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Unplanned interruptions reduce tumor control, yet no validated management guidelines exist. The Italian Association of Radiation and Clinical Oncology (AIRO) conducted a national survey to assess the prevalence, causes, and management strategies for RT interruptions across Italy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional survey was conducted between April and June 2022. A 34-question survey was emailed to directors of all Italian ROT centers, covering: (1) demographic and institutional characteristics; (2) radiobiological knowledge of ROT interruptions; (3) clinical management and compensation strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 104 centers responded. Respondents had a median age of 57\u00a0years (range 34\u201374), and most worked in General Hospitals (64%). Centers had a median of 2 LINACs (range 1\u20136), with 16% operating only one LINAC. 96% of radiation oncologists (Ros) considered ROT interruptions a critical issue, particularly in curative (51%) and adjuvant (29%) settings. 42% defined an interruption of\u2009&gt;\u20095\u00a0days as critical, and 63% believed treatment phase did not influence impact. 29% of ROs followed formal guidelines [e.g., Royal College of Radiographers (RCR)]. The main causes of interruptions were LINAC breakdowns (22%), toxicity (22%), and patient compliance issues (22%). 24% of ROs followed codified procedures for managing interruptions; 84% regularly monitored treatment breaks. Dose recovery strategies: 28% always compensated, 59% occasionally compensated, primarily by increasing total dose (48%) or working on Saturdays (20%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals variability in ROT interruption management, stressing the need for AIRO guidelines, collaboration, and modern radiobiological integration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12094-025-04211-6","type":"journal-article","created":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T12:19:01Z","timestamp":1769948341000},"page":"2911-2920","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Managing unplanned radiotherapy interruptions in Italy: results from an AIRO survey"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-5070","authenticated-orcid":false,"given":"Francesco","family":"Deodato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Pezzulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Macchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Manfrida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Dinapoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia Falchetto","family":"Osti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Sanguineti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio Giuseppe","family":"Morganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvio Grazioso","family":"Russi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"4211_CR1","first-page":"239","volume-title":"Cancer: disease control priorities","author":"DA Jaffray","year":"2015","unstructured":"Jaffray DA, Gospodarowicz MK. 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