{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:00:58Z","timestamp":1784977258347,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Purpose<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the feasibility of implementing volumetric modulated arc therapy (VMAT)\u2013based techniques and extended CBCT image guidance for total body irradiation (TBI) treatment using a conventional linear accelerator.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients eligible for TBI between November 2016 and December 2024 were included in the analysis.<\/jats:p>\n                    <jats:p>Patients received a total dose of 4\u201312\u00a0Gy, given in six fractions within 3\u00a0days, two fractions\/day with 6\u00a0h minimum interval between fractions, or 2\u00a0Gy in one fraction, depending on the clinical indication.<\/jats:p>\n                    <jats:p>During the initial phase of the protocol, PET\u2013CT imaging was used to obtain full-body CT datasets. Subsequently, CT simulation was performed using a multislice Siemens CT scanner available in the Radiation Oncology Department. In this setting, two CT studies were acquired per patient, one extending from the pelvis to the head (upper scan) and a second from the pelvis to the feet (lower scan), which were merged into a single dataset for treatment planning.<\/jats:p>\n                    <jats:p>Dosimetric planning was performed using a multi-isocenter approach with the Eclipse\u2122 treatment planning system, employing volumetric modulated arc therapy (VMAT) to achieve the prescribed dose distribution. In the initial stage of the treatment program, treatments were delivered on a Varian CLINAC DHX linear accelerator. Following its decommissioning, treatment delivery was transitioned to Varian TrueBeam linear accelerators (models SN3790 and SN2137). Treatment delivery, including verification and patient positioning, was performed sequentially, beginning with the upper body followed by the lower body. Image guidance was initially based on kV\u2013MV imaging and was later replaced by extended-field cone-beam computed tomography (CBCT), which was registered to the simulation CT to enable automated setup corrections. Dosimetric parameters and setup verification metrics were subsequently analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between November 2016 to December 2024, 27 patients fulfilled the inclusion criteria. All scheduled sessions were completed, amounting to a total of 148 treatment fractions. The average number of isocenters used to generate the treatment plans was 7,11 (6\u201312). The mean lung dose was 10.12\u00a0Gy (range 8.97\u201311.07\u00a0Gy). Dose homogeneity achieved across all sessions was 1.24 (1.11\u20131.41). After image acquisition, mean setup corrections were 0.06\u00a0cm lateral (range 0.00\u20132.00\u00a0cm), 0.26\u00a0cm vertical (0.00\u20132.00\u00a0cm), and 0.03\u00a0cm longitudinal (0.00\u20131.30\u00a0cm) in head-first plan. Laterally, 0.26\u00a0cm (range: 0.00\u20132.00\u00a0cm) vertically, and 0.03\u00a0cm (range: 0.00\u20131.30\u00a0cm) longitudinally in feet first plan. The average duration of each session, from the first image acquisition to the completion of the final field, was 87\u00a0min (range 60\u2013159).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study demonstrates that VMAT-based TBI is a feasible and promising alternative to conventional 2D-TBI, providing improved dose homogeneity, enhanced organ sparing and with reproducibility comparable to previously reported HT systems. These findings support the integration of VMAT techniques on conventional LINACs for TBI treatments, although further prospective studies are needed to confirm long-term clinical benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s12094-026-04245-4","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:47:03Z","timestamp":1771343223000},"page":"3527-3538","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["VMAT-based total body irradiation on a conventional LINAC: workflow, procedure and preliminary results"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3898-343X","authenticated-orcid":false,"given":"I.","family":"Rey