{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:22:44Z","timestamp":1788823364766,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-025-04100-y","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T19:58:50Z","timestamp":1761854330000},"page":"1303-1313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patterns of practice for breast cancer post-operative radiation therapy in Italy according to the ESTRO-ACROP consensus and AIRO position paper: a national survey on the behalf of the Italian association of radiotherapy and clinical oncology (AIRO)"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4275-0080","authenticated-orcid":false,"given":"Samantha","family":"Dicuonzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-7537","authenticated-orcid":false,"given":"Carlotta","family":"Becherini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Borghesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cucciarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4201-5852","authenticated-orcid":false,"given":"Alba","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4223-8925","authenticated-orcid":false,"given":"Ruggero","family":"Spoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edy","family":"Ippolito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Perrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8151-3673","authenticated-orcid":false,"given":"Barbara Alicja","family":"Jereczek-Fossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6529-8328","authenticated-orcid":false,"given":"Maria Cristina","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-2895","authenticated-orcid":false,"given":"Icro","family":"Meattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Aristei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"issue":"12","key":"4100_CR1","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","volume":"378","author":"S Darby","year":"2011","unstructured":"Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378(12):1707\u201316. https:\/\/doi.org\/10.1016\/S0140-6736(11)61629-2.","journal-title":"Lancet"},{"issue":"9935","key":"4100_CR2","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1016\/S0140-6736(14)60488-8","volume":"383","author":"P McGale","year":"2014","unstructured":"McGale P, Taylor C, Correa C, Cutter D, Duane F, Ewertz M, et al. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet. 2014;383(9935):2127\u201335. https:\/\/doi.org\/10.1016\/S0140-6736(14)60488-8.","journal-title":"Lancet"},{"issue":"5","key":"4100_CR3","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.clon.2022.03.001","volume":"34","author":"JR Yarnold","year":"2022","unstructured":"Yarnold JR, Brunt AM, Chatterjee S, Somaiah N, Kirby AM. From 25 fractions to five: how hypofractionation has revolutionised adjuvant breast radiotherapy. Clin Oncol (R Coll Radiol). 2022;34(5):332\u20139. https:\/\/doi.org\/10.1016\/j.clon.2022.03.001.","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"11","key":"4100_CR4","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/S1470-2045(13)70386-3","volume":"14","author":"JS Haviland","year":"2013","unstructured":"Haviland JS, Owen JR, Dewar JA, Agrawal RK, Barrett J, Barrett-Lee PJ, et al. The UK standardisation of breast radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol. 2013;14(11):1086\u201394. https:\/\/doi.org\/10.1016\/S1470-2045(13)70386-3.","journal-title":"Lancet Oncol"},{"issue":"11","key":"4100_CR5","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1056\/NEJMoa0906260","volume":"362","author":"TJ Whelan","year":"2010","unstructured":"Whelan TJ, Pignol JP, Levine MN, Julian JA, MacKenzie R, Parpia S, et al. Long-term results of hypofractionated radiation therapy for breast cancer. N Engl J Med. 2010;362(11):513\u201320. https:\/\/doi.org\/10.1056\/NEJMoa0906260.","journal-title":"N Engl J Med"},{"issue":"1","key":"4100_CR6","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1200\/JCO.20.01363","volume":"38","author":"BV Offersen","year":"2020","unstructured":"Offersen BV, Alsner J, Nielsen HM, Jakobsen EH, Nielsen MH, Krause M, et al. Hypofractionated versus standard fractionated radiotherapy in patients with early breast cancer or ductal carcinoma in situ in a randomized phase III trial: the DBCG HYPO trial. J Clin Oncol. 2020;38(1):3615\u201325. https:\/\/doi.org\/10.1200\/JCO.20.01363.","journal-title":"J Clin Oncol"},{"key":"4100_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-079089","volume":"386","author":"SF Lee","year":"2024","unstructured":"Lee SF, Kennedy SKF, Caini S, Wong HCY, Yip PL, Poortmans PM, et al. Randomised controlled trials on radiation dose fractionation in breast cancer: systematic review and meta-analysis with emphasis on side effects and cosmesis. BMJ. 2024;386:e079089. https:\/\/doi.org\/10.1136\/bmj-2023-079089.","journal-title":"BMJ"},{"issue":"1","key":"4100_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-1463-1","volume":"15","author":"L Liu","year":"2020","unstructured":"Liu L, Yang Y, Guo Q, Ren B, Peng Q, Zou L, et al. Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review. Radiat Oncol. 