{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:27:06Z","timestamp":1791894426118,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-025-04000-1","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T08:56:40Z","timestamp":1753520200000},"page":"374-380","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["First unscheduled hospitalization in advanced cancer as a prognostic indicator of poor survival and trigger for palliative care referral"],"prefix":"10.1007","volume":"28","author":[{"given":"Alberto","family":"Alonso-Babarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7471-1325","authenticated-orcid":false,"given":"Juan Luis","family":"Torres-Tenor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Garc\u00eda-Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar\u00edo","family":"S\u00e1nchez-Cabrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Ostios-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Miranda-Poma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Guti\u00e9rrez-Sainz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Villamayor-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Abelardo","family":"Blanco-Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Mateo-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Va\u00f1\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bruera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,26]]},"reference":[{"issue":"2","key":"4000_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1177\/0269216318812633","volume":"33","author":"JJ Fulton","year":"2019","unstructured":"Fulton JJ, LeBlanc TW, Cutson TM, Porter Starr KN, Kamal A, Ramos K, et al. Integrated outpatient palliative care for patients with advanced cancer: a systematic review and meta-analysis. Palliat Med. 2019;33(2):123\u201334.","journal-title":"Palliat Med"},{"issue":"9930","key":"4000_CR2","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/S0140-6736(13)62416-2","volume":"383","author":"C Zimmermann","year":"2014","unstructured":"Zimmermann C, Swami N, Krzyzanowska M, Hannon B, Leighl N, Oza A, et al. Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial. Lancet. 2014;383(9930):1721\u201330.","journal-title":"Lancet"},{"issue":"8","key":"4000_CR3","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1056\/NEJMoa1000678","volume":"363","author":"JS Temel","year":"2010","unstructured":"Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 2010;363(8):733\u201342.","journal-title":"N Engl J Med"},{"issue":"1","key":"4000_CR4","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1200\/JCO.2016.70.1474","volume":"35","author":"BR Ferrell","year":"2017","unstructured":"Ferrell BR, Temel JS, Temin S, Alesi ER, Balboni TA, Basch EM, et al. Integration of palliative care into standard oncology care: American Society of Clinical Oncology clinical practice guideline update. JCO. 2017;35(1):96\u2013112.","journal-title":"JCO"},{"issue":"1","key":"4000_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/ONCO.13515","volume":"26","author":"L Mo","year":"2021","unstructured":"Mo L, Urbauer DL, Bruera E, Hui D. Recommendations for palliative and hospice care in NCCN guidelines for treatment of cancer. Oncologist. 2021;26(1):77\u201383.","journal-title":"Oncologist"},{"issue":"1","key":"4000_CR6","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1093\/annonc\/mdx757","volume":"29","author":"K Jordan","year":"2018","unstructured":"Jordan K, Aapro M, Kaasa S, Ripamonti CI, Scott\u00e9 F, Strasser F, et al. European Society for Medical Oncology (ESMO) position paper on supportive and palliative care. Ann Oncol. 2018;29(1):36\u201343.","journal-title":"Ann Oncol"},{"issue":"9","key":"4000_CR7","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1200\/JCO.18.02123","volume":"38","author":"D Hui","year":"2020","unstructured":"Hui D, Bruera E. Models of palliative care delivery for patients with cancer. J Clin Oncol. 2020;38(9):852\u201365.","journal-title":"J Clin Oncol"},{"issue":"1","key":"4000_CR8","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1377\/hlthaff.2015.0752","volume":"35","author":"P May","year":"2016","unstructured":"May P, Garrido MM, Cassel JB, Kelley AS, Meier DE, Normand C, et al. Palliative care teams\u2019 cost-saving effect is larger for cancer patients with higher numbers of comorbidities. Health Aff (Millwood). 