{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:45:24Z","timestamp":1793727924296,"version":"4.6.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-025-04172-w","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:33:48Z","timestamp":1770892428000},"page":"2993-3004","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of cytoreductive surgery in the management of peritoneal metastases for gastrointestinal stromal tumors"],"prefix":"10.1007","volume":"28","author":[{"given":"Irene","family":"L\u00f3pez-Rojo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6334-3014","authenticated-orcid":false,"given":"Paula","family":"Mu\u00f1oz-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Gonz\u00e1lez","family":"Bay\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobal","family":"Mu\u00f1oz-Casares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan \u00c1ngel A.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Bretcha-Boix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Gonz\u00e1lez-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Asencio-Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"4172_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.32074\/1591-951X-213","volume":"113","author":"M Sbaraglia","year":"2021","unstructured":"Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO classification of soft tissue tumours: news and perspectives. Pathologica. 2021;113:70\u201384.","journal-title":"Pathologica"},{"issue":"4","key":"4172_CR2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ciresp.2013.01.014","volume":"92","author":"FJ Medina Fern\u00e1ndez","year":"2014","unstructured":"Medina Fern\u00e1ndez FJ, Mu\u00f1oz-Casares FC, Arjona-S\u00e1nchez A, Casado-Adam A, Rufi\u00e1n Pe\u00f1a S. Gistosis peritoneal: Papel de la cirug\u00eda de citorreducci\u00f3n y quimioterapia intraperitoneal perioperatoria [Peritoneal GISTosis: role of cytoreductive surgery and perioperative intraperitoneal chemotherapy]. Cir Esp. 2014;92(4):289\u201390.","journal-title":"Cir Esp"},{"key":"4172_CR3","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1097\/01.sla.0000236630.93587.59","volume":"245","author":"RP DeMatteo","year":"2007","unstructured":"DeMatteo RP, Maki RG, Singer S, Gonen M, Brennan MF, Antonescu CR. Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor. Ann Surg. 2007;245:347\u201352.","journal-title":"Ann Surg"},{"key":"4172_CR4","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1200\/JCO.2005.05.3439","volume":"24","author":"CP Raut","year":"2006","unstructured":"Raut CP, Posner M, Desai J, Morgan JA, George S, Demetri GD, et al. Surgical management of advanced gastrointestinal stromal tumors after targeted systemic therapy using kinase inhibitors. J Clin Oncol. 2006;24:2325\u201331.","journal-title":"J Clin Oncol"},{"key":"4172_CR5","doi-asserted-by":"publisher","first-page":"175883592311923","DOI":"10.1177\/17588359231192388","volume":"15","author":"C Serrano","year":"2023","unstructured":"Serrano C, Mart\u00edn-Broto J, Asencio-Pascual JM, L\u00f3pez-Guerrero JA, Rubi\u00f3-Casadevall J, Bagu\u00e9 S, et al. 2023 GEIS Guidelines for gastrointestinal stromal tumors. Ther Adv Med Oncol. 2023;15:17588359231192388.","journal-title":"Ther Adv Med Oncol"},{"issue":"4","key":"4172_CR6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/jso.21067","volume":"98","author":"CR Rossi","year":"2008","unstructured":"Rossi CR, Casali P, Kusamura S, Baratti D, Deraco M. The consensus statement on the locoregional treatment of abdominal sarcomatosis. J Surg Oncol. 2008;98(4):291\u20134.","journal-title":"J Surg Oncol"},{"key":"4172_CR7","first-page":"279a","volume":"19","author":"RP DeMatteo","year":"2000","unstructured":"DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors. Proc Am Soc Clin Oncol. 2000;19:279a.","journal-title":"Proc Am Soc Clin Oncol"},{"issue":"5350","key":"4172_CR8","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1126\/science.279.5350.577","volume":"279","author":"S Hirota","year":"1998","unstructured":"Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279(5350):577\u201380.","journal-title":"Science"},{"key":"4172_CR9","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1056\/NEJM200104053441404","volume":"344","author":"H Joensuu","year":"2001","unstructured":"Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med. 2001;344:1052\u20136.","journal-title":"N Engl J Med"},{"issue":"13","key":"4172_CR10","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1245\/s10434-013-3281-2","volume":"20","author":"CP Raut","year":"2013","unstructured":"Raut CP, Gronchi A. Cytoreductive surgery in advanced GIST: timing is everything. Ann Surg Oncol. 