{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:51:07Z","timestamp":1781877067413,"version":"3.54.5"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-025-04198-0","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T06:39:32Z","timestamp":1768372772000},"page":"2721-2730","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of image-guided radiation therapy with intraprostatic seeds on long-term toxicity in prostate cancer patients undergoing risk-adapted intensification therapy"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-2312","authenticated-orcid":false,"given":"Almudena","family":"Zapatero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Martin de Vidales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Roch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Montes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Alfonso","family":"Cruz Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Stoica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Villalba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Nafr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feliciano","family":"Garc\u00eda Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"4198_CR1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","volume":"86","author":"P Cornford","year":"2024","unstructured":"Cornford P, van den Bergh RCN, Briers E, den Van Broeck T, Brunckhorst O, Darraugh J, et al. EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate cancer-2024 update. Part I: screening, diagnosis, and local treatment with curative intent. Eur Urol. 2024;86:148\u201363.","journal-title":"Eur Urol"},{"key":"4198_CR2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.radonc.2013.09.026","volume":"110","author":"WD Heemsbergen","year":"2014","unstructured":"Heemsbergen WD, Al-Mamgani A, Slot A, Dielwart MFH, Lebesque JV. Long-term results of the Dutch randomized prostate cancer trial: impact of dose-escalation on local, biochemical, clinical failure, and survival. Radiother Oncol. 2014;110:104\u20139.","journal-title":"Radiother Oncol"},{"key":"4198_CR3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/S1470-2045(14)70040-3","volume":"15","author":"DP Dearnaley","year":"2014","unstructured":"Dearnaley DP, Jovic G, Syndikus I, Khoo V, Cowan RA, Graham JD, et al. Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial. Lancet Oncol. 2014;15:464\u201373.","journal-title":"Lancet Oncol"},{"key":"4198_CR4","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.juro.2006.06.002","volume":"176","author":"MJ Zelefsky","year":"2006","unstructured":"Zelefsky MJ, Chan H, Hunt M, Yamada Y, Shippy AM, Amols H. Long-term outcome of high dose intensity modulated radiation therapy for patients with clinically localized prostate cancer. J Urol. 2006;176:1415\u20139.","journal-title":"J Urol"},{"key":"4198_CR5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.4_suppl.LBA259","author":"C Hennequin","year":"2025","unstructured":"Hennequin C, Sargos P, Roca L, Silva M, Latorzeff I, Peiffert D, et al. Long-term results of dose escalation (80 vs 70 Gy) combined with long-term androgen deprivation in high-risk prostate cancers: GETUG-AFU 18 randomized trial. J Clin Oncol Internet. 2025. https:\/\/doi.org\/10.1200\/JCO.2024.42.4_suppl.LBA259.","journal-title":"J Clin Oncol Internet"},{"key":"4198_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.07.041","author":"JM Michalski","year":"2013","unstructured":"Michalski JM, Yan Y, Watkins-Bruner D, Bosch W, Winter K, Galvin JM, et al. Preliminary toxicity analysis of 3DCRT versus IMRT on the high dose arm of the RTOG 0126 prostate cancer trial. Int J Radiat Oncol Biol Phys. 2013. https:\/\/doi.org\/10.1016\/j.ijrobp.2013.07.041.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"25","key":"4198_CR7","first-page":"00025","volume":"S0923\u20137534","author":"A Dal Pra","year":"2025","unstructured":"Dal Pra A, Ghadjar P, Ryu HM, Proudfoot JA, Hayoz S, Michalski JM, et al. Predicting dose response to prostate cancer radiotherapy: validation of a radiation signature in the randomized phase III NRG\/RTOG 0126 and SAKK 09\/10 trials. Ann Oncol. 2025;S0923\u20137534(25):00025.","journal-title":"Ann Oncol"},{"key":"4198_CR8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ijrobp.2011.11.047","volume":"84","author":"MJ Zelefsky","year":"2012","unstructured":"Zelefsky MJ, Kollmeier M, Cox B, Fidaleo A, Sperling D, Pei X, et al. Improved clinical outcomes with high-dose image guided radiotherapy compared with non-IGRT for the treatment of clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 2012;84:125\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4198_CR9","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.rpor.2016.01.005","volume":"21","author":"M Becker-Schiebe","year":"2016","unstructured":"Becker-Schiebe M, Abaci A, Ahmad T, Hoffmann W. Reducing radiation-associated toxicity using online image guidance (IGRT) in prostate cancer patients undergoing dose-escalated radiation therapy. Rep Practical Oncol Radiotherapy. 