2016;35(1):44\u201353.","journal-title":"Health Aff (Millwood)"},{"issue":"13","key":"4000_CR9","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1200\/JCO.2014.58.6362","volume":"33","author":"MA Bakitas","year":"2015","unstructured":"Bakitas MA, Tosteson TD, Li Z, Lyons KD, Hull JG, Li Z, et al. Early versus delayed initiation of concurrent palliative oncology care: patient outcomes in the ENABLE III randomized controlled trial. J Clin Oncol. 2015;33(13):1438\u201345.","journal-title":"J Clin Oncol"},{"issue":"24","key":"4000_CR10","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1056\/NEJMsb1305469","volume":"369","author":"RB Parikh","year":"2013","unstructured":"Parikh RB, Kirch RA, Smith TJ, Temel JS. Early specialty palliative care\u2014translating data in oncology into practice. N Engl J Med. 2013;369(24):2347\u201351.","journal-title":"N Engl J Med"},{"issue":"6","key":"4000_CR11","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1001\/jama.2024.10398","volume":"332","author":"JS Temel","year":"2024","unstructured":"Temel JS, Jackson VA, El-Jawahri A, Rinaldi SP, Petrillo LA, Kumar P, et al. Stepped palliative care for patients with advanced lung cancer: a randomized clinical trial. JAMA. 2024;332(6):471\u201381.","journal-title":"JAMA"},{"issue":"6","key":"4000_CR12","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1001\/jamainternmed.2018.0750","volume":"178","author":"P May","year":"2018","unstructured":"May P, Normand C, Cassel JB, Del Fabbro E, Fine RL, Menz R, et al. Economics of palliative care for hospitalized adults with serious illness: a meta-analysis. JAMA Intern Med. 2018;178(6):820\u20139.","journal-title":"JAMA Intern Med"},{"issue":"5","key":"4000_CR13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11864-020-00743-x","volume":"21","author":"N Kayastha","year":"2020","unstructured":"Kayastha N, LeBlanc TW. When to integrate palliative care in the trajectory of cancer care. Curr Treat Options Oncol. 2020;21(5):41.","journal-title":"Curr Treat Options Oncol"},{"issue":"25","key":"4000_CR14","doi-asserted-by":"publisher","first-page":"6240","DOI":"10.1200\/JCO.2005.06.866","volume":"23","author":"M Maltoni","year":"2005","unstructured":"Maltoni M, Caraceni A, Brunelli C, Broeckaert B, Christakis N, Eychmueller S, et al. Prognostic factors in advanced cancer patients: evidence-based clinical recommendations\u2014a study by the Steering Committee of the European Association for Palliative Care. J Clin Oncol. 2005;23(25):6240\u20138.","journal-title":"J Clin Oncol"},{"issue":"5","key":"4000_CR15","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jpainsymman.2016.12.330","volume":"53","author":"CPL Simmons","year":"2017","unstructured":"Simmons CPL, McMillan DC, McWilliams K, Sande TA, Fearon KC, Tuck S, et al. Prognostic tools in patients with advanced cancer: a systematic review. J Pain Symptom Manag. 2017;53(5):962\u2013970.e10.","journal-title":"J Pain Symptom Manag"},{"issue":"3","key":"4000_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nrclinonc.2015.201","volume":"13","author":"D Hui","year":"2016","unstructured":"Hui D, Bruera E. Integrating palliative care into the trajectory of cancer care. Nat Rev Clin Oncol. 2016;13(3):159\u201371.","journal-title":"Nat Rev Clin Oncol"},{"issue":"2","key":"4000_CR17","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.jpainsymman.2020.02.001","volume":"60","author":"EA Kistler","year":"2020","unstructured":"Kistler EA, Stevens E, Scott E, Philpotts LL, Greer JA, Greenwald JL. Triggered palliative care consults: a systematic review of interventions for hospitalized and emergency department patients. J Pain Symptom Manag. 2020;60(2):460\u201375.","journal-title":"J Pain Symptom Manag"},{"issue":"1","key":"4000_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1200\/JOP.2012.000698","volume":"9","author":"GB Rocque","year":"2013","unstructured":"Rocque GB, Barnett AE, Illig LC, Eickhoff JC, Bailey HH, Campbell TC, et al. Inpatient hospitalization of oncology patients: are we missing an opportunity for end-of-life care? J Oncol Pract. 2013;9(1):51\u20134.","journal-title":"J Oncol Pract"},{"issue":"2","key":"4000_CR19","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jpainsymman.2018.03.022","volume":"56","author":"A Collins","year":"2018","unstructured":"Collins A, Sundararajan V, Burchell J, Millar J, McLachlan SA, Krishnasamy M, et al. Transition points for the routine integration of palliative care in patients with advanced cancer. J Pain Symptom Manag. 2018;56(2):185\u201394.","journal-title":"J Pain Symptom Manag"},{"issue":"7","key":"4000_CR20","first-page":"3441","volume":"28","author":"R Gemmell","year":"2020","unstructured":"Gemmell R, Yousaf N, Droney J. \u201cTriggers\u201d for early palliative care referral in patients with cancer: a review of urgent unplanned admissions and outcomes. Support Care Cancer. 