{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:00:34Z","timestamp":1789502434439,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M672072"],"award-info":[{"award-number":["2020M672072"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qilu hygiene and health outstanding youth project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-024-03558-6","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T16:10:42Z","timestamp":1718381442000},"page":"151-159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pan-immune-inflammation value: a new prognostic index in operative laryngeal and pharyngeal carcinomas"],"prefix":"10.1007","volume":"27","author":[{"given":"Jiaqi","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6045-2829","authenticated-orcid":false,"given":"Chen","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"issue":"1","key":"3558_CR1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","volume":"6","author":"DE Johnson","year":"2020","unstructured":"Johnson DE, et al. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6(1):92.","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"3558_CR2","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.mayocp.2015.12.017","volume":"91","author":"S Marur","year":"2016","unstructured":"Marur S, Forastiere AA. Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment. Mayo Clin Proc. 2016;91(3):386\u201396.","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"3558_CR3","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","volume":"140","author":"SI Grivennikov","year":"2010","unstructured":"Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883\u201399.","journal-title":"Cell"},{"key":"3558_CR4","volume":"148","author":"U Rothschild","year":"2018","unstructured":"Rothschild U, et al. Immunotherapy in head and neck cancer - scientific rationale, current treatment options and future directions. Swiss Med Wkly. 2018;148: w14625.","journal-title":"Swiss Med Wkly"},{"key":"3558_CR5","doi-asserted-by":"publisher","first-page":"E1068","DOI":"10.1002\/hed.24159","volume":"38","author":"S Rachidi","year":"2016","unstructured":"Rachidi S, et al. Neutrophil-to-lymphocyte ratio and overall survival in all sites of head and neck squamous cell carcinoma. Head Neck. 2016;38:E1068\u201374.","journal-title":"Head Neck"},{"issue":"1","key":"3558_CR6","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1186\/s12885-021-08793-6","volume":"21","author":"Y Kawashita","year":"2021","unstructured":"Kawashita Y, et al. Association of neutrophil-to-lymphocyte ratio with severe radiation-induced mucositis in pharyngeal or laryngeal cancer patients: a retrospective study. BMC Cancer. 2021;21(1):1064.","journal-title":"BMC Cancer"},{"issue":"12","key":"3558_CR7","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1002\/hed.25366","volume":"40","author":"Y Takenaka","year":"2018","unstructured":"Takenaka Y, et al. Platelet count and platelet-lymphocyte ratio as prognostic markers for head and neck squamous cell carcinoma: Meta-analysis. Head Neck. 2018;40(12):2714\u201323.","journal-title":"Head Neck"},{"key":"3558_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/ijms21207507","volume":"21","author":"C Polasky","year":"2020","unstructured":"Polasky C, et al. Platelet Induced Functional Alteration of CD4(+) and CD8(+) T Cells in HNSCC. Int J Mol Sci. 2020;21:20.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3558_CR9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13045-017-0430-2","volume":"10","author":"L Yang","year":"2017","unstructured":"Yang L, Zhang Y. Tumor-associated macrophages: from basic research to clinical application. J Hematol Oncol. 2017;10(1):58.","journal-title":"J Hematol Oncol"},{"issue":"3","key":"3558_CR10","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/s41416-020-0894-7","volume":"123","author":"G Fuc\u00e0","year":"2020","unstructured":"Fuc\u00e0 G, et al. The Pan-Immune-Inflammation Value is a new prognostic biomarker in metastatic colorectal cancer: results from a pooled-analysis of the Valentino and TRIBE first-line trials. Br J Cancer. 2020;123(3):403\u20139.","journal-title":"Br J Cancer"},{"issue":"1","key":"3558_CR11","doi-asserted-by":"publisher","DOI":"10.1097\/AS9.0000000000000113","volume":"3","author":"Y Baba","year":"2022","unstructured":"Baba Y, et al. Pan-immune-inflammation Value and Prognosis in Patients With Esophageal Cancer. Ann Surg Open. 2022;3(1): e113.","journal-title":"Ann Surg Open"},{"key":"3558_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.830138","volume":"12","author":"F Lin","year":"2022","unstructured":"Lin F, et al. Pan-Immune-Inflammation Value: A New Prognostic Index in Operative Breast Cancer. Front Oncol. 2022;12: 830138.","journal-title":"Front Oncol"},{"issue":"2","key":"3558_CR13","doi-asserted-by":"publisher","first-page":"e24804","DOI":"10.1016\/j.heliyon.2024.e24804","volume":"10","author":"N Zhang","year":"2024","unstructured":"Zhang N, et al. Prognostic significance of pan-immune-inflammation value (PIV) in nasopharyngeal carcinoma patients. Heliyon. 2024;10(2):e24804.","journal-title":"Heliyon"},{"issue":"1","key":"3558_CR14","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13045-018-0669-2","volume":"11","author":"M Schlesinger","year":"2018","unstructured":"Schlesinger M. Role of platelets and platelet receptors in cancer metastasis. J Hematol Oncol. 