{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:42:10Z","timestamp":1788183730054,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Zhejiang Province Public Welfare Technology Application Research Project of China","award":["LGF22H160080"],"award-info":[{"award-number":["LGF22H160080"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300607"],"award-info":[{"award-number":["32300607"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373308"],"award-info":[{"award-number":["82373308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of Zhejiang Provincial Natural Science Foundation","award":["LZ23H160007"],"award-info":[{"award-number":["LZ23H160007"]}]},{"name":"Key Project of Health Bureau of Zhejiang Province","award":["WKJ-ZJ-2325"],"award-info":[{"award-number":["WKJ-ZJ-2325"]}]},{"name":"Basic Scientific Research Funds of Department of Education of Zhejiang Province","award":["KYYB202212"],"award-info":[{"award-number":["KYYB202212"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-025-04094-7","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:44:38Z","timestamp":1764668678000},"page":"1928-1939","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Local efficacy and safety of CT-guided Iodine-125 seed implantation in the treatment of recurrent malignant tumors: a retrospective study"],"prefix":"10.1007","volume":"28","author":[{"given":"Jiahong","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luying","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihong","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7587-312X","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"4094_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.717180","volume":"11","author":"S Wei","year":"2021","unstructured":"Wei S, Li C, Li M, Xiong Y, Jiang Y, Sun H, et al. Radioactive iodine-125 in tumor therapy: advances and future directions. Front Oncol. 2021;11:717180. https:\/\/doi.org\/10.3389\/fonc.2021.717180.","journal-title":"Front Oncol"},{"key":"4094_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00432-019-03050-7","volume":"146","author":"Z Ji","year":"2020","unstructured":"Ji Z, Jiang Y, Guo F, Peng R, Sun H, Fan J, et al. Safety and efficacy of CT-guided radioactive iodine-125 seed implantation assisted by a 3D printing template for the treatment of thoracic malignancies. J Cancer Res Clin Oncol. 2020;146:229\u201336. https:\/\/doi.org\/10.1007\/s00432-019-03050-7.","journal-title":"J Cancer Res Clin Oncol"},{"key":"4094_CR3","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.ijrobp.2018.10.034","volume":"103","author":"Z Ji","year":"2019","unstructured":"Ji Z, Jiang Y, Tian S, Guo F, Peng R, Xu F, et al. The effectiveness and prognostic factors of CT-guided radioactive I-125 seed implantation for the treatment of recurrent head and neck cancer after external beam radiation therapy. Int J Radiat Oncol Biol Phys. 2019;103:638\u201345. https:\/\/doi.org\/10.1016\/j.ijrobp.2018.10.034.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4094_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-32-106","volume":"32","author":"H Wang","year":"2013","unstructured":"Wang H, Wang J, Jiang Y, Li J, Tian S, Ran W, et al. The investigation of 125I seed implantation as a salvage modality for unresectable pancreatic carcinoma. J Exp Clin Cancer Res. 2013;32:106. https:\/\/doi.org\/10.1186\/1756-9966-32-106.","journal-title":"J Exp Clin Cancer Res"},{"key":"4094_CR5","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.4103\/jcrt.JCRT_434_19","volume":"15","author":"J Wang","year":"2019","unstructured":"Wang J, Chai S, Wang R, Zheng G, Zhang K, Huo B, et al. Expert consensus on computed tomography-assisted three-dimensional-printed coplanar template guidance for interstitial permanent radioactive (125)I seed implantation therapy. J Cancer Res Ther. 2019;15:1430\u20134. https:\/\/doi.org\/10.4103\/jcrt.JCRT_434_19.","journal-title":"J Cancer Res Ther"},{"key":"4094_CR6","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s12032-009-9212-1","volume":"27","author":"J Wang","year":"2010","unstructured":"Wang J, Yuan H, Ma Q, Liu X, Wang H, Jiang Y, et al. Interstitial 125I seeds implantation to treat spinal metastatic and primary paraspinal malignancies. Med Oncol. 2010;27:319\u201326. https:\/\/doi.org\/10.1007\/s12032-009-9212-1.","journal-title":"Med Oncol"},{"key":"4094_CR7","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8265907","volume":"2016","author":"L Yao","year":"2016","unstructured":"Yao L, Cao Q, Wang J, Yang J, Meng N, Guo F, et al. CT-guided (125)I seed interstitial brachytherapy as a salvage treatment for recurrent spinal metastases after external beam radiotherapy. Biomed Res Int. 2016;2016:8265907. https:\/\/doi.org\/10.1155\/2016\/8265907.","journal-title":"Biomed Res Int"},{"key":"4094_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1005876","volume":"12","author":"L Yang","year":"2022","unstructured":"Yang L, Wang C, Zhang W, Liu S, Xuan T, Jiang H, et al. Iodine-125 brachytherapy treatment for newly diagnosed brain metastasis in non-small cell lung cancer: a biocentric analysis. Front Oncol. 