2013;20(13):4059\u201360.","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"4172_CR11","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1056\/NEJMoa020461","volume":"347","author":"GD Demetri","year":"2002","unstructured":"Demetri GD, von Mehren M, Blanke CD, den Van Abbeele AD, Eisenberg B, Roberts PJ, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347(7):472\u201380.","journal-title":"N Engl J Med"},{"key":"4172_CR12","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0140-6736(06)69446-4","volume":"368","author":"GD Demetri","year":"2006","unstructured":"Demetri GD, van Oosterom AT, Garrett CR, Blackstein M, Shah MH, Verweij J, et al. Efficacy and safety of sunitinib in advanced GIST after imatinib failure: a randomized controlled trial. Lancet. 2006;368:1329\u201338.","journal-title":"Lancet"},{"key":"4172_CR13","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0140-6736(12)61857-1","volume":"381","author":"GD Demetri","year":"2013","unstructured":"Demetri GD, Reichardt P, Kang YK, Blay JY, Rutkowski P, Gelderblom H, et al. Regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): a phase 3 trial. Lancet. 2013;381:295\u2013302.","journal-title":"Lancet"},{"issue":"7","key":"4172_CR14","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/S1470-2045(20)30269-2","volume":"21","author":"MC Heinrich","year":"2020","unstructured":"Heinrich MC, Jones RL, von Mehren M, Sch\u00f6ffski P, Serrano C, Kang YK, et al. Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial. Lancet Oncol. 2020;21(7):935\u201346.","journal-title":"Lancet Oncol"},{"issue":"7","key":"4172_CR15","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/S1470-2045(20)30168-6","volume":"21","author":"JY Blay","year":"2020","unstructured":"Blay JY, Serrano C, Bramwell V, Bauer S, Bl\u00fcmel S, Duffaud F, et al. Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomized, placebo-controlled, phase 3 trial. Lancet Oncol. 2020;21(7):923\u201334.","journal-title":"Lancet Oncol"},{"issue":"10","key":"4172_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2020.100812","volume":"13","author":"H Zhang","year":"2020","unstructured":"Zhang H, Liu Q. Prognostic indicators for gastrointestinal stromal tumors: a review. Transl Oncol. 2020;13(10):100812.","journal-title":"Transl Oncol"},{"issue":"9","key":"4172_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2023.05.017","volume":"49","author":"P Brink","year":"2023","unstructured":"Brink P, Kalisvaart GM, Schrage YM, Eekhof J, Gelderblom H, van der Graaf WTA, et al. Local treatment in metastatic GIST patients: A multicentre analysis from the Dutch GIST Registry. Eur J Surg Oncol. 2023;49(9):106942.","journal-title":"Eur J Surg Oncol"},{"key":"4172_CR18","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1007\/s12094-019-02094-y","volume":"21","author":"DY Yang","year":"2019","unstructured":"Yang DY, Wang X, Yuan WJ, Chen ZH. Metastatic pattern and prognosis of gastrointestinal stromal tumor (GIST): a SEER-based analysis. Clin Transl Oncol. 2019;21:1654\u201362.","journal-title":"Clin Transl Oncol"},{"key":"4172_CR19","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1200\/JCO.2007.13.4403","volume":"26","author":"CD Blanke","year":"2008","unstructured":"Blanke CD, Demetri GD, von Mehren M, Rankin C, Benjamin RS, Fletcher CD, et al. Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for unresectable or metastatic GIST. J Clin Oncol. 2008;26:620\u20135.","journal-title":"J Clin Oncol"},{"key":"4172_CR20","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/S0140-6736(09)60500-6","volume":"373","author":"RP DeMatteo","year":"2009","unstructured":"DeMatteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD, et al. Adjuvant imatinib mesylate after resection of localized, primary GIST: a randomized, double-blind, placebo-controlled trial. Lancet. 