L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Alay\u00f3n Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Meli\u00e1n Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mad\u00e1n Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"D\u00edaz Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"S\u00e1nchez Carrascal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ruiz Egea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lloret S\u00e1ez-Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"4245_CR1","doi-asserted-by":"publisher","first-page":"153303382311807","DOI":"10.1177\/15330338231180779","volume":"22","author":"E Keit","year":"2023","unstructured":"Keit E, Liveringhouse C, Figura N, Weygand J, Sandoval ML, Garcia G, et al. Feasibility and toxicity of full-body volumetric modulated arc therapy technique for high-dose total body irradiation. Technol Cancer Res Treat. 2023;22:15330338231180780.","journal-title":"Technol Cancer Res Treat."},{"issue":"3","key":"4245_CR2","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ijrobp.2018.04.071","volume":"101","author":"JYC Wong","year":"2018","unstructured":"Wong JYC, Filippi AR, Dabaja BS, Yahalom J, Specht L. Total Body Irradiation: Guidelines from the International Lymphoma Radiation Oncology Group (ILROG). Int J Radiat Oncol Biol Phys. 2018;101(3):521\u20139.","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"4","key":"4245_CR3","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/S0360-3016(00)01491-7","volume":"49","author":"S Bieri","year":"2001","unstructured":"Bieri S, Helg C, Chapuis B, Miralbell R. Total body irradiation before allogeneic bone marrow transplantation: is more dose better? Int J Radiat Oncol Biol Phys. 2001;49(4):1071\u20137.","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"8","key":"4245_CR4","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/sj.bmt.1702230","volume":"25","author":"RM Sobecks","year":"2000","unstructured":"Sobecks RM, Daugherty CK, Hallahan DE, Laport GF, Wagner ND, Larson RA. A dose escalation study of total body irradiation followed by high-dose etoposide and allogeneic blood stem cell transplantation for the treatment of advanced hematologic malignancies. Bone Marrow Transpl abril de. 2000;25(8):807\u201313.","journal-title":"Bone Marrow Transpl abril de"},{"issue":"6","key":"4245_CR5","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/0360-3016(80)90240-0","volume":"6","author":"TH Kim","year":"1980","unstructured":"Kim TH, Khan FM, Galvin JM. A report of the work party: comparison of total body irradiation techniques for bone marrow transplantation. Int J Radiat Oncol Biol Phys. 1980;6(6):779\u201384.","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"4245_CR6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/0167-8140(90)90180-5","volume":"18","author":"B Shank","year":"1990","unstructured":"Shank B, O\u2019Reilly RJ, Cunningham I, Kernan N, Yaholom J, Brochstein J, et al. Total body irradiation for bone marrow transplantation: the Memorial sloan-Kettering cancer center experience. Radiother Oncol. 1990;18:68\u201381.","journal-title":"Radiother Oncol."},{"issue":"3","key":"4245_CR7","first-page":"91","volume":"5","author":"SH Benedict","year":"2004","unstructured":"Benedict SH. Review of radiation oncology physics: a handbook for teachers and students. J Appl Clin Med Phys. 2004;5(3):91\u20132.","journal-title":"J Appl Clin Med Phys."},{"issue":"4","key":"4245_CR8","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.meddos.2009.07.001","volume":"35","author":"AH Zhuang","year":"2010","unstructured":"Zhuang AH, Liu A, Schultheiss TE, Wong JYC. Dosimetric study and verification of total body irradiation using helical tomotherapy and its comparison to extended SSD technique. Med Dosim. 2010;35(4):243\u20139.","journal-title":"Med Dosim."},{"key":"4245_CR9","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13014-016-0625-7","volume":"11","author":"A Springer","year":"2016","unstructured":"Springer A, Hammer J, Winkler E, Track C, Huppert R, B\u00f6hm A, et al. Total body irradiation with volumetric modulated arc therapy: Dosimetric data and first clinical experience. Radiat Oncol Lond Engl. 2016;11:46.","journal-title":"Radiat Oncol Lond Engl."