2020;28(7):3441\u20139.","journal-title":"Support Care Cancer"},{"issue":"5","key":"4000_CR21","first-page":"356","volume":"68","author":"D Hui","year":"2018","unstructured":"Hui D, Hannon BL, Zimmermann C, Bruera E. Improving patient and caregiver outcomes in oncology: team-based, timely, and targeted palliative care. CA Cancer J Clin. 2018;68(5):356\u201376.","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"4000_CR22","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.3390\/cancers14041047","volume":"14","author":"D Hui","year":"2022","unstructured":"Hui D, Heung Y, Bruera E. Timely palliative care: personalizing the process of referral. Cancers (Basel). 2022;14(4):1047.","journal-title":"Cancers (Basel)"},{"issue":"5","key":"4000_CR23","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1002\/jhm.2160","volume":"9","author":"RJ Lin","year":"2014","unstructured":"Lin RJ, Adelman RD, Diamond RR, Evans AT. The sentinel hospitalization and the role of palliative care. J Hosp Med. 2014;9(5):320\u20133.","journal-title":"J Hosp Med"},{"issue":"Suppl 2","key":"4000_CR24","doi-asserted-by":"publisher","first-page":"S87","DOI":"10.3747\/co.27.5223","volume":"27","author":"K Esfahani","year":"2020","unstructured":"Esfahani K, Roudaia L, Buhlaiga N, Del Rincon SV, Papneja N, Miller WH. A review of cancer immunotherapy: from the past, to the present, to the future. Curr Oncol. 2020;27(Suppl 2):S87\u201397.","journal-title":"Curr Oncol"},{"issue":"11","key":"4000_CR25","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1001\/jamaoncol.2017.1059","volume":"3","author":"Y Schenker","year":"2017","unstructured":"Schenker Y, Arnold R. Toward palliative care for all patients with advanced cancer. JAMA Oncol. 2017;3(11):1459\u201360.","journal-title":"JAMA Oncol"},{"issue":"1","key":"4000_CR26","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1186\/s12916-020-01829-x","volume":"18","author":"RI Jordan","year":"2020","unstructured":"Jordan RI, Allsop MJ, ElMokhallalati Y, Jackson CE, Edwards HL, Chapman EJ, et al. Duration of palliative care before death in international routine practice: a systematic review and meta-analysis. BMC Med. 2020;18(1):368.","journal-title":"BMC Med"},{"issue":"9","key":"4000_CR27","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1002\/cncr.32738","volume":"126","author":"D Hui","year":"2020","unstructured":"Hui D, De La Rosa A, Chen J, Dibaj S, Delgado Guay M, Heung Y, et al. State of palliative care services at US cancer centers: an updated national survey. Cancer. 2020;126(9):2013\u201323.","journal-title":"Cancer"},{"issue":"10128","key":"4000_CR28","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/S0140-6736(17)32513-8","volume":"391","author":"FM Knaul","year":"2018","unstructured":"Knaul FM, Farmer PE, Krakauer EL, De Lima L, Bhadelia A, Jiang Kwete X, et al. Alleviating the access abyss in palliative care and pain relief-an imperative of universal health coverage: the Lancet Commission report. Lancet. 2018;391(10128):1391\u2013454.","journal-title":"Lancet"},{"issue":"5","key":"4000_CR29","doi-asserted-by":"publisher","first-page":"e000372","DOI":"10.1136\/esmoopen-2018-000372","volume":"3","author":"D Hui","year":"2018","unstructured":"Hui D, Cherny NI, Wu J, Liu D, Latino NJ, Strasser F. Indicators of integration at ESMO designated centres of integrated oncology and palliative care. ESMO Open. 2018;3(5): e000372.","journal-title":"ESMO Open"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04000-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-025-04000-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04000-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T21:05:55Z","timestamp":1768165555000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-025-04000-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,26]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["4000"],"URL":"https:\/\/doi.org\/10.1007\/s12094-025-04000-1","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,26]]},"assertion":[{"value":"6 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The project was approved by the Ethics and Clinical Research Committee of both hospitals. Informed consent was not applicable, as this retrospective study based on medical record review did not require it according to institutional and national regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}