2009;373:1097\u2013104.","journal-title":"Lancet"},{"issue":"3","key":"4172_CR21","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/01.sla.0000242710.36384.1b","volume":"245","author":"A Gronchi","year":"2007","unstructured":"Gronchi A, Fiore M, Miselli F, Lagonigro MS, Coco P, Messina A, et al. Surgery of residual disease following molecular-targeted therapy with imatinib mesylate in advanced\/metastatic GIST. Ann Surg. 2007;245(3):341\u20136.","journal-title":"Ann Surg"},{"key":"4172_CR22","unstructured":"National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in Oncology: Soft Tissue Sarcoma. Version 2.2024. Accessed May 2025."},{"key":"4172_CR23","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ejca.2019.07.028","volume":"120","author":"P Hohenberger","year":"2019","unstructured":"Hohenberger P, Bonvalot S, van Coevorden F, Rutkowski P, Fiore M, Liti\u00e8re S, et al. Quality of surgery and surgical reporting for patients with primary gastrointestinal stromal tumours participating in the EORTC STBSG 62024 adjuvant imatinib study. Eur J Cancer. 2019;120:47\u201353.","journal-title":"Eur J Cancer"},{"key":"4172_CR24","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1200\/JCO.2006.09.0183","volume":"25","author":"JY Blay","year":"2007","unstructured":"Blay JY, Le Cesne A, Ray-Coquard I, Bui BN, Duffaud F, Adenis A, et al. Prospective multicentric randomized phase III study of imatinib in patients with advanced GIST comparing interruption versus continuation of treatment beyond 1 year: the BFR14 trial. J Clin Oncol. 2007;25:1107\u201313.","journal-title":"J Clin Oncol"},{"key":"4172_CR25","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.3390\/cancers14071832","volume":"14","author":"D Van de Wal","year":"2022","unstructured":"Van de Wal D, Elie M, Le Cesne A, Fumagalli E, Ray-Coquard I, Italiano A, et al. Health-related quality of life and side effects in gastrointestinal stromal tumor (GIST) patients treated with tyrosine kinase inhibitors: a systematic review. Cancers (Basel). 2022;14:1832.","journal-title":"Cancers (Basel)"},{"key":"4172_CR26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.annonc.2021.09.005","volume":"33","author":"PG Casali","year":"2022","unstructured":"Casali PG, Blay JY, Abecassis N, Bajpai J, Bauer S, Biagini R, et al. Gastrointestinal stromal tumours: ESMO\u2013EURACAN\u2013GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2022;33:20\u201333.","journal-title":"Ann Oncol"},{"key":"4172_CR27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40644-017-0129-1","volume":"17","author":"A Dimitrakopoulou-Strauss","year":"2017","unstructured":"Dimitrakopoulou-Strauss A, Ronellenfitsch U, Cheng C, Pan L, Sachpekidis C, Hohenberger P, et al. Imaging therapy response of gastrointestinal stromal tumors (GIST) with FDG-PET, CT and MRI: a systematic review. Cancer Imaging. 2017;17:27.","journal-title":"Cancer Imaging"},{"issue":"8","key":"4172_CR28","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1177\/02841851211027389","volume":"63","author":"ME Revheim","year":"2022","unstructured":"Revheim ME, Hole KH, Mo T, Bruland \u00d8S, Reitan E, Julsrud L, et al. Multimodal functional imaging for early response assessment in patients with gastrointestinal stromal tumor treated with tyrosine kinase inhibitors. Acta Radiol. 2022;63(8):995\u20131004.","journal-title":"Acta Radiol"},{"key":"4172_CR29","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/0002-9610(92)90556-7","volume":"163","author":"CP Karakousis","year":"1992","unstructured":"Karakousis CP, Blumenson LE, Cavanese G, et al. Surgery for disseminated abdominal sarcoma. Am J Surg. 1992;163:560\u2013656.","journal-title":"Am J Surg"},{"key":"4172_CR30","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S1055-3207(03)00048-6","volume":"12","author":"PH Sugarbaker","year":"2003","unstructured":"Sugarbaker PH. Peritonectomy procedures. Surg Oncol Clin N Am. 2003;12:703\u201327.","journal-title":"Surg Oncol Clin N Am"},{"issue":"8","key":"4172_CR31","doi-asserted-by":"publisher","first-page":"e362","DOI":"10.1016\/S1470-2045(12)70210-3","volume":"13","author":"PH Sugarbaker","year":"2012","unstructured":"Sugarbaker PH, Jablonski KA, Chang D, Koslowe P, Chu DZ. Cytoreductive surgery plus hyperthermic perioperative chemotherapy to treat peritoneal metastases from colorectal cancer: standard of care or an experimental approach? Lancet Oncol. 