},{"issue":"4","key":"4245_CR10","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.adro.2016.07.001","volume":"1","author":"SJ Stephens","year":"2016","unstructured":"Stephens SJ, Thomas S, Rizzieri DA, Horwitz ME, Chao NJ, Engemann AM, et al. Myeloablative conditioning with total body irradiation for AML: Balancing survival and pulmonary toxicity. Adv Radiat Oncol. 2016;1(4):272\u201380.","journal-title":"Adv Radiat Oncol."},{"issue":"9","key":"4245_CR11","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1182\/blood.V76.9.1867.1867","volume":"76","author":"RA Clift","year":"1990","unstructured":"Clift RA, Buckner CD, Appelbaum FR, Bearman SI, Petersen FB, Fisher LD, et al. Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens. Blood. 1990;76(9):1867\u201371.","journal-title":"Blood."},{"issue":"4","key":"4245_CR12","first-page":"71","volume":"5","author":"SK Hui","year":"2004","unstructured":"Hui SK, Das RK, Thomadsen B, Henderson D. CT-based analysis of dose homogeneity in total body irradiation using lateral beam. J Appl Clin Med Phys. 2004;5(4):71\u20139.","journal-title":"J Appl Clin Med Phys."},{"issue":"4","key":"4245_CR13","doi-asserted-by":"publisher","first-page":"e13513","DOI":"10.1002\/acm2.13513","volume":"23","author":"SMH Luk","year":"2022","unstructured":"Luk SMH, Wallner K, Glenn MC, Ermoian R, Phillips MH, Tseng YD, et al. Effect of total body irradiation lung block parameters on lung doses using three-dimensional dosimetry. J Appl Clin Med Phys. 2022;23(4):e13513.","journal-title":"J Appl Clin Med Phys."},{"issue":"10","key":"4245_CR14","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1118\/1.2044428","volume":"32","author":"SK Hui","year":"2005","unstructured":"Hui SK, Kapatoes J, Fowler J, Henderson D, Olivera G, Manon RR, et al. Feasibility study of helical tomotherapy for total body or total marrow irradiation. Med Phys. 2005;32(10):3214\u201324.","journal-title":"Med Phys"},{"issue":"3","key":"4245_CR15","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.bbmt.2005.10.026","volume":"12","author":"JYC Wong","year":"2006","unstructured":"Wong JYC, Liu A, Schultheiss T, Popplewell L, Stein A, Rosenthal J, et al. Targeted total marrow irradiation using three-dimensional image-guided tomographic intensity-modulated radiation therapy: an alternative to standard total body irradiation. Biol Blood Marrow Transpl. 2006;12(3):306\u201315.","journal-title":"Biol Blood Marrow Transpl."},{"issue":"2","key":"4245_CR16","first-page":"113.e1","volume":"28","author":"ER Zhang-Velten","year":"2022","unstructured":"Zhang-Velten ER, Parsons D, Lee P, Chambers E, Abdulrahman R, Desai NB, et al. Volumetric modulated arc therapy enabled total body irradiation (VMAT-TBI): six-year clinical experience and treatment outcomes. Transpl Cell Ther. 2022;28(2):113.e1-113.e8.","journal-title":"Transpl Cell Ther."},{"key":"4245_CR17","doi-asserted-by":"publisher","first-page":"785917","DOI":"10.3389\/fonc.2022.785917","volume":"12","author":"AA Loginova","year":"2022","unstructured":"Loginova AA, Tovmasian DA, Lisovskaya AO, Kobyzeva DA, Maschan MA, Chernyaev AP, et al. Optimized conformal total body irradiation methods with helical tomotherapy and elekta VMAT: implementation, imaging, planning and dose delivery for pediatric patients. Front Oncol. 2022;12:785917.","journal-title":"Front Oncol."},{"issue":"3","key":"4245_CR18","doi-asserted-by":"publisher","first-page":"e303","DOI":"10.1016\/j.ijrobp.2021.07.950","volume":"111","author":"C Liveringhouse","year":"2021","unstructured":"Liveringhouse C, Robinson TJ, Garcia G, Peters J, Kim S, Latifi K. Dosimetric comparison of volumetric modulated arc therapy with tomotherapy based total body irradiation for patients undergoing conditioning prior to hematopoietic stem cell transplantation for acute lymphocytic leukemia. Int J Radiat Oncol noviembre de. 2021;111(3):e303.","journal-title":"Int J Radiat Oncol noviembre de"},{"key":"4245_CR19","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s13014-021-01959-3","volume":"16","author":"T Uehara","year":"2021","unstructured":"Uehara T, Monzen H, Tamura M, Inada M, Otsuka M, Doi H, et al. Feasibility study of volumetric modulated arc therapy with HalcyonTM linac for total body irradiation. Radiat Oncol Lond Engl. 2021;16:236.","journal-title":"Radiat Oncol Lond Engl."