2016;21:188\u201394.","journal-title":"Rep Practical Oncol Radiotherapy"},{"key":"4198_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00018","volume":"5","author":"NP Nguyen","year":"2015","unstructured":"Nguyen NP, Davis R, Bose SR, Dutta S, Vinh-Hung V, Chi A, et al. Potential applications of image-guided radiotherapy for radiation dose escalation in patients with early stage high-risk prostate cancer. Front Oncol. 2015;5:18.","journal-title":"Front Oncol"},{"key":"4198_CR11","doi-asserted-by":"publisher","first-page":"503","DOI":"10.4236\/ijmpcero.2018.74043","volume":"7","author":"P Castro","year":"2018","unstructured":"Castro P, Roch M, Zapatero A, B\u00fcchser D, Garayoa J, Ans\u00f3n C, et al. Multicomponent assessment of the geometrical uncertainty and consequent margins in prostate cancer radiotherapy treatment using fiducial markers. Int J Med Phys, Clin Eng Radiation Oncol. 2018;7:503\u201321.","journal-title":"Int J Med Phys, Clin Eng Radiation Oncol"},{"key":"4198_CR12","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/j.ijrobp.2012.07.2376","volume":"85","author":"J Singh","year":"2013","unstructured":"Singh J, Greer PB, White MA, Parker J, Patterson J, Tang CI, et al. Treatment-related morbidity in prostate cancer: a\u00a0comparison of 3-dimensional conformal radiation therapy with and without image guidance using implanted fiducial markers. Int J Radiation Oncol*Biol*Phys. 2013;85:1018\u201323.","journal-title":"Int J Radiation Oncol*Biol*Phys"},{"key":"4198_CR13","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1007\/s12094-017-1655-9","volume":"19","author":"A Zapatero","year":"2017","unstructured":"Zapatero A, Roch M, B\u00fcchser D, Castro P, Fern\u00e1ndez-Banda L, Pozo G, et al. Reduced late urinary toxicity with high-dose intensity-modulated radiotherapy using intra-prostate fiducial markers for localized prostate cancer. Clin Transl Oncol. 2017;19:1161\u20137.","journal-title":"Clin Transl Oncol"},{"key":"4198_CR14","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20160296","volume":"89","author":"AGM O\u2019Neill","year":"2016","unstructured":"O\u2019Neill AGM, Jain S, Hounsell AR, O\u2019Sullivan JM. Fiducial marker guided prostate radiotherapy: a review. Br J Radiol. 2016;89:20160296.","journal-title":"Br J Radiol"},{"issue":"1","key":"4198_CR15","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13014-025-02665-0","volume":"20","author":"A Zapatero","year":"2025","unstructured":"Zapatero A, Roch M, de Mart\u00edn Vidales C, Castro P, Montes N, Cruz Conde A, et al. Risk-adapted intensification therapy in high-risk prostate cancer: how relevant is the role of radiation dose. Radiat Oncol. 2025;20(1):102. https:\/\/doi.org\/10.1186\/s13014-025-02665-0.","journal-title":"Radiat Oncol"},{"key":"4198_CR16","first-page":"105","volume":"93","author":"D Sevillano-Mart\u00ednez","year":"2008","unstructured":"Sevillano-Mart\u00ednez D, Garc\u00eda-Vicente F, Zapatero A, Ferrer-Gracia C, G\u00f3mez-Barrado A, P\u00e9rez-Gonzalez L, et al. Study on the use of gold seeds in prostate cancer treatment verification. Rev Fis Med. 2008;93:105\u201312.","journal-title":"Rev Fis Med"},{"key":"4198_CR17","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.radonc.2019.10.017","volume":"142","author":"J Murray","year":"2020","unstructured":"Murray J, Griffin C, Gulliford S, Syndikus I, Staffurth J, Panades M, et al. A randomised assessment of image guided radiotherapy within a phase 3 trial of conventional or hypofractionated high dose intensity modulated radiotherapy for prostate cancer. Radiother Oncol. 2020;142:62\u201371.","journal-title":"Radiother Oncol"},{"key":"4198_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-6-145","volume":"6","author":"S Gill","year":"2011","unstructured":"Gill S, Thomas J, Fox C, Kron T, Rolfo A, Leahy M, et al. Acute toxicity in prostate cancer patients treated with and without image-guided radiotherapy. Radiat Oncol. 2011;6:145.","journal-title":"Radiat Oncol"},{"key":"4198_CR19","first-page":"940","volume":"26","author":"J Stuk","year":"2021","unstructured":"Stuk J, Vanasek J, Odrazka K, Dolezel M, Kolarova I, Hlavka A, et al. Image-guided radiation therapy produces lower acute and chronic gastrointestinal and genitourinary toxicity in prostate cancer patients. J BUON. 2021;26:940\u20138.","journal-title":"J BUON"},{"key":"4198_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-8-137","volume":"8","author":"M Valeriani","year":"2013","unstructured":"Valeriani M, Bracci S, Osti MF, Falco T, Agolli L, De Sanctis V, et al. Intermediate-risk prostate cancer patients treated with androgen deprivation therapy and a hypofractionated radiation regimen with or without image guided radiotherapy. Radiat Oncol. 2013;8:137.","journal-title":"Radiat Oncol"},{"key":"4198_CR21","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.ijrobp.2014.12.017","volume":"91","author":"RC Wortel","year":"2015","unstructured":"Wortel RC, Incrocci L, Pos FJ, Lebesque JV, Witte MG, van der Heide UA, et al. Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients. Int J Radiat Oncol*Biol*Phys. 2015;91:737\u201344.","journal-title":"Int J Radiat Oncol*Biol*Phys"},{"key":"4198_CR22","first-page":"81","volume":"38","author":"S Wang","year":"2023","unstructured":"Wang S, Tang W, Luo H, Jin F, Wang Y. The role of image-guided radiotherapy in prostate cancer: a systematic review and meta-analysis. Clin Transl Radiat Oncol. 2023;38:81\u20139.","journal-title":"Clin Transl Radiat Oncol"},{"key":"4198_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2024.101612","volume":"9","author":"I Serizawa","year":"2024","unstructured":"Serizawa I, Kozuka T, Soyano T, Sasamura K, Kamima T, Kunogi H, et al. Clinical and dosimetric comparison between non-image guided radiation therapy and fiducial-based image guided radiation therapy with or without reduced margin in intensity modulated radiation therapy for prostate cancer. Adv Radiat Oncol. 2024;9:101612.","journal-title":"Adv Radiat Oncol"},{"key":"4198_CR24","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20200456","volume":"94","author":"Y-H Kuo","year":"2021","unstructured":"Kuo Y-H, Liang J-A, Chen G-H, Li C-C, Chien C-R. Safety of image-guided radiotherapy in definitive radiotherapy for localized prostate cancer: a population-based analysis. Br J Radiol. 2021;94:20200456.","journal-title":"Br J Radiol"},{"key":"4198_CR25","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s10147-023-02456-1","volume":"29","author":"R Aizawa","year":"2024","unstructured":"Aizawa R, Inokuchi H, Ikeda I, Nakamura K, Ogata T, Akamatsu S, et al. Impact of prostate position-based image-guidance in intensity-modulated radiation therapy for localized prostate cancer. Int J Clin Oncol. 2024;29:325\u201332.","journal-title":"Int J Clin Oncol"},{"key":"4198_CR26","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.ijrobp.2004.01.031","volume":"59","author":"A Zapatero","year":"2004","unstructured":"Zapatero A, Garc\u00eda-Vicente F, Modolell I, Alc\u00e1ntara P, Floriano A, Cruz-Conde A, et al. Impact of mean rectal dose on late rectal bleeding after conformal radiotherapy for prostate cancer: dose-volume effect. Int J Radiat Oncol Biol Phys. 2004;59:1343\u201351.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4198_CR27","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/S0360-3016(02)03742-2","volume":"54","author":"EH Huang","year":"2002","unstructured":"Huang EH, Pollack A, Levy L, Starkschall G, Dong L, Rosen I, et al. Late rectal toxicity: dose-volume effects of conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2002;54:1314\u201321.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4198_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0167-8140(02)00147-0","volume":"64","author":"C Fiorino","year":"2002","unstructured":"Fiorino C, Cozzarini C, Vavassori V, Sanguineti G, Bianchi C, Cattaneo GM, et al. Relationships between DVHs and late rectal bleeding after radiotherapy for prostate cancer: analysis of a large group of patients pooled from three institutions. Radiother Oncol. 2002;64:1\u201312.","journal-title":"Radiother Oncol"},{"key":"4198_CR29","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.ijrobp.2012.10.042","volume":"85","author":"DA Hamstra","year":"2013","unstructured":"Hamstra DA, Stenmark MH, Ritter T, Litzenberg D, Jackson W, Johnson S, et al. Age and comorbid illness are associated with late rectal toxicity following dose-escalated radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2013;85:1246\u201353.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4198_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105246","volume":"106","author":"J Iacovacci","year":"2024","unstructured":"Iacovacci J, Serafini MS, Avuzzi B, Badenchini F, Cicchetti A, Devecchi A, et al. Intestinal microbiota composition is predictive of radiotherapy-induced acute gastrointestinal toxicity in prostate cancer patients. EBioMedicine. 2024;106:105246.","journal-title":"EBioMedicine"},{"key":"4198_CR31","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41391-022-00520-x","volume":"26","author":"R David","year":"2023","unstructured":"David R, Buckby A, Kahokehr AA, Lee J, Watson DI, Leung J, et al. Long term genitourinary toxicity following curative intent intensity-modulated radiotherapy for prostate cancer: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2023;26:8\u201315.","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"4198_CR32","doi-asserted-by":"crossref","unstructured":"Takeda K, Umezawa R, Ishikawa Y, Yamamoto T, Takahashi N, Takeda K, et al. Clinical predictors of severe late urinary toxicity after curative intensity-modulated radiation therapy for localized prostate cancer. J Radiat Res. 2021;rrab074.","DOI":"10.1093\/jrr\/rrab074"},{"key":"4198_CR33","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.clon.2017.03.006","volume":"29","author":"K Byrne","year":"2017","unstructured":"Byrne K, Hruby G, Kneebone A, Whalley D, Guo L, McCloud P, et al. Late genitourinary toxicity outcomes in 300 prostate cancer patients treated with dose-escalated image-guided intensity-modulated radiotherapy. Clin Oncol (R Coll Radiol). 