2012;13(8):e362\u20139.","journal-title":"Lancet Oncol"},{"key":"4172_CR32","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.ejso.2005.04.010","volume":"31","author":"S Bonvalot","year":"2005","unstructured":"Bonvalot S, Cavalcanti A, Le Pechoux C, Terrier P, Vanel D, Blay JY, et al. Randomized trial of cytoreduction followed by intraperitoneal chemotherapy versus cytoreduction alone in patients with peritoneal sarcomatosis. Eur J Surg Oncol. 2005;31:917\u201323.","journal-title":"Eur J Surg Oncol"},{"key":"4172_CR33","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1245\/s10434-010-1229-3","volume":"18","author":"M Gitonga","year":"2011","unstructured":"Gitonga M, Deraco M, Kusamura S, Baratti D, Gavazzi C, Guaglio M, et al. Systematic review on the efficacy of multimodal treatment of sarcomatosis CRS + HIPEC 2011. Ann Surg Oncol. 2011;18:207\u201313.","journal-title":"Ann Surg Oncol"},{"key":"4172_CR34","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/j.annonc.2021.07.006","volume":"32","author":"A Gronchi","year":"2021","unstructured":"Gronchi A, Miah AB, Dei Tos AP, Abecassis N, Bajpai J, Bauer S, et al. Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021;32:1348\u201365.","journal-title":"Ann Oncol"},{"key":"4172_CR35","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3390\/cancers17081295","volume":"17","author":"R Lopes-Br\u00e1s","year":"2025","unstructured":"Lopes-Br\u00e1s R, Mu\u00f1oz P, Netto C, Faria S, Fern\u00e1ndez-Hern\u00e1ndez J, Marques R, et al. Ibero-American consensus for the management of liver metastases of soft tissue sarcoma: updated review and clinical recommendations. Cancers. 2025;17:1295.","journal-title":"Cancers"},{"key":"4172_CR36","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.3390\/cancers16152646","volume":"16","author":"FC Mu\u00f1oz-Casares","year":"2024","unstructured":"Mu\u00f1oz-Casares FC, Mart\u00edn-Broto J, Cascales-Campos A, Padillo Ruiz FJ, Gonz\u00e1lez de Pedro C, Fuster-P\u00e9rez S, et al. Ibero-American consensus for the management of peritoneal sarcomatosis: updated review and clinical recommendations. Cancers. 2024;16:2646.","journal-title":"Cancers"},{"issue":"2","key":"4172_CR37","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1097\/SLA.0000000000002281","volume":"268","author":"M Fairweather","year":"2018","unstructured":"Fairweather M, Balachandran VP, Li GZ, Bertagnolli MM, Antonescu C, Tap W, et al. Cytoreductive surgery for metastatic gastrointestinal stromal tumors treated with tyrosine kinase inhibitors: a 2-institutional analysis. Ann Surg. 2018;268(2):296\u2013302.","journal-title":"Ann Surg"},{"issue":"12","key":"4172_CR38","doi-asserted-by":"publisher","first-page":"3220","DOI":"10.1245\/s10434-010-1178-x","volume":"17","author":"D Baratti","year":"2010","unstructured":"Baratti D, Pennacchioli E, Kusamura S, Fiore M, Balestra MR, Colombo C, et al. Peritoneal sarcomatosis: is there a subset of patients who may benefit from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy? Ann Surg Oncol. 2010;17(12):3220\u20138.","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"4172_CR39","first-page":"519","volume":"44","author":"S Pasquali","year":"2018","unstructured":"Pasquali S, Bonvalot S, Tzanis D, Casali PG, Gronchi A. The role of surgery in metastatic GIST: a review of the literature. Eur J Surg Oncol. 2018;44(5):519\u201327.","journal-title":"Eur J Surg Oncol"},{"key":"4172_CR40","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1080\/13651820601156108","volume":"9","author":"D Gomez","year":"2007","unstructured":"Gomez D, Al-Mukthar A, Menon KV, Toogood GJ, Lodge JP, Prasad KR. Aggressive surgical resection for the management of hepatic metastases from gastrointestinal stromal tumours: a single centre experience. HPB. 2007;9:64\u201370.","journal-title":"HPB"},{"key":"4172_CR41","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10534-002-0813-9","volume":"10","author":"Y Shima","year":"2003","unstructured":"Shima Y, Horimi T, Ishikawa T, Ichikawa J, Okabayashi T, Nishioka Y, et al. Aggressive surgery for liver metastases from gastrointestinal stromal tumors. J Hepatobiliary Pancreat Dis Int. 2003;10:77\u201380.","journal-title":"J Hepatobiliary Pancreat Dis Int"},{"issue":"6","key":"4172_CR42","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/bjs.10774","volume":"105","author":"M