2020;15(1):17. https:\/\/doi.org\/10.1186\/s13014-020-1463-1.","journal-title":"Radiat Oncol"},{"issue":"23","key":"4100_CR9","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1016\/S0140-6736(20)30932-6","volume":"395","author":"A Murray Brunt","year":"2020","unstructured":"Murray Brunt A, Haviland JS, Wheatley DA, Sydenham MA, Alhasso A, Bloomfield DJ, et al. Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial. Lancet. 2020;395(23):1613\u201326. https:\/\/doi.org\/10.1016\/S0140-6736(20)30932-6.","journal-title":"Lancet"},{"issue":"3","key":"4100_CR10","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/S1470-2045(18)30813-1","volume":"20","author":"SL Wang","year":"2019","unstructured":"Wang SL, Fang H, Song YW, Wang WH, Hu C, Liu YP, et al. Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: a randomised, non-inferiority, open-label, phase 3 trial. Lancet Oncol. 2019;20(3):352\u201360. https:\/\/doi.org\/10.1016\/S1470-2045(18)30813-1.","journal-title":"Lancet Oncol"},{"key":"4100_CR11","doi-asserted-by":"publisher","first-page":"103090","DOI":"10.1016\/j.critrevonc.2020.103090","volume":"156","author":"GN Marta","year":"2020","unstructured":"Marta GN, Coles C, Kaidar-Person O, Meattini I, Hijal T, Zissiadis Y, et al. The use of moderately hypofractionated post-operative radiation therapy for breast cancer in clinical practice: a critical review. Crit Rev Oncol Hematol. 2020;156:103090. https:\/\/doi.org\/10.1016\/j.critrevonc.2020.103090.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"1","key":"4100_CR12","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1016\/S1470-2045(21)00539-8","volume":"23","author":"I Meattini","year":"2022","unstructured":"Meattini I, Becherini C, Boersma L, Kaidar-Person O, Marta GN, Montero A, et al. European society for radiotherapy and oncology advisory committee in radiation oncology practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer. Lancet Oncol. 2022;23(1):e21\u201331. https:\/\/doi.org\/10.1016\/S1470-2045(21)00539-8.","journal-title":"Lancet Oncol"},{"issue":"12","key":"4100_CR13","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s11547-022-01563-9","volume":"127","author":"I Meattini","year":"2022","unstructured":"Meattini I, Palumbo I, Becherini C, Borghesi S, Cucciarelli F, Dicuonzo S, et al. The Italian association for radiotherapy and clinical oncology (AIRO) position statements for postoperative breast cancer radiation therapy volume, dose, and fractionation. Radiol Med. 2022;127(12):1407\u201311. https:\/\/doi.org\/10.1007\/s11547-022-01563-9.","journal-title":"Radiol Med"},{"issue":"9","key":"4100_CR14","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/S0140-6736(17)31145-5","volume":"390","author":"CE Coles","year":"2017","unstructured":"Coles CE, Griffin CL, Kirby AM, Titley J, Agrawal RK, Alhasso A, et al. Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial. Lancet. 2017;390(9):1048\u201360. https:\/\/doi.org\/10.1016\/S0140-6736(17)31145-5.","journal-title":"Lancet"},{"issue":"10215","key":"4100_CR15","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1016\/S0140-6736(19)32514-0","volume":"394","author":"FA Vicini","year":"2019","unstructured":"Vicini FA, Cecchini RS, White JR, Arthur DW, Julian TB, Rabinovitch RA, et al. Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial. Lancet. 2019;394(10215):2155\u201364. https:\/\/doi.org\/10.1016\/S0140-6736(19)32514-0.","journal-title":"Lancet"},{"issue":"14","key":"4100_CR16","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1016\/S0140-6736(19)32515-2","volume":"394","author":"TJ Whelan","year":"2019","unstructured":"Whelan TJ, Julian JA, Berrang TS, Kim DH, Germain I, Nichol AM, et al. External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial. Lancet. 2019;394(14):2165\u201372. https:\/\/doi.org\/10.1016\/S0140-6736(19)32515-2.","journal-title":"Lancet"},{"issue":"35","key":"4100_CR17","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.1200\/JCO.20.00650","volume":"38","author":"I Meattini","year":"2020","unstructured":"Meattini I, Marrazzo L, Saieva C, Desideri I, Scotti V, Simontacchi G, et al. Accelerated partial-breast irradiation compared with whole-breast irradiation for early breast cancer: long-term results of the randomized phase III APBI-IMRT-Florence trial. J Clin Oncol. 2020;38(35):4175\u201383. https:\/\/doi.org\/10.1200\/JCO.20.00650.","journal-title":"J Clin Oncol"},{"issue":"3","key":"4100_CR18","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.6.3.e34","volume":"6","author":"G Eysenbach","year":"2004","unstructured":"Eysenbach G. Improving the quality of web surveys: the checklist for reporting results of internet E-surveys (CHERRIES). J Med Internet Res. 2004;6(3):e34. https:\/\/doi.org\/10.2196\/jmir.6.3.e34.","journal-title":"J Med Internet Res"},{"key":"4100_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.radonc.2021.01.003","volume":"157","author":"D Rodin","year":"2021","unstructured":"Rodin D, Tawk B, Mohamad O, Grover S, Moraes YF, Yap LM, et al. Hypofractionated radiotherapy in the real-world setting: an international ESTRO-GIRO survey. Radiother Oncol. 2021;157:32\u20139. https:\/\/doi.org\/10.1016\/j.radonc.2021.01.003.","journal-title":"Radiother Oncol"},{"key":"4100_CR20","doi-asserted-by":"publisher","DOI":"10.1200\/GO.22.00127","volume":"9","author":"M Mushonga","year":"2023","unstructured":"Mushonga M, Weiss J, Liu ZA, Nyakabau AM, Mohamad O, Tawk B, et al. Hypofractionation in breast cancer radiotherapy across world bank income groups: results of an international survey. JCO Glob Oncol. 