{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:14:44Z","timestamp":1790162084689,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Transl Oncol"],"DOI":"10.1007\/s12094-026-04344-2","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T19:29:50Z","timestamp":1775849390000},"page":"4758-4766","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immune phenotype and RAS\/BRAF status predict outcomes after lung metastasectomy for colorectal cancer"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-3570","authenticated-orcid":false,"given":"Berta","family":"Martin-Cullell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Piedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Cristina","family":"Virgili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Fumagalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Cerd\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Mirallas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Trujillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Belda-Sanch\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Szafranska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"P\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"issue":"3","key":"4344_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL,\u00a0Laversanne M, Soerjomataram I, Jemal A\u00a0et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"key":"4344_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/srep29765","volume":"6","author":"M Riihim\u00e4ki","year":"2016","unstructured":"Riihim\u00e4ki M, Hemminki A, Sundquist K, Hemminki K. Patterns of metastasis in colon and rectal cancer. Sci Rep. 2016;6:29765.","journal-title":"Sci Rep"},{"issue":"8","key":"4344_CR3","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","volume":"27","author":"E Van Cutsem","year":"2016","unstructured":"Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol. 2016;27(8):1386\u2013422.","journal-title":"Ann Oncol"},{"issue":"10","key":"4344_CR4","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1136\/gut.2010.211557","volume":"59","author":"E Mitry","year":"2010","unstructured":"Mitry E, Guiu B, Cosconea S, Jooste V, Faivre J, Bouvier AM. Epidemiology, management and prognosis of colorectal cancer with lung metastases: a 30-year population-based study. Gut. 2010;59(10):1383\u20138.","journal-title":"Gut"},{"issue":"2","key":"4344_CR5","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1245\/s10434-012-2726-3","volume":"20","author":"M Gonzalez","year":"2013","unstructured":"Gonzalez M, Poncet A, Combescure C, Robert J, Ris HB, Gervaz P. Risk factors for survival after lung metastasectomy in colorectal cancer patients: a systematic review and meta-analysis. Ann Surg Oncol. 2013;20(2):572\u20139.","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"4344_CR6","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.athoracsur.2007.02.093","volume":"84","author":"J Pfannschmidt","year":"2007","unstructured":"Pfannschmidt J, Dienemann H, Hoffmann H. Surgical resection of pulmonary metastases from colorectal cancer: a systematic review of published series. Ann Thorac Surg. 2007;84(1):324\u201338.","journal-title":"Ann Thorac Surg"},{"issue":"22","key":"4344_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16223741","volume":"16","author":"C Berlin","year":"2024","unstructured":"Berlin C, Andrieux G, Menzel M, St\u00f6ger GJ, Gengenbach A, Sch\u00e4fer L et al. Long-term outcome after resection of hepatic and pulmonary metastases in multivisceral colorectal cancer. Cancers (Basel). 2024;16(22):3741.","journal-title":"Cancers (Basel)"},{"issue":"5","key":"4344_CR8","doi-asserted-by":"publisher","first-page":"FSO471","DOI":"10.2144\/fsoa-2019-0120","volume":"6","author":"F Londero","year":"2020","unstructured":"Londero F, Grossi W, Morelli A, Parise O, Masullo G, Tetta C et al. Surgery versus stereotactic radiotherapy for treatment of pulmonary metastases: a systematic review of the literature. Future Sci OA. 2020;6(5):FSO471.","journal-title":"Future Sci OA"},{"issue":"3","key":"4344_CR9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1097\/00000658-199909000-00004","volume":"230","author":"Y Fong","year":"1999","unstructured":"Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer. Ann Surg. 1999;230(3):309\u201318.","journal-title":"Ann Surg"},{"issue":"9","key":"4344_CR10","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1002\/bjs.10838","volume":"105","author":"GA Margonis","year":"2018","unstructured":"Margonis GA, Sasaki K, Gholami S, Kim Y, Andreatos N, Rezaee N et al. Genetic and morphological evaluation (GAME) score for patients with colorectal liver metastases. Br J Surg. 2018;105(9):1210\u201320.","journal-title":"Br J Surg"},{"issue":"3","key":"4344_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znae016","volume":"111","author":"B Mart\u00edn-Cullell","year":"2024","unstructured":"Mart\u00edn-Cullell B, Virgili AC, Riera P, Fumagalli C, Mirallas O, Pelegrin FJ et al. Histopathological, clinical, and molecular (HICAM) score for patients with colorectal liver metastases. Br J Surg. 2024;111(3):znae016.","journal-title":"Br J Surg"},{"issue":"3","key":"4344_CR12","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezad059","volume":"63","author":"A Gkikas","year":"2023","unstructured":"Gkikas A, Kakos C, Lampridis S, Godolphin PJ, Patrini D. Preoperative prognostic factors for 5-year survival following pulmonary metastasectomy from colorectal cancer: a systematic review and meta-analysis. Eur J Cardiothorac Surg. 2023;63(3):ezad059.","journal-title":"Eur J Cardiothorac Surg"},{"key":"4344_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2021.153414","volume":"222","author":"E Pilozzi","year":"2021","unstructured":"Pilozzi E, Fedele D, Montori A, Lorenzon L, Peritore V, Mannocchi G et al. Histological growth patterns and molecular analysis of resected colorectal lung metastases. Pathol Res Pract. 