{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:10:21Z","timestamp":1758723021372,"version":"3.44.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-025-03919-9","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T22:43:38Z","timestamp":1745189018000},"page":"4011-4019","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Where is clinical research in radiation oncology going? a snapshot from Lombardy, Italy\u2014a study endorsed by AIRO Lombardia"],"prefix":"10.1007","volume":"27","author":[{"given":"Mattia","family":"Zaffaroni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7830-3149","authenticated-orcid":false,"given":"Maria Giulia","family":"Vincini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Arcangeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Cocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostina","family":"De Stefani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Riccardo","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Franceschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micaela","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Piccolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Tomasini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara Alicja","family":"Jereczek-Fossa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Laudati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Alterio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"3919_CR1","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/cncr.21324","volume":"104","author":"G Delaney","year":"2005","unstructured":"Delaney G, Jacob S, Featherstone C, Barton M. The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines. Cancer. 2005;104:1129\u201337. https:\/\/doi.org\/10.1002\/cncr.21324.","journal-title":"Cancer"},{"key":"3919_CR2","doi-asserted-by":"publisher","first-page":"110076","DOI":"10.1016\/j.radonc.2023.110076","volume":"190","author":"M Baumann","year":"2024","unstructured":"Baumann M. Clinical research for global needs of radiation oncology. Radiother Oncol. 2024;190:110076.","journal-title":"Radiother Oncol"},{"key":"3919_CR3","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1016\/S1470-2045(22)00540-X","volume":"24","author":"M Lawler","year":"2023","unstructured":"Lawler M, Davies L, Oberst S, Oliver K, Eggermont A, Schmutz A, et al. European groundshot-addressing europe\u2019s cancer research challenges: a Lancet oncology commission. Lancet Oncol. 2023;24:e11\u201356. https:\/\/doi.org\/10.1016\/S1470-2045(22)00540-X.","journal-title":"Lancet Oncol"},{"key":"3919_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-01489-4","author":"S Park","year":"2020","unstructured":"Park S. Where is clinical research for radiotherapy going? Cross-sectional comparison of past and contemporary phase III clinical trials. Radiat Oncol. 2020. https:\/\/doi.org\/10.1186\/s13014-020-01489-4.","journal-title":"Radiat Oncol."},{"key":"3919_CR5","doi-asserted-by":"publisher","first-page":"100978","DOI":"10.1016\/j.conctc.2022.100978","volume":"29","author":"N Nikzad","year":"2022","unstructured":"Nikzad N. Analyzing factors associated with clinical trial publication in radiation oncology. Contemp Clin Trials Commun. 2022;29:100978.","journal-title":"Contemp Clin Trials Commun"},{"issue":"2","key":"3919_CR6","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.radi.2023.01.001","volume":"29","author":"A Hancock","year":"2023","unstructured":"Hancock A. Barriers and facilitators to conducting radiotherapy clinical trials: findings from a UK survey. Radiography. 2023;29(2):369\u201378.","journal-title":"Radiography."},{"key":"3919_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2022.100939","volume":"28","author":"G Kumar","year":"2022","unstructured":"Kumar G, Chaudhary P, Quinn A, Su D. Barriers for cancer clinical trial enrollment: a qualitative study of the perspectives of healthcare providers. Contemp Clin Trials Commun. 2022;28: 100939. https:\/\/doi.org\/10.1016\/j.conctc.2022.100939.","journal-title":"Contemp Clin Trials Commun"},{"key":"3919_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.conctc.2018.08.001","volume":"11","author":"DB Fogel","year":"2018","unstructured":"Fogel DB. Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: a review. Contemp Clin Trials Commun. 2018;11:156\u201364. https:\/\/doi.org\/10.1016\/j.conctc.2018.08.001.","journal-title":"Contemp Clin Trials Commun"},{"key":"3919_CR9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1089\/ees.2016.0223","volume":"34","author":"MA Edwards","year":"2017","unstructured":"Edwards MA, Roy S. Academic research in the 21st Century: maintaining scientific integrity in a climate of perverse incentives and hypercompetition. Environ Eng Sci. 2017;34:51\u201361. https:\/\/doi.org\/10.1089\/ees.2016.0223.","journal-title":"Environ Eng Sci"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-03919-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-025-03919-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-03919-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:48:45Z","timestamp":1758721725000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-025-03919-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":9,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["3919"],"URL":"https:\/\/doi.org\/10.1007\/s12094-025-03919-9","relation":{},"ISSN":["1699-3055"],"issn-type":[{"type":"electronic","value":"1699-3055"}],"subject":[],"published":{"date-parts":[[2025,4,21]]},"assertion":[{"value":"3 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Division of RT IEO received research funding from AIRC (Italian Association for Cancer Research), and Fondazione IEO-CCM (Istituto Europeo di Oncologia-Centro Cardiologico Monzino) (all outside the current project). IEO, the European Institute of Oncology IRCCS, was partially supported by institutional grants from Accuray Inc. and IBA (Ion Beam Applications, Louvain-la-Neuve, Belgium). The sponsors did not play any role in the study design, collection, analysis, and interpretation of data, nor in the writing of the manuscript, nor in the decision to submit the manuscript for publication. The remaining authors declare no conflicts of interest that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}