2022;12:1005876. https:\/\/doi.org\/10.3389\/fonc.2022.1005876.","journal-title":"Front Oncol"},{"key":"4094_CR9","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.ijrobp.2015.01.029","volume":"92","author":"KK Mishra","year":"2015","unstructured":"Mishra KK, Quivey JM, Daftari IK, Weinberg V, Cole TB, Patel K, et al. Long-term results of the UCSF-LBNL randomized trial: charged particle with helium ion versus iodine-125 plaque therapy for choroidal and ciliary body melanoma. Int J Radiat Oncol Biol Phys. 2015;92:376\u201383. https:\/\/doi.org\/10.1016\/j.ijrobp.2015.01.029.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4094_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0395-8","volume":"32","author":"W Li","year":"2015","unstructured":"Li W, Guan J, Yang L, Zheng X, Yu Y, Jiang J. Iodine-125 brachytherapy improved overall survival of patients with inoperable stage III\/IV non-small cell lung cancer versus the conventional radiotherapy. Med Oncol. 2015;32:395. https:\/\/doi.org\/10.1007\/s12032-014-0395-8.","journal-title":"Med Oncol"},{"key":"4094_CR11","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/s0039-6109(16)40394-4","volume":"54","author":"WF Whitmore Jr.","year":"1974","unstructured":"Whitmore WF Jr., Hilaris B, Grabstald H, Batata M. Implantation of 125I in prostatic cancer. Surg Clin North Am. 1974;54:887\u201395. https:\/\/doi.org\/10.1016\/s0039-6109(16)40394-4.","journal-title":"Surg Clin North Am"},{"key":"4094_CR12","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/lary.1991.101.4.405","volume":"101","author":"RI Park","year":"1991","unstructured":"Park RI, Liberman FZ, Lee DJ, Goldsmith MM, Price JC. Iodine-125 seed implantation as an adjunct to surgery in advanced recurrent squamous cell cancer of the head and neck. Laryngoscope. 1991;101:405\u201310. https:\/\/doi.org\/10.1002\/lary.1991.101.4.405.","journal-title":"Laryngoscope"},{"key":"4094_CR13","doi-asserted-by":"publisher","first-page":"e469","DOI":"10.1016\/S1470-2045(22)00447-8","volume":"23","author":"N Andratschke","year":"2022","unstructured":"Andratschke N, Willmann J, Appelt AL, Alyamani N, Balermpas P, Baumert BG, et al. European society for radiotherapy and oncology and European organisation for research and treatment of cancer consensus on re-irradiation: definition, reporting, and clinical decision making. Lancet Oncol. 2022;23:e469\u201378. https:\/\/doi.org\/10.1016\/S1470-2045(22)00447-8.","journal-title":"Lancet Oncol"},{"key":"4094_CR14","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.brachy.2020.02.009","volume":"19","author":"Y Chen","year":"2020","unstructured":"Chen Y, Jiang Y, Ji Z, Jiang P, Xu F, Zhang Y, et al. Dosimetry, efficacy, and safety of three-dimensional printing noncoplanar template-assisted and CT-guided (125)I seed implantation for recurrent retroperitoneal lymphatic metastasis after external beam radiotherapy. Brachytherapy. 2020;19:380\u20138. https:\/\/doi.org\/10.1016\/j.brachy.2020.02.009.","journal-title":"Brachytherapy"},{"key":"4094_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-68","volume":"5","author":"YL Jiang","year":"2010","unstructured":"Jiang YL, Meng N, Wang JJ, Jiang P, Yuan H, Liu C, et al. CT-guided iodine-125 seed permanent implantation for recurrent head and neck cancers. Radiat Oncol. 2010;5:68. https:\/\/doi.org\/10.1186\/1748-717X-5-68.","journal-title":"Radiat Oncol"},{"key":"4094_CR16","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.brachy.2015.05.008","volume":"14","author":"L Yao","year":"2015","unstructured":"Yao L, Jiang Y, Jiang P, Wang H, Meng N, Qu A, et al. CT-guided permanent 125I seed interstitial brachytherapy for recurrent retroperitoneal lymph node metastases after external beam radiotherapy. Brachytherapy. 2015;14:662\u20139. https:\/\/doi.org\/10.1016\/j.brachy.2015.05.008.","journal-title":"Brachytherapy"},{"key":"4094_CR17","doi-asserted-by":"publisher","first-page":"8685","DOI":"10.2147\/OTT.S164880","volume":"11","author":"Y Liu","year":"2018","unstructured":"Liu Y, Lyu SC, Wang XQ, Wang YB. Application of preoperative three-dimensional model design in radioactive particle implantation for advanced pancreatic cancer. Onco Targets Ther. 2018;11:8685\u201393. https:\/\/doi.org\/10.2147\/OTT.S164880.","journal-title":"Onco Targets Ther"},{"key":"4094_CR18","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1186\/s12957-020-02087-0","volume":"18","author":"W Jiang","year":"2020","unstructured":"Jiang W, Jiang P, Wei S, Jiang Y, Ji Z, Sun H, et al. The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma. World J Surg Oncol. 