Fairweather","year":"2018","unstructured":"Fairweather M, Cavnar MJ, Li GZ, Bertagnolli MM, DeMatteo RP, Raut CP. Prediction of morbidity following cytoreductive surgery for metastatic gastrointestinal stromal tumour in patients on tyrosine kinase inhibitor therapy. Br J Surg. 2018;105(6):743\u201350.","journal-title":"Br J Surg"},{"key":"4172_CR43","doi-asserted-by":"publisher","first-page":"14","DOI":"10.21037\/tgh.2018.02.02","volume":"3","author":"H Kikuchi","year":"2018","unstructured":"Kikuchi H, Hiramatsu Y, Kamiya K, Morita Y, Sakaguchi T, Konno H, et al. Surgery for metastatic gastrointestinal stromal tumor: to whom and how to? Transl Gastroenterol Hepatol. 2018;3:14.","journal-title":"Transl Gastroenterol Hepatol"},{"issue":"5","key":"4172_CR44","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-021-00837-0","volume":"22","author":"JA Yonkus","year":"2021","unstructured":"Yonkus JA, Alva-Ruiz R, Grotz TE. Surgical management of metastatic gastrointestinal stromal tumors. Curr Treat Options Oncol. 2021;22(5):37.","journal-title":"Curr Treat Options Oncol"},{"issue":"8","key":"4172_CR45","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.cireng.2024.05.015","volume":"102","author":"FC Mu\u00f1oz Casares","year":"2024","unstructured":"Mu\u00f1oz Casares FC, Padillo Ruiz FJ, de Gonz\u00e1lez Pedro C, G\u00f3mez Barbadillo J, Mart\u00edn Broto J, Almoguera Gonz\u00e1lez F, et al. Radical cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal sarcomatosis: results from a reference center and considerations based on current evidence. Cirug\u00eda Espa\u00f1ola (English Edition). 2024;102(8):433\u201342.","journal-title":"Cirug\u00eda Espa\u00f1ola (English Edition)"},{"key":"4172_CR46","unstructured":"Guti\u00e9rrez Fern\u00e1ndez AI. 2024 Multi-institutional registry of patients with gastrointestinal stromal tumors (GIST) with peritoneal dissemination or sarcomatosis (GISTosis) [doctoral thesis]. Murcia: University of Murcia. http:\/\/hdl.handle.net\/10201\/142785"},{"issue":"2","key":"4172_CR47","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-015-0384-y","volume":"17","author":"EZ Keung","year":"2016","unstructured":"Keung EZ, Fairweather M, Raut CP. The role of surgery in metastatic gastrointestinal stromal tumors. Curr Treat Options Oncol. 2016;17(2):8.","journal-title":"Curr Treat Options Oncol"},{"issue":"2","key":"4172_CR48","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1245\/s10434-009-0784-y","volume":"17","author":"CP Raut","year":"2010","unstructured":"Raut CP, Wang Q, Manola J, Morgan JA, George S, Wagner AJ, et al. Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with tyrosine kinase inhibitors: a prospective analysis. Ann Surg Oncol. 2010;17(2):407\u201315.","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"4172_CR49","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1177\/000313481408000923","volume":"80","author":"ML Bryan","year":"2014","unstructured":"Bryan ML, Fitzgerald NC, Levine EA, Shen P, Stewart JH, Votanopoulos KI. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in sarcomatosis from gastrointestinal stromal tumor. Am Surg. 2014;80(9):890\u20135.","journal-title":"Am Surg"},{"issue":"9","key":"4172_CR50","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1245\/s10434-014-4360-8","volume":"22","author":"J Rubi\u00f3-Casadevall","year":"2015","unstructured":"Rubi\u00f3-Casadevall J, Martinez-Trufero J, Garcia-Albeniz X, Pousa A, Garc\u00eda-Del-Muro X, L\u00f3pez-Pousa A, et al. Role of surgery in patients with recurrent, metastatic, or unresectable locally advanced gastrointestinal stromal tumors sensitive to imatinib: a retrospective analysis of the Spanish Group for Research on Sarcoma (GEIS). Ann Surg Oncol. 2015;22(9):2948\u201357.","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"4172_CR51","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ejso.2018.08.001","volume":"45","author":"X Zhang","year":"2019","unstructured":"Zhang X, Zhou Y, Wu X, Nie M, Zhang B, Zhou Y, et al. Cytoreductive surgery for metastatic gastrointestinal stromal tumors\u00a0followed by sunitinib compared to followed by imatinib-a\u00a0multi-center cohort study. Eur J Surg Oncol. 