2017;29:617\u201325.","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"4198_CR34","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41391-017-0028-3","volume":"21","author":"MA Awad","year":"2018","unstructured":"Awad MA, Gaither TW, Osterberg EC, Murphy GP, Baradaran N, Breyer BN. Prostate cancer radiation and urethral strictures: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2018;21:168\u201374.","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"4198_CR35","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.ijrobp.2013.10.042","volume":"88","author":"P Ghadjar","year":"2014","unstructured":"Ghadjar P, Zelefsky MJ, Spratt DE, Munck af Rosensch\u00f6ld P, Oh JH, Hunt M, et al. Impact of dose to the bladder trigone on long-term urinary function after high-dose intensity modulated radiation therapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2014;88:339\u201344.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1131","key":"4198_CR36","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210683","volume":"95","author":"A Zapatero","year":"2022","unstructured":"Zapatero A, Roch M, Castro Tejero P, B\u00fcchser D, de Martin Vidales C, Gonz\u00e1lez S, et al. MRI-guided focal boost to dominant intraprostatic lesion using volumetric modulated arc therapy in prostate cancer. Results of a phase II trial. Br J Radiol. 2022;95(1131):20210683. https:\/\/doi.org\/10.1259\/bjr.20210683.","journal-title":"Br J Radiol"},{"key":"4198_CR37","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.ijrobp.2023.03.057","volume":"117","author":"T Zilli","year":"2023","unstructured":"Zilli T, Jorcano S, Bral S, Symon Z, Rubio C, Bruynzeel AME, et al. Every-other-day versus once-a-week urethra-sparing prostate stereotactic body radiation therapy: 5-year results of a randomized phase 2 trial. Int J Radiat Oncol Biol Phys. 2023;117:791\u20138.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"4198_CR38","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.1007\/s00345-023-04579-6","volume":"41","author":"J Le Guevelou","year":"2023","unstructured":"Le Guevelou J, Bosetti DG, Castronovo F, Angrisani A, de Crevoisier R, Zilli T. State of the art and future challenges of urethra-sparing stereotactic body radiotherapy for prostate cancer: a systematic review of literature. World J Urol. 2023;41:3287\u201399.","journal-title":"World J Urol"},{"key":"4198_CR39","unstructured":"Armstrong AJ, Liu VYT, Selvaraju RR, Chen E, Simko JP, DeVries S, et al. Development and validation of an artificial intelligence digital pathology biomarker to predict benefit of long-term hormonal therapy and radiotherapy in men with high-risk prostate cancer across multiple phase III trials. JCO. 2025;0:JCO.24.00365."},{"key":"4198_CR40","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.urology.2005.03.081","volume":"66","author":"AB Jani","year":"2005","unstructured":"Jani AB, Gratzle J. Late radiotherapy toxicity after prostate cancer treatment: influence of hormonal therapy. Urology. 2005;66:566\u201370.","journal-title":"Urology"},{"key":"4198_CR41","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ijrobp.2007.06.050","volume":"70","author":"CA Lawton","year":"2008","unstructured":"Lawton CA, Bae K, Pilepich M, Hanks G, Shipley W. Long-term treatment sequelae after external beam irradiation with or without hormonal manipulation for adenocarcinoma of the prostate: analysis of radiation therapy oncology group studies 85-31, 86-10, and 92-02. Int J Radiat Oncol Biol Phys. 2008;70:437\u201341.","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04198-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-025-04198-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-025-04198-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:58:03Z","timestamp":1781873883000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-025-04198-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["4198"],"URL":"https:\/\/doi.org\/10.1007\/s12094-025-04198-0","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"11 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors did not receive support from any organization for the submitted work. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective study, which includes patients that participated in several risk-intensification studies approved by the IRB of the Hospital Universitario de la Princesa, was conducted according to the 1964 Helsinki Declaration and its later amendments or comparable ethical and the Good Clinical Practice Guidelines of the International Conference on Harmonization.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}