2021;222:153414.","journal-title":"Pathol Res Pract"},{"issue":"7","key":"4344_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16071408","volume":"16","author":"F Petrella","year":"2024","unstructured":"Petrella F, Danuzzo F, Sibilia MC, Vaquer S, Longarini R, Guidi A et al. Colorectal cancer pulmonary metastasectomy: when, why and how. Cancers (Basel). 2024;16(7):1408.","journal-title":"Cancers (Basel)"},{"key":"4344_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3837-y","volume":"20","author":"T Treasure","year":"2019","unstructured":"Treasure T, Farewell V, Macbeth F,\u00a0Monson K, Williams NR, Brew-Graves C  et al. Pulmonary metastasectomy versus continued active monitoring in colorectal cancer (PulMiCC): a multicentre randomized clinical trial. Trials. 2019;20:718.","journal-title":"Trials"},{"issue":"1","key":"4344_CR16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s13019-023-02434-8","volume":"18","author":"Y Shishido","year":"2023","unstructured":"Shishido Y, Ishii M, Maeda T, Kokado Y, Masuya D, Kusama T et al. Survival outcomes of lung metastases from colorectal cancer treated with pulmonary metastasectomy or modern systemic chemotherapy: a single institution experience. J Cardiothorac Surg. 2023;18(1):327.","journal-title":"J Cardiothorac Surg"},{"issue":"6","key":"4344_CR17","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1097\/SLA.0b013e31826eda3b","volume":"257","author":"T Iida","year":"2013","unstructured":"Iida T, Nomori H, Shiba M, Nakajima J, Okumura S, Horio H et al. Prognostic factors after pulmonary metastasectomy for colorectal cancer and rationale for determining surgical indications: a retrospective analysis. Ann Surg. 2013;257(6):1059\u201364.","journal-title":"Ann Surg"},{"issue":"10","key":"4344_CR18","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1093\/annonc\/mds100","volume":"23","author":"S Salah","year":"2012","unstructured":"Salah S, Watanabe K, Welter S, Park JS, Park JW, Zabaleta J et al. Colorectal cancer pulmonary oligometastases: pooled analysis and construction of a clinical lung metastasectomy prognostic model. Ann Oncol. 2012;23(10):2649\u201355.","journal-title":"Ann Oncol"},{"issue":"24","key":"4344_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246206","volume":"13","author":"R Chandra","year":"2021","unstructured":"Chandra R, Karalis JD, Liu C, Murimwa GZ, Park JV, Heid CA et al. The colorectal cancer tumor microenvironment and its impact on liver and lung metastasis. Cancers (Basel). 2021;13(24):6206.","journal-title":"Cancers (Basel)"},{"issue":"5","key":"4344_CR20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1089\/jir.2021.0214","volume":"42","author":"W Da","year":"2022","unstructured":"Da W, Yinhang W, Jing Z, Jiamin X, Xinyi G, Yongmao S, Yuefen P. Immune-related biomarkers associated with lung metastasis from the colorectal cancer microenvironment. J Interferon Cytokine Res. 2022;42(5):220\u201334.","journal-title":"J Interferon Cytokine Res"},{"issue":"3","key":"4344_CR21","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkab026","volume":"5","author":"DJ H\u00f6ppener","year":"2021","unstructured":"H\u00f6ppener DJ, Galjart B, Nierop PMH, Buisman FE, Van der Stok E,  Coebergh van den Braak RR et al. Histopathological growth patterns and survival after resection of colorectal liver metastasis: an external validation study. JNCI Cancer Spectr. 2021;5(3):pkab026.","journal-title":"JNCI Cancer Spectr"},{"issue":"4","key":"4344_CR22","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/bjc.2014.499","volume":"112","author":"S Renaud","year":"2015","unstructured":"Renaud S, Romain B, Falcoz PE, Olland A, Santelmo N, Brigand C et al. KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colorectal cancer. Br J Cancer. 2015;112(4):720\u20138.","journal-title":"Br J Cancer"},{"issue":"7","key":"4344_CR23","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1002\/jso.26631","volume":"124","author":"JC Kim","year":"2021","unstructured":"Kim JC, Ha YJ, Park IJ, Kim CW, Yoon YS, Lee JL et al. Tumor immune microenvironment of primary colorectal adenocarcinomas metastasizing to the liver or lungs. J Surg Oncol. 2021;124(7):1136\u201345.","journal-title":"J Surg Oncol"}],"container-title":["Clinical and Translational Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-026-04344-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12094-026-04344-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12094-026-04344-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:41:34Z","timestamp":1790160094000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12094-026-04344-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":23,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["4344"],"URL":"https:\/\/doi.org\/10.1007\/s12094-026-04344-2","relation":{},"ISSN":["1699-3055"],"issn-type":[{"value":"1699-3055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"13 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"O. Mirallas reports writing support from Roche, speakers\u00b4 bureau honoraria from MSD Merck and Sharp, Janssen Pharmaceuticals, Pfizer, and Astra Zeneca; and travel support from Takeda, and Recordati. All other authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study was approved by the Ethics Committee of Hospital de la Santa Creu i Sant Pau (protocol IIBSP-CCR-2023-90, approved February 2024). The requirement for informed consent was waived due to the retrospective nature of the study, in accordance with institutional and national regulations.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}]}}