2019;45(3):318\u201323.","journal-title":"Eur J Surg Oncol"},{"issue":"2","key":"4172_CR52","first-page":"151","volume":"129","author":"TM Lwin","year":"2024","unstructured":"Lwin TM, Fairweather M. Cytoreductive surgery for metastatic gastrointestinal stromal tumor: a narrative review of patient selection, objectives, and options. J Surg Oncol. 2024;129(2):151\u201362.","journal-title":"J Surg Oncol"},{"issue":"1","key":"4172_CR53","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00423-023-03052-7","volume":"408","author":"A Rahimi-Ardabily","year":"2023","unstructured":"Rahimi-Ardabily A, Murdande S, Dong M, Gu KW, Zhang B, Miller K, et al. Liver resection for metastatic GIST tumor improves survival in the era of tyrosine kinase inhibitors: a systematic review and meta-analysis. Langenbecks Arch Surg. 2023;408(1):373.","journal-title":"Langenbecks Arch Surg"},{"issue":"4","key":"4172_CR54","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.ejso.2013.12.020","volume":"40","author":"S Bauer","year":"2014","unstructured":"Bauer S, Rutkowski P, Hohenberger P, Miceli R, Fumagalli E, Siedlecki JA, et al. Long-term follow-up of patients with GIST undergoing metastasectomy in the era of imatinib -- analysis of prognostic factors (EORTC-STBSG collaborative study). Eur J Surg Oncol. 2014;40(4):412\u20139. https:\/\/doi.org\/10.1016\/j.ejso.2013.12.020.","journal-title":"Eur J Surg Oncol"},{"key":"4172_CR55","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1002\/cncr.10504","volume":"94","author":"MM Bilimoria","year":"2002","unstructured":"Bilimoria MM, Holtz DJ, Mirza NQ, Feig BW, Pisters PW, Patel S, et al. Tumor volume as a prognostic factor for sarcomatosis. Cancer. 2002;94:2441\u20136.","journal-title":"Cancer"},{"key":"4172_CR56","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1002\/cncr.20192","volume":"100","author":"CR Rossi","year":"2004","unstructured":"Rossi CR, Deraco M, De Simone M, Mocellin S, Pilati P, Foletto M, et al. Hyperthermic intraperitoneal intraoperative chemotherapy after cytoreductive surgery for the treatment of abdominal sarcomatosis. Cancer. 2004;100:1943\u201350.","journal-title":"Cancer"},{"issue":"3","key":"4172_CR57","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1097\/01.sla.0000236630.93587.59","volume":"245","author":"RP DeMatteo","year":"2007","unstructured":"DeMatteo RP, Maki RG, Singer S, Gonen M, Brennan MF, Antonescu CR. Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor. Ann Surg. 2007;245(3):347\u201352.","journal-title":"Ann Surg"},{"key":"4172_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.10.013","author":"LCK Wong","year":"2022","unstructured":"Wong LCK, Li Z, Fan Q, Tan JW, Tan QX, Wong JSM, et al. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal sarcomatosis-a systematic review and meta-analysis. Eur J Surg Oncol. 2022. https:\/\/doi.org\/10.1016\/j.ejso.2021.10.013.","journal-title":"Eur J Surg Oncol"},{"key":"4172_CR59","first-page":"15","volume":"24","author":"C Serrano","year":"2023","unstructured":"Serrano C, Mart\u00edn-Broto J, Asencio-Pascual JM, L\u00f3pez-Guerrero JA, Rubi\u00f3-Casadevall J, Bagu\u00e9 S, et al. 2023 GEIS Guidelines for gastrointestinal stromal tumors. Ther Adv Med Oncol. 2023;24:15.","journal-title":"Ther Adv Med Oncol"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04172-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-025-04172-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04172-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T12:02:16Z","timestamp":1784980936000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-025-04172-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":59,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["4172"],"URL":"https:\/\/doi.org\/10.1007\/s12094-025-04172-w","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"25 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest related to the content of this manuscript.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article is a narrative review and does not contain any studies with human participants or animals performed by any of the authors. Therefore, approval by an Institutional Review Board or Ethics Committee was not required.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No human participants were involved in this work; informed consent was not applicable.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}