2018;11(1):125.","journal-title":"J Hematol Oncol"},{"issue":"20","key":"3558_CR15","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1182\/blood-2018-11-844548","volume":"133","author":"MA Giese","year":"2019","unstructured":"Giese MA, Hind LE, Huttenlocher A. Neutrophil plasticity in the tumor microenvironment. Blood. 2019;133(20):2159\u201367.","journal-title":"Blood"},{"issue":"5","key":"3558_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188762","volume":"1877","author":"H Que","year":"2022","unstructured":"Que H, et al. Tumor-associated neutrophils and neutrophil-targeted cancer therapies. Biochim Biophys Acta Rev Cancer. 2022;1877(5): 188762.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"1","key":"3558_CR17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","volume":"141","author":"BZ Qian","year":"2010","unstructured":"Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141(1):39\u201351.","journal-title":"Cell"},{"issue":"1","key":"3558_CR18","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12916-021-02006-4","volume":"19","author":"S Wang","year":"2021","unstructured":"Wang S, et al. Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors. BMC Med. 2021;19(1):140.","journal-title":"BMC Med"},{"key":"3558_CR19","doi-asserted-by":"publisher","first-page":"883639","DOI":"10.3389\/fimmu.2022.883639","volume":"13","author":"B Seliger","year":"2022","unstructured":"Seliger B, Massa C. Modulation of Lymphocyte Functions in the Microenvironment by Tumor Oncogenic Pathways. Front Immunol. 2022;13:883639.","journal-title":"Front Immunol"},{"issue":"6","key":"3558_CR20","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1055\/s-0037-1613413","volume":"89","author":"S Taucher","year":"2003","unstructured":"Taucher S, et al. Impact of pretreatment thrombocytosis on survival in primary breast cancer. Thromb Haemost. 2003;89(6):1098\u2013106.","journal-title":"Thromb Haemost"},{"key":"3558_CR21","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.2147\/CMAR.S307368","volume":"13","author":"R Chen","year":"2021","unstructured":"Chen R, et al. Absolute Neutrophil Count in the Peripheral Blood Predicts Prognosis in Lung Cancer Patients Treated with Anlotinib. Cancer Manag Res. 2021;13:3619\u201327.","journal-title":"Cancer Manag Res"},{"issue":"12","key":"3558_CR22","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.1245\/s10434-016-5354-5","volume":"23","author":"K Shigeta","year":"2016","unstructured":"Shigeta K, et al. High Absolute Monocyte Count Predicts Poor Clinical Outcome in Patients with Castration-Resistant Prostate Cancer Treated with Docetaxel Chemotherapy. Ann Surg Oncol. 2016;23(12):4115\u201322.","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"3558_CR23","doi-asserted-by":"publisher","first-page":"7566","DOI":"10.1038\/s41598-023-34145-4","volume":"13","author":"S Li","year":"2023","unstructured":"Li S, et al. Severe lymphopenia as a prognostic factor in rectal cancer patients receiving adjuvant chemoradiotherapy: a retrospective study. Sci Rep. 2023;13(1):7566.","journal-title":"Sci Rep"},{"issue":"4","key":"3558_CR24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3343\/alm.2019.39.4.345","volume":"39","author":"AY Gasparyan","year":"2019","unstructured":"Gasparyan AY, et al. The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases. Ann Lab Med. 2019;39(4):345\u201357.","journal-title":"Ann Lab Med"},{"issue":"1","key":"3558_CR25","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2019.20","volume":"63","author":"\u00c1 Velasco","year":"2020","unstructured":"Velasco \u00c1, et al. Neutrophil-to-lymphocyte ratio: A potential new peripheral biomarker of suicidal behavior. Eur Psychiatry. 2020;63(1): e14.","journal-title":"Eur Psychiatry"},{"key":"3558_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.975400","volume":"13","author":"Y Tang","year":"2022","unstructured":"Tang Y, et al. Systemic immune-inflammation index and bone mineral density in postmenopausal women: A cross-sectional study of the national health and nutrition examination survey (NHANES) 2007\u20132018. Front Immunol. 2022;13: 975400.","journal-title":"Front Immunol"},{"issue":"14","key":"3558_CR27","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1002\/cncr.30057","volume":"122","author":"Q Qi","year":"2016","unstructured":"Qi Q, et al. A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy. Cancer. 2016;122(14):2158\u201367.","journal-title":"Cancer"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-024-03558-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-024-03558-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-024-03558-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T01:27:52Z","timestamp":1736904472000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-024-03558-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["3558"],"URL":"https:\/\/doi.org\/10.1007\/s12094-024-03558-6","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]},"assertion":[{"value":"24 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This study was approved by the Research Ethics Committee of Qilu Hospital, Shandong University (Approval Number: KYLL-202307\u2013001).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}