2023;9:e2200127. https:\/\/doi.org\/10.1200\/GO.22.00127.","journal-title":"JCO Glob Oncol"},{"issue":"2_suppl","key":"4100_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/03008916221088885","volume":"108","author":"A Ciabattoni","year":"2022","unstructured":"Ciabattoni A, Gregucci F, De Rose F, Falivene S, Fozza A, Daidone A, et al. AIRO breast cancer group best clinical practice 2022 update. Tumori. 2022;108(2_suppl):1\u2013144. https:\/\/doi.org\/10.1177\/03008916221088885.","journal-title":"Tumori"},{"issue":"7","key":"4100_CR22","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1007\/s11547-020-01147-5","volume":"125","author":"F Gregucci","year":"2020","unstructured":"Gregucci F, Fozza A, Falivene S, Smaniotto D, Morra A, Daidone A, et al. Present clinical practice of breast cancer radiotherapy in Italy: a nationwide survey by the Italian Society of Radiotherapy and Clinical Oncology (AIRO) Breast Group. Radiol Med. 2020;125(7):674\u201382. https:\/\/doi.org\/10.1007\/s11547-020-01147-5.","journal-title":"Radiol Med"},{"issue":"5","key":"4100_CR23","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.clon.2020.03.006","volume":"32","author":"CE Coles","year":"2020","unstructured":"Coles CE, Aristei C, Bliss J, Boersma L, Brunt AM, Chatterjee S, et al. International guidelines on radiation therapy for breast cancer during the COVID-19 pandemic. Clin Oncol (R Coll Radiol). 2020;32(5):279\u201381. https:\/\/doi.org\/10.1016\/j.clon.2020.03.006.","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"4100_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2024.100764","volume":"46","author":"I Ratosa","year":"2024","unstructured":"Ratosa I, Montero A, Ciervide R, Alvarez B, Garc\u00eda-Aranda M, Valero J, et al. Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer: acute toxicity results. Clin Transl Radiat Oncol. 2024;46:100764. https:\/\/doi.org\/10.1016\/j.ctro.2024.100764.","journal-title":"Clin Transl Radiat Oncol"},{"key":"4100_CR25","doi-asserted-by":"publisher","first-page":"S75","DOI":"10.1016\/S0167-8140(22)02477-X","volume":"170","author":"D Wheatley","year":"2022","unstructured":"Wheatley D, Haviland J, Patel J, Sydenham M, Alhasso A, Chan C, et al. OC-0101 first results of FAST-Forward phase 3 RCT nodal substudy: 3-year normal tissue effects. Radiother Oncol. 2022;170:S75\u20136. https:\/\/doi.org\/10.1016\/S0167-8140(22)02477-X.","journal-title":"Radiother Oncol"},{"issue":"16","key":"4100_CR26","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.3390\/cancers14163927","volume":"14","author":"A Ciabattoni","year":"2022","unstructured":"Ciabattoni A, Gregucci F, D\u2019Ermo G, Dolfi A, Cucciarelli F, Palumbo I, et al. Patterns of care for breast radiotherapy in Italy: breast IRRadiATA (Italian repository of radiotherapy dATA) feasibility study. Cancers (Basel). 2022;14(16):3927. https:\/\/doi.org\/10.3390\/cancers14163927.","journal-title":"Cancers (Basel)"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04100-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-025-04100-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04100-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:10:50Z","timestamp":1774415450000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-025-04100-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["4100"],"URL":"https:\/\/doi.org\/10.1007\/s12094-025-04100-y","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]},"assertion":[{"value":"29 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"-The Division of Radiation Oncology of IEO received research funding from AIRC (Italian Association for Cancer Research), Fondazione IEO-CCM (Istituto Europeo di Oncologia-Centro Cardiologico Monzino), ACCURAY, IBA (Ion Beam applications). -BAJF received speakers fees from Bayer, Accuray, Astellas, IBA, Ipsen, AstraZeneca, Tecnologie avanzate, Recordati, and Novartis. BAJ-F participated in the advisory boards of Accuray, Bayer, and Seagen, all outside the current project. These companies had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and\/or in the decision to publish the results. -IM declares occasional fees for advisory boards, with unrestricted support from Eli Lilly, Novartis, Pfizer, Gilead, MSD, AstraZeneca, Daiichi Sankyo, Menarini StemLine, Exact Sciences, and TEMA Sinergie, all outside the current project. These companies had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and\/or in the decision to publish the results. -The remaining authors declare no conflicts of interest that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable because of the nature of the present paper (national survey).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable because of the nature of the present paper (national survey).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Not applicable because of the nature of the present paper (national survey).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable because of the nature of the present paper (national survey).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}