},{"key":"4245_CR20","unstructured":"Seravalli E, Bosman ME, Han C, Losert C, Pazos M, Engstr\u00f6m PE, et\u00a0al. Technical recommendations for implementation of Volumetric Modulated Arc Therapy and Helical Tomotherapy Total Body Irradiation. Radiother Oncol [Internet]. 1 de agosto de 2024 [citado 26 de agosto de 2025];197. Disponible en: https:\/\/www.thegreenjournal.com\/article\/S0167-8140(24)00636-4\/fulltext"},{"issue":"3","key":"4245_CR21","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.radonc.2018.08.005","volume":"129","author":"B Tas","year":"2018","unstructured":"Tas B, Durmus IF, Okumus A, Uzel OE, Gokce M, Goksoy HS, et al. Total-body irradiation using linac-based volumetric modulated arc therapy: Its clinical accuracy, feasibility and reliability. Radiother Oncol. 2018;129(3):527\u201333.","journal-title":"Radiother Oncol."},{"key":"4245_CR22","unstructured":"Siemens Healthineers. (s.f.). Retrieved July 24 from https:\/\/www.siemens-healthineers.com\/en-us."},{"key":"4245_CR23","unstructured":"3D Slicer. (n.d.). 3D Slicer: A multi-platform, free and open source software package for visualization and medical image computing. Retrieved June 2, 2024, from https:\/\/www.slicer.org\/."},{"key":"4245_CR24","unstructured":"Varian Medical Systems. (n.d.). Velocity: Information systems software. Retrieved June 2, 2024, from https:\/\/www.varian.com\/es-xl\/products\/software\/information-systems\/velocity."},{"issue":"3","key":"4245_CR25","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/acm2.13189","volume":"22","author":"JR Teruel","year":"2021","unstructured":"Teruel JR, Taneja S, Galavis PE, Osterman KS, McCarthy A, Malin M, et al. Automatic treatment planning for VMAT-based total body irradiation using Eclipse scripting. J Appl Clin Med Phys. 2021;22(3):119\u201330.","journal-title":"J Appl Clin Med Phys."},{"key":"4245_CR26","unstructured":"ICRU Report 83, Prescribing, Recording, and Reporting Intensity-Modulated Photon-Beam Therapy (IMRT) \u2013 ICRU [Internet]. [citado 26 de agosto de 2025]. Disponible en: https:\/\/www.icru.org\/report\/prescribing-recording-and-reporting-intensity-modulated-photon-beam-therapy-imrticru-report-83\/"},{"issue":"1","key":"4245_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00066-011-0015-x","volume":"188","author":"N Hodapp","year":"2012","unstructured":"Hodapp N. Der ICRU-Report 83: Verordnung, Dokumentation und Kommunikation der fluenzmodulierten Photonenstrahlentherapie (IMRT). Strahlenther Onkol. 2012;188(1):97\u2013100.","journal-title":"Strahlenther Onkol."},{"issue":"4","key":"4245_CR28","doi-asserted-by":"publisher","first-page":"e53","DOI":"10.1002\/mp.12810","volume":"45","author":"M Miften","year":"2018","unstructured":"Miften M, Olch A, Mihailidis D, Moran J, Pawlicki T, Molineu A, et al. Tolerance limits and methodologies for IMRT measurement-based verification QA: Recommendations of AAPM Task Group No. 218. Med Phys. 2018;45(4):e53-83.","journal-title":"Med Phys."},{"key":"4245_CR29","unstructured":"IBM Corp. IBM SPSS Statistics for Windows, Version 28.0. Armonk, NY: IBM Corp; 2021."},{"issue":"17","key":"4245_CR30","doi-asserted-by":"publisher","first-page":"4220","DOI":"10.3390\/cancers15174220","volume":"15","author":"M K\u00f6ksal","year":"2023","unstructured":"K\u00f6ksal M, \u00d6zkan O, Holderried T, Heine A, Brossart P, Gawish A, et al. Optimized conformal total body irradiation with VMAT using a linear-accelerator-based radiosurgery treatment system in comparison to the golden standard helical tomotherapy. Cancers. 2023;15(17):4220.","journal-title":"Cancers."},{"issue":"4","key":"4245_CR31","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.31557\/APJCP.2023.24.4.1239","volume":"24","author":"V Kaliyaperumal","year":"2023","unstructured":"Kaliyaperumal V, Kataria T, Tamilselvan S, Gupta D, Abraham SK, Narang K, et al. Optimal combination of pitch, modulation factor and dosimetric considerations in treatment planning for total body irradiation using helical tomotherapy. Asian Pac J Cancer Prev APJCP. 