2020;18:307. https:\/\/doi.org\/10.1186\/s12957-020-02087-0.","journal-title":"World J Surg Oncol"},{"key":"4094_CR19","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5114\/jcb.2019.84503","volume":"11","author":"Z Ji","year":"2019","unstructured":"Ji Z, Sun H, Jiang Y, Guo F, Peng R, Fan J, et al. Comparative study for CT-guided (125)I seed implantation assisted by 3D printing coplanar and non-coplanar template in peripheral lung cancer. J Contemp Brachytherapy. 2019;11:169\u201373. https:\/\/doi.org\/10.5114\/jcb.2019.84503.","journal-title":"J Contemp Brachytherapy"},{"key":"4094_CR20","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2019.30.e9","volume":"30","author":"A Qu","year":"2019","unstructured":"Qu A, Jiang P, Sun H, Jiang W, Jiang Y, Tian S, et al. Efficacy and dosimetry analysis of image-guided radioactive (1)(2)(5)I seed implantation as salvage treatment for pelvic recurrent cervical cancer after external beam radiotherapy. J Gynecol Oncol. 2019;30:e9. https:\/\/doi.org\/10.3802\/jgo.2019.30.e9.","journal-title":"J Gynecol Oncol"},{"key":"4094_CR21","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/hed.21955","volume":"34","author":"L Zheng","year":"2012","unstructured":"Zheng L, Zhang J, Zhang J, Song T, Huang M, Yu G. Preliminary results of (125)I interstitial brachytherapy for locally recurrent parotid gland cancer in previously irradiated patients. Head Neck. 2012;34:1445\u20139. https:\/\/doi.org\/10.1002\/hed.21955.","journal-title":"Head Neck"},{"key":"4094_CR22","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1089\/cbr.2017.2425","volume":"33","author":"W Lu","year":"2018","unstructured":"Lu W, Du P, Yang C, Jiang F, Xie P, Yang J, et al. The effect of computed tomography-guided (125)I radioactive particle implantation in treating cancer and its pain. Cancer Biother Radiopharm. 2018;33:176\u201381. https:\/\/doi.org\/10.1089\/cbr.2017.2425.","journal-title":"Cancer Biother Radiopharm"},{"key":"4094_CR23","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1186\/s12885-020-07223-3","volume":"20","author":"GS Zhao","year":"2020","unstructured":"Zhao GS, Liu S, Yang L, Li C, Wang RY, Zhou J, et al. Evaluation of radioactive (125)I seed implantation for the treatment of refractory malignant tumours based on a CT-guided 3D template-assisted technique: efficacy and safety. BMC Cancer. 2020;20:718. https:\/\/doi.org\/10.1186\/s12885-020-07223-3.","journal-title":"BMC Cancer"},{"key":"4094_CR24","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1080\/09553002.2020.1704300","volume":"96","author":"SN Jia","year":"2020","unstructured":"Jia SN, Wen FX, Gong TT, Li X, Wang HJ, Sun YM, et al. A review on the efficacy and safety of iodine-125 seed implantation in unresectable pancreatic cancers. Int J Radiat Biol. 2020;96:383\u20139. https:\/\/doi.org\/10.1080\/09553002.2020.1704300.","journal-title":"Int J Radiat Biol"},{"key":"4094_CR25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13014-022-02196-y","volume":"18","author":"L Wu","year":"2023","unstructured":"Wu L, Zhao X, Tian S, Zhang K, He C, Feng Y, et al. Efficacy and toxicity of Iodine-125 seed implantation for lymph node recurrence secondary to esophageal cancer after radiotherapy: a multicenter retrospective study. Radiat Oncol. 2023;18:18. https:\/\/doi.org\/10.1186\/s13014-022-02196-y.","journal-title":"Radiat Oncol"},{"key":"4094_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13014-023-02254-z","volume":"18","author":"Y Li","year":"2023","unstructured":"Li Y, Jiang Y, Wang J. Safety and efficacy of CT-guided radioactive iodine-125 seed implantation as a salvage treatment for recurrent head and neck cancer after two or more courses of radiotherapy. Radiat Oncol. 2023;18:73. https:\/\/doi.org\/10.1186\/s13014-023-02254-z.","journal-title":"Radiat Oncol"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04094-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-025-04094-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04094-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T09:53:02Z","timestamp":1776765182000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-025-04094-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["4094"],"URL":"https:\/\/doi.org\/10.1007\/s12094-025-04094-7","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]},"assertion":[{"value":"1 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}