n M, Kelsey KT, Provencio M, Parente-Lamelas I, et al. Residential radon, genetic polymorphisms in DNA damage and repair-related. Lung Cancer Amst Neth. 2019;135:10\u20135.","journal-title":"Lung Cancer Amst Neth"},{"issue":"6","key":"3308_CR45","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.gaceta.2018.05.006","volume":"33","author":"A Ruano-Ravina","year":"2019","unstructured":"Ruano-Ravina A, Narocki C, L\u00f3pez-Jacob MJ, Garc\u00eda Oliver A, de la Calle Tierno MC, Pe\u00f3n-Gonz\u00e1lez J, et al. Indoor radon in Spanish workplaces A pilot study before the introduction of the European Directive 2013\/59\/Euratom. Gac Sanit. 2019;33(6):563\u20137.","journal-title":"Gac Sanit"},{"issue":"487","key":"3308_CR46","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.canlet.2020.05.022","volume":"1","author":"A Casal-Mouri\u00f1o","year":"2020","unstructured":"Casal-Mouri\u00f1o A, Ruano-Ravina A, Torres-Dur\u00e1n M, Parente-Lamelas I, Provencio-Pulla M, Castro-A\u00f1\u00f3n O, et al. Lung cancer survival in never-smokers and exposure to residential radon: Results of the LCRINS study. Cancer Lett. 2020;1(487):21\u20136.","journal-title":"Cancer Lett"},{"issue":"20","key":"3308_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijerph17207439","volume":"17","author":"S G\u00f3mez-Anca","year":"2020","unstructured":"G\u00f3mez-Anca S, Barros-Dios JM. Radon exposure and neurodegenerative disease. Int J Environ Res Public Health. 2020;17(20):1.","journal-title":"Int J Environ Res Public Health"},{"key":"3308_CR48","doi-asserted-by":"publisher","first-page":"939","DOI":"10.2147\/COPD.S245982","volume":"15","author":"A Conde-Sampayo","year":"2020","unstructured":"Conde-Sampayo A, Lorenzo-Gonz\u00e1lez M, Fern\u00e1ndez-Villar A, Barros-Dios JM, Ruano-Ravina A. Exposure to residential radon and COPD: a systematic review. Int J Chron Obstruct Pulmon Dis. 2020;15:939\u201348.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"3308_CR49","doi-asserted-by":"publisher","first-page":"111372","DOI":"10.1016\/j.envres.2021.111372","volume":"199","author":"A Ruano-Ravina","year":"2021","unstructured":"Ruano-Ravina A, Varela Lema L, Garc\u00eda Talavera M, Garc\u00eda G\u00f3mez M, Gonz\u00e1lez Mu\u00f1oz S, Santiago-P\u00e9rez MI, et al. Lung cancer mortality attributable to residential radon exposure in Spain and its regions. Environ Res. 2021;199:111372.","journal-title":"Environ Res"},{"issue":"10","key":"3308_CR50","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.arbres.2020.11.015","volume":"57","author":"A Ruano-Ravina","year":"2021","unstructured":"Ruano-Ravina A, Cameselle-Lago C, Torres-Dur\u00e1n M, Pando-Sandoval A, Dacal-Quintas R, Vald\u00e9s-Cuadrado L, et al. Indoor radon exposure and COPD, synergic association? A multicentric, hospital-based case\u2013control study in a radon-prone area. Arch Bronconeumol. 2021;57(10):630\u20136.","journal-title":"Arch Bronconeumol"},{"issue":"7","key":"3308_CR51","first-page":"405","volume":"114","author":"V Mauriz-Barreiro","year":"2022","unstructured":"Mauriz-Barreiro V, Barreiro-de Acosta M, Bast\u00f3n-Rey I, Ferreiro-Iglesias R, Calvi\u00f1o-Su\u00e1rez C, Barros-Dios JM, et al. Radon exposure and inflammatory bowel disease in a radon prone area. Rev Esp Enferm Dig. 2022;114(7):405\u20139.","journal-title":"Rev Esp Enferm Dig"},{"issue":"3","key":"3308_CR52","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/s41370-022-00506-w","volume":"33","author":"L Martin-Gisbert","year":"2023","unstructured":"Martin-Gisbert L, Ruano-Ravina A, Varela-Lema L, Penabad M, Giraldo-Osorio A, Candal-Pedreira C, et al. Lung cancer mortality attributable to residential radon: a systematic scoping review. J Expo Sci Environ Epidemiol. 2023;33(3):368\u201376.","journal-title":"J Expo Sci Environ Epidemiol"},{"issue":"1","key":"3308_CR53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1158\/1541-7786.MCR-18-0357","volume":"17","author":"JA Barta","year":"2019","unstructured":"Barta JA, McMahon SB. Lung-enriched mutations in the p53 tumor suppressor: a paradigm for tissue-specific gain of oncogenic function. Mol Cancer Res MCR. 2019;17(1):3\u20139.","journal-title":"Mol Cancer Res MCR"},{"issue":"3","key":"3308_CR54","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/humu.10182","volume":"21","author":"K V\u00e4h\u00e4kangas","year":"2003","unstructured":"V\u00e4h\u00e4kangas K. TP53 mutations in workers exposed to occupational carcinogens. Hum Mutat. 