2023;24(4):1239\u201348.","journal-title":"Asian Pac J Cancer Prev APJCP"},{"issue":"1","key":"4245_CR32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.zemedi.2019.05.002","volume":"30","author":"T Wilhelm-Buchstab","year":"2020","unstructured":"Wilhelm-Buchstab T, Leitzen C, Schmeel LC, Simon B, Koch D, Schmeel FC, et al. Total body irradiation: Significant dose sparing of lung tissue achievable by helical tomotherapy. Z F\u00fcr Med Phys. 2020;30(1):17\u201323.","journal-title":"Z F\u00fcr Med Phys."},{"key":"4245_CR33","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13014-015-0412-x","volume":"10","author":"L Yao","year":"2015","unstructured":"Yao L, Zhu L, Wang J, Liu L, Zhou S, Jiang S, et al. Positioning accuracy during VMAT of gynecologic malignancies and the resulting dosimetric impact by a 6-degree-of-freedom couch in combination with daily kilovoltage cone beam computed tomography. Radiat Oncol Lond Engl. 2015;10:104.","journal-title":"Radiat Oncol Lond Engl."},{"issue":"2","key":"4245_CR34","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1080\/02841860802245155","volume":"48","author":"M Nielsen","year":"2009","unstructured":"Nielsen M, Bertelsen A, Westberg J, Jensen HR, Brink C. Cone beam CT evaluation of patient set-up accuracy as a QA tool. Acta Oncol. 2009;48(2):271\u20136.","journal-title":"Acta Oncol"},{"key":"4245_CR35","doi-asserted-by":"crossref","unstructured":"Sandt M, Marcet S, Guesnel N, Claude L, Martel I, Biston MC. Implementation of Linac-based VMAT total body irradiation technique on Elekta platform using surface-guided radiation therapy. Phys Medica Eur J Med Phys [Internet]. 1 de marzo de 2025 [citado 26 de agosto de 2025];131. Disponible en: https:\/\/www.physicamedica.com\/article\/S1120-1797(25)00050-X\/fulltext","DOI":"10.1016\/j.ejmp.2025.104940"},{"key":"4245_CR36","doi-asserted-by":"publisher","first-page":"1459287","DOI":"10.3389\/fonc.2024.1459287","volume":"14","author":"C Hui","year":"2024","unstructured":"Hui C, Simiele E, Lozko Y, Romero I, Skinner L, Binkley MS, et al. Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation. Front Oncol. 2024;14:1459287.","journal-title":"Front Oncol."},{"key":"4245_CR37","doi-asserted-by":"publisher","first-page":"1573334","DOI":"10.3389\/fped.2025.1573334","volume":"13","author":"PRD Pelegrina","year":"2025","unstructured":"Pelegrina PRD, de Tavares CB, Rodrigues AM, Loth G, Nichele S, Kuwahara C, et al. Clinical outcomes and relapse patterns in pediatric acute leukemia patients undergoing hematopoietic cell transplantation: a multicenter Brazilian experience. Front Pediatr. 2025;13:1573334.","journal-title":"Front Pediatr."},{"issue":"4","key":"4245_CR38","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.bbmt.2017.11.025","volume":"24","author":"P Kebriaei","year":"2018","unstructured":"Kebriaei P, Anasetti C, Zhang MJ, Wang HL, Aldoss I, de Lima M, et al. Intravenous busulfan compared to total body irradiation pre-transplant conditioning for adults with acute lymphoblastic leukemia. Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl. 2018;24(4):726\u201333.","journal-title":"Biol Blood Marrow Transpl J Am Soc Blood Marrow Transpl."}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-026-04245-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-026-04245-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-026-04245-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:29:03Z","timestamp":1784975343000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-026-04245-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":38,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["4245"],"URL":"https:\/\/doi.org\/10.1007\/s12094-026-04245-4","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"assertion":[{"value":"24 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The manuscript describes routine clinical practice and does not involve research interventions; therefore, formal ethical committee approval was not required according to our regional legislation. Informed consent was obtained from all patients in accordance with standard clinical practice.","order":2,"name":"Ethics","label":"Ethical approval and informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The data supporting the findings of this study are not publicly available due to confidentiality and data protection considerations.","order":3,"name":"Ethics","label":"Data availability","group":{"name":"EthicsHeading","label":"Declarations"}}]}}