{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:38:25Z","timestamp":1769582305079,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-024-03788-8","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T17:28:09Z","timestamp":1732901289000},"page":"2651-2657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of worst patterns of invasion on survival outcomes in oral cavity cancer: implications for adjuvant therapy and prognostic stratification"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1320-9105","authenticated-orcid":false,"given":"Beste Melek","family":"Atasoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl\u015fah","family":"\u00d6zden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyla","family":"Cinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Cemal","family":"Yumu\u015fakhuylu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Akdeniz Do\u011fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"3788_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209\u201349. https:\/\/doi.org\/10.3322\/caac.21660.","journal-title":"CA Cancer J Clin"},{"key":"3788_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105451","volume":"121","author":"A Chamoli","year":"2021","unstructured":"Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A. Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics. Oral Oncol. 2021;121: 105451. https:\/\/doi.org\/10.1016\/j.oraloncology.2021.105451.","journal-title":"Oral Oncol"},{"key":"3788_CR3","volume-title":"AJCC Cancer staging manual","author":"JA Ridge","year":"2017","unstructured":"Ridge JA, Lydiatt WM, Patel SG, et al. Lip and oral cavity. In: Amin MB, editor., et al., AJCC Cancer staging manual. 8th ed. New York: Springer; 2017.","edition":"8"},{"key":"3788_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106972","author":"S Das","year":"2024","unstructured":"Das S, Ghosh Laskar S, Kane V, S, D\u2019Cruz AK. Adjuvant therapy for intermediate risk factors in oral cancer: can we reach a consensus? Oral Oncol. 2024. https:\/\/doi.org\/10.1016\/j.oraloncology.2024.106972.","journal-title":"Oral Oncol"},{"key":"3788_CR5","unstructured":"https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/head-and-neck.pdf. Available in September 2024."},{"key":"3788_CR6","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1097\/PAS.0b013e3181d95c37","volume":"34","author":"M Brandwein-Gensler","year":"2010","unstructured":"Brandwein-Gensler M, Smith RV, Wang B, Penner C, Theilken A, Broughel D, Schiff B, Owen RP, Smith J, Sarta C, Hebert T, Nason R, Ramer M, DeLacure M, Hirsch D, Myssiorek D, Heller K, Prystowsky M, Schlecht NF, Negassa A. Validation of the histologic risk model in a new cohort of patients with head and neck squamous cell carcinoma. Am J Surg Pathol. 2010;34:676\u201388. https:\/\/doi.org\/10.1097\/PAS.0b013e3181d95c37.","journal-title":"Am J Surg Pathol"},{"key":"3788_CR7","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21389","author":"WM Lydiatt","year":"2017","unstructured":"Lydiatt WM, Patel SG, O\u2019Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, Loomis AM, Shah JP. Head and neck cancers-major changes in the American joint committee on cancer eighth edition cancer staging manual. Cancer J Clin. 2017. https:\/\/doi.org\/10.3322\/caac.21389.","journal-title":"Cancer J Clin"},{"key":"3788_CR8","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s12070-014-0787-2","volume":"67","author":"BV Manjula","year":"2015","unstructured":"Manjula BV, Augustine S, Selvam S, Mohan AM. Prognostic and predictive factors in gingivo buccal complex squamous cell carcinoma: role of tumor budding and pattern of invasion. Indian J Otolaryngol Head Neck Surg. 2015;67:98\u2013104. https:\/\/doi.org\/10.1007\/s12070-014-0787-2.","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"3788_CR9","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.jobcr.2022.08.027","volume":"12","author":"A Mishra","year":"2022","unstructured":"Mishra A, Das A, Dhal I, Shankar R, Bhavya BM, Singh N, Tripathi P, Daga D, Rai A, Gupta M, Sahu GC. Worst pattern of invasion in oral squamous cell carcinoma is an independent prognostic factor. J Oral Biol Craniofac Res. 2022;12:771\u20136. https:\/\/doi.org\/10.1016\/j.jobcr.2022.08.027.","journal-title":"J Oral Biol Craniofac Res"},{"key":"3788_CR10","unstructured":"Hui Huang, MD; Nora Katabi, MD; William Lydiatt, MD; Brian O\u2019Sullivan, MB BCh; Snehal Patel, MD; Jason Pettus, MD; Lindsay Williams, MD. With guidance from the CAP Cancer and CAP Pathology Electronic Reporting Committees. https:\/\/www.cap.org\/protocols-and-guidelines\/cancer-reporting-tools\/cancer-protocol-templates. Available in September 2024."},{"key":"3788_CR11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/his.12754","volume":"68","author":"MG Heerema","year":"2016","unstructured":"Heerema MG, Melchers LJ, Roodenburg JL, Schuuring E, de Bock GH, van der Vegt B. Reproducibility and prognostic value of pattern of invasion scoring in low-stage oral squamous cell carcinoma. Histopathology. 2016;68:388\u201397.","journal-title":"Histopathology"},{"key":"3788_CR12","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s12105-023-01571-9","volume":"17","author":"S Mohamed","year":"2023","unstructured":"Mohamed S, Jawad H, Sullivan RO, Callanan D, Sheahan P, Feeley L. Significance of worst pattern of invasion-5 in early-stage oral cavity squamous cell carcinoma. Head Neck Pathol. 2023;17:679\u201387. https:\/\/doi.org\/10.1007\/s12105-023-01571-9.\u00a0","journal-title":"Head Neck Pathol"},{"key":"3788_CR13","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1002\/lary.28241","volume":"130","author":"AR Larson","year":"2020","unstructured":"Larson AR, Kemmer J, Formeister E, El-Sayed I, Ha P, George J, Ryan W, Chan E, Heaton C. Beyond depth of invasion: adverse pathologic tumor features in early oral tongue squamous cell carcinoma. Laryngoscope. 2020;130:1715\u201320. https:\/\/doi.org\/10.1002\/lary.28241.","journal-title":"Laryngoscope"},{"key":"3788_CR14","doi-asserted-by":"publisher","first-page":"9727","DOI":"10.1007\/s00432-023-04873-1","volume":"149","author":"S Goyal","year":"2023","unstructured":"Goyal S, Ikkurthi V, Geeta SN. Efficacy of adjuvant radiation in early-stage cancers of buccal mucosa: an institutional experience. J Cancer Res Clin Oncol. 2023;149:9727\u201332. https:\/\/doi.org\/10.1007\/s00432-023-04873-1.","journal-title":"J Cancer Res Clin Oncol"},{"key":"3788_CR15","unstructured":"https:\/\/seer.cancer.gov\/survivalcalculator\/index.php: Available in September 2024."},{"key":"3788_CR16","doi-asserted-by":"publisher","DOI":"10.21873\/cdp.10239","author":"M Yamauchi","year":"2023","unstructured":"Yamauchi M, Ishida T, Minesaki A, Kuratomi Y. Correlates with lymph node recurrence and poor prognosis in early-stage tongue squamous cell carcinoma. Cancer Diagn Progn. 2023. https:\/\/doi.org\/10.21873\/cdp.10239.","journal-title":"Cancer Diagn Progn"},{"key":"3788_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2351-z","author":"YM Pu","year":"2018","unstructured":"Pu YM, Yang Y, Wang YJ, Ding L, Huang XF, Wang ZY, Ni YH, Hu QG. Postoperative radiotherapy is dispensable for OSCC patients with micrometastases in lymph nodes. Virchows Arch. 2018. https:\/\/doi.org\/10.1007\/s00428-018-2351-z.","journal-title":"Virchows Arch"},{"key":"3788_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.oor.2023.100141","author":"B Ram","year":"2024","unstructured":"Ram B, Rao LMCS, Fonseca D, Kumar S, Gondi J, Akula AK, et al. Worst pattern of invasion: a prognostic indicator in early-stage oral tongue cancer: a single-center cohort study. Oral Oncol Report. 2024. https:\/\/doi.org\/10.1016\/j.oor.2023.100141.","journal-title":"Oral Oncol Report"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-024-03788-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-024-03788-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-024-03788-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T14:17:00Z","timestamp":1747405020000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-024-03788-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,29]]},"references-count":18,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["3788"],"URL":"https:\/\/doi.org\/10.1007\/s12094-024-03788-8","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,29]]},"assertion":[{"value":"13 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Ethics Committee of Marmara University School of Medicine approved this study (Number 09.20024.1005 and date 16.10.2024).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}