2003;21(3):240\u201351.","journal-title":"Hum Mutat"},{"issue":"8793","key":"3308_CR55","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/0140-6736(92)90866-2","volume":"339","author":"KH V\u00e4h\u00e4kangas","year":"1992","unstructured":"V\u00e4h\u00e4kangas KH, Samet JM, Metcalf RA, Welsh JA, Bennett WP, Lane DP, et al. Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet Lond Engl. 1992;339(8793):576\u201380.","journal-title":"Lancet Lond Engl"},{"issue":"15","key":"3308_CR56","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1200\/JCO.2016.72.0722","volume":"35","author":"C Taylor","year":"2017","unstructured":"Taylor C, Correa C, Duane FK, Aznar MC, Anderson SJ, Bergh J, et al. Estimating the risks of breast cancer radiotherapy: evidence from modern radiation doses to the lungs and heart and from previous randomized trials. J Clin Oncol Off J Am Soc Clin Oncol. 2017;35(15):1641\u20139.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"8967","key":"3308_CR57","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0140-6736(95)92144-3","volume":"346","author":"H Bartsch","year":"1995","unstructured":"Bartsch H, Hollstein M, Mustonen R, Schmidt J, Spiethoff A, Wesch H, et al. Screening for putative radon-specific p53 mutation hotspot in German uranium miners. Lancet Lond Engl. 1995;346(8967):121.","journal-title":"Lancet Lond Engl"},{"issue":"7","key":"3308_CR58","first-page":"791","volume":"4","author":"JW McDonald","year":"1995","unstructured":"McDonald JW, Taylor JA, Watson MA, Saccomanno G, Devereux TR. p53 and K-ras in radon-associated lung adenocarcinoma. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 1995;4(7):791\u20133.","journal-title":"Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol"},{"issue":"5","key":"3308_CR59","first-page":"433","volume":"8","author":"A Yngveson","year":"1999","unstructured":"Yngveson A, Williams C, Hjerpe A, Lundeberg J, S\u00f6derkvist P, Pershagen G. p53 Mutations in lung cancer associated with residential radon exposure. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 1999;8(5):433\u20138.","journal-title":"Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol"},{"key":"3308_CR60","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.mrgentox.2018.12.007","volume":"838","author":"K Walczak","year":"2019","unstructured":"Walczak K, Olszewski J, Domeradzka-Gajda K, Polita\u0144ski P, Zmy\u015blony M, Kowalczyk K, et al. Micronuclei frequency in peripheral blood lymphocytes and levels of anti-p53 autoantibodies in serum of residents of Kowary city regions (Poland) with elevated indoor concentrations of radon. Mutat Res Genet Toxicol Environ Mutagen. 2019;838:67\u201375.","journal-title":"Mutat Res Genet Toxicol Environ Mutagen"},{"issue":"9\u201310","key":"3308_CR61","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1080\/15287394.2016.1176629","volume":"79","author":"X Liu","year":"2016","unstructured":"Liu X, Wang X, Tong J. Radon-induced alterations in p53-mediated energy metabolism of malignantly transformed human bronchial epithelial cells. J Toxicol Environ Health A. 2016;79(9\u201310):436\u201341.","journal-title":"J Toxicol Environ Health A"},{"issue":"2","key":"3308_CR62","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.etap.2015.08.009","volume":"40","author":"Z Chen","year":"2015","unstructured":"Chen Z, Wang D, Gu C, Liu X, Pei W, Li J, et al. Down-regulation of let-7 microRNA increased K-ras expression in lung damage induced by radon. Environ Toxicol Pharmacol. 2015;40(2):541\u20138.","journal-title":"Environ Toxicol Pharmacol"},{"issue":"6","key":"3308_CR63","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1158\/1055-9965.EPI-12-0166","volume":"21","author":"M Taga","year":"2012","unstructured":"Taga M, Mechanic LE, Hagiwara N, V\u00e4h\u00e4kangas KH, Bennett WP, Alavanja MCR, et al. EGFR somatic mutations in lung tumours: radon exposure and passive smoking in former- and never-smoking US women. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol. 2012;21(6):988\u201392.","journal-title":"Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol."},{"issue":"162","key":"3308_CR64","first-page":"1","volume":"30","author":"PR Benusiglio","year":"2021","unstructured":"Benusiglio PR, Fallet V, Sanchis-Borja M, Coulet F, Cadranel J. Lung cancer is also a hereditary disease. Eur Respir Rev Off J Eur Respir Soc. 2021;30(162):1.","journal-title":"Eur Respir Rev Off J Eur Respir Soc"},{"issue":"6","key":"3308_CR65","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1002\/ijc.22002","volume":"119","author":"MR Bonner","year":"2006","unstructured":"Bonner MR, Bennett WP, Xiong W, Lan Q, Brownson RC, Harris CC, et al. Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women. Int J Cancer. 2006;119(6):1462\u20137.","journal-title":"Int J Cancer"},{"issue":"6","key":"3308_CR66","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3109\/09553002.2015.1012306","volume":"91","author":"MY Sinitsky","year":"2015","unstructured":"Sinitsky MY, Larionov AV, Asanov MA, Druzhinin VG. Associations of DNA-repair gene polymorphisms with a genetic susceptibility to ionizing radiation in residents of areas with high radon (222Rn) concentration. Int J Radiat Biol. 2015;91(6):486\u201394.","journal-title":"Int J Radiat Biol"},{"issue":"5","key":"3308_CR67","doi-asserted-by":"publisher","first-page":"57009","DOI":"10.1289\/EHP2503","volume":"126","author":"J Gaskin","year":"2018","unstructured":"Gaskin J, Coyle D, Whyte J, Krewksi D. Global estimate of lung cancer mortality attributable to residential radon. Environ Health Perspect. 2018;126(5):57009.","journal-title":"Environ Health Perspect"},{"key":"3308_CR68","unstructured":"Consejo de Seguridad Nuclear. Cartograf\u00eda del potencial de rad\u00f3n en Espa\u00f1a [Internet]. [cited 2019 Oct 28]. Available from: https:\/\/www.csn.es\/documents\/10182\/914801\/FDE-02.17%20Cartograf%C3%ADa%20del%20potencial%20de%20rad%C3%B3n%20de%20Espa%C3%B1a."},{"key":"3308_CR69","unstructured":"M\u00f3nica P\u00e9rez R\u00edos, Marta Garc\u00eda Talavera, Montserrat Garc\u00eda G\u00f3mez, Santiago Gonz\u00e1lez Mu\u00f1oz, Juan Miguel Barros Dios, Alberto Ruano Ravi\u00f1a. Mortalidad atribuible a la exposici\u00f3n a rad\u00f3n residencial en Espa\u00f1a. Ministerio de Sanidad; p. 50."},{"issue":"9","key":"3308_CR70","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/bjc.2015.324","volume":"113","author":"M Kreuzer","year":"2015","unstructured":"Kreuzer M, Fenske N, Schnelzer M, Walsh L. Lung cancer risk at low radon exposure rates in German uranium miners. Br J Cancer. 2015;113(9):1367\u20139.","journal-title":"Br J Cancer"},{"issue":"12","key":"3308_CR71","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1136\/oemed-2013-101582","volume":"70","author":"M Kreuzer","year":"2013","unstructured":"Kreuzer M, Sogl M, Br\u00fcske I, M\u00f6hner M, Nowak D, Schnelzer M, et al. Silica dust, radon and death from non-malignant respiratory diseases in German uranium miners. Occup Environ Med. 2013;70(12):869\u201375.","journal-title":"Occup Environ Med"},{"issue":"5","key":"3308_CR72","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1093\/jnci\/87.5.378","volume":"87","author":"SC Darby","year":"1995","unstructured":"Darby SC, Whitley E, Howe GR, Hutchings SJ, Kusiak RA, Lubin JH, et al. Radon and cancers other than lung cancer in underground miners: a collaborative analysis of 11 studies. J Natl Cancer Inst. 1995;87(5):378\u201384.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"3308_CR73","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00411-022-00992-4","volume":"61","author":"V Bozkurt","year":"2022","unstructured":"Bozkurt V, Erturk S. Evaluation of radon gas concentration in indoor air of spas and in spring water in the central Anatolia region of Turkey. Radiat Environ Biophys. 2022;61(4):609\u201314.","journal-title":"Radiat Environ Biophys"},{"issue":"9","key":"3308_CR74","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s10661-022-10157-x","volume":"194","author":"AS Silva","year":"2022","unstructured":"Silva AS, de Dinis ML. Assessment of indoor radon concentration and time-series analysis of gamma dose rate in three thermal spas from Portugal. Environ Monit Assess. 2022;194(9):611.","journal-title":"Environ Monit Assess"},{"issue":"35","key":"3308_CR75","doi-asserted-by":"publisher","first-page":"35242","DOI":"10.1007\/s11356-018-3428-6","volume":"25","author":"SH Hwang","year":"2018","unstructured":"Hwang SH, Park WM. Radon and PM10 concentrations in underground parking lots and subway stations with health risks in South Korea. Environ Sci Pollut Res Int. 2018;25(35):35242\u20138.","journal-title":"Environ Sci Pollut Res Int"},{"key":"3308_CR76","doi-asserted-by":"crossref","unstructured":"Borja Frutos, Fernando Mart\u00edn-Consuegra, Carmen Alonso, Gloria P\u00e9rez, Joaqu\u00edn Pe\u00f3n, Alberto Ruano, et al. Inner wall filler as a singular and significant source of indoor radon pollution in heritage buildings: An exhalation method-based approach. Building and Environment [Internet]. 2021 Aug 15;201. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0360132321004091.","DOI":"10.1016\/j.buildenv.2021.108005"},{"issue":"2","key":"3308_CR77","first-page":"676","volume":"46","author":"KP Messier","year":"2017","unstructured":"Messier KP, Serre ML. Lung and stomach cancer associations with groundwater radon in North Carolina, USA. Int J Epidemiol. 2017;46(2):676\u201385.","journal-title":"Int J Epidemiol"},{"issue":"11","key":"3308_CR78","first-page":"805","volume":"31","author":"B Chen","year":"2018","unstructured":"Chen B, Yuan TW, Wang AQ, Zhang H, Fang LJ, Wu QQ, et al. Exposure to radon and kidney cancer: a systematic review and meta-analysis of observational epidemiological studies. Biomed Environ Sci BES. 2018;31(11):805\u201315.","journal-title":"Biomed Environ Sci BES"},{"issue":"6","key":"3308_CR79","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1097\/HP.0000000000001687","volume":"124","author":"NH Harley","year":"2023","unstructured":"Harley NH, Leslie LA. Radon-222 and Leukemia. Health Phys. 2023;124(6):475\u20137.","journal-title":"Health Phys"},{"key":"3308_CR80","doi-asserted-by":"publisher","first-page":"111714","DOI":"10.1016\/j.envres.2021.111714","volume":"202","author":"J Moon","year":"2021","unstructured":"Moon J, Yoo H. Residential radon exposure and leukemia: a meta-analysis and dose-response meta-analyses for ecological, case\u2013control, and cohort studies. Environ Res. 2021;202:111714.","journal-title":"Environ Res"},{"issue":"3\u20134","key":"3308_CR81","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1093\/rpd\/ncz068","volume":"184","author":"J Chen","year":"2019","unstructured":"Chen J, Xie L. Domestic radon exposure and childhood Leukaemia and lymphoma: a population-based study in Canada. Radiat Prot Dosimetry. 2019;184(3\u20134):486\u201392.","journal-title":"Radiat Prot Dosimetry"},{"issue":"4","key":"3308_CR82","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijerph14040344","volume":"14","author":"M Ha","year":"2017","unstructured":"Ha M, Hwang SS, Kang S, Park NW, Chang BU, Kim Y. Geographical Correlations between Indoor Radon Concentration and Risks of Lung Cancer, Non-Hodgkin\u2019s Lymphoma, and Leukemia during 1999\u20132008 in Korea. Int J Environ Res Public Health. 2017;14(4):1.","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"3308_CR83","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/ajim.23449","volume":"66","author":"X Zeng","year":"2023","unstructured":"Zeng X, Berriault C, Arrandale VH, DeBono NL, Harris MA, Demers PA. Radon exposure and risk of neurodegenerative diseases among male miners in Ontario, Canada: a cohort study. Am J Ind Med. 2023;66(2):132\u201341.","journal-title":"Am J Ind Med"},{"issue":"5","key":"3308_CR84","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1183\/09031936.00058211","volume":"39","author":"MC Turner","year":"2012","unstructured":"Turner MC, Krewski D, Chen Y, Pope CA, Gapstur SM, Thun MJ. Radon and COPD mortality in the American Cancer Society Cohort. Eur Respir J. 2012;39(5):1113\u20139.","journal-title":"Eur Respir J"},{"key":"3308_CR85","first-page":"1","volume":"2023","author":"JR Enjo-Barreiro","year":"2023","unstructured":"Enjo-Barreiro JR, Ruano-Ravina A, Diz-de-Almeida S, Cruz R, Quintela I, Rey-Brandariz J, et al. A genome-wide association study of small cell lung cancer. Arch Bronconeumol. 2023;2023:1.","journal-title":"Arch Bronconeumol"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-023-03308-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-023-03308-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-023-03308-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:15:50Z","timestamp":1698308150000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-023-03308-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":85,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3308"],"URL":"https:\/\/doi.org\/10.1007\/s12094-023-03308-0","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]},"assertion":[{"value":"8 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The present study did not involved human participants, their data or biological material at any step of the process, in any way; thus ethical approval and inform consent do not apply to this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and informed consent"}}]}}