{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T14:31:11Z","timestamp":1763562671150,"version":"3.45.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004435","name":"Universidad de Navarra","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004435","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Due to the labor intensity demanded by proton beam therapy (PBT) in pediatric patients, information on operational procedures related to efficiency is crucial to optimize quality and safety. We aimed to identify patient factors that affect the duration of the pediatric PBT session and to develop an easy-to-use predictive score of extended duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\/patients<\/jats:title>\n                    <jats:p>This is an observational retrospective cohort study in an academic medical centre, between May 2020 and February 2024. Seventy seven ASA III pediatric patients treated with PBT were recruited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was 4.8\u00a0years [standard deviation (SD): 2.1] and 52% were women. The mean duration of the PBT session was 50\u00a0min (SD: 17). Extended duration of the PBT session (&gt;\u200945\u00a0min) occurred in 39 patients (51%). Five predictors of extended duration were selected for the final prediction model. In the multivariable model, an age\u2009&gt;\u200945\u00a0months showed a near eightfold increased odds of extended duration [Odds ratio (OR): 7.76, 95% confidence interval (95% CI) 1.63\u201336.99,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.010]. The OR (95% CI) for long-term venous access, no recurrent tumors, hydrocephalus, and craniospinal location were 5.91 (1.47 to 23.79), 3.81 (0.67 to 21.69), 3.79 (0.90 to 15.97), and 2.59 (0.69 to 9.76), respectively. This five-variable model was used to build a nomogram-based score with an area under the receiver operating characteristic curve of 0.84 (95% CI 0.76\u20130.93).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A simple nomogram based on readily available pretreatment data has potential for planning pediatric PBT standard clinical expert practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12094-025-03972-4","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T12:25:10Z","timestamp":1750335910000},"page":"4526-4532","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a practice-based score to predict extended duration of proton beam therapy session in pediatric patients"],"prefix":"10.1007","volume":"27","author":[{"given":"Jos\u00e9 M.","family":"Fern\u00e1ndez-de Miguel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Garc\u00eda-Aroca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Manrique Yera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe A.","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Aymerich de Francesci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Manuel","family":"\u00c1lvarez Avello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Panizo Morgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-1069","authenticated-orcid":false,"given":"Jorge M.","family":"N\u00fa\u00f1ez-C\u00f3rdoba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"3972_CR1","first-page":"10","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A. Cancer statistics, 2025. CA Cancer J Clin. 2025;75:10\u201345.","journal-title":"CA Cancer J Clin"},{"key":"3972_CR2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2176\/nmc.ra.2017-0003","volume":"57","author":"M Mizumoto","year":"2017","unstructured":"Mizumoto M, Oshiro Y, Yamamoto T, Kohzuki H, Sakurai H. Proton beam therapy for pediatric brain tumor. Neurol Med Chir (Tokyo). 2017;57:343\u201355.","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"3972_CR3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/MOP.0000000000000724","volume":"31","author":"S Baliga","year":"2019","unstructured":"Baliga S, Yock TI. Proton beam therapy in pediatric oncology. Curr Opin Pediatr. 2019;31:28\u201334.","journal-title":"Curr Opin Pediatr"},{"key":"3972_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1053\/j.seminoncol.2020.02.002","volume":"47","author":"BA Greenberger","year":"2020","unstructured":"Greenberger BA, Yock TI. The role of proton therapy in pediatric malignancies: recent advances and future directions. Semin Oncol. 2020;47:8\u201322.","journal-title":"Semin Oncol"},{"key":"3972_CR5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.14338\/IJPT-20-00069.1","volume":"8","author":"MT Spiotto","year":"2021","unstructured":"Spiotto MT, McGovern SL, Gunn GB, Grosshans D, McAleer MF, Frank SJ, et al. Proton radiotherapy to reduce late complications in childhood head and neck cancers. Int J Part Ther. 2021;8:155\u201367.","journal-title":"Int J Part Ther"},{"key":"3972_CR6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/jrr\/rrad022","volume":"64","author":"M Mizumoto","year":"2023","unstructured":"Mizumoto M, Fukushima H, Miyamoto T, Oshiro Y, Sumiya T, Iizumi T, et al. Analysis of person-hours required for proton beam therapy for pediatric tumors. 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Project number: 2024.11) and adhered to the Revised Declaration of Helsinki [\n                      \n                      ]. The need to obtain informed written consent from patients was waived due to